PFKFB3 Cancer Research Results

PFKFB3, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3: Click to Expand ⟱
Source:
Type:

PFKFB3 (6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3) — Bifunctional metabolic enzyme that regulates cellular glycolytic flux by controlling levels of fructose-2,6-bisphosphate (F2,6BP), a potent allosteric activator of phosphofructokinase-1 (PFK1). PFKFB3 has relatively high kinase activity and strongly promotes glycolysis.

Typical modulation in cancer: Frequently ↑ and generally unfavorable. Elevated PFKFB3 supports aerobic glycolysis, glucose utilization, proliferation, angiogenesis, cell-cycle progression, migration, and resistance to metabolic stress. PFKFB3 inhibition is being investigated as an anticancer strategy.

Typical mechanistic relationship: PFKFB3 activity ↑ → fructose-2,6-bisphosphate ↑ → PFK1 activation ↑ → glycolytic flux ↑ → ATP and biosynthetic precursor production ↑ → proliferation and tumor growth ↑.

Additional cancer relevance: PFKFB3 is also expressed in endothelial cells and can promote tumor angiogenesis and vascular sprouting through enhanced glycolytic metabolism.
Scientific Papers found: Click to Expand⟱
9244- ISO, IH,    Isorhamnetin inhibits bladder cancer progression by mediating glycolysis through targeting the SRC/PI3K/Akt axis
- in-vitro, Bladder, 5637
TumCP↓, TumCMig↓, TumCI↓, TumCA↓, Glycolysis↓, TumCCA↑, Apoptosis↑, p‑Src↓, PI3K↓, Akt↓, mTOR↓, HK2↓, GLUT1↓, PFKFB3↓, ECAR↓, OCR↓, GlucoseCon↓, lactateProd↓,
9080- MGF,    Mangiferin targets PFKFB3 to inhibit glioblastoma progression by suppressing glycolysis and PI3K/AKT/mTOR signaling
- vitro+vivo, GBM, NA
PI3K?, Akt?, mTOR?, PFKFB3↓, TumCCA↑, Apoptosis↑, Glycolysis↓, TumCP↓, TumCMig↓, toxicity↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR↓, 1,   GlucoseCon↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   PFKFB3↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt?, 1,   Akt↓, 1,   mTOR?, 1,   mTOR↓, 1,   PI3K?, 1,   PI3K↓, 1,   p‑Src↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 2,  

Migration(tgid=13) ⓘ

TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PFKFB3, 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1920  State#:%  Dir#:1
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