P-gp/ABCB1 Cancer Research Results

P-gp/ABCB1, permeability-glycoprotein: Click to Expand ⟱
Source:
Type:
P-glycoprotein (P-gp), also known as multidrug resistance protein 1 (MDR1), is a membrane protein that plays a crucial role in the transport of various substances across cellular membranes. It is part of the ATP-binding cassette (ABC) transporter family.
P-glycoprotein is often overexpressed in a variety of cancers, including breast cancer, lung cancer, leukemia, and ovarian cancer.

- The overexpression of P-glycoprotein (P-gp), is widely considered as an important reason for the MDR (multidrug resistance).

ABCB1 - ATP-Binding Cassette Subfamily B Member 1 / P-Glycoprotein

Abbreviation: ABCB1, P-gp, P-glycoprotein, MDR1

Type: ATP-dependent membrane efflux transporter / multidrug resistance protein

Function: ABCB1 encodes P-glycoprotein, an ATP-binding cassette transporter that exports a broad range of drugs, xenobiotics, lipids, and other substrates across cellular membranes. It is highly expressed in barrier tissues including the intestine, liver, kidney, placenta, and blood-brain barrier, where it limits tissue accumulation of potentially harmful compounds.

Cancer: ↑ Frequently overexpressed or functionally activated in drug-resistant tumors. Increased ABCB1 lowers intracellular concentrations of many anticancer agents by actively transporting them out of cancer cells, producing multidrug resistance and reducing chemotherapy effectiveness.

Alzheimer's Disease: ↓ Reduced ABCB1/P-glycoprotein expression or transport activity at the blood-brain barrier is associated with impaired amyloid-β clearance from the brain. Lower P-gp function correlates with increased cerebral Aβ accumulation and may contribute to Alzheimer's disease progression.
Scientific Papers found: Click to Expand⟱
5431- AG,    Advances in research on the anti-tumor mechanism of Astragalus polysaccharides
- Review, Var, NA
AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
557- ART/DHA,    Artemisinin and Its Derivatives in Cancer Care
- Review, Var, NA
*BioAv↓, *BioAv↑, Apoptosis↑, EGFR↓, CD31/PECAM-1↓, Ki-67↓, P53↓, TfR1/CD71↑, P-gp/ABCB1↓, PD-1↝,
5497- Ba,    Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics
- Review, Var, NA
*Inflam↓, AntiCan↑, BioAv↝, BioAv⇅, BioAv↓, CYP3A2↓, P-gp/ABCB1↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
2608- Ba,    Baicalein sensitizes hepatocellular carcinoma cells to 5-FU and Epirubicin by activating apoptosis and ameliorating P-glycoprotein activity
- in-vitro, HCC, Bel-7402
Apoptosis↑, TumAuto↑, P-gp/ABCB1↓, Bcl-xL↓, ChemoSen↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
5644- BCA,    Phytochemicals reverse P-glycoprotein mediated multidrug resistance via signal transduction pathways
- Review, Var, NA
P-gp/ABCB1↓,
