Alanine Cancer Research Results

Alanine, Alanine: Click to Expand ⟱
Source:
Type:

Alanine (Ala) — Nonessential amino acid produced primarily through transamination of pyruvate. Alanine participates in amino-acid metabolism, nitrogen transport, gluconeogenesis, and the glucose-alanine cycle and can serve as an alternative carbon source for cellular metabolism.

Typical modulation in cancer: Context-dependent. Alanine can support tumor metabolism as a carbon and nitrogen source, particularly in metabolically stressed tumors. In pancreatic cancer, stromal cells can supply alanine to tumor cells, where it contributes carbon to the TCA cycle and supports biosynthesis and growth.

Typical mechanistic relationships: Pyruvate ↔ alanine via ALT/GPT; alanine → pyruvate → TCA cycle / gluconeogenesis.
Scientific Papers found: Click to Expand⟱
8846- DIM,  ORM,    Diindolylmethane Promotes Metabolic Crisis and Enhances the Efficacy of Centchroman in Breast Cancer: A 1H NMR-Based Approach
- vitro+vivo, BC, NA
AntiCan↑, EPR↑, Synergy↑, TumCG↓, Glycolysis↓, PKM2↓, GLUT1↓, Hif1a↓, eff↑, Glycine↓, Alanine↓, toxicity↓, Dose↝, TumW↓, Ki-67↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

Alanine↓, 1,   Glycine↓, 1,   Glycolysis↓, 1,   PKM2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

Ki-67↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Ki-67↓, 1,   TumCG↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,  

Barriers & Transport(tgid=15) ⓘ

EPR↑, 1,   GLUT1↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,   eff↑, 1,   Synergy↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   toxicity↓, 1,   TumW↓, 1,  
Total Targets: 16

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Alanine, Alanine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1899  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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