MMP9 Cancer Research Results

MMP9, MMP9: Click to Expand ⟱
Source: HalifaxProj(suppress)
Type:
Matrix metalloproteinase-9 (MMP-9) is an enzyme that plays a significant role in the degradation of extracellular matrix components.
MMP-9 facilitates the breakdown of the extracellular matrix, which can enable cancer cells to invade surrounding tissues and spread to distant sites (metastasis).
Elevated levels of MMP-9 have been associated with poor prognosis in several cancers, including breast, lung, and colorectal cancers.
MMP2 and MMP9: two enzymes are critical to tumor invasion.
Scientific Papers found: Click to Expand⟱
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
6462- 1,8-Cin,    Modes of Action of 1,8-Cineol in Infections and Inflammation
- Review, Var, NA - Review, AD, NA
*BioAv↑, *BBB↑, *AntiViral↑, *Bacteria↓, *AntiFungal↑, *Inflam↓, *BioAv↑, *MUC2↓, *MUC19↓, *NF-kB↓, *ICAM-1↓, *VCAM-1↓, DNAdam↑, *lipid-P↓, *PGE2↓, *IL4↓, *IL6↓, *IL1β↓, *IL6↓, eff↑, TGF-β↓, fascin↓, VEGF↓, MMP9↓, *MAPK↓, *ERK↓, JNK↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↑, *neuroP↑, *GSK‐3β↓, *AGEs↓, *BBB↑, *NLRP3↓,
2423- 2DG,  SRF,    2-Deoxyglucose and sorafenib synergistically suppress the proliferation and motility of hepatocellular carcinoma cells
- in-vitro, HCC, NA
ChemoSen↑, TumCP↓, cycD1/CCND1↓, MMP9↓,
5260- 3BP,    Systemic Delivery of Microencapsulated 3-Bromopyruvate for the Therapy of Pancreatic Cancer
- in-vivo, PC, NA
TumCG↓, toxicity↓, BioAv↝, GAPDH↓, toxicity↑, Dose↝, ATP↓, eff↑, TumCI↓, MMP9↓, toxicity↓,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
4559- AgNPs,    Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation
- in-vitro, BC, SkBr3 - in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, Colon, Caco-2
MMP2↓, MMP9↓, ROS↑, TumAuto↑, Apoptosis↑, ER Stress↑,
359- AgNPs,    Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells
- in-vitro, Lung, A549 - in-vitro, Nor, HEK293
Casp3↑, Casp9↑, P53↑, ROS↑, MMP2↓, MMP9↓, TumCCA↑, *toxicity↓, TumCMig↓, TumCI↓,
385- AgNPs,    Probiotic-derived silver nanoparticles target mTOR/MMP-9/BCL-2/dependent AMPK activation for hepatic cancer treatment
- in-vitro, Hepat, HepG2 - in-vitro, Hepat, WI38
TNF-α↑, IL33↑, mTOR↓, MMP9↓, Bcl-2↓, ROS↑, Apoptosis↑,
247- AL,    Allicin inhibits the invasion of lung adenocarcinoma cells by altering tissue inhibitor of metalloproteinase/matrix metalloproteinase balance via reducing the activity of phosphoinositide 3-kinase/AKT signaling
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
MMP2↓, MMP9↓, TIMP1↑, TIMP2↑, p‑Akt↓, PI3K/Akt↓,
282- ALA,    Alpha-lipoic acid induced apoptosis of PC3 prostate cancer cells through an alteration on mitochondrial membrane depolarization and MMP-9 mRNA expression
- in-vitro, Pca, PC3
MMP↓, Casp↑, MMP9↓,
283- ALA,    alpha-Lipoic acid reduces matrix metalloproteinase activity in MDA-MB-231 human breast cancer cells
- in-vitro, BC, MDA-MB-231
MMP2↓, MMP9↓, TumMeta↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
299- ALA,  Cisplatin,  PacT,    Anti-cancer effects of alpha lipoic acid, cisplatin and paclitaxel combination in the OVCAR-3 ovarian adenocarcinoma cell line
- in-vitro, Ovarian, OVCAR-3
MMP9↓, MMP11↓, MAPK↓,
1123- aLinA,    Linoleic acid induces an EMT-like process in mammary epithelial cells MCF10A
- in-vitro, BC, NA - in-vitro, NA, MCF10
TumCP↑, E-cadherin↓, Snail↑, Twist↑, ZEB2↑, FAK↑, NF-kB↑, MMP2↓, MMP9↓, *EMT↑, TumCI↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
1093- And,    Andrographolide attenuates epithelial‐mesenchymal transition induced by TGF‐β1 in alveolar epithelial cells