5643- BCA,  GEN,  QC,  SIL,  KAE  P-glycoprotein inhibitors of natural origin as potential tumor chemo-sensitizers: A review
- in-vitro, NA, NA
P-gp/ABCB1↓,
5642- BCA,    Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo
- vitro+vivo, Nor, NA
P-gp/ABCB1↓, BioAv↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
5656- BNL,    Role of borneol as enhancer in drug formulation: A review
- Review, Nor, NA - Review, Stroke, NA - Review, AD, NA
*eff↑, BBB↑, ChemoSen↑, *Inflam↓, *NO↓, *TNF-α↓, *IL6↓, *Bacteria↓, *eff↑, *Aβ↓, *SOD↑, *neuroP↑, *EPR↑, toxicity↓, P-gp/ABCB1↓, eff↑, other↝,
5659- BNL,    Borneol, a messenger agent, improves central nervous system drug delivery through enhancing blood–brain barrier permeability: a preclinical systematic review and meta-analysis
- Review, Var, NA
BBB↑, P-gp/ABCB1↓, MDR1↓, HIST1H3B?,
5660- BNL,    Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
- Review, Var, NA
TumMeta↓, BBB↑, EPR↑, toxicity↓, BioAv↑, ChemoSen↑, eff↑, other↑, P-gp/ABCB1↓, MDR1↓, ROS↑, TumCCA↑, other↝, BioAv↓, DNAdam↑, BioEnh↑,
5663- BNL,    Osthole/borneol thermosensitive gel via intranasal administration enhances intracerebral bioavailability to improve cognitive impairment in APP/PS1 transgenic mice
- in-vivo, AD, NA
*ZO-1↓, *cl‑Casp3↓, *Bax:Bcl2↓, *MDA↓, *Apoptosis↓, *Aβ↓, *BACE/β-secretase↓, *cognitive↑, *BioAv↑, memory↑, P-gp/ABCB1↓, BioEnh↑,
5851- CAP,    Capsaicin Potentiates Anticancer Drug Efficacy Through Autophagy-Mediated Ribophorin II Downregulation and Necroptosis in Oral Squamous Cell Carcinoma Cells
- in-vitro, Oral, NA
ChemoSen↑, TumAuto↑, ER Stress↑, P-gp/ABCB1↓,
5850- CAP,    Anticancer Activity of Natural and Synthetic Capsaicin Analogs
- Review, Var, NA
TRPV1↑, Ca+2↑, ROS↑, mitResp↓, ChemoSen↑, P-gp/ABCB1↓,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
5212- CAP,  PI,  Chemo,    Capsaicin and Piperine Can Overcome Multidrug Resistance in Cancer Cells to Doxorubicin
- in-vitro, Colon, Caco-2
ChemoSen↑, P-gp/ABCB1↓, eff↑,
5765- CAPE,    Absorption properties and effects of caffeic acid phenethyl ester and its p-nitro-derivative on P-glycoprotein in Caco-2 cells and rats
- vitro+vivo, Colon, Caco-2
P-gp/ABCB1↓,
5965- CEL,  Cisplatin,    Celecoxib enhances anticancer effect of cisplatin and induces anoikis in osteosarcoma via PI3K/Akt pathway
- in-vitro, OS, MG63
COX2/PTGS2↓, ChemoSen↑, MDR1↓, MRP1/ABCC1↓, E-cadherin↓, β-catenin/ZEB1↓, Apoptosis↑, TumCCA↑, TumCG↓, P-gp/ABCB1↓, PI3K↓, Akt↓,
6640- Cen,    Asiaticoside Antagonizes Proliferation and Chemotherapeutic Drug Resistance in Hepatocellular Carcinoma (HCC) Cells
- in-vitro, HCC, Bel-7402 - in-vitro, HCC, QGY-7703
TumCP↓, Apoptosis↑, TumCCA↑, PI3K↓, Akt↓, MAPK↓, ERK↓, P-gp/ABCB1↓, ROS↓, p‑pRB↓, cycD1/CCND1↓, p27/CDKN1B↑,
