TNF-α Cancer Research Results

TNF-α, TNF-α: Click to Expand ⟱
Source: HalifaxProj (block)
Type:
Tumor Necrosis Factor-alpha (TNF-α) is a cytokine that plays a complex role in cancer biology. It is primarily produced by activated macrophages and is involved in systemic inflammation. TNF-α is a pro-inflammatory cytokine that can promote inflammation, which is a known factor in cancer development.
Overall, the expression of TNF-α in cancers is often linked to inflammation, tumor progression, and the tumor microenvironment.
Scientific Papers found: Click to Expand⟱
2326- 2DG,    Caloric Restriction Mimetic 2-Deoxyglucose Alleviated Inflammatory Lung Injury via Suppressing Nuclear Pyruvate Kinase M2–Signal Transducer and Activator of Transcription 3 Pathway
- in-vivo, Nor, NA
PKM2↓, Inflam↓, TNF-α↓, IL6↓, OS↑,
5444- AG,    A Systematic Review of Phytochemistry, Pharmacology and Pharmacokinetics on Astragali Radix: Implications for Astragali Radix as a Personalized Medicine
- Review, Var, NA
*Imm↑, *antiOx↑, *Inflam↓, AntiTum↑, eff↑, chemoP↑, Dose↝, TumCMig↓, TumCP↓, Akt↓, GSK‐3β↓, MMP2↓, MMP9↓, EMT↓, PI3K↓, Akt↓, NF-kB↓, Inflam↓, TGF-β1↓, TNF-α↓, IL6↓, Fas↓, FasL↓, NOTCH1↓, JNK↓, TumCG↓,
1594- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓, antiOx↑, TumCP↓,
4387- AgNPs,    Attenuation of diethylnitrosamine (DEN) - Induced hepatic cancer in experimental model of Wistar rats by Carissa carandas embedded silver nanoparticles
- in-vitro, Liver, NA
IL6↓, TNF-α↓, IL1β↓, hepatoP↑,
4363- AgNPs,    Immunomodulatory properties of silver nanoparticles contribute to anticancer strategy for murine fibrosarcoma
- in-vivo, fibroS, NA
TumVol↓, TNF-α↓, IL6↓, IL1β↓, *toxicity↝, TumCG↓, selectivity↑, selectivity↑, Weight↑, ROS↑, NO↑,
389- AgNPs,  Citrate,    Silver Citrate Nanoparticles Inhibit PMA-Induced TNFα Expression via Deactivation of NF-κB Activity in Human Cancer Cell-Lines, MCF-7
- in-vitro, BC, MCF7
TNF-α↓, NF-kB↓,
301- ALA,  PacT,  doxoR,    Role of alpha-lipoic acid in counteracting paclitaxel- and doxorubicin-induced toxicities: a randomized controlled trial in breast cancer patients
- Human, BC, NA
BNP↓, TNF-α↓, MDA↓, NeuroT↓,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2/PTGS2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
6394- ANE,    Anethole blocks both early and late cellular responses transduced by tumor necrosis factor: effect on NF-kappaB, AP-1, JNK, MAPKK and apoptosis
TNF-α↓, NF-kB↓, Casp↑, tumCV↓,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
1545- Api,    The Potential Role of Apigenin in Cancer Prevention and Treatment
- Review, NA, NA
TNF-α↓, IL6↓, IL1α↓, P53↑, Bcl-xL↓, Bcl-2↓, BAX↑, Hif1a↓, VEGF↓, TumCCA↑, DNAdam↑, Apoptosis↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK1↓, PI3K↓, Akt↓, mTOR↓, IKKα↓, ERK↓, p‑Akt↓, p‑P70S6K↓, p‑S6↓, p‑ERK↓, p‑P90RSK↑, STAT3↓, MMP2↓, MMP9↓, TumCP↓, TumCMig↓, TumCI↓, Wnt/(β-catenin)↓,
