Snail Cancer Research Results

Snail, Snail: Click to Expand ⟱
Source:
Type:
Snail gene may show a role in recurrence of breast cancer by downregulating E-cadherin and inducing an epithelial to mesenchymal transition. Snail promotes metastasis of breast cancer cells and overexpression of Snail is a biomarker of poor clinical outcome for patients with breast cancer.
Snail, a repressor of E-cadherin and an inducer of EMT.
Snail (SNAI1):
A transcription factor that plays a key role in the regulation of the epithelial-to-mesenchymal transition (EMT).
It suppresses the expression of epithelial markers (such as E-cadherin) and upregulates mesenchymal markers, facilitating changes in cell adhesion and motility.
EMT Induction:
Snail actively represses genes such as E-cadherin, a protein critical for cell–cell adhesion. Its upregulation leads to a loss of epithelial characteristics and the acquisition of a mesenchymal phenotype, enhancing migratory potential.
Invasion and Metastasis:
Through EMT induction, Snail facilitates tumor cell dissemination and invasion into surrounding tissues, thereby playing a central role in metastasis.

Elevated levels of Snail have been observed in a variety of cancers, including breast, colorectal, pancreatic, and head and neck cancers.
Elevated Snail expression is frequently associated with a worse prognosis, including lower overall survival rates and increased likelihood of metastasis.
Scientific Papers found: Click to Expand⟱
6465- 1,8-Cin,    Eucalyptol targets PI3K/Akt/mTOR pathway to inhibit skin cancer metastasis
- vitro+vivo, Melanoma, NA
TumMeta↓, TumCMig↓, TumCI↓, Vim↓, Snail↓, Slug↓, Twist↓, E-cadherin↓, EMT↓, MMP2↓, MMP9↓, PI3K↓, Akt↓, mTOR↓,
1333- AG,    Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
- in-vitro, BC, NA
TumCMig↓, TumCI↓, Ki-67↓, TumCP↓, Snail↓, Vim↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓,
278- ALA,    The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment
- Review, NA, NA
ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,
1124- ALA,    Alpha lipoic acid inhibits proliferation and epithelial mesenchymal transition of thyroid cancer cells
- in-vitro, Thyroid, BCPAP - in-vitro, Thyroid, HTH-83 - in-vitro, Thyroid, CAL-62 - in-vitro, Thyroid, FTC-133 - in-vivo, NA, NA
TumCP↓, AMPK↑, mTOR↓, TumCMig↓, TumCI↓, EMT↓, E-cadherin↑, β-catenin/ZEB1↓, Vim↓, Snail↓, Twist↓, TGF-β↓, p‑SMAD2↓, TumCG↓,
7394- Amla,    Emblica officinalis extract downregulates pro-angiogenic molecules via upregulation of cellular and exosomal miR-375 in human ovarian cancer cells
- vitro+vivo, Ovarian, NA
antiNeop↑, TumCP↓, TumCMig↓, TumCI↓, TumCG↓, miR-375↑, IGFR↓, Snail↓, E-cadherin↑,
1095- Api,    Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway
- Analysis, Colon, NA
Snail↓, EMT↓, NF-kB↓,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
210- Api,    Apigenin inhibits migration and invasion via modulation of epithelial mesenchymal transition in prostate cancer