6202- Cuc,    Cucurbitacins as potential anticancer agents: new insights on molecular mechanisms
- Review, Var, NA
*Inflam↓, *antiOx↑, *hepatoP↑, AntiTum↑, AntiCan↑, *chemoPv↑, *AntiDiabetic↑, *Imm↑, Hif1a↓, P-gp/ABCB1↓, mTORC1↓, ERK↓, Akt↓, Casp3↑, Casp7↑, ATP↓, RadioS↑, ChemoSen↑,
441- CUR,    Curcumin Regulates ERCC1 Expression and Enhances Oxaliplatin Sensitivity in Resistant Colorectal Cancer Cells through Its Effects on miR-409-3p
- in-vitro, CRC, HCT116
ERCC1↓, Bcl-2↓, GSTP1/GSTπ↓, MRP↓, P-gp/ABCB1↓, miR-409-3p↑, survivin↓,
6238- CUSP9,    A phase Ib/IIa trial of 9 repurposed drugs combined with temozolomide for the treatment of recurrent glioblastoma: CUSP9v3
- Trial, GBM, NA
toxicity↓, TrxR↓, ROS↓, TumCI↓, TumCMig↓, TumCA↓, MMP2↓, MMP9↓, COX2/PTGS2↓, ALDH↓, TumAuto↑, P-gp/ABCB1↓, eff↑,
6237- CUSP9,    CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide
- NA, GBM, NA
PI3K↓, Akt↓, ROS↑, NF-kB↓, TNF-α↓, TLR2↓, other↓, TrxR↓, STAT3↓, MMPs↓, COX1↓, COX2/PTGS2↓, CA↓, ALDH↓, P-gp/ABCB1↓, HH↓, 5LO↓, mTOR↓, CycD3↓, Proteasome↓, other↓, MMP2↓, MMP9↓, ALDH↓, Copper↓,
4914- DSF,  immuno,    Disulfiram and cancer immunotherapy: Advanced nano-delivery systems and potential therapeutic strategies
- Review, Var, NA
AntiTum↑, eff↑, ALDH↓, Dose↝, RadioS↑, angioG↓, TumMeta↓, BioAv↝, ROS↑, DNAdam↑, P-gp/ABCB1↓, CSCs↓, EMT↓, Imm↑, SOD↓, MAPK↓, NF-kB↓, ChemoSen↑, eff↑, toxicity↝, BioAv↑, *Inflam↓, Sepsis↓,
5013- DSF,  Cu,  Z,    Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease
- vitro+vivo, Melanoma, NA - Case Report, Melanoma, NA
P-gp/ABCB1↓, NF-kB↓, ChemoSen↑, angioG↓, TumCG↓, TumMeta↓, Remission↑, toxicity↓, ATF2↓, CREB↓, cycA1/CCNA1↓, TumCG↓, angioG↓, Dose↝, toxicity↝,
2992- EGCG,    Effects of Epigallocatechin-3-Gallate on Matrix Metalloproteinases in Terms of Its Anticancer Activity
- Review, Var, NA
AP-1↓, Sp1/3/4↓, NF-kB↓, ERK↓, P-gp/ABCB1↓, HSP27↓, β-catenin/ZEB1↓, MMPs↓, TNF-α↓, IL1β↓, MMP2↓,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6820- EMD,    The Health Benefits of Emodin, a Natural Anthraquinone Derived from Rhubarb—A Summary Update
- Review, Nor, NA - Review, Arthritis, NA - Review, AD, NA
*diuretic↑, *Bacteria↓, *Inflam↓, AntiCan↑, TumCP↓, TumCI↓, angioG↓, *toxicity↓, IFN-γ↑, IL12↑, ROS↑, TNF-α↓, TNF-α↓, TGF-β↓, MAPK↓, PKCδ↓, NF-kB↓, HER2/EBBR2↓, VEGF↓, DNAdam↑, Necroptosis↑, Glycolysis↓, GLUT1↓, PI3K↓, Akt↓, Casp9↑, Casp3↑, BAX↑, Bcl-2↓, eff↑, MMP2↓, MMP9↓, eff↑, ChemoSen↑, P-gp/ABCB1↓, SREBP2↓, eff↑, *other↝, *COX2/PTGS2↓, *Hif1a↓, *HDAC↓, *tau↓, *PKCδ↑, *ROS↓, *Inflam↓, AntiAg?,
2839- FIS,    Dietary flavonoid fisetin for cancer prevention and treatment
- Review, Var, NA