- in-vitro, Lung, A549
TGF-β↓, TumCMig↓, MMP2↓, MMP9↓, ECM/TCF↓, p‑SMAD2↓, p‑SMAD3↓, SMAD4↓, p‑ERK↓, ROS↓, NOX4↓, SOD2↑, SIRT1↑, FOXO3↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
7907- Api,  IVT,    Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells
- Review, Var, NA
ChemoSen↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, MMP↓, TumMeta↓, MAPK↓, VEGF↓, MMP9↓, TGF-β↓, Inflam↓, COX2/PTGS2↓, IL6↓, NF-kB↓, TumCCA↑, P53↑, cycD1/CCND1↓, BAX↑, Casp↓, Bcl-2↓, CD133↓, Nanog↓, SOX2↓, Akt↓, TumCP↓, TumCMig↓, YAP/TEAD↓, CCN2/CTGF↓, CCN1/CYR61↓, SIRT3↓, SIRT6↓, PCNA↓, DNMT1↓, miR-34a↑,
176- Api,    Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells
- in-vitro, BC, BT474
cl‑Casp8↑, cl‑Casp3↑, p‑JAK1↓, p‑JAK2↓, p‑STAT3↓, P53↑, VEGF↓, Hif1a↓, MMP9↓, TumCG↓, TumCCA↑, cl‑PARP↑,
244- Api,    Inhibition of the STAT3 signaling pathway contributes to apigenin-mediated anti-metastatic effect in melanoma
- in-vivo, Melanoma, B16-F10 - in-vivo, Melanoma, A375 - in-vivo, Melanoma, G361
STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, E-cadherin↑, N-cadherin↓, EMT↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2583- Api,  Rad,    The influence of apigenin on cellular responses to radiation: From protection to sensitization
- Review, Var, NA
radioP↑, RadioS↑, *COX2/PTGS2↓, *ROS↓, VEGF↓, MMP2↓, STAT3↓, AMPK↑, Apoptosis↑, MMP9↓, glucose↓,
1150- Api,    Apigenin inhibits the TNFα-induced expression of eNOS and MMP-9 via modulating Akt signalling through oestrogen receptor engagement
- in-vitro, Lung, EAhy926
eNOS↓, MMP9↓, Akt↓, p38↓, JNK↓,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1560- Api,    Apigenin as an anticancer agent
- Review, NA, NA
Apoptosis↑, Casp3∅, Casp8∅, TNF-α∅, Cyt‑c↑, MMP2↓, MMP9↓, Snail↓, Slug↓, NF-kB↓, p50↓, PI3K↓, Akt↓, p‑Akt↓,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
1148- ART/DHA,    Artemisinin inhibits extracellular matrix metalloproteinase inducer (EMMPRIN) and matrix metalloproteinase-9 expression via a protein kinase Cδ/p38/extracellular signal-regulated kinase pathway in phorbol myristate acetate-induced THP-1 macrophages
- in-vitro, AML, THP1
MMP9↓, EMMPRIN↓, p‑PKCδ↓, p‑JNK↓, p‑p38↓, p‑ERK↓,
5380- ART/DHA,    Artemisinin and Its Derivatives as Potential Anticancer Agents
- Review, Var, NA
TumCG↓, angioG↓, Ferroptosis↑, TumCP↑, TumAuto↑, CSCs↑, eff↑, YAP/TEAD↓, TumCCA↑, ROS↑, ChemoSen↑, N-cadherin↓, Vim↓, MMP9↓, eff↑, STAT3↓, CD133↓, CD44↓, Nanog↓, cMyc↓, OCT4↓, Akt↓, mTOR↓,
564- ART/DHA,  Cisplatin,    Dihydroartemisinin as a Putative STAT3 Inhibitor, Suppresses the Growth of Head and Neck Squamous Cell Carcinoma by Targeting Jak2/STAT3 Signaling
- in-vitro, NA, HN30
JAK2↓, STAT3↓, MMP2↓, MMP9↓, Mcl-1↓, Bcl-xL↓, cycD1/CCND1↓, VEGF↓, TumCCA↑, ChemoSen↑,
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
1177- Ash,    Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
- in-vivo, EC, NA
TumVol↓, MMP2↓, MMP9↓, NF-kB↓, COX2/PTGS2↓, NO↓, IL1β↓, IL6↓,
5384- AsP,  MEL,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
1146- AsP,    Potential use of nanoformulated ascorbyl palmitate as a promising anticancer agent: First comparative assessment between nano and free forms
- in-vivo, Nor, NA
TumCCA↑, Apoptosis↑, IL6↓, STAT3↓, angioG↓, TumMeta↓, VEGF↓, MMP9↓, SOD↑, Catalase↑, GSH↓, MDA↓, NO↓, *BioAv↑,
4811- ASTX,    Astaxanthin reduces MMP expressions, suppresses cancer cell migrations, and triggers apoptotic caspases of in vitro and in vivo models in melanoma
- vitro+vivo, Melanoma, A375 - vitro+vivo, Melanoma, A2058
ROS↓, MMPs↓, TumCMig↓, TumMeta↓, TumCCA↑, antiOx↑, MMP1↓, MMP2↓, MMP9↓,
