IL2 Cancer Research Results

IL2, Interleukin-2: Click to Expand ⟱
Source:
Type:
The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and regulatory T (Treg) cells.

IL-2 is often expressed in various cancers, including melanoma, renal cell carcinoma, and certain hematological malignancies. Its expression can vary depending on the tumor type and the immune context.
Tumor-infiltrating lymphocytes (TILs), particularly activated T cells, are significant sources of IL-2 in the tumor microenvironment.

IL-2 is primarily known for its role in promoting anti-tumor immunity. It stimulates the proliferation and activation of T cells, enhancing their ability to recognize and kill tumor cells.
Scientific Papers found: Click to Expand⟱
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
6214- CUR,    Curcumin Nanoparticles-related Non-invasive Tumor Therapy, and Cardiotoxicity Relieve
TumCD↓, TumCI↓, *Inflam↓, *antiOx↓, *AntiTum↓, NF-kB↓, COX2/PTGS2↓, Casp9↓, ROS↑, BioAv↑, RadioS↑, ChemoSen↑, Imm↑, PhotoS↑, sonoS↑, 5LO↓, iNOS↓, IL2↓, TNF-α↓, Casp9↑, Casp3↑, Bcl-2↓, BAX↑, Apoptosis↑, ER Stress↑, cycD1/CCND1↓, CDK2↓, CycB/CCNB1↓, TumCCA↑, MMPs↓, *radioP↑, chemoP↑, hepatoP↑, cardioP↑, eff↑, PhotoS↑, eff↑, ROS↑, GSH↓,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
13- CUR,    Role of curcumin in regulating p53 in breast cancer: an overview of the mechanism of action
- Review, BC, NA
P53↑, DR5↑, JNK↑, NRF2↑, PPARγ↑, HER2/EBBR2↓, IR↓, ER(estro)↓, Fas↑, PDGF↓, TGF-β↓, FGF↓, EGFR↓, JAK↓, PAK↓, MAPK↓, ATPase↓, COX2/PTGS2↓, MMPs↓, IL1↓, IL2↓, IL5↓, IL6↓, IL8↓, IL12↓, IL18↓, NF-kB↓, NOTCH1↓, STAT1↓, STAT4↓, STAT5↓, STAT3↓,
8318- LIN,    Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity
- NA, BC, T47D - NA, CRC, SW-620 - NA, Liver, HepG2
TumCCA↑, IFN-γ↓, IL13↓, IL2↓, IL4↓, IL6↓, TNF-α↓, Th1 response?,
2927- LT,    Luteolin Causes 5′CpG Demethylation of the Promoters of TSGs and Modulates the Aberrant Histone Modifications, Restoring the Expression of TSGs in Human Cancer Cells
- in-vitro, Cerv, HeLa
TumCMig↓, DNMTs↓, HDAC↓, HATs↓, ac‑H3↓, ac‑H4↓, MMP2↓, MMP9↓, HO-1↓, E-cadherin↑, EZH2↓, HER2/EBBR2↓, IL18↓, IL8↓, IL2↓,
5044- SAS,    xCT inhibitor sulfasalazine depletes paclitaxel-resistant tumor cells through ferroptosis in uterine serous carcinoma
- in-vitro, Var, NA
xCT/SLC7A11↓, Ferroptosis↑, ROS↑, IL1↓, IL2↓, NF-kB↓, GSH↓, TumCG↓, ChemoSen↑,
596- VitC,    High-Dose Vitamin C in Advanced-Stage Cancer Patients
- Review, NA, NA
ChemoSideEff↓, ROS↑, H2O2↑, Fenton↑, Hif1a↝, Dose↑, BioAv↓, Dose↝, Half-Life↝, IL1β↓, IL2↓, IL8↓, TNF-α↓,

Showing Research Papers: 1 to 10 of 10

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IL13↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Fenton↑, 1,   Ferroptosis↑, 1,   GSH↓, 3,   H2O2↑, 1,   HO-1↓, 2,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↑, 5,   SOD↑, 1,   xCT/SLC7A11↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   cMyc↓, 1,   IR↓, 1,   PKM2↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   p‑Akt↓, 1,   APAF1↑, 1,   Apoptosis↑, 4,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp↑, 1,   Casp3↓, 1,   Casp3↑, 1,   Casp9↓, 1,   Casp9↑, 2,   Cyt‑c↓, 1,   DR5↑, 1,   Fas↑, 1,   Ferroptosis↑, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 2,   TumCD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   PAK↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   EZH2↓, 1,   ac‑H3↓, 1,   ac‑H4↓, 1,   HATs↓, 1,   other↓, 1,   PhotoS↑, 2,   sonoS↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 2,   HSP27↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3I↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   DNMTs↓, 1,   P53↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 2,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 2,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   CD133↑, 1,   CD44↓, 1,   cFos↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 1,   FGF↓, 1,   GSK‐3β↓, 1,   HDAC↓, 1,   HDAC10↓, 1,   p‑mTOR↓, 1,   NOTCH1↓, 1,   PI3K↓, 2,   Shh↓, 1,   STAT↓, 1,   STAT1↓, 1,   STAT3↓, 2,   STAT4↓, 1,   STAT5↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 2,   ATPase↓, 1,   E-cadherin↑, 1,   MMP2↓, 2,   MMP9↓, 4,   MMPs↓, 2,   PDGF↓, 1,   PKCδ↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumCP↓, 1,   TumMeta↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 2,   Hif1a↓, 1,   Hif1a↝, 1,   VEGF↓, 2,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 4,   CXCR4↓, 1,   IFN-γ↓, 2,   p‑IKKα↓, 1,   IL1↓, 4,   IL12↓, 2,   IL18↓, 2,   IL1β↓, 2,   IL2↓, 10,   IL4↓, 3,   IL5↓, 1,   IL6↓, 5,   IL8↓, 4,   Imm↑, 2,   JAK↓, 2,   MCP1/CCL2↓, 1,   NF-kB↓, 7,   PD-L1↓, 1,   Th1 response?, 1,   TNF-α↓, 4,  

Protein Aggregation(tgid=19) ⓘ

XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ER(estro)↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 2,   ChemoSen↑, 3,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 3,   Half-Life↝, 1,   RadioS↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 2,   EZH2↓, 1,   HER2/EBBR2↓, 2,   IL6↓, 5,   PD-L1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   chemoP↑, 1,   ChemoSideEff↓, 1,   hepatoP↑, 1,  
Total Targets: 147

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 2,   MDA↓, 1,   NRF2↑, 2,   ROS↓, 2,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Barriers & Transport(tgid=15) ⓘ

GLUT3↑, 1,   GLUT4↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CRP↓, 1,   IL6↓, 1,   Inflam↓, 3,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   eff↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BMD↑, 1,   CRP↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↓, 1,   cognitive↓, 1,   neuroP↑, 2,   Pain↓, 1,   radioP↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   Diar↓, 1,  
Total Targets: 35

Scientific Paper Hit Count for: IL2, Interleukin-2
3 Curcumin
1 Baicalein
1 Bromelain
1 Boswellia (frankincense)
1 Linalool
1 Luteolin
1 Sulfasalazine
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:366  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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