DNAdam↑, ROS↑, Apoptosis↑, Bcl-2↓, BAX↑, cl‑Casp9↑, cl‑Casp3↑, Cyt‑c↑, lipid-P↓, TumCG↓, TumCA↓, TumCMig↓, TumCI↓, uPA↓, ERK↓, MMP9↓, NF-kB↓, cFos↓, cJun↓, AP-1↓, TumCCA↑, AR↓, mTORC1↓, mTORC2↓, TSC2↑, EGF↓, TGF-β↓, EMT↓, P-gp/ABCB1↓, PI3K↓, Akt↓, mTOR↓, eff↑, ROS↓, ER Stress↑, IRE1↑, ATF4↑, GRP78/BiP↑, ChemoSen↑, CDK2↓, CDK4↓, cycE/CCNE↓, cycD1/CCND1↓, P21↑, COX2/PTGS2↓, Wnt↓, EGFR↓, β-catenin/ZEB1↓, TCF-4↓, MMP7↓, RadioS↑, eff↑,
6974- Form,    Formononetin Defeats Multidrug-Resistant Cancers by Induction of Oxidative Stress and Suppression of P-Glycoprotein
- in-vitro, Cerv, HeLa
ROS↑, MMP↓, P-gp/ABCB1↓, ATPase↑, ChemoSen↑, eff↓,
7065- GamB,    Gambogic acid: A review of its pharmacological mechanisms against cancer
- Review, Var, NA
AntiTum↑, Apoptosis↑, TumCCA↑, angioG↓, Hif1a↓, VEGF↓, MMPs↓, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, mTOR↓, MAPK↓, P-gp/ABCB1↓, Shh↓, Pyro↑, Casp3↑, GSDME↑, ChemoSen↑, RadioS↑, BioAv↓, Bcl-2↓, Mcl-1↓, BAX↑, Half-Life↓, ROS↑, miR-21↓, MMP2↓, MMP9↓,
5152- GamB,    Gambogic Acid as a Candidate for Cancer Therapy: A Review
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumCI↓, TumMeta↓, angioG↓, eff↑, NF-kB↓, P53↑, P21↑, MDM2↓, HSP90↓, Bcl-2↓, Cyt‑c↑, Casp↑, MMP↓, Casp3↑, Casp9↑, cl‑PARP↑, Bax:Bcl2↑, ROS↑, SIRT1↓, TrxR1↓, Fas↓, FasL↑, FADD↑, APAF1↑, DNAdam↑, NF-kB↓, STAT3↓, MAPK↓, cFos↓, EGFR↓, Akt↓, mTOR↓, AMPK↑, TumCCA↑, ChemoSen↑, P-gp/ABCB1↓, survivin↓,
1972- GamB,  doxoR,    Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression
- in-vitro, BC, NA
eff↑, P-gp/ABCB1↓, ROS↑, survivin↓, p38↑,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, eff↑, BioAv↓,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, FOXM1↓, p27/CDKN1B↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp/ABCB1↓,
7567- HYP,    Hyperoside: A review on its sources, biological activities, and molecular mechanisms
- Review, Var, NA
*AntiCan↑, *Bacteria↓, *AntiViral↑, *antiD↓, *RenoP↑, *hepatoP↑, *eff↑, *Sepsis↓, *AntiArt↑, *Stroke↓, TumCMig↓, TumCI↓, MTA1↓, TIMP2↓, MMP2↓, MMP↓, Cyt‑c↑, Akt↓, mTOR↓, P70S6K↓, TumAuto↑, PD-L1↓, TNF-α↓, IL1β↓, IL6↓, IL8↓, Bcl-2↓, Bcl-xL↓, BAX↑, BAD↑, Bak↑, VEGF↓, Casp3↑, Casp8↑, P53↑, GSH↓, SOD↓, Catalase↓, TAC↓, XIAP↓, ROS↓, NF-kB↓, TLR4↓, P-gp/ABCB1↓, LRP1↓, Fas↑, p27/CDKN1B↑, *cardioP↑, *AntiThr↑, *PAI-1/SERPINE1↓, *BUN↓, *ALAT↓, *AST↓, *neuroP?,
7992- itraC,    Cellular pharmacokinetic aspects of reversal effect of itraconazole on P-glycoprotein-mediated resistance of anticancer drugs
P-gp/ABCB1↓, BioEnh↑,
7990- itraC,    A Novel Approach to Reducing Chemoresistance in Advanced Ovarian Cancer: The Effect of Itraconazole-A Single-Institution Randomized Placebo-Controlled Trial
- Trial, Ovarian, NA
Dose↝, DCR↑, PFS↑, CA125↓, P-gp/ABCB1↓, VEGFR2/KDR/Flk1↑, toxicity↓, QoL↑, toxicity↝,
8001- itraC,    Repurposing itraconazole as an anticancer agent
- Review, Var, NA
*AntiFungal↑, AntiCan↑, P-gp/ABCB1↓, HH↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, angioG↓, LymphAG↓, ChemoSen↑, OS↑, Gli1↓, Ki-67↓, CSCs↓,