- in-vitro, Pca, DU145
EMT↓, E-cadherin↑, Snail↓, Vim↓,
240- Api,    The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, CD44+
P21↑, p27/CDKN1B↑, Casp3↑, Casp8↑, Slug↓, Snail↓, NF-kB↓, PI3K↓, Akt↓,
1560- Api,    Apigenin as an anticancer agent
- Review, NA, NA
Apoptosis↑, Casp3∅, Casp8∅, TNF-α∅, Cyt‑c↑, MMP2↓, MMP9↓, Snail↓, Slug↓, NF-kB↓, p50↓, PI3K↓, Akt↓, p‑Akt↓,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
5172- Ash,    Withaferin-A suppress AKT induced tumor growth in colorectal cancer cells
Akt↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, Snail↓, Slug↓, β-catenin/ZEB1↓, Vim↓, angioG↓,
2617- Ba,    Potential of baicalein in the prevention and treatment of cancer: A scientometric analyses based review
- Review, Var, NA
Ca+2↑, MMP2↓, MMP9↓, Vim↓, Snail↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓, p‑Akt↓, p‑mTOR↓, NF-kB↓, i-ROS↑, Bcl-2↓, BAX↑, Cyt‑c↑, Casp3↑, Casp9↑, STAT3↓, IL6↓, MMP2↓, MMP9↓, NOTCH↓, PPARγ↓, p‑NRF2↓, HK2↓, LDHA↓, PDK1 / PDPK1↓, Glycolysis↓, PTEN↑, Akt↓, Hif1a↓, MMP↓, VEGF↓, VEGFR2/KDR/Flk1↓, TOP2↓, uPA↓, TIMP1↓, TIMP2↓, cMyc↓, TrxR↓, ASK1↑, Vim↓, ZO-1↑, E-cadherin↑, SOX2↓, OCT4↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, XIAP↓,
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,
1398- BBR,    Berberine inhibits the progression of renal cell carcinoma cells by regulating reactive oxygen species generation and inducing DNA damage
- in-vitro, Kidney, NA
TumCP↓, TumCMig↓, ROS↑, Apoptosis↑, BAX↑, BAD↑, Bak↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp9↑, E-cadherin↑, TIMP1↑, γH2AX↑, Bcl-2↓, N-cadherin↓, Vim↓, Snail↓, RAD51↓, PCNA↓,
1392- BBR,    Based on network pharmacology and experimental validation, berberine can inhibit the progression of gastric cancer by modulating oxidative stress
- in-vitro, GC, AGS - in-vitro, GC, MKN45
TumCG↓, TumCMig↓, ROS↑, MDA↑, SOD↓, NRF2↓, HO-1↓, Hif1a↓, EMT↓, Snail↓, Vim↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2047- Buty,    Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells
- in-vitro, CRC, T24/HTB-9 - in-vitro, Nor, SV-HUC-1 - in-vitro, Bladder, 5637 - in-vivo, NA, NA
HDAC↓, AntiTum↑, TumCMig↓, AMPK↑, mTOR↑, TumAuto↑, ROS↑, miR-139-5p↑, BMI1↓, TumCI?, E-cadherin↑, N-cadherin↓, Vim↓, Snail↓, cl‑PARP↑, cl‑Casp3↑, BAX↑, Bcl-2↓, Bcl-xL↓, MMP↓, PINK1↑, PARK2↑, TumMeta↓, TumCG↓, LC3II↑, p62↓, eff↓,
1652- CA,    Caffeic Acid and Diseases—Mechanisms of Action
- Review, Var, NA
Dose∅, ROS⇅, NF-kB↓, STAT3↓, VEGF↓, MMP9↓, HSP70/HSPA5↑, AST↝, ALAT↝, ALP↝, Hif1a↓, IL6↓, IGF-1R↓, P21↑, iNOS↓, ERK↓, Snail↓, BID↑, BAX↑, Casp3↑, Casp7↑, Casp9↑, cycD1/CCND1↓, Vim↓, β-catenin/ZEB1↓, COX2/PTGS2↓, ROS↑,
5849- CAP,    The Impact of TRPV1 on Cancer Pathogenesis and Therapy: A Systematic Review
- Review, Var, NA
TRPV1↑, Ca+2↑, TumCD↑, TumCCA↑, Apoptosis↑, P53↑, Fas↑, PI3K↑, AR↑, STAT3↓, ROS↑, MMP↓, ATP↓, CHOP/DDIT3↑, TumCMig↓, Twist↓, Snail↓, MMP2↓, MMP9↓, E-cadherin↑,