1543- Api,    Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
- Review, NA, NA
TNF-α↓, IL1β↓, IL6↓, IL10↓, COX2/PTGS2↓, iNOS↓, Inflam↓, Dose∅, Dose∅,
556- ART/DHA,    Artemisinins as a novel anti-cancer therapy: Targeting a global cancer pandemic through drug repurposing
- Review, NA, NA
IL6↓, IL1↓, TNF-α↓, TGF-β↓, NF-kB↓, MIP2↓, PGE2↓, NO↓, Hif1a↓, VEGFR2/KDR/Flk1↓, VEGF↓, MMP2↓, TIMP2↑, ITGB1↑, NCAM↑, p‑ATM↑, p‑ATR↑, p‑CHK1↑, p‑Chk2↑, Wnt/(β-catenin)↓, PI3K↓, Akt↓, ERK↓, cMyc↓, mTOR↓, survivin↓, cMET↓, EGFR↓, cycD1/CCND1↓, cycE1↓, CDK4/6↓, p16↑, p27/CDKN1B↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, oncosis↑, TumCCA↑, ROS↑, DNAdam↑, RAD51↓, HR↓,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2/PTGS2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
3155- Ash,    Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera
- Review, Var, NA
Half-Life↝, Inflam↓, antiOx↓, angioG↓, ROS↑, BAX↑, Bak↑, E6↓, E7↓, P53↑, Casp3↑, cl‑PARP↑, STAT3↓, eff↑, HSP90↓, TGF-β↓, TNF-α↓, EMT↑, mTOR↓, NOTCH1↓, p‑Akt↓, NF-kB↓, Dose↝,
4981- ATV,    Crosstalk between Statins and Cancer Prevention and Therapy: An Update
Apoptosis↑, selectivity↑, eff↑, HMG-CoA↓, *cardioP↑, OS↑, IL1β↓, IL6↓, IL8↓, TNF-α↓, TumAuto↑, Histones↝, ac‑H3↑, ac‑H4↑, HDAC↓,
5568- B-Gluc,  immuno,    Beta-glucans in oncology: revolutionizing treatment with immune power & tumor targeting
- Review, Var, NA
TNF-α↓, IL6↓, NF-kB↓, PD-L1↓, Imm↑, BAX↑, Bcl-2↓, TumCCA↑, angioG↓, VEGF↓, MMPs↓, OS↑, chemoP↑, eff↑, BioAv↑,
2699- BBR,    Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line
- in-vitro, Lung, A549
HDAC↓, TumCCA↑, TNF-α↓, COX2/PTGS2↓, MMP2↓, MMP9↓, P21↑, P53↑, Casp↑, ac‑H3↑, ac‑H4↑, ROS↑, MMP↓,
2705- BBR,    Mechanism underlying berberine's effects on HSP70/TNFα under heat stress: Correlation with the TATA boxes
- in-vivo, Nor, NA - in-vitro, Nor, PC12
HSP70/HSPA5↓, TNF-α↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
1092- BBR,    Berberine as a Potential Anticancer Agent: A Comprehensive Review
- Review, NA, NA
Apoptosis↑, TumCCA↑, TumAuto↑, TumCI↓, IL1↓, IL6↓, TNF-α↓, LDH↓, P2X7↓, proCasp1↓, Casp1↓, ASC↓,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,
6503- BCP,    The Potential Therapeutic Role of Beta-Caryophyllene as a Chemosensitizer and an Inhibitor of Angiogenesis in Cancer
- Review, Var, NA
ChemoSen↑, angioG↓, TumCI↓, TumMeta↓, ROS↑, *ROS↓, chemoP↑, CB2 / CNR2↑, Inflam↓, AntiTum↑, *BioAv↑, *BBB↑, Apoptosis↑, TumCP↑, TumCCA↑, RadioS↑, DNArepair↓, ROS↑, STAT3↓, *BioEnh↑, Pain↓, AntiBio↓, ROS↑, Dose↝, NF-kB↓, MAPK↓, TNF-α↓, IL1β↓, IL6↓, cl‑PARP↑, Casp↑, BAX↑, Bcl-2↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP2↓, p‑p38↓, p‑ERK↓, EPR↑, P-gp/ABCB1↓, MRP1/ABCC1↓, *NRF2↑, *antiOx↑,
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
718- Bor,    Boric Acid Exhibits Anticancer Properties in Human Endometrial Cancer Ishikawa Cells
- in-vitro, NA, NA