8016- itraC,    Impact of combination chemotherapy with itraconazole on survival for patients with recurrent or persistent ovarian clear cell carcinoma
- Human, Ovarian, NA
P-gp/ABCB1↓, angioG↓, HH↓, OS↑, Dose↝,
2179- itraC,    Repurposing itraconazole for the treatment of cancer
- Review, Var, NA
HH↓, angioG↓, TumCCA↑, MDR1↓, P-gp/ABCB1↓, mTOR↓, VEGF↓, Smo↓, Gli1↓, OS↑, PSA↓,
8031- IVM,    Antiparasitic agents in oncology: Innovative mechanisms, emerging evidence and clinical potential in cancer treatment
*AntiP↑, Wnt↓, β-catenin/ZEB1↓, PI3K↓, Akt↓, mTOR↓, HH↓, Imm↑, CSCs↓, P-gp/ABCB1↓, Chl↓, angioG↓,
8030- IVM,    Metabolism and interactions of Ivermectin with human cytochrome P450 enzymes and drug transporters, possible adverse and toxic effects
- Review, Var, NA
P450↓, P-gp/ABCB1↓, ABCC2↓, ABCG2↓, OATPs↓,
8027- IVM,    Progress in Understanding the Molecular Mechanisms Underlying the Antitumour Effects of Ivermectin
- Review, Var, NA
*AntiP↑, TumCD↑, PAK1↑, TumAuto↑, Casp↑, ICD↑, TCF↝, Hippo↓, Akt↓, mTOR↓, angioG↓, CSCs↓, MMP↓, Cyt‑c↑, Apoptosis↑, BAX↑, P53↑, Bcl-2↓, cycE/CCNE↓, cycD1/CCND1↓, CDK2↓, CDK6↓, CDK4↓, YAP/TEAD↓, TFE3↑, mTORC1↓, mitResp↓, OCR↓, compI↓, MMP↓, ROS↑, SOD2↑, ATP↓, eff↓, mitA↓, P-gp/ABCB1↓, TumVol↓,
8047- IVM,    The multitargeted drug ivermectin: from an antiparasitic agent to a repositioned cancer drug
- Review, Var, NA
Half-Life↝, MDR1↓, P-gp/ABCB1↓, mtDam↑, ROS↑, OCR↓, compI↓, MMP↓, mt-SOD↑, ATP↓, p‑Akt↓, p‑mTOR↓, eff↓, ICD↑, TumAuto↑, PAK1↓, Wnt↓, TCF↓, Nanog↓, SOX2↓, CSCs↓, CD44↓, CD24↓, Dose↝,
8040- IVM,    Ivermectin, a potential anticancer drug derived from an antiparasitic drug
- Review, Var, NA
Akt↓, mTOR↓, TumAuto↑, TumCP↓, TumCCA↑, Wnt↓, YAP/TEAD↓, MMP↓, mitResp↓, ATP↓, eff↓, eff↑, ROS↑, ChemoSen↑, PAK1↓, MAPK↓, EMT↓, Beclin-1/ATG6↑, ATG5↑, CSCs↓, STAT3↝, P-gp/ABCB1↓, MDR1↓, HSP27↓, Chl↑, TFE3↑,

Showing Research Papers: 1 to 50 of 74
Page 1 of 2 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 74

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ABCC2↓, 1,   AntiBio↓, 1,   DCR↑, 1,   miR-106b↓, 1,   MTA1↓, 1,   MYCN↓, 1,   PFS↑, 1,   TFE3↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 1,   compI↓, 2,   Copper↓, 1,   CYP1A1↓, 1,   CYP1A1↑, 1,   Fenton↑, 2,   Ferroptosis↑, 1,   GPx4↓, 2,   GSH↓, 8,   GSTP1/GSTπ↓, 1,   HO-1↓, 1,   HO-1↑, 4,   ICD↑, 2,   Iron↓, 1,   Iron↑, 1,   c-Iron↑, 1,   lipid-P↓, 2,   lipid-P↑, 2,   NRF2↑, 4,   Prx4↑, 1,   ROS↓, 7,   ROS↑, 39,   i-ROS↓, 1,   SIRT3↑, 1,   SOD↓, 2,   mt-SOD↑, 1,   SOD2↑, 1,   TAC↓, 1,   TrxR↓, 3,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 6,   EGF↓, 1,   mitResp↓, 3,   MMP↓, 20,   mtDam↑, 1,   OCR↓, 2,   OCR↑, 1,   e-Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 3,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   