5502- Ba,    An overview of pharmacological activities of baicalin and its aglycone baicalein: New insights into molecular mechanisms and signaling pathways
- Review, Var, NA
*AntiCan↑, *antiOx↑, *hepatoP↑, *neuroP↑, *ROS↓, Ca+2↑, ROS↑, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, MMP↓, Mcl-1↓, PI3K↓, Akt↓, mTOR↓, BAD↓, ERK↓, MEK↓, DR5↑, Fas↑, TumMeta↓, EMT↓, SMAD4↓, TGF-β↓, MMP9↓, MMP2↓, HIF-1↓, 12LOX↓,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
2606- Ba,    Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma
- Review, HCC, NA
ChemoSen↑, TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, MMPs↓, MAPK↓, TGF-β↓, ZFX↓, p‑MEK↓, ERK↓, MMP2↓, MMP9↓, uPA↓, TIMP1↓, TIMP2↓, NF-kB↓, p65↓, p‑IKKα↓, Fas↑, Casp2↑, Casp3↑, Casp8↑, Casp9↑, Bcl-xL↓, BAX↑, ER Stress↑, Ca+2↑, JNK↑, P53↑, ROS↑, H2O2↑, cMyc↓, CD24↓, 12LOX↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2615- Ba,    The Multifaceted Role of Baicalein in Cancer Management through Modulation of Cell Signalling Pathways
- Review, Var, NA
*AntiCan↓, *Inflam↓, TumCP↓, NF-kB↓, PPARγ↑, TumCCA↑, JAK2↓, STAT3↓, TumCMig↓, Glycolysis↓, MMP2↓, MMP9↓, selectivity↑, VEGF↓, Hif1a↓, cMyc↓, ChemoSen↑, ROS↑, p‑mTOR↓, PTEN↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
5543- BBM,    Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo
- in-vivo, Lung, B16-F10 - vitro+vivo, Lung, A549 - in-vitro, BC, MDA-MB-231
BioAv↓, Half-Life↓, eff↑, TumMeta↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, MMP2↓, MMP9↓, VEGF↓, Bcl-2↓, eff↑, EPR↑,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,

Showing Research Papers: 1 to 50 of 360
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 360

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

p‑AMT/GCST/T-protein↑, 1,   CBR1↓, 1,   CCN1/CYR61↓, 1,   compV↓, 1,   CTSK↓, 1,   CXCL16↓, 1,   ERCC3↑, 1,   HES1↓, 2,   Ingr↝, 1,   IQGAP3↓, 1,   KAI1/CD82↑, 1,   miR-106b↓, 1,   miR-107↑, 2,   miR-149↑, 1,   miR-195↑, 1,   miR-224↓, 2,   miR-422a↑, 2,   MMP16↓, 3,   NA↓, 1,   O-Glc↓, 1,   PLA2↓, 1,   PTN↓, 1,   SERPINH1/HSP47↓, 1,   URGCP/URG4↓, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 10,   antiOx⇅, 1,   ATF3↑, 1,   Catalase↓, 5,   Catalase↑, 3,   compI↓, 1,   Copper↓, 1,   Copper↑, 1,   CYP1A1↓, 3,   CYP1A1↑, 2,   Ferroptosis↑, 4,   frataxin↑, 1,   GPx↓, 2,   GPx↑, 4,   GPx4↓, 4,   GSH↓, 19,   GSH↑, 5,   GSR↑, 2,   GSTA1↑, 1,   GSTs↓, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 5,   HK1↓, 1,   HO-1↓, 9,   HO-1↑, 14,   HO-2↓, 1,   ICD↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 4,   lipid-P↑, 10,   MAD↓, 1,   MDA↓, 5,   MDA↑, 3,   MPO↓, 1,   NOX4↓, 1,   NQO1↓, 1,   NQO1↑, 3,   NRF2↓, 12,   NRF2↑, 15,   NRF2↝, 1,   p‑NRF2↓, 1,   mt-OXPHOS↓, 1,   PARK2↑, 1,   Prx↓, 1,   Prx4↑, 1,   PrxII↓, 1,   ROS?, 2,   ROS↓, 23,   ROS↑, 152,   ROS⇅, 7,   ROS∅, 1,   i-ROS↓, 2,   i-ROS↑, 2,   mt-ROS↑, 1,   SIRT3↓, 2,   SIRT3↑, 3,   SOD↓, 5,   SOD↑, 7,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 3,   TBARS↑, 1,   Thiols↓, 1,   Trx1↑, 1,   TrxR↓, 7,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 2,   Tf↓, 1,   TfR1/CD71↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 2,   AIF↑, 10,   ATP↓, 11,   Bfl-1↓, 1,   CDC2↓, 7,   CDC25↓, 9,   compIII↓, 1,   EGF↓, 5,   ETC↓, 1,   FGFR1↓, 3,   MEK↓, 5,   p‑MEK↓, 2,   mitResp↓, 1,   mitResp↑, 1,   MKK4↓, 1,   MKK7↓, 1,   MMP↓, 70,   MMP↑, 1,   MMP∅, 1,   MPT↑, 5,   mtDam↑, 6,   OCR↓, 3,   PINK1↑, 1,   Raf↓, 5,   e-Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 25,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 3,   ACC↑, 1,   AKT1↓, 