OSI↑, TNF-α↓, IL1↓, Casp3↑, Apoptosis↑, TOS↑,
726- Bor,    Redox Mechanisms Underlying the Cytostatic Effects of Boric Acid on Cancer Cells—An Issue Still Open
- Review, NA, NA
NAD↝, SAM-e↝, PSA↓, IGF-1↓, Cyc↓, P21↓, p‑MEK↓, p‑ERK↓, ROS↑, SOD↓, Catalase↓, MDA↑, GSH↓, IL1↓, IL6↓, TNF-α↓, BRAF↝, MAPK↝, PTEN↝, PI3K/Akt↝, eIF2α↑, ATF4↑, ATF6↑, NRF2↑, BAX↑, BID↑, Casp3↑, Casp9↑, Bcl-2↓, Bcl-xL↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
1080- Buty,    Butyrate suppresses Cox-2 activation in colon cancer cells through HDAC inhibition
- in-vitro, CRC, HT-29
HDAC↓, TNF-α↓, COX2/PTGS2↓,
5203- CAP,    Capsaicin Promotes Apoptosis and Inhibits Cell Migration via the Tumor Necrosis Factor-Alpha (TNFα) and Nuclear Factor Kappa B (NFκB) Signaling Pathway in Oral Cancer Cells
- in-vitro, OS, KB
tumCV↓, TNF-α↓, NF-kB↓, selectivity↑, Apoptosis↑, TumCMig↓,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5922- Cats,    Uncaria tomentosa acts as a potent TNF-α inhibitor through NF-κB
- in-vitro, AML, THP1
NF-kB↓, AP-1↓, TNF-α↓,
5948- Cela,    Recent Trends in anti-tumor mechanisms and molecular targets of celastrol
TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
2392- Cela,    The role of natural products targeting macrophage polarization in sepsis-induced lung injury
- Review, Sepsis, NA
TNF-α↓, IL1β↓, IL6↓, Warburg↓, PKM2↓, NRF2↑, HO-1↑, NF-kB↓, iNOS↓, M1↓,
6615- Cen,    Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
Dose↝, TumCP↓, selectivity↑, MMP↓, Apoptosis↑, TumCCA↑, NF-kB↓, CDK4↓, cycD1/CCND1↓, Casp9↑, Casp3↑, Bax:Bcl2↑, TumCG↓, ChemoSen↑, TNF-α↓, IL1β↓, P53↑, P21↑,
6651- Cen,    Study of the cytotoxicity of asiaticoside on rats and tumour cells
- vitro+vivo, BC, MCF7
Casp3↑, TNF-α↓, IL1β↓, Apoptosis↑, TumCCA↑, TumVol↓, radioP↑, Inflam↓,
6641- Cen,    Asiaticoside Increases Caspase-9 Activity in MCF-7 Cells and Inhibits TNF-α and IL-6 Expression in Nude Mouse Xenografts via the NF-κB Pathway
- in-vitro, BC, MCF7
Casp9↑, TNF-α↓, IL6↓, NF-kB↓, TumCG↓, Inflam↓, TumCP↓, EMT↓,
6017- CGA,    Therapeutic Potential of Chlorogenic Acid in Chemoresistance and Chemoprotection in Cancer Treatment
- Review, Var, NA
AntiCan↑, *chemoP↑, TNF-α↓, COX2/PTGS2↓, IL6↓, eff↑, PD-L1↓, *cognitive↓, *Aβ↓, *TAC↑, *SOD↑, *eff↑, *eff↑, ChemoSen↑, tumCV↓, Apoptosis↑, ERK↓, chemoP↑, *GPx↑, *GSTs↑, *GSH↑, *SOD↑, *Catalase↑, *ROS↓, *lipid-P↓, *MDA↓, *Casp3↓, *HO-1↓, cardioP↑, radioP↑,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2/PTGS2↓, TNF-α↓, IL1β↓, IL6↓,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
2787- CHr,    Network pharmacology unveils the intricate molecular landscape of Chrysin in breast cancer therapeutics
- Analysis, Var, MCF7
TumCP↓, angioG↓, TumCI↓, TumMeta↓, TP53↑, Akt↓, Casp3↑, tumCV↓, TNF-α↓, BioAv↑, BioAv↑, AKT1↓,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
6304- Cro,    Crocin attenuates NF-κB-mediated inflammation and proliferation in breast cancer cells by down-regulating PRKCQ