AMPK↑, 5,   ATG7↑, 1,   cMyc↓, 6,   cMyc↑, 1,   CREB↓, 1,   CYP3A2↓, 1,   ECAR↓, 1,   ERCC1↓, 1,   GLO-I↓, 1,   GlucoseCon↓, 2,   Glycolysis↓, 5,   HK2↓, 2,   lactateProd↓, 1,   LDH↑, 1,   LDL↓, 1,   PI3K/Akt↓, 1,   PKM2↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 22,   p‑Akt↓, 6,   APAF1↑, 1,   Apoptosis↑, 26,   ATF2↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↓, 1,   BAX↑, 16,   Bax:Bcl2↑, 4,   Bcl-2↓, 15,   Bcl-xL↓, 6,   BID↑, 1,   p‑BID↓, 1,   Casp↑, 5,   Casp10↑, 1,   Casp12↑, 1,   Casp3↑, 13,   cl‑Casp3↑, 3,   Casp7↑, 3,   Casp8↑, 4,   cl‑Casp8↑, 1,   Casp9↑, 10,   cl‑Casp9↑, 2,   cFLIP↓, 1,   Cyt‑c↑, 9,   DR5↑, 3,   Endon↑, 1,   FADD↑, 1,   Fas↓, 1,   Fas↑, 3,   FasL↑, 1,   Ferroptosis↑, 1,   GSDME↑, 1,   Hippo↓, 1,   iNOS↓, 2,   JNK↓, 2,   JNK↑, 2,   MAPK↓, 9,   MAPK↑, 2,   Mcl-1↓, 2,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 2,   Necroptosis↑, 1,   p27/CDKN1B↑, 3,   p38↓, 2,   p38↑, 2,   p‑p38↓, 1,   Proteasome↓, 1,   Pyro↑, 1,   survivin↓, 11,   Telomerase↓, 1,   TNFR 1↑, 1,   TRAILR↑, 1,   TRPV1↑, 1,   TRPV1↝, 1,   TumCD↑, 1,   YAP/TEAD↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

CaMKII ↓, 1,   EF-1α↓, 1,   HER2/EBBR2↓, 2,   SOX9↓, 1,   Sp1/3/4↓, 4,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cJun↑, 1,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   miR-21↓, 1,   miR-409-3p↑, 1,   other↓, 3,   other↑, 3,   other↝, 2,   p‑pRB↓, 1,   tumCV↓, 7,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 3,   cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 9,   GRP78/BiP↑, 3,   HSP27↓, 3,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   IRE1↑, 1,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↑, 3,   LC3II↑, 2,   SESN2↑, 1,   TumAuto↑, 12,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   p‑BRCA1↑, 1,   DFF45↑, 1,   DNAdam↑, 13,   DNArepair↓, 1,   DNMT1↓, 1,   HIST1H3B?, 1,   P53↓, 1,   P53↑, 13,   PARP↑, 2,   cl‑PARP↑, 8,   PCNA↓, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   CDK2↓, 5,   CDK4↓, 8,   p‑CDK4↓, 1,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 4,   cycD1/CCND1↓, 10,   p‑cycD1/CCND1↓, 1,   CycD3↓, 1,   cycE/CCNE↓, 3,   mitA↓, 1,   mitA↑, 1,   P21?, 1,   P21↑, 10,   p‑RB1↓, 2,   TumCCA↑, 30,   TumCCA⇅, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 5,   ALDH1A1↓, 1,   CD133↓, 3,   CD24↓, 1,   CD44↓, 3,   cFos↓, 2,   cMET↓, 1,   CSCs↓, 14,   Diff↑, 1,   EMT↓, 12,   EpCAM↓, 1,   ERK↓, 7,   p‑ERK↓, 1,   FOXM1↓, 1,   FOXO4↑, 1,   Gli1↓, 2,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   HDAC↓, 1,   HDAC10↓, 1,   HH↓, 6,   IGF-1↓, 1,   miR-34a↓, 1,   mTOR↓, 17,   p‑mTOR↓, 4,   mTORC1↓, 4,   mTORC2↓, 1,   Nanog↓, 4,   Nestin↓, 1,   NOTCH1↓, 5,   NOTCH3↓, 2,   OCT4↓, 2,   P70S6K↓, 1,   p‑P70S6K↓, 1,   PI3K↓, 15,   PTEN↑, 1,   RAS↓, 4,   Shh↓, 3,   Smo↓, 1,   SOX2↓, 3,   STAT1↓, 1,   STAT3↓, 10,   STAT3↝, 1,   STAT6↓, 1,   TCF↓, 1,   TCF↝, 1,   TCF-4↓, 1,   TOP2↓, 1,   TumCG↓, 12,   Wnt↓, 10,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg?, 1,   AntiAg↑, 1,   AP-1↓, 5,   ATPase↑, 1,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 5,   Ca+2↝, 1,   CD31/PECAM-1↓, 1,   Chl↓, 1,   Chl↑, 1,   COL1↓, 1,   COL3A1↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 1,   ER-α36↓, 1,   p‑FAK↓, 1,   Ki-67↓, 4,   KRAS↓, 1,   LEF1↓, 1,   LRP1↓, 1,   miR-133a-3p↑, 1,   MMP2↓, 15,   MMP7↓, 2,   MMP9↓, 13,   MMPs↓, 7,   PAK1↓, 2,   PAK1↑, 1,   PKA↓, 1,   PKCδ↓, 2,   RAGE↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 3,   SMAD3↑, 1,   Snail↓, 2,   SOX4↓, 1,   SOX4↑, 1,   TGF-β↓, 3,   TIMP1↑, 2,   TIMP2↓, 1,   TIMP2↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCA↓, 2,   TumCI↓, 13,   TumCMig↓, 8,   TumCP↓, 16,   TumCP↑, 1,   TumMeta↓, 14,   TumMeta↑, 1,   Twist↓, 4,   uPA↓, 1,   VCAM-1↓, 1,   Vim↓, 4,   Zeb1↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 11,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 20,   ATF4↑, 1,   ATF4↝, 1,   EGFR↓, 5,   EPR↑, 4,   HIF-1↓, 1,   Hif1a↓, 6,   LymphAG↓, 1,   VEGF↓, 13,   VEGFR2/KDR/Flk1↓, 3,   VEGFR2/KDR/Flk1↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   CellMemb↑, 1,   GLUT1↓, 2,   MRP↓, 1,   OATPs↓, 1,   P-gp/ABCB1↓, 75,   sonoP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 10,   CXCR4↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   IL12↑, 2,   IL1β↓, 5,   IL2↓, 1,   IL2↑, 1,   IL6↓, 6,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 4,   NF-kB↓, 20,   NF-kB↑, 1,   p65↓, 1,   PD-1↝, 1,   PD-L1↓, 3,   PGE2↓, 2,   PSA↓, 3,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 8,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 2,   BioAv↓, 10,   BioAv↑, 7,   BioAv⇅, 1,   BioAv↝, 2,   BioEnh↑, 11,   chemoR↓, 1,   ChemoSen↑, 40,   Dose↝, 8,   eff↓, 6,   eff↑, 35,   eff↝, 1,   Half-Life↓, 2,   Half-Life↝, 5,   MDR1↓, 12,   MRP1/ABCC1↓, 4,   P450↓, 3,   RadioS↑, 9,   selectivity?, 1,   selectivity↑, 11,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 2,   BloodF↑, 1,   BMPs↑, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   EGFR↓, 5,   FOXM1↓, 1,   HER2/EBBR2↓, 2,   IL6↓, 6,   Ki-67↓, 4,   KRAS↓, 1,   LDH↑, 1,   PD-L1↓, 3,   PSA↓, 3,   RAGE↓, 1,   TG/TAG↓, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 8,   AntiTum↑, 7,   chemoP↑, 4,   chemoPv↑, 2,   ChemoSideEff↓, 1,   memory↑, 1,   OS↑, 4,   Pain↓, 1,   QoL↑, 3,   radioP↑, 1,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 1,   toxicity↓, 5,   toxicity↝, 3,   TumVol↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 416

