GRB2 Cancer Research Results

GRB2, ASH, Growth Factor Receptor Bound Protein 2: Click to Expand ⟱
Source:
Type:

GRB2 (Growth Factor Receptor Bound Protein 2) — Cytoplasmic adaptor protein containing one SH2 and two SH3 domains that couples activated receptor tyrosine kinases and other phosphorylated signaling proteins to downstream pathways. GRB2 commonly recruits SOS proteins, promoting RAS activation and subsequent RAF/MEK/ERK signaling.

Typical modulation in cancer: Frequently functionally activated and generally tumor-promoting when upstream growth-factor signaling is elevated. Increased GRB2-dependent signaling can support proliferation, survival, migration, invasion, transformation, and resistance to therapy. GRB2 itself is an adaptor rather than a kinase.

Typical mechanistic relationship: Growth factor receptor activation → receptor tyrosine phosphorylation → GRB2 recruitment → SOS1/SOS2 recruitment → RAS-GTP ↑ → RAF → MEK → ERK signaling ↑ → proliferation and survival ↑.

Additional signaling: GRB2 can also participate in PI3K/AKT, cytoskeletal, immune-receptor, and integrin-associated signaling depending on cellular context.
Scientific Papers found: Click to Expand⟱
9233- AITC,    Allyl isothiocyanate inhibits cell migration and invasion in human gastric cancer AGS cells via affecting PI3K/AKT and MAPK signaling pathway in vitro
- in-vitro, GC, AGS
tumCV↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, p‑Akt↓, GRB2↓, Vim↓,
9205- BITC,    Benzyl Isothiocyanate (BITC) Inhibits Migration and Invasion of Human Colon Cancer HT29 Cells by Inhibiting Matrix Metalloproteinase-2/-9 and Urokinase Plasminogen (uPA) through PKC and MAPK Signaling Pathway
- in-vitro, CRC, HT-29
TumCMig↓, TumCI↓, MMP2↓, uPA↓, p‑JNK↓, p‑ERK↓, PI3K↓, PKCδ↓, cFos↓, cJun↓, RAS↓, FAK↓, GRB2↓,
9199- BITC,    Benzyl isothiocyanate (BITC) inhibits migration and invasion of human gastric cancer AGS cells via suppressing ERK signal pathways
- in-vitro, GC, NA
TumCMig↓, TumCI↓, ERK↓, RAS↓, GRB2↓, Rho↓, iNOS↓, COX2/PTGS2↓, MMP2↓, MMP7↓, MMP9↓,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   ERK↓, 1,   p‑ERK↓, 1,   GRB2↓, 3,   p‑JNK↓, 1,   PI3K↓, 1,   PKCδ↓, 1,   RAS↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cFos↓, 1,  

Migration(tgid=13) ⓘ

FAK↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 2,   Rho↓, 1,   TumCI↓, 3,   TumCMig↓, 3,   uPA↓, 1,   Vim↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,  
Total Targets: 22

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: GRB2, ASH, Growth Factor Receptor Bound Protein 2
2 Benzyl isothiocyanate
1 Allyl isothiocyanate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1928  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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