AhR Cancer Research Results

AhR, Aryl Hydrocarbon Receptor: Click to Expand ⟱
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AHR (Aryl Hydrocarbon Receptor; AhR) — Ligand-activated basic helix-loop-helix PAS-family transcription factor that functions as an environmental, dietary, microbial-metabolite, and endogenous chemical sensor. Following ligand binding, AHR translocates to the nucleus, heterodimerizes with ARNT/HIF-1β, and binds xenobiotic response elements (XREs) to regulate genes involved in xenobiotic metabolism, immunity, inflammation, barrier integrity, development, metabolism, and cellular differentiation.

Typical modulation in cancer: Highly context-dependent. Persistent or tumor-derived AHR activation frequently promotes tumor-cell survival, EMT, migration, invasion, cancer stemness, immune suppression, and resistance to therapy. However, AHR activation can also produce cell-cycle arrest or tumor-suppressive effects in selected cancers and with specific ligands.

Typical modulation in Alzheimer’s disease: Context-dependent. AHR regulates neuroimmune signaling, microglial responses, tryptophan-derived metabolites, oxidative stress, and inflammatory pathways. Dysregulated AHR signaling has been implicated in neurodegenerative disease, but both protective and detrimental effects have been reported depending on ligand, cell type, and disease context.

Typical mechanistic relationship: AHR ligand → AHR activation → nuclear translocation → ARNT heterodimerization → XRE binding → CYP1A1/CYP1B1/AHRR and other target-gene transcription. AHR also interacts with STAT3, NF-κB, estrogen-receptor, and immune-regulatory pathways.
Scientific Papers found: Click to Expand⟱
8851- DIM,    3,3’-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs
- Review, Var, NA
Apoptosis↑, NF-kB↓, Akt↓, Wnt↓, PI3K↓, mTOR↓, PSA↓, Let-7↓, miR-34a↓, EZH2↓, NOTCH1↓, AR↓, E-cadherin↑, Zeb1↓, Vim↓, Slug↓, EMT↓, MTA2↓, NF-kB↓, IRAK1↓, EGFR↓, SOX4↓, FOXM1↓, p27/CDKN1B↓, AhR↓, EZH2↓, Wnt↓, PUMA↓, AEG1↑, ROS↑, PPARα↑, CycB/CCNB1↑,
8853- DIM,    Chemopreventive properties of 3,3′-diindolylmethane in breast cancer: evidence from experimental and human studies
- Review, Var, NA
AhR↓, NRF2↑, *ROS↓, *p‑BRCA1↑, *COX2/PTGS2↓, CYP19↓, uPA↓, VEGF↓, MMP9↓, TumCMig↓, FOXM1↓, mTOR↓, Akt↓, radioP↑, ATM?, BioAv↑, BioAv↓, Dose↝, BioAv↑, Half-Life↝,
8852- DIM,    3,3'-Diindolylmethane modulates aryl hydrocarbon receptor of esophageal squamous cell carcinoma to reverse epithelial-mesenchymal transition through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway
- in-vitro, ESCC, TE1 - in-vitro, ESCC, KYSE-30
AhR↓, TumCMig↓, TumCI↓, β-catenin/ZEB1↓, Vim↓, Slug↓, CLDN1↑, COX2/PTGS2↓, PGE2↓, ROCK1↓, ROCK1↓, EMT↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↑, 1,   ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   PUMA↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 2,   EGFR↓, 1,   mTOR↓, 2,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 2,   FOXM1↓, 2,   miR-34a↓, 1,   MTA2↓, 1,   SOX4↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM?, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↑, 1,   p27/CDKN1B↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↓, 1,   NOTCH1↓, 1,   Wnt↓, 2,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   E-cadherin↑, 1,   EMT↓, 2,   MMP9↓, 1,   ROCK1↓, 2,   Slug↓, 2,   TumCI↓, 1,   TumCMig↓, 2,   uPA↓, 1,   Vim↓, 2,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IRAK1↓, 1,   NF-kB↓, 2,   PGE2↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 3,   AR↓, 1,   CYP19↓, 1,   PPARα↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 2,   Dose↝, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   EZH2↓, 2,   FOXM1↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

radioP↑, 1,  
Total Targets: 52

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p‑BRCA1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

p‑BRCA1↑, 1,  
Total Targets: 4

Scientific Paper Hit Count for: AhR, Aryl Hydrocarbon Receptor
3 Diindolylmethane
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1897  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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