- in-vitro, BC, NA
NF-kB↓, tumCV↓, TumCP↓, TNF-α↓, IL1β↓, Inflam↓, PRKCQ/PKCθ↓,
6301- Cro,    Crocin Inhibits Angiogenesis and Metastasis in Colon Cancer via TNF-α/NF-kB/VEGF Pathways
- vitro+vivo, Colon, HT29 - in-vitro, Colon, Caco-2
tumCV↓, selectivity↑, TumCMig↓, TumCI↓, angioG↓, TNF-α↓, NF-kB↓, VEGF↓, TumMeta↓,
6294- Cro,    Crocetin and Crocin from Saffron in Cancer Chemotherapy and Chemoprevention
- Review, Var, NA
*chemoPv↑, *antiOx↑, Apoptosis↑, TumCP↓, Diff↑, TumCCA↑, TumCG↓, TOP2↓, hTERT/TERT↓, Inflam↓, IL1β↓, TNF-α↓, Casp8↑, BAX↑, Cyt‑c↑, ChemoSen↑, RadioS↑, Apoptosis↑, cycD1/CCND1↓, P21↑, p27/CDKN1B↑, Bcl-2↓, Bax:Bcl2↑, Casp9↑, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, N-cadherin↓,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, eff↑, PhotoS↑, eff↑, ROS↑, GSH↓,
182- CUR,  RES,  GI,    Chemopreventive anti-inflammatory activities of curcumin and other phytochemicals mediated by MAP kinase phosphatase-5 in prostate cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3 - in-vitro, Pca, LNCaP - in-vitro, Pca, LAPC-4
p38↓, MKP5↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓,

Showing Research Papers: 1 to 50 of 144
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 144

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↓, 1,   ASAP2↓, 1,   CDK7↓, 1,   CTSK↓, 1,   IL13↓, 1,   IL7↓, 1,   IRF1↑, 1,   LRIG1↑, 1,   miR-134↑, 1,   MTA1↓, 1,   MYCN↓, 1,   NA↑, 1,   PRKCQ/PKCθ↓, 1,   PSEN1/PS1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 8,   Catalase↓, 5,   Catalase↑, 4,   Copper↓, 1,   CYP1A1↓, 1,   Fenton↑, 1,   Ferroptosis↑, 2,   GPx↑, 6,   GPx4↓, 1,   GSH↓, 12,   GSH↑, 6,   GSR↑, 1,   GSTA1↑, 2,   GSTs↑, 1,   H2O2↑, 1,   HO-1↓, 1,   HO-1↑, 7,   Keap1↓, 1,   lipid-P↓, 1,   lipid-P↑, 4,   MDA↓, 4,   MDA↑, 1,   MPO↓, 3,   NRF2↓, 5,   NRF2↑, 14,   OSI↑, 1,   Prx↓, 2,   PrxII↓, 1,   ROS?, 1,   ROS↓, 11,   ROS↑, 61,   ROS⇅, 4,   mt-ROS↑, 2,   SAM-e↝, 1,   SOD↓, 6,   SOD↑, 7,   SOD2↓, 2,   TAC↓, 1,   TBARS↑, 1,   TOS↑, 1,   Trx↓, 1,   Trx1↑, 1,   TrxR↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   ATP↓, 2,   ATP↑, 1,   mt-ATP↓, 1,   Bfl-1↓, 1,   CDC2↓, 3,   CDC25↓, 4,   EGF↓, 4,   FGFR1↓, 1,   Insulin↓, 1,   p‑MEK↓, 1,   mitResp↓, 1,   MKP5↑, 1,   MMP↓, 23,   MMP↑, 1,   MMP↝, 1,   MPT↑, 1,   mtDam↑, 5,   OCR↓, 1,   Raf↓, 1,   UCP1↓, 1,   XIAP?, 1,   XIAP↓, 14,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACAA1↓, 1,   ACC↓, 1,   ACC↑, 1,   AKT1↓, 1,   ALAT↓, 4,   AMPK↑, 6,   p‑AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 13,   CREB↓, 1,   FABP4↓, 1,   FASN↓, 2,   glucose↝, 1,   GlucoseCon↓, 2,   Glycolysis↓, 6,   Histones↝, 1,   HK2↓, 4,   HMG-CoA↓, 1,   lactateProd↓, 2,   LDH↓, 4,   LDH↑, 1,   i-LDH↓, 1,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NAD↝, 1,   PCK1↓, 2,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PFK↓, 2,   