2,   ALAT↓, 6,   ALAT↝, 1,   AMPK↓, 2,   AMPK↑, 19,   AMPK↝, 1,   p‑AMPK↑, 2,   ATG7↑, 1,   CAIX/CA9↑, 1,   cMyc↓, 38,   cMyc↑, 1,   p‑cMyc↑, 1,   ECAR↓, 1,   ECAR↝, 1,   FABP4↑, 1,   FASN↓, 3,   FASN↑, 1,   FGF21↓, 1,   GAPDH↓, 2,   GLO-I↓, 1,   glucoNG↓, 1,   glucose↓, 1,   GlucoseCon↓, 9,   GlutMet↓, 2,   Glycolysis↓, 20,   HK2↓, 10,   lactateProd↓, 9,   LDH↓, 3,   LDH↑, 4,   LDHA↓, 6,   LDL↓, 1,   lipidLev↓, 1,   NADPH↓, 3,   NADPH↑, 3,   PDH↝, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 5,   p‑PDK1 / PDPK1↓, 1,   PFK↓, 1,   PI3K/Akt↓, 4,   PKM2↓, 8,   PKM2↑, 1,   POLD1↓, 1,   PPARα↓, 2,   PPARα↑, 1,   PPARα↝, 1,   cl‑PPARα↓, 1,   PPARγ↓, 2,   PPARγ↑, 8,   p‑S6↓, 1,   p‑S6K↓, 1,   SIRT1↓, 6,   SIRT1↑, 9,   SIRT2↑, 1,   SREBP1/SREBF1↓, 2,   SREBP2↓, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 117,   Akt↑, 3,   p‑Akt↓, 35,   APAF1↑, 4,   Apoptosis↓, 4,   Apoptosis↑, 128,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 5,   Bak↑, 5,   BAX↓, 2,   BAX↑, 88,   BAX⇅, 1,   BAX↝, 1,   Bax:Bcl2↑, 21,   Bcl-2↓, 95,   Bcl-2↑, 3,   Bcl-xL↓, 31,   BID↓, 2,   BID↑, 6,   p‑BID↓, 1,   BIM↑, 3,   BMP2↓, 2,   Casp↓, 1,   Casp↑, 20,   Casp∅, 1,   cl‑Casp↑, 1,   Casp1↓, 1,   Casp1↑, 1,   Casp12?, 1,   Casp12↑, 2,   Casp2↑, 1,   Casp3↓, 5,   Casp3↑, 109,   Casp3∅, 1,   cl‑Casp3↑, 13,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 12,   cl‑Casp7↑, 1,   Casp8↑, 27,   Casp8∅, 1,   cl‑Casp8↑, 4,   proCasp8↑, 2,   Casp9↓, 1,   Casp9↑, 73,   p‑Casp9↑, 1,   cl‑Casp9↑, 8,   proCasp9↓, 1,   proCasp9↑, 1,   CBP↓, 1,   cFLIP↓, 4,   Chk2↓, 2,   CK2↓, 4,   Cyt‑c↓, 1,   Cyt‑c↑, 60,   Diablo↑, 12,   DR4↑, 8,   DR5↑, 21,   Endon↑, 2,   FADD↑, 2,   Fap1↓, 1,   Fas↓, 1,   Fas↑, 17,   FasL↓, 1,   FasL↑, 5,   FasL⇅, 1,   Ferroptosis↑, 4,   GSDME↑, 1,   HEY1↓, 2,   HGF/c-Met↓, 2,   hTERT/TERT↓, 10,   IAP1↓, 14,   IAP2/BIRC3↓, 6,   ICAD↓, 1,   iNOS↓, 18,   JNK↓, 12,   JNK↑, 17,   p‑JNK↓, 4,   p‑JNK↑, 2,   p‑JNK↝, 1,   MAPK↓, 32,   MAPK↑, 13,   p‑MAPK↓, 1,   Mcl-1?, 1,   Mcl-1↓, 24,   p‑Mcl-1↓, 1,   MDM2↓, 8,   MDM2↑, 1,   MOMP↑, 2,   Myc↓, 5,   Necroptosis↑, 1,   necrosis↑, 1,   NICD↓, 1,   NOXA↑, 3,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 19,   p38↓, 11,   p38↑, 13,   p‑p38↓, 3,   p‑p38↑, 4,   p‑p38↝, 1,   Proteasome↓, 1,   PUMA↑, 5,   Pyro↑, 3,   RIP1↑, 1,   survivin↓, 49,   Telomerase↓, 14,   TRAIL↑, 3,   TRAILR↑, 2,   TRPV1↑, 3,   TumCD↑, 7,   YAP/TEAD↓, 5,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   cSrc↓, 3,   FOXD3↑, 2,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   miR-25-5p↑, 1,   p70S6↓, 1,   SOX9?, 1,   SOX9↓, 2,   SOX9↑, 1,   Sp1/3/4↓, 10,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 8,   cJun↑, 1,   p‑cJun↓, 1,   EZH2↓, 5,   H3↑, 1,   ac‑H3↓, 1,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↓, 1,   ac‑H4↑, 2,   HATs↓, 7,   HATs↑, 1,   Matr↓, 1,   miR-21↓, 7,   miR-21↑, 1,   miR-27a-3p↓, 1,   miR-27a-3p↑, 1,   other↓, 3,   other↑, 1,   other↝, 3,   other∅, 1,   PhotoS↑, 1,   pRB↓, 1,   pRB↑, 1,   p‑pRB↓, 1,   tumCV↓, 26,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 15,   eIF2α↓, 1,   p‑eIF2α↑, 3,   ER Stress↓, 1,   ER Stress↑, 28,   GRP78/BiP↓, 1,   GRP78/BiP↑, 11,   GRP78/BiP↝, 1,   HSF1↓, 1,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 7,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 10,   HSPs↓, 1,   IRE1↑, 4,   PERK↑, 2,   UPR↑, 4,   XBP-1↓, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↓, 1,   ATG5↑, 2,   Beclin-1/ATG6↓, 5,   Beclin-1/ATG6↑, 8,   BNIP3↑, 3,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3A↑, 1,   LC3B↓, 1,   LC3B-II↓, 1,   LC3B-II↑, 3,   LC3II↓, 3,   LC3II↑, 8,   LC3s↓, 1,   LC3s↑, 1,   p62↓, 4,   p62↑, 2,   TumAuto↑, 28,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CHK1↓, 2,   p‑CHK1↑, 1,   CYP1B1↑, 1,   DFF45↓, 2,   DNAdam↓, 3,   DNAdam↑, 39,   DNArepair↓, 2,   DNArepair↑, 1,   DNMT1↓, 6,   DNMTs↓, 7,   GADD45A↑, 1,   MGMT↓, 1,   p16↑, 4,   P53?, 2,   P53↓, 2,   P53↑, 71,   P53↝, 1,   p‑P53↑, 1,   PARP↓, 2,   PARP↑, 14,   cl‑PARP↓, 1,   cl‑PARP↑, 49,   PARP1↑, 1,   PCNA↓, 17,   SIRT6↓, 2,   SIRT6↑, 1,   TP53↑, 3,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 6,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 11,   p‑CDK1↓, 1,   CDK1/2/5/9↓, 1,   CDK2↓, 36,   CDK2↑, 2,   CDK4↓, 44,   CDK4↑, 1,   p‑CDK4↓, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 17,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 77,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 3,   cycE/CCNE↓, 21,   E2Fs↓, 5,   P21↓, 4,   P21↑, 48,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 5,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 10,   TumCCA↑, 133,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1,   ALDH↓, 6,   ALDH1A1↓, 3,   CD133↓, 10,   CD133↑, 1,   CD24↓, 4,   CD34↓, 1,   CD44↓, 15,   p‑cDC2↓, 1,   CDK8↓, 1,   cFos↓, 8,   p‑cFos↓, 1,   CIP2A↓, 2,   cMET↓, 2,   p‑cMET↓, 1,   cMYB↓, 1,   CSCs↓, 36,   CSCs↑, 1,   CTSB↓, 2,   CTSD↓, 2,   Diff↓, 1,   Diff↑, 2,   EMT↓, 87,   EMT↑, 2,   EpCAM↓, 4,   ERK↓, 51,   ERK↑, 8,   p‑ERK↓, 22,   p‑ERK↝, 1,   FGF↓, 3,   FGF↑, 1,   FGFR2↓, 1,   FOXM1↓, 2,   FOXO↑, 3,   FOXO1↓, 2,   FOXO3↓, 2,   FOXO3↑, 7,   FOXO3↝, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   Gli↓, 2,   Gli1↓, 9,   GSK‐3β↓, 10,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 2,   HDAC↓, 18,   HDAC1↓, 5,   HDAC10↓, 1,   HDAC2↓, 3,   HDAC3↓, 2,   HDAC4↓, 1,   HDAC6↓, 2,   HDAC8↓, 1,   HH↓, 8,   IGF-1↓, 8,   IGF-1R↓, 5,   IGF-2↓, 1,   IGFBP3↓, 1,   IGFBP3↑, 2,   IGFR↓, 1,   Jun↓, 1,   Let-7↑, 5,   LRP6↓, 1,   p‑LRP6↓, 1,   p‑MAP2K1/MEK1↓, 1,   miR-194↑, 1,   miR-34a↑, 4,   mTOR↓, 57,   mTOR↝, 1,   p‑mTOR↓, 10,   mTORC1↓, 4,   p‑mTORC1↓, 1,   mTORC2↓, 2,   mTORC2↑, 1,   n-MYC↓, 2,   Nanog↓, 10,   Nestin↓, 2,   NOTCH↓, 18,   NOTCH1↓, 10,   NOTCH1↑, 2,   NOTCH1↝, 1,   NOTCH2↓, 1,   NOTCH3↓, 2,   OCT4↓, 13,   p300↓, 2,   P70S6K↓, 1,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PDGFRA↓, 1,   PI3K↓, 95,   PI3K↑, 1,   p‑PI3K↓, 5,   p‑PI3K↑, 1,   PTCH1↓, 2,   PTEN↑, 25,   RAS↓, 10,   Shh↓, 7,   SHP1↑, 2,   Smo↓, 3,   SOX2↓, 10,   Src↓, 2,   p‑Src↓, 1,   STAT↓, 4,   STAT1↓, 1,   p‑STAT1↓, 1,   p‑STAT2↓, 1,   STAT3↓, 67,   STAT3↑, 2,   p‑STAT3↓, 13,   p‑STAT3↑, 3,   STAT5↓, 2,   STAT6↓, 2,   Sufu↓, 1,   TAZ↓, 1,   TCF-4↓, 2,   TOP1↓, 6,   TOP2↓, 6,   TOP2↑, 2,   TOPflash↓, 1,   TRPM7↓, 1,   TumCG↓, 57,   TumCG↑, 2,   tyrosinase↓, 2,   Wnt↓, 38,   Wnt/(β-catenin)↓, 5,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 6,   AEG1↓, 1,   Akt2↓, 1,   AntiAg?, 1,   AntiAg↓, 1,   AntiAg↑, 2,   AP-1↓, 18,   AP-1↝, 1,   ATPase↓, 1,   AXL↓, 2,   CA↓, 3,   Ca+2↓, 1,   Ca+2↑, 31,   Ca+2↝, 1,   i-Ca+2?, 1,   i-Ca+2↑, 1,   CAFs/TAFs↓, 2,   cal2↓, 1,   CCN2/CTGF↓, 2,   CD31/PECAM-1↓, 3,   Cdc42↑, 1,   CDK4/6↓, 1,   CDKN1C/p57↑, 1,   CLDN1↓, 2,   CLDN2↓, 1,   COL1A1↓, 1,   COL3A1↓, 1,   CXCL12↓, 2,   DLC1↑, 1,   E-cadherin↓, 12,   E-cadherin↑, 62,   EMMPRIN↓, 1,   ER-α36↓, 2,   F-actin↓, 2,   FAK↓, 22,   FAK↑, 2,   p‑FAK↓, 4,   fascin↓, 1,   Fibronectin↓, 6,   GIT1↓, 1,   GLI2↓, 2,   ITGA5↓, 3,   ITGB1↓, 4,   ITGB3↓, 1,   Ki-67↓, 24,   LAMs↓, 1,   MALAT1↓, 1,   MARK4↓, 2,   MET↓, 1,   miR-133a-3p↑, 1,   miR-139-5p↑, 2,   miR-155↓, 5,   miR-200b↑, 