1103- CBD,    Cannabidiol inhibits invasion and metastasis in colorectal cancer cells by reversing epithelial-mesenchymal transition through the Wnt/β-catenin signaling pathway
- vitro+vivo, NA, NA
Apoptosis↑, TumCP↓, TumCMig↓, TumMeta↓, EMT↓, E-cadherin↑, N-cadherin↓, Snail↓, Vim↓, Hif1a↓, Wnt/(β-catenin)↓, AXIN1↑, TumVol↓, TumW↓,
1106- CGA,    Chlorogenic Acid Inhibits Epithelial-Mesenchymal Transition and Invasion of Breast Cancer by Down-Regulating LRP6
- vitro+vivo, BC, MCF7
E-cadherin↑, ZO-1↑, Zeb1↓, N-cadherin↓, Vim↓, Snail↓, Slug↓, MMP2↓, MMP9↓, TumCMig↓, TumCI↓, LRP6↓, p‑LRP6↓, β-catenin/ZEB1↓, TumVol↓, TumW↓,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
1107- CHr,    Chrysin inhibits metastatic potential of human triple-negative breast cancer cells by modulating matrix metalloproteinase-10, epithelial to mesenchymal transition, and PI3K/Akt signaling pathway
- in-vitro, BC, NA
TumCP↓, Apoptosis↑, MMP-10↓, E-cadherin↑, Vim↓, Snail↓, Slug↓, EMT↓,
1587- Citrate,    ATP citrate lyase: A central metabolic enzyme in cancer
- Review, NA, NA
ACLY↓, other↓, PFK1↓, ATP↓, PFK2↓, Mcl-1↓, Casp3↑, Casp2↑, Casp9↑, IGF-1R↓, PI3K↓, Akt↓, p‑Akt↓, p‑ERK↓, PTEN↑, Snail↓, E-cadherin↑, ChemoSen↑,
433- CUR,    Curcumin Inhibits the Migration and Invasion of Non-Small-Cell Lung Cancer Cells Through Radiation-Induced Suppression of Epithelial-Mesenchymal Transition and Soluble E-Cadherin Expression
- in-vitro, Lung, A549
E-cadherin↓, Vim↓, Slug↓, N-cadherin↓, Snail↓, MMP9↓, EMT↓,
443- CUR,    Reduced Caudal Type Homeobox 2 (CDX2) Promoter Methylation Is Associated with Curcumin’s Suppressive Effects on Epithelial-Mesenchymal Transition in Colorectal Cancer Cells
- in-vitro, CRC, SW480
DNMT1↓, DNMT3A↓, N-cadherin↓, Vim↓, Wnt↓, Snail↓, Twist↓, β-catenin/ZEB1↓, E-cadherin↑, EMT↓, CDX2↓,
6245- Cyc,    Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
- vitro+vivo, PC, NA
HH↓, Snail↓, E-cadherin↑, EMT↓, TumCI↓, ChemoSen↑, TumMeta↓, ALDH↓, eff↑,
6248- Cyc,    The Hedgehog Inhibitor Cyclopamine Reduces β-Catenin-Tcf Transcriptional Activity, Induces E-Cadherin Expression, and Reduces Invasion in Colorectal Cancer Cells
- in-vitro, CRC, NA
HH↓, Apoptosis↑, Slug↓, Snail↓, Twist↓, EMT↓, β-catenin/ZEB1↓, E-cadherin↑, TumCI↓,
16- Cyc,  RES,    Resveratrol inhibits the hedgehog signaling pathway and epithelial-mesenchymal transition and suppresses gastric cancer invasion and metastasis
- in-vitro, GC, SGC-7901
HH↓, Gli1↓, EMT↓, N-cadherin↓, E-cadherin↑, Snail↓, TumCI↓, TumMeta↓,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
1605- EA,    Ellagic Acid and Cancer Hallmarks: Insights from Experimental Evidence
- Review, Var, NA