PI3K/Akt↓, 1,   PI3K/Akt↝, 1,   PKM2↓, 6,   p‑PKM2↓, 1,   PLIN1↓, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 6,   p‑S6↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   SREBP2↓, 1,   STK11/LKB1↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 38,   p‑Akt↓, 7,   APAF1↑, 1,   Apoptosis?, 1,   Apoptosis↓, 1,   Apoptosis↑, 44,   ATF2↓, 1,   BAD↓, 1,   BAD↑, 2,   Bak↑, 4,   BAX↓, 1,   BAX↑, 35,   BAX⇅, 1,   Bax:Bcl2↑, 6,   Bcl-2↓, 37,   Bcl-2↑, 1,   Bcl-xL↓, 12,   BID↓, 1,   BID↑, 2,   Casp↓, 1,   Casp↑, 13,   Casp1↓, 1,   proCasp1↓, 1,   Casp10↑, 1,   Casp12?, 1,   Casp3↓, 2,   Casp3↑, 42,   cl‑Casp3↑, 1,   Casp7↑, 3,   Casp8↑, 14,   Casp9↓, 1,   Casp9↑, 26,   proCasp9↓, 1,   CBP↓, 1,   cFLIP↓, 1,   Chk2↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   Cyt‑c↑, 21,   Diablo↑, 4,   DR4↑, 1,   DR5↑, 7,   FADD↑, 1,   Fas↓, 2,   Fas↑, 8,   FasL↓, 1,   FasL↑, 2,   Ferroptosis↑, 2,   GranB/GZMB↓, 1,   GSDMD↑, 1,   hTERT/TERT↓, 6,   IAP1↓, 8,   IAP2/BIRC3↓, 4,   IAP2/BIRC3↑, 1,   iNOS↓, 21,   JNK↓, 5,   JNK↑, 3,   p‑JNK↓, 1,   MAPK↓, 11,   MAPK↑, 4,   MAPK↝, 2,   Mcl-1↓, 7,   MDM2↓, 2,   MDM2↑, 1,   Myc↓, 1,   Necroptosis↑, 1,   oncosis↑, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 9,   P2X7↓, 1,   p38↓, 2,   p38↑, 4,   p‑p38↓, 2,   Paraptosis↑, 1,   PPP2R1A↑, 1,   Proteasome↓, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 16,   Telomerase↓, 3,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TumCD↓, 1,   TumCD∅, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 1,   HER2/EBBR2↓, 2,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1,   p‑cJun↓, 1,   EZH2↓, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   ac‑H4↑, 2,   HATs↓, 3,   miR-21↓, 2,   miR-21↑, 1,   other↓, 4,   other↑, 1,   other↝, 1,   PhotoS↑, 2,   pRB↑, 1,   p‑pRB↓, 3,   sonoS↑, 1,   tumCV↓, 14,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 2,   CHOP/DDIT3↑, 6,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↑, 7,   GRP78/BiP↑, 3,   HSP27↓, 2,   HSP27↝, 1,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 5,   HSPs↑, 1,   p‑IRE1↓, 1,   UPR↑, 2,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↑, 6,   BNIP3↑, 1,   LC3B-II↑, 1,   LC3II↑, 4,   LC3s↑, 1,   p62↓, 1,   TumAuto↑, 9,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   p‑ATM↑, 1,   p‑ATR↑, 1,   BRCA1↑, 1,   BRCA2↑, 1,   CHK1↓, 1,   CHK1↑, 1,   p‑CHK1↑, 1,   CYP1B1↑, 1,   DFF45↓, 1,   DFF45↑, 1,   DNAdam↓, 1,   DNAdam↑, 14,   DNArepair↓, 1,   DNMT1↓, 4,   DNMT3A↓, 1,   DNMTs↓, 2,   HR↓, 1,   p16↑, 3,   P53?, 1,   P53↓, 1,   P53↑, 27,   P53↝, 1,   p‑P53↓, 1,   PARP↓, 2,   PARP↑, 4,   cl‑PARP↓, 1,   cl‑PARP↑, 17,   PCNA↓, 10,   RAD51↓, 1,   TP53↑, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 3,   CDK2↓, 10,   CDK2↑, 1,   CDK4↓, 11,   Cyc↓, 1,   cycA1/CCNA1↓, 3,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 11,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 