2,   miR-203↑, 1,   miR-221↓, 1,   miR-301a-3p↓, 1,   miR-340↓, 2,   miR-384↑, 2,   MMP-10↓, 2,   MMP1↓, 13,   MMP11↓, 1,   MMP13↓, 8,   MMP14↓, 1,   MMP2↓, 235,   MMP2↑, 1,   MMP3↓, 13,   MMP7↓, 15,   MMP7∅, 1,   MMP9↓, 363,   pro‑MMP9↓, 1,   MMPs↓, 27,   MUC4↓, 2,   N-cadherin↓, 38,   NCAM↓, 1,   PAI-1/SERPINE1↓, 1,   PAK1↓, 2,   PDGF↓, 7,   PKA↓, 2,   PKCδ↓, 14,   p‑PKCδ↓, 1,   Rac1↓, 1,   RAGE↓, 1,   RECK↑, 1,   Rho↓, 5,   RIP3↑, 1,   ROCK1↓, 5,   ROCK1↑, 1,   Slug?, 1,   Slug↓, 17,   Smad1↓, 1,   Smad1↑, 1,   SMAD2↓, 1,   p‑SMAD2↓, 2,   SMAD3↓, 2,   SMAD3↑, 1,   p‑SMAD3↓, 2,   SMAD4↓, 2,   Snail?, 2,   Snail↓, 31,   Snail↑, 1,   SOX4↓, 1,   SOX4↑, 1,   STAC2↓, 1,   TET1↓, 1,   TET1↑, 3,   TGF-β↓, 20,   TGF-β↑, 2,   TGF-β1↓, 1,   TIMP1↓, 7,   TIMP1↑, 23,   TIMP2↓, 5,   TIMP2↑, 17,   TIMP3↑, 2,   Treg lymp↓, 1,   TSP-1↑, 3,   TumCA↓, 6,   TumCI↓, 113,   TumCI↑, 1,   TumCMig↓, 100,   TumCP?, 1,   TumCP↓, 110,   TumCP↑, 2,   TumMeta↓, 85,   TumMeta↑, 5,   TumPF↓, 1,   Twist↓, 28,   Twist↑, 1,   uPA↓, 34,   uPAR↓, 4,   VCAM-1↓, 3,   VEGFR1↓, 4,   Vim?, 1,   Vim↓, 50,   Zeb1↓, 16,   ZEB2↓, 3,   ZEB2↑, 1,   ZO-1↑, 4,   α-SMA↓, 4,   α-SMA↑, 1,   α-tubulin↑, 3,   β-catenin/ZEB1↓, 45,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 90,   angioG↑, 1,   angioS↑, 1,   ATF4↓, 1,   ATF4↑, 5,   ATF4↝, 1,   ECM/TCF↓, 1,   EGFR↓, 31,   p‑EGFR↓, 3,   Endoglin↑, 1,   eNOS↓, 3,   EPR↑, 5,   HIF-1↓, 4,   Hif1a↓, 56,   Hif1a↑, 1,   Hif1a↝, 1,   LOX1↓, 1,   miR-17↓, 1,   miR-34b-5p↑, 1,   NO↓, 7,   NO↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PHDs↓, 1,   TAMS↝, 1,   TXA2↓, 1,   VEGF↓, 140,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 18,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB∅, 1,   GLUT1↓, 8,   GLUT1↑, 1,   GLUT3↑, 1,   GLUT4↓, 1,   NHE1↓, 2,   P-gp/ABCB1↓, 14,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↑, 1,   CCR7↓, 1,   CD4+↓, 1,   CD4+↑, 1,   COX1↓, 5,   COX2/PTGS2↓, 102,   COX2/PTGS2↑, 1,   CRP↓, 3,   CXCL1↓, 1,   CXCR2↓, 2,   CXCR4↓, 23,   CXCR4↑, 1,   FOXP3↓, 2,   FOXP3↑, 1,   HMGB1↓, 3,   ICAM-1↓, 11,   IFN-γ↓, 2,   IFN-γ↑, 2,   Igs↑, 1,   IKKα↓, 10,   IKKα↝, 1,   p‑IKKα↓, 2,   IL1↓, 7,   IL1↑, 1,   IL10↓, 6,   IL10↑, 3,   IL12↓, 4,   IL12↑, 1,   IL17↓, 1,   IL18↓, 1,   IL1α↓, 2,   IL1β↓, 11,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 3,   IL22↓, 1,   IL23↓, 1,   IL33↑, 1,   IL4↓, 2,   IL4↑, 2,   IL6↓, 47,   IL6↑, 1,   IL8↓, 12,   IL8↑, 1,   Imm↑, 2,   Imm↝, 3,   Inflam↓, 26,   p‑IκB↓, 2,   p‑IκB↑, 1,   JAK↓, 5,   p‑JAK↓, 1,   JAK1↓, 4,   p‑JAK1↓, 1,   JAK2↓, 14,   p‑JAK2↓, 3,   p‑JAK3↓, 1,   M2 MC↓, 2,   MCP1/CCL2↓, 7,   MIP2↓, 1,   mPGES-1↓, 2,   NF-kB?, 1,   NF-kB↓, 152,   NF-kB↑, 1,   NF-kB↝, 1,   p‑NF-kB↓, 2,   p‑NF-kB↑, 1,   NK cell↑, 3,   p50↓, 3,   p65↓, 11,   p65↑, 1,   p‑p65↓, 1,   PD-1↓, 2,   PD-L1↓, 6,   PD-L1↑, 1,   PGE2↓, 24,   PSA↓, 4,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 2,   TLR2↓, 1,   TLR4↓, 3,   TLR4↝, 1,   TNF-α↓, 30,   TNF-α↑, 6,   TNF-α∅, 1,   TRAF1↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   NLRP3↑, 2,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 11,   AR↑, 1,   CDK6↓, 22,   CDK6↑, 1,   ER(estro)↓, 1,   ERα/ESR1↓, 1,   GR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 34,   BioAv↑, 35,   BioAv↝, 9,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 104,   CYP1A2↓, 1,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 6,   Dose↝, 28,   Dose∅, 9,   eff↓, 17,   eff↑, 137,   eff↝, 9,   Half-Life↓, 8,   Half-Life↑, 4,   Half-Life↝, 8,   Half-Life∅, 1,   MDR1↓, 6,   MRP1/ABCC1↓, 2,   P450↓, 1,   RadioS↑, 35,   selectivity?, 2,   selectivity↑, 41,   selectivity∅, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 6,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 11,   AR↑, 1,   ascitic↓, 2,   AST↓, 4,   AST↝, 1,   BMPs↑, 1,   BRCA1↓, 1,   BRCA1↑, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CRP↓, 3,   E6↓, 2,   E7↓, 2,   EGFR↓, 31,   p‑EGFR↓, 3,   ERα/ESR1↓, 1,   EZH2↓, 5,   Ferritin↓, 1,   FOXM1↓, 2,   GutMicro↑, 3,   HER2/EBBR2↓, 13,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 10,   IL6↓, 47,   IL6↑, 1,   Ki-67↓, 24,   LDH↓, 3,   LDH↑, 4,   Myc↓, 5,   PD-L1↓, 6,   PD-L1↑, 1,   PSA↓, 4,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 33,   AntiCan?, 1,   AntiDiabetic↑, 2,   antiNeop↑, 3,   AntiTum↑, 17,   cardioP↑, 7,   CardioT↑, 2,   chemoP↑, 16,   chemoPv↑, 15,   ChemoSideEff↓, 4,   hepatoP↓, 1,   hepatoP↑, 6,   NDRG1↑, 1,   neuroP↑, 5,   OS↑, 7,   Pin1↓, 1,   QoL↑, 2,   radioP↑, 6,   Remission↑, 1,   RenoP↑, 5,   Risk↓, 4,   toxicity↓, 12,   toxicity↑, 5,   toxicity↝, 4,   toxicity∅, 1,   TumVol↓, 14,   TumVol∅, 1,   TumW↓, 5,   TumW∅, 1,   Weight↑, 1,   Weight∅, 1,   Wound Healing↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,   Sepsis↓, 3,  
Total Targets: 947

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,   CD19↑, 1,   diuretic↑, 2,   Ingr↝, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5,   antiOx↑, 57,   ARE↑, 1,   Catalase↑, 21,   Copper↓, 1,   CYP2E1↓, 1,   Ferroptosis↓, 1,   GPx↑, 16,   GPx1↑, 1,   GPx4↑, 1,   GSH↑, 15,   GSR↑, 4,   GSTA1↑, 1,   GSTs↑, 9,   H2O2↓, 3,   HDL↑, 2,   HO-1↑, 8,   Iron↓, 2,   i-Iron↓, 1,   Keap1↓, 1,   lipid-P↓, 13,   MDA↓, 11,   MPO↑, 1,   NADH↓, 1,   Nrf1↑, 1,   NRF2↑, 19,   Prx↑, 1,   RNS↓, 3,   ROS↓, 55,   SOD↑, 27,   SOD1↑, 3,   SOD2↑, 2,   xCT/SLC7A11↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 3,   MMP∅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↑, 1,   ALAT↓, 5,   AMPK↑, 2,   p‑cMyc↑, 1,   CREB↑, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,   LDH↓, 3,   LDH↑, 1,   LDL↓, 1,   NAD↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   BAX↓, 2,   BMP2↑, 1,   Casp3?, 1,   Casp3↓, 2,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c↓, 2,   Cyt‑c∅, 1,   Ferroptosis↓, 1,   iNOS↓, 8,   p‑JNK↓, 1,   MAPK↓, 4,   MAPK↑, 1,   necrosis↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   cJun↓, 1,   other↓, 4,   other↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   p16↓, 1,   P53↓, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   E2Fs↑, 1,   P21↓, 1,   RB1↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↑, 1,   ERK↓, 1,   ERK↑, 2,   GSK‐3β↓, 2,   HDAC↓, 1,   IGF-1↑, 1,   IGF-1R↓, 1,   neuroG↑, 1,   PI3K↑, 1,   PTEN↑, 1,   RUNX2↑, 1,   STAT↓, 1,   STAT3↓, 2,   TRPM7↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↑, 7,   AP-1↓, 3,   Ca+2↝, 1,   COL1↑, 1,   LAMs↑, 1,   MMP2↓, 1,   MMP3↓, 1,   PKCδ↑, 1,   Smad1↑, 1,   TIMP1↓, 1,   TumMeta↓, 1,   VCAM-1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   Hif1a↓, 1,   NO↓, 8,   NO↑, 3,   PDGFR-BB↓, 1,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 7,   GastroP↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 2,   COX2/PTGS2↓, 20,   CRP↓, 3,   HMGB1↓, 1,   ICAM-1↓, 1,   IL1↓, 2,   IL10↑, 2,   IL12↓, 1,   IL1β↓, 6,   IL4↓, 2,   IL5↓, 1,   IL6↓, 14,   IL8↓, 3,   Imm↑, 10,   Inflam↓, 55,   Inflam↑, 1,   JAK↓, 1,   MUC2↓, 1,   NF-kB↓, 23,   NK cell↑, 1,   PGE2↓, 7,   PGE2↑, 2,   Th1 response↓, 1,   Th2↑, 2,   TLR2↓, 2,   TLR4↓, 1,   TNF-α↓, 12,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 6,   AChE↑, 1,   BChE↓, 1,   BDNF↑, 3,   GABA↑, 3,   tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 3,   Aβ↓, 4,   BACE/β-secretase↓, 1,   NLRP3↓, 2,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CYP19↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 21,   BioAv↑, 23,   BioAv↝, 10,   Dose↝, 3,   eff↑, 11,   Half-Life↓, 1,   Half-Life↝, 3,   Half-Life∅, 1,   P450↓, 3,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 3,   AST↓, 8,   BMD↑, 1,   BP↓, 1,   CRP↓, 3,   GutMicro↑, 2,   IL6↓, 14,   LDH↓, 3,   LDH↑, 1,   MUC19↓, 1,   NOS2↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 1,   AntiArt↑, 3,   AntiCan↓, 1,   AntiCan↑, 13,   AntiDiabetic↓, 1,   AntiDiabetic↑, 8,   AntiP↑, 1,   antiPs↑, 1,   AntiTum↑, 2,   cardioP↑, 23,   CardioT↓, 1,   chemoP↑, 4,   chemoPv↑, 3,   cognitive↓, 1,   cognitive↑, 5,   hepatoP↓, 1,   hepatoP↑, 16,   memory↑, 10,   motorD↑, 2,   neuroP↓, 2,   neuroP↑, 39,   Obesity↓, 3,   Pain↓, 4,   radioP↑, 2,   RenoP↑, 3,   toxicity↓, 16,   toxicity↑, 1,   toxicity↝, 5,   toxicity∅, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 2,   AntiViral↑, 3,   Bacteria↓, 16,   Diar↓, 1,  
Total Targets: 231

Scientific Paper Hit Count for: MMP9, MMP9
14 Fisetin
14 Resveratrol
12 Curcumin
10 Thymoquinone
9 Apigenin (mainly Parsley)
9 Berberine
9 Quercetin
9 Lycopene
9 Sulforaphane (mainly Broccoli)
8 Baicalein
8 Garcinol
8 Luteolin
7 Boswellia (frankincense)
6 Artemisinin
6 Capsaicin
6 Eugenol
6 Honokiol
6 Kaempferol
5 Betulinic acid
5 Caffeic acid
5 Chrysin
5 Dandelion Root
5 Ellagic acid
5 Ferulic acid
5 Gambogic Acid
5 Rosmarinic acid
4 Alpha-Lipoic-Acid
4 Cisplatin
4 Cucurbitacin
4 EGCG (Epigallocatechin Gallate)
4 Formononetin
4 Magnolol
4 Nimbolide
4 Piperine
4 Pterostilbene
4 Silymarin (Milk Thistle) silibinin
4 Shikonin
3 Silver-NanoParticles
3 Propolis -bee glue
3 Hydroxycinnamic-acid
3 D-limonene
3 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
3 Phenethyl isothiocyanate
3 Piperlongumine
3 Urolithin
2 1,8-Cineole
2 Sorafenib (brand name Nexavar)
2 Astragalus
2 Paclitaxel/Taxol
2 alpha Linolenic acid
2 Radiotherapy/Radiation
2 Ashwagandha(Withaferin A)
2 Ascorbyl Palmitate
2 Melatonin
2 Berbamine
2 Caffeic Acid Phenethyl Ester (CAPE)
2 Carvacrol
2 Thymol-Thymus vulgaris
2 Celecoxib
2 Celastrol
2 chitosan
2 Cinnamon
2 Crocetin
2 CUSP9
2 Deguelin
2 Emodin
2 Evodiamine
2 Fucoidan
2 Ginkgolic acids
2 Genistein (soy isoflavone)
2 Ginger/6-Shogaol/Gingerol
2 Graviola
2 Hibiscus sabdariffa
2 HydroxyTyrosol
2 Inositol
2 Ivermectin
2 Juglone
2 Licorice
2 Naringin
2 Marjoram (Origanum majorana)
2 Selenite (Sodium)
1 2-DeoxyGlucose
1 3-bromopyruvate
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Andrographis
1 Anethole/trans-Anethole
1 Isovitexin
1 Aspirin
1 Astaxanthin
1 Baicalin
1 Biochanin A
1 Beta-Caryophyllene
1 Chemotherapy
1 Brucea javanica
1 brusatol
1 Bacopa monnieri
1 Carnosic acid
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Selenium NanoParticles
1 Cyclopamine
1 Cysteamine
1 Vitamin A, Retinoic Acid
1 Bortezomib
1 Gallic acid
1 Ginkgo biloba
1 Geraniol
1 Ginkgetin
1 Grapeseed extract
1 Hops (Humulus lupulus)
1 Hyperoside
1 Indole-3-carbinol
1 Isobavachalcone
1 Isoliquiritigenin
1 isoorientin
1 Plumbagin
1 Lactobacillus
1 Licochalcone A
1 Magnetic Field Rotating
1 Magnetic Fields
1 Methylglyoxal
1 Myricetin
1 Niclosamide (Niclocide)
1 Propyl gallate
1 temozolomide
1 Polyphenols
1 Parthenolide
1 Sanguinarine
1 Salvia miltiorrhiza
1 Aflavin-3,3′-digallate
1 Turmerones
1 VitK3,menadione
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:203  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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