Polyps Cancer Research Results

Polyps, Polyps: Click to Expand ⟱
Source:
Type:

Polyps — Abnormal tissue growths projecting from a mucosal surface. In cancer-prevention studies, the term most commonly refers to colorectal or intestinal polyps, particularly adenomatous polyps that can serve as precursor lesions for colorectal cancer.

Typical modulation: Polyp number ↓, polyp size ↓, polyp burden ↓, or recurrence ↓ are generally favorable outcomes. Increased polyp number, size, dysplasia, or progression is generally unfavorable.

Cancer relevance: High for colorectal cancer prevention and familial adenomatous polyposis studies. Adenomatous polyps are recognized precancerous lesions, whereas hyperplastic, inflammatory, and other polyp types may have different malignant potential.

Recommended interpretation: Record the most specific endpoint available, such as adenoma number, adenoma size, total polyp burden, advanced adenoma, or polyp recurrence, rather than using a generic polyp endpoint when the study provides histologic classification.
Scientific Papers found: Click to Expand⟱
9193- ITCs,  PEITC,  BITC,  SFN,    Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research
- Review, Var, NA
Risk↓, TumCCA↑, TumCD↑, selectivity↑, TumCP↓, angioG↓, EMT↓, CSCs↓, NF-kB↓, NOTCH↑, BioAv↑, AntiCan↑, Synergy↑, Polyps↓, ROS↑, compIII↓, ChemoSen↑, RadioS↑, *p‑4E-BP1↓,
9057- PatchO,    Essential Oil Compound, Patchouli Alcohol, Represses Tumor Formation in Vivo and Causes G1 Arrest by Downregulating β-catenin Transcriptional Activity in Colon Cancer Cells (FS13-02-19)
- vitro+vivo, CRC, HT-29 - vitro+vivo, Colon, Caco-2
*Inflam↓, *Obesity↓, *AntiCan↑, Dose?, TumNum↓, TumCCA↑, TumCP↓, Polyps↓, β-catenin/ZEB1↓,
8985- PCorn,    Efficacy and safety of lyophilized concentrate purple corn (Zea mays L.) in preventing the formation of colonic polyps
- Trial, CRC, NA
Dose↝, Polyps↓, eff↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compIII↓, 1,  

Cell Death(tgid=5) ⓘ

TumCD↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   NOTCH↑, 1,   TumCP↓, 2,  

Migration(tgid=13) ⓘ

EMT↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 1,   Dose?, 1,   Dose↝, 1,   eff↑, 1,   RadioS↑, 1,   selectivity↑, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Polyps↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   Risk↓, 1,   TumNum↓, 1,  
Total Targets: 23

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   Obesity↓, 1,  
Total Targets: 4

Scientific Paper Hit Count for: Polyps, Polyps
1 Isothiocyanates
1 Phenethyl isothiocyanate
1 Benzyl isothiocyanate
1 Sulforaphane (mainly Broccoli)
1 Patchouli Oil (Pogostemon cablin)
1 Purple Corn / Purple Maize
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1907  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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