23,   cycD1/CCND1↑, 2,   CycD3↓, 1,   cycE/CCNE↓, 5,   cycE1↓, 1,   E2Fs↓, 1,   P21↓, 2,   P21↑, 16,   RB1↑, 2,   TumCCA↓, 1,   TumCCA↑, 39,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 1,   BRAF↝, 1,   CD133↓, 2,   CD44↓, 3,   cFos↓, 2,   cMET↓, 4,   cMYB↓, 1,   CSCs↓, 8,   Diff↑, 1,   EMT↓, 18,   EMT↑, 2,   EP2↓, 1,   ERK↓, 21,   ERK↑, 4,   p‑ERK↓, 5,   FGF↓, 2,   FOXM1↓, 1,   FOXO↑, 3,   FOXO1↓, 1,   FOXO3↓, 1,   Gli1↓, 2,   GSK‐3β↓, 4,   GSK‐3β↑, 3,   HDAC↓, 9,   HDAC1↓, 1,   HDAC2↓, 1,   HH↓, 4,   IGF-1↓, 5,   IGFBP3↑, 2,   miR-34a↑, 2,   mTOR↓, 22,   p‑mTOR↓, 1,   mTORC1↓, 2,   mTORC2↓, 1,   Nanog↓, 1,   NOTCH↓, 6,   NOTCH1↓, 7,   NOTCH1↑, 2,   OCT4↓, 1,   p300↓, 1,   P70S6K↓, 3,   p‑P70S6K↓, 1,   p‑P90RSK↑, 1,   PI3K↓, 27,   PI3K↝, 1,   PTCH1↓, 1,   PTEN↑, 4,   PTEN↝, 1,   RAS↓, 6,   SCF↓, 1,   Shh↓, 3,   Smo↓, 1,   Src↓, 1,   STAT↓, 2,   STAT3↓, 26,   STAT3↑, 1,   p‑STAT3↓, 6,   STAT5↓, 1,   TOP1↓, 2,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 10,   Wnt↓, 10,   Wnt↝, 1,   Wnt/(β-catenin)↓, 3,  

Migration(tgid=13) ⓘ

5LO↓, 4,   ACTA2↓, 1,   AntiAg?, 1,   AP-1↓, 8,   CA↓, 1,   Ca+2↑, 4,   Ca+2↝, 1,   Cartilage↑, 1,   CDK4/6↓, 2,   CEA↓, 1,   CLDN1↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   COL4↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 10,   ER-α36↓, 1,   FAK↓, 5,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 1,   ITGA11↓, 1,   ITGA5↓, 1,   ITGB1↑, 1,   Ki-67↓, 9,   LAMB3↑, 1,   LEF1↓, 1,   LRP1↓, 1,   MMP-10↓, 1,   MMP1↓, 3,   MMP13↓, 3,   MMP2↓, 30,   MMP3↓, 3,   MMP7↓, 6,   MMP9↓, 29,   MMP9↑, 1,   MMPs↓, 15,   MUC4↓, 1,   N-cadherin↓, 10,   NCAM↑, 1,   NeuroT↓, 1,   PDGF↓, 3,   PKA↓, 2,   PKCδ↓, 1,   Rac1↓, 1,   RAGE↓, 1,   Rho↓, 3,   ROCK1↓, 3,   Slug↓, 3,   Snail↓, 7,   TET1↑, 1,   TGF-β↓, 7,   TGF-β1↓, 1,   THBS2↓, 1,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 3,   TIMP3↑, 1,   TSP-1↑, 2,   TumCI↓, 18,   TumCMig↓, 17,   TumCP↓, 36,   TumCP↑, 1,   TumMeta↓, 18,   TumMeta↑, 1,   Twist↓, 7,   uPA↓, 5,   uPAR↓, 1,   VCAM-1↓, 1,   Vim↓, 6,   Zeb1↓, 2,   ZEB2↓, 1,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 11,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 33,   ATF4↑, 1,   EGFR↓, 12,   p‑EGFR↓, 1,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 13,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 5,   NO↑, 1,   NO↝, 1,   VEGF↓, 38,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GLUT1↓, 3,   GLUT3↓, 1,   P-gp/ABCB1↓, 7,   P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CB2 / CNR2↑, 1,   CD4+↓, 2,   COX1↓, 1,   COX2/PTGS2↓, 60,   COX2/PTGS2↑, 1,   CRP↓, 4,   CXCL1↓, 1,   CXCR4↓, 7,   CXCR4↑, 1,   HMGB1↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 6,   IFN-γ↑, 2,   IKKα↓, 4,   IL1↓, 11,   IL1↑, 1,   IL10↓, 6,   IL10↑, 4,   IL12↓, 4,   IL12↑, 1,   IL17↓, 3,   IL18↓, 2,   IL1α↓, 1,   IL1β↓, 46,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 4,   