β-Tubulin Cancer Research Results

β-Tubulin, TUBB, Beta-Tubulin: Click to Expand ⟱
Source:
Type:

Beta-Tubulin (β-Tubulin; TUBB family) — Structural protein family that heterodimerizes with alpha-tubulin to form microtubules. Microtubules are essential components of the cytoskeleton and mitotic spindle and participate in chromosome segregation, intracellular transport, cell morphology, migration, and division.

Typical modulation in cancer: β-Tubulin expression and isotype composition can be altered in cancer. Disruption of β-tubulin polymerization or microtubule dynamics can inhibit mitosis and induce cell-cycle arrest and apoptosis. Increased expression of specific isotypes, particularly TUBB3, is associated in several cancers with aggressive behavior and resistance to microtubule-targeting chemotherapy.

Typical mechanistic relationship: Alpha-tubulin + beta-tubulin → microtubule polymerization → mitotic spindle formation and chromosome segregation. Microtubule destabilization or excessive stabilization → spindle dysfunction → mitotic arrest → apoptosis / cell death.

Drug relevance: β-Tubulin is a major target of taxanes, vinca alkaloids, colchicine-site microtubule inhibitors, and several benzimidazole compounds. Different drug classes either stabilize or destabilize microtubules but can ultimately disrupt mitosis.
Scientific Papers found: Click to Expand⟱
9226- AITC,  Cisplatin,    Synergistic effect of allyl isothiocyanate (AITC) on cisplatin efficacy in vitro and in vivo
- vitro+vivo, Var, NA
ChemoSen↑, Apoptosis↑, Bcl-2↓, survivin↓, TumCG↓, toxicity↓, TumCCA↑, β-Tubulin↓, CDC2↓, CycB/CCNB1↓, CDC25↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   survivin↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CycB/CCNB1↓, 1,   TumCCA↑, 1,   β-Tubulin↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: β-Tubulin, TUBB, Beta-Tubulin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1930  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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