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   diuretic↑, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 9,   Catalase↑, 2,   GPx↑, 2,   GSH↑, 3,   GSR↑, 1,   H2O2↑, 1,   HO-1↑, 2,   Keap1↑, 1,   lipid-P↓, 2,   MDA↓, 3,   Nrf1↑, 1,   NRF2↑, 5,   ROS↓, 10,   SIRT3↑, 1,   SOD↑, 5,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 2,   AMPK↓, 1,   BUN↓, 1,   NAD↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 2,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Casp3↓, 3,   cl‑Casp3↓, 1,   Casp9↓, 2,   Cyt‑c↓, 1,   GADD34↓, 1,   iNOS↓, 2,   JNK↓, 2,   MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 2,   GSK‐3β↓, 1,   HDAC↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   PAI-1/SERPINE1↓, 1,   PKCδ↑, 1,   Rho↓, 1,   ZO-1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↓, 1,   EPR↑, 1,   Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 4,   IFN-γ↓, 1,   IL10↓, 2,   IL17↓, 2,   IL1β↓, 1,   IL6↓, 2,   Imm↓, 1,   Imm↑, 1,   Inflam↓, 12,   MCP1/CCL2↓, 1,   NF-kB↓, 2,   PGE2↓, 2,   TNF-α↓, 4,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↓, 1,   tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   BACE/β-secretase↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 4,   BioAv↝, 2,   BioEnh↑, 2,   Dose↝, 1,   eff↑, 4,   Half-Life↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   AST↓, 2,   BP↓, 1,   IL6↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiArt↑, 1,   AntiCan↑, 3,   antiD↓, 1,   AntiDiabetic↑, 3,   AntiP↑, 2,   cardioP↑, 6,   CardioT↓, 1,   chemoP↑, 1,   chemoPv↑, 1,   cognitive↑, 1,   hepatoP↑, 4,   memory↑, 1,   neuroP?, 1,   neuroP↑, 8,   Pain↓, 1,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 3,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   Sepsis↓, 1,  
Total Targets: 112

Scientific Paper Hit Count for: P-gp/ABCB1, permeability-glycoprotein
6 Quercetin
5 itraconazole
5 Ivermectin
4 Baicalein
4 borneol
4 Capsaicin
3 Biochanin A
3 Gambogic Acid
3 doxorubicin
3 Magnetic Fields
3 Rosmarinic acid
2 Astragalus
2 Silymarin (Milk Thistle) silibinin
2 Kaempferol
2 CUSP9
2 Disulfiram
2 Emodin
2 Honokiol
2 Naringin
2 Rutin
1 Artemisinin
1 Berbamine
1 Genistein (soy isoflavone)
1 Beta-Caryophyllene
1 Piperine
1 Chemotherapy
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Celecoxib
1 Cisplatin
1 Centella asiatica / Gotu kola → asiaticoside
1 Cucurbitacin
1 Curcumin
1 immunotherapy
1 Copper and Cu NanoParticles
1 Zinc
1 EGCG (Epigallocatechin Gallate)
1 Fisetin
1 Formononetin
1 Hyperoside
1 SDG/lignans
1 Linalool
1 Atorvastatin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 Docetaxel
1 Paclitaxel/Taxol
1 tamoxifen
1 buckwheat sprouts
1 salinomycin
1 SonoDynamic Therapy UltraSound
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:232  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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