IL22↓, 3,   IL23↓, 2,   IL28↓, 1,   IL4↓, 3,   IL4↑, 2,   IL6↓, 74,   IL8↓, 10,   IL9↓, 1,   Imm↑, 3,   Imm↝, 1,   INF-γ↓, 1,   Inflam↓, 33,   IRAK4↓, 1,   IκB↓, 3,   JAK↓, 1,   JAK1↓, 3,   JAK1↑, 1,   JAK2↓, 5,   M1↓, 1,   MCP1/CCL2↓, 4,   MIP‑1α/CCL3↓, 1,   MIP2↓, 2,   mPGES-1↓, 1,   NF-kB↓, 82,   NF-kB↑, 1,   p‑NF-kB↓, 2,   NK cell↑, 3,   p50↓, 3,   p65↓, 5,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-L1↓, 5,   PGE1↓, 1,   PGE2↓, 11,   PSA↓, 4,   PSA∅, 1,   RANTES↓, 1,   Resistin↓, 1,   SOCS1↑, 1,   Th1 response?, 1,   TLR2↓, 1,   TLR4↓, 6,   TNF-α↓, 145,   TNF-α↑, 2,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 3,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 3,   BNP↓, 1,   CDK6↓, 5,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 17,   BioAv↑, 17,   BioAv↝, 3,   ChemoSen↑, 34,   Dose?, 1,   Dose↓, 1,   Dose↑, 4,   Dose↝, 19,   Dose∅, 4,   eff↓, 3,   eff↑, 33,   eff↝, 3,   Half-Life↓, 2,   Half-Life↝, 5,   Half-Life∅, 1,   MDR1↓, 1,   MRP1/ABCC1↓, 2,   P450↓, 3,   RadioS↑, 10,   selectivity↑, 18,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 4,   ALP↓, 1,   AR↓, 3,   AST↓, 3,   BMD↑, 2,   BRAF↝, 1,   BRCA1↑, 1,   CA125↓, 1,   CEA↓, 1,   CRP↓, 4,   CYFRA21-1↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 12,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   GutMicro↑, 2,   HER2/EBBR2↓, 2,   hTERT/TERT↓, 6,   IL6↓, 74,   Ki-67↓, 9,   LDH↓, 4,   LDH↑, 1,   i-LDH↓, 1,   Myc↓, 1,   NOS2↑, 1,   PD-L1↓, 5,   PSA↓, 4,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 10,   AntiTum↑, 4,   cardioP↑, 4,   CardioT↑, 1,   chemoP↑, 15,   chemoPv↑, 4,   ChemoSideEff↓, 3,   hepatoP↓, 1,   hepatoP↑, 5,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 12,   Pain↓, 1,   QoL↑, 4,   radioP↑, 3,   RenoP↑, 4,   Risk↓, 2,   toxicity↓, 5,   toxicity↑, 1,   TumVol↓, 7,   TumW↓, 3,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↓, 1,  
Total Targets: 637

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   diuretic↑, 1,   Stroke↓, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 16,   Catalase↑, 12,   GPx↑, 9,   GSH↑, 8,   GSR↑, 2,   GSTs↑, 5,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 4,   Keap1↓, 1,   lipid-P↓, 7,   MDA↓, 5,   MPO↓, 1,   NQO1↑, 2,   NRF2↑, 8,   ROS↓, 23,   ROS∅, 1,   SOD↑, 14,   SOD2↑, 1,   TAC↑, 2,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 3,   AMPK↑, 2,   BUN↓, 1,   LDH↓, 1,   PPARα↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Casp1↓, 1,   Casp3↓, 2,   Casp9↓, 1,   GRP58↓, 1,   iNOS↓, 3,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 1,   p38↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 2,   UPR↓, 1,   XBP-1↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 2,   HDAC3↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ki-67↓, 1,   PAI-1/SERPINE1↓, 1,   PKCδ↑, 1,   TXNIP↓, 1,   ZO-1↑, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   Hif1a↓, 1,   NO↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 5,   IFN-γ↓, 2,   IL18↓, 1,   IL1β↓, 3,   IL2↓, 1,   IL6↓, 3,   Imm↑, 2,   Inflam↓, 19,   MyD88↓, 1,   NF-kB↓, 4,   PGE2↓, 1,   TLR2↓, 1,   TLR4↓, 2,   TNF-α↓, 3,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   EndoR↑, 1,   monoA↑, 1,   tau↓, 1,   p‑tau↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 4,   BACE/β-secretase↓, 1,   NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 8,   BioAv↑, 6,   BioAv↝, 7,   BioEnh↑, 3,   Dose↝, 1,   eff↑, 4,   Half-Life↝, 1,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 1,   AST↓, 4,   BG↓, 1,   GutMicro↑, 3,   GutMicro↝, 1,   IL6↓, 3,   Ki-67↓, 1,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   antiAll↑, 1,   AntiArt↑, 2,   AntiCan↑, 2,   antiD↓, 1,   AntiDiabetic↓, 1,   AntiDiabetic↑, 1,   antiPs↑, 1,   AntiTum↓, 1,   cardioP↑, 6,   chemoP↑, 3,   chemoPv↑, 2,   cognitive↓, 2,   hepatoP↑, 8,   motorD↓, 1,   neuroP?, 1,   neuroP↑, 9,   Obesity↓, 1,   radioP↑, 2,   RenoP↑, 2,   toxicity↓, 4,   toxicity↝, 2,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 2,   IRF3↓, 1,   Sepsis↓, 1,  
Total Targets: 134

Scientific Paper Hit Count for: TNF-α, TNF-α
7 Quercetin
6 Propolis -bee glue
6 Thymoquinone
5 Lycopene
4 Silver-NanoParticles
4 Berberine
4 Crocetin
4 Resveratrol
4 EGCG (Epigallocatechin Gallate)
4 Rosmarinic acid
4 Sulforaphane (mainly Broccoli)
3 Beta-Caryophyllene
3 Boron
3 Celastrol
3 Centella asiatica / Gotu kola → asiaticoside
3 Chrysin
3 Fisetin
3 Honokiol
3 Luteolin
3 Silymarin (Milk Thistle) silibinin
2 Citric Acid
2 Anethole/trans-Anethole
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Chlorogenic acid
2 Curcumin
2 Ginger/6-Shogaol/Gingerol
2 Chemotherapy
2 Gambogic Acid
2 Hyperoside
2 Inositol
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 lambertianic acid
2 Magnetic Fields
2 Naringin
2 Shikonin
1 2-DeoxyGlucose
1 Astragalus
1 Alpha-Lipoic-Acid
1 Paclitaxel/Taxol
1 doxorubicin
1 alpha Linolenic acid
1 Andrographis
1 Artemisinin
1 Atorvastatin
1 beta-glucans
1 immunotherapy
1 Boswellia (frankincense)
1 Butyrate
1 Capsaicin
1 Carvacrol
1 Cat’s Claw
1 CUSP9
1 Deguelin
1 Dandelion Root
1 Ellagic acid
1 Radiotherapy/Radiation
1 Docetaxel
1 Emodin
1 Evodiamine
1 Exercise
1 Fucoidan
1 Shilajit/Fulvic Acid
1 Galloflavin
1 Garcinol
1 Geraniol
1 Grapeseed extract
1 Hydrogen Gas
1 HydroxyTyrosol
1 capecitabine
1 Isoliquiritigenin
1 isoflavones
1 isoorientin
1 Kaempferol
1 Linalool
1 5-fluorouracil
1 Cisplatin
1 Melatonin
1 Magnetic Field Rotating
1 Oleocanthal
1 Piperine
1 probiotics
1 Bifidobacterium
1 Perilla
1 Rutin
1 buckwheat sprouts
1 Sulfasalazine
1 Turmerones
1 Ursolic acid
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Zerumbone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:309  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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