*BioAv↓, antiOx↓, Inflam↓, TumCP↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, P53↑, P21↑, COX2/PTGS2↓, NF-kB↓, Akt↑, NOTCH↓, CDK2↓, CDK6↓, JAK↓, STAT3↓, EGFR↓, p‑ERK↓, p‑Akt↓, p‑STAT3↓, TGF-β↓, SMAD3↓, CDK6↓, Wnt/(β-catenin)↓, Myc↓, survivin↓, CDK8↓, PKCδ↓, tumCV↓, RadioS↑, eff↑, MDM2↓, XIAP↓, p‑RB1↓, PTEN↑, p‑FAK↓, Bax:Bcl2↑, Bcl-xL↓, Mcl-1↓, PUMA↑, NOXA↑, MMP↓, Cyt‑c↑, ROS↑, Ca+2↝, Endoglin↑, Diablo↑, AIF↑, iNOS↓, Casp9↑, Casp3↑, cl‑PARP↑, RadioS↑, Hif1a↓, HO-1↓, HO-2↓, SIRT1↓, selectivity↑, Dose∅, NHE1↓, Glycolysis↓, GlucoseCon↓, lactateProd↓, PDK1 / PDPK1?, PDK1 / PDPK1?, ECAR↝, COX1↓, Snail↓, Twist↓, cMyc↓, Telomerase↓, angioG↓, MMP2↓, MMP9↓, VEGF↓, Dose↝, PD-L1↓, eff↑, SIRT6↑, DNAdam↓,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
27- EA,    Ellagic acid inhibits human pancreatic cancer growth in Balb c nude mice
- in-vivo, PC, PANC1
HH↓, Gli1↓, GLI2↓, CDK1/2/5/9↓, p‑Akt↓, NOTCH1↓, Shh↓, Snail↓, E-cadherin↑, NOTCH3↓, HEY1↓, TumCG↓, TumCP↓, Casp3↑, cl‑PARP↑, Bcl-2↓, cycD1/CCND1↓, CDK2↓, CDK6↓, BAX↑, COX2/PTGS2↓, Hif1a↓, VEGF↓, VEGFR2/KDR/Flk1↓, IL6↓, IL8↓, MMP2↓, MMP9↓, NA↓,
22- EGCG,    Inhibition of sonic hedgehog pathway and pluripotency maintaining factors regulate human pancreatic cancer stem cell characteristics
- in-vitro, PC, CD133+ - in-vitro, PC, CD44+ - in-vitro, PC, CD24+ - in-vitro, PC, ESA+
HH↓, Smo↓, PTCH1↓, PTCH2↓, Gli1↓, GLI2↓, Gli↓, Bcl-2↓, XIAP↓, Shh↓, survivin↓, Casp3↑, Casp7↑, CSCs↓, Nanog↓, cMyc↓, OCT4↓, EMT↓, Snail↓, Slug↓, Zeb1↓, TumCMig↓, TumCI↓, eff↑,
685- EGCG,  CUR,  SFN,  RES,  GEN  The “Big Five” Phytochemicals Targeting Cancer Stem Cells: Curcumin, EGCG, Sulforaphane, Resveratrol and Genistein
- Analysis, NA, NA
Bcl-2↓, survivin↓, XIAP↓, EMT↓, Apoptosis↑, Nanog↓, cMyc↓, OCT4↓, Snail↓, Slug↓, Zeb1↓, TCF↓,
4682- EGCG,    Human cancer stem cells are a target for cancer prevention using (−)-epigallocatechin gallate
- Review, Var, NA
CSCs↓, EMT↓, ChemoSen↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, TumCP↓, Apoptosis↑, p‑GSK‐3β↓, GSK‐3β↑, β-catenin/ZEB1↓, cMyc↓, XIAP↓, Bcl-2↓, survivin↓, Vim↓, Slug↓, Snail↓,
4685- EGCG,    Epigallocathechin gallate, polyphenol present in green tea, inhibits stem-like characteristics and epithelial-mesenchymal transition in nasopharyngeal cancer cell lines
- in-vitro, NPC, TW01 - in-vitro, NPC, TW06
CSCs↓, EMT↓, TumCMig↓, TumCI↓, OCT4↓, Snail↓, Vim↓, E-cadherin↓, HSP70/HSPA5↓, HSP90↓, AntiTum↓,
6390- Eug,    Molecular mechanisms of eugenol as an antitumour bioactive compound: A comprehensive review
- Review, Var, NA
TumCCA↑, angioG↓, TumMeta↓, tumCV↓, Casp3↑, Casp6↑, DFF45↑, PARP↑, ROS↑, Cyt‑c↑, MPT↑, *ROS↓, NF-kB↓, COX2/PTGS2↓, 5LO↓, EMT↓, Snail↓, E-cadherin↑, Vim↓, PI3K↓, Akt↓, mTORC2↓, TumAuto↑, FOXO3↓, Apoptosis↑, ChemoSen↑, RadioS↑, DNMT1↓, DNMT3A↓,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,
6330- Eug,    Molecular Mechanisms of Action of Eugenol in Cancer: Recent Trends and Advancement
- Review, Var, NA
TumCD↑, TumCCA↑, AntiCan↑, Apoptosis↑, angioG↓, TumCI↓, TumMeta↓, ChemoSen↑, ALDH↓, NF-kB↓, IL6↓, IL8↓, BAX↑, cl‑Casp3↑, cl‑Casp9↑, cl‑PARP↑, Bcl-2↓, MMP2↓, MMP9↓, EMT↓, N-cadherin↓, Snail↓, E-cadherin↑, SOX2↓, ROS↑, PCNA↓, MMP1↓, Cyt‑c↑, LDH↑, CSCs↓, OCT4↓, NOTCH1↓, EpCAM↓, CD44↓, HER2/EBBR2↓, VEGF↓, TIMP2↑, eff↑, Ca+2↑, TumVol↓, DNAdam↑, GSH↓, H2O2↑, lipid-P↑,
