MRP5 Cancer Research Results

MRP5, ABCC5, ATP Binding Cassette Subfamily C Member 5; Multidrug Resistance-Associated Protein 5: Click to Expand ⟱
Source:
Type:

ABCC5 (ATP Binding Cassette Subfamily C Member 5; Multidrug Resistance-Associated Protein 5, MRP5) — ATP-dependent membrane efflux transporter of the ABC transporter family. ABCC5 transports endogenous organic anions, including cyclic nucleotides such as cGMP and cAMP, and can export selected nucleotide analogues and drug metabolites.

Typical modulation in cancer: Frequently ↑ in drug-resistant tumor cells and generally unfavorable when increased expression reduces intracellular exposure to anticancer agents. Elevated ABCC5/MRP5 can contribute to multidrug resistance, altered nucleotide signaling, and reduced therapeutic sensitivity.

Typical mechanistic relationship: ABCC5/MRP5 expression or activity ↑ → drug/metabolite efflux ↑ → intracellular drug concentration ↓ → treatment resistance ↑.

Drug-resistance relevance: ABCC5 has been associated with resistance to selected nucleoside and nucleotide analogues and other anticancer compounds, although substrate specificity differs from other MRP family members such as ABCC1/MRP1 and ABCC2/MRP2.

Physiologic relevance: ABCC5 also regulates extracellular and intracellular cyclic-nucleotide balance through transport of cGMP and cAMP and therefore has functions beyond drug resistance.
Scientific Papers found: Click to Expand⟱
9255- ISO, IH,    Isorhamnetin Modulates Drug-Resistance-Related Biomarkers in Colon Cancer Cells
- in-vitro, Colon, SW48 - in-vitro, CRC, HT-29
CYP1A1↓, CYP1B1↓, MRP1/ABCC1↓, MRP5↓, P-gp/ABCB1↓, GSTs↓, tumCV↓, TumCP↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSTs↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

CYP1A1↓, 1,   CYP1B1↓, 1,   MRP1/ABCC1↓, 1,   MRP5↓, 1,   P-gp/ABCB1↓, 1,  
Total Targets: 8

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: MRP5, ABCC5, ATP Binding Cassette Subfamily C Member 5; Multidrug Resistance-Associated Protein 5
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1933  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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