6915- FIS,  SRF,    Fisetin, a dietary flavonoid, augments the anti-invasive and anti-metastatic potential of sorafenib in melanoma
- in-vitro, Melanoma, NA
EMT↓, TumCP↓, PI3K↓, eff↑, N-cadherin↓, Vim↓, Fibronectin↓, E-cadherin↑, Snail↓, Twist↓, Slug↓, Zeb1↓, MMP2↓, MMP9↓, TumCI↓, TumMeta↓, ChemoSen↑,
2857- FIS,    A review on the chemotherapeutic potential of fisetin: In vitro evidences
- Review, Var, NA
COX2/PTGS2↓, PGE2↓, EGFR↓, Wnt↓, β-catenin/ZEB1↓, TCF↑, Apoptosis↑, Casp3↑, cl‑PARP↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, Akt↓, mTOR↓, ACC↑, Cyt‑c↑, Diablo↑, cl‑Casp8↑, Fas↑, DR5↑, TRAIL↑, Securin↓, CDC2↓, CDC25↓, HSP70/HSPA5↓, CDK2↓, CDK4↓, cycD1/CCND1↓, MMP2↓, uPA↓, NF-kB↓, cFos↓, cJun↓, MEK↓, p‑ERK↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↓, NF-kB↑, ROS↑, DNAdam↑, MMP↓, CHOP/DDIT3↑, eff↑, ChemoSen↑,
2845- FIS,    Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, p38↓, *antiOx↑, *neuroP↑, Casp3↑, Bcl-2↓, Mcl-1↓, BAX↑, BIM↑, BAD↑, AMPK↑, ACC↑, DNAdam↑, MMP↓, eff↑, ROS↑, cl‑PARP↑, Cyt‑c↑, Diablo↑, P53↑, p65↓, Myc↓, HSP70/HSPA5↓, HSP27↓, COX2/PTGS2↓, Wnt↓, EGFR↓, NF-kB↓, TumCCA↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycA1/CCNA1↓, P21↑, MMP2↓, MMP9↓, TumMeta↓, MMP1↓, MMP3↓, MMP7↓, MET↓, N-cadherin↓, Vim↓, Snail↓, Fibronectin↓, E-cadherin↑, uPA↓, ChemoSen↑, EMT↓, Twist↓, Zeb1↓, cFos↓, cJun↓, EGF↓, angioG↓, VEGF↓, eNOS↓, *NRF2↑, HO-1↑, NRF2↓, GSTs↓, ATF4↓,
1155- Fuc,    The anti-cancer effects of fucoidan: a review of both in vivo and in vitro investigations
- Review, NA, NA
*toxicity↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, VEGF↓, angioG↓, PI3K↓, Akt↓, PARP↑, Bak↑, BID↑, Fas↑, Mcl-1↓, survivin↓, XIAP↓, ERK↓, EMT↓, EM↑, IM↓, Snail↓, Slug↓, Twist↓,
1116- GI,    6-Shogaol Inhibits the Cell Migration of Colon Cancer by Suppressing the EMT Process Through the IKKβ/NF-κB/Snail Pathway
- in-vitro, Colon, Caco-2 - in-vitro, CRC, HCT116
TumCG↓, Apoptosis↑, TumCMig↓, MMP2↓, N-cadherin↓, IKKα↓, p‑NF-kB↓, Snail↓, VEGF↓,
7243- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathwa
- vitro+vivo, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, *toxicity↓,
7254- Gink,    Integrating network pharmacology prediction and experimental investigation to verify ginkgetin anti-invasion and metastasis of human lung adenocarcinoma cells via the Akt/GSK-3β/Snail and Wnt/β-catenin pathway
- in-vitro, Lung, A549 - in-vitro, Lung, H1299
TumCI↓, TumMeta↓, Akt↓, GSK‐3β↓, Snail↓, Wnt↓, β-catenin/ZEB1↓, tumCV↓, Dose↝, N-cadherin↓, Vim↓, EMT↓,
1643- HCAs,    Mechanisms involved in the anticancer effects of sinapic acid
- Review, Var, NA
*BioAv↓, *toxicity↓, Dose∅, ROS⇅, ROS↑, Igs↑, TumCCA↑, TumAuto↑, eff↑, angioG↓, TumCI↓, TumMeta↓, EMT↓, Vim↓, MMP9↓, MMP2↓, Snail↓, E-cadherin↑, p‑Akt↓, GSK‐3β↓, TumCP↓, ChemoSen↑,
4659- HNK,    Honokiol Eliminates Human Oral Cancer Stem-Like Cells Accompanied with Suppression of Wnt/β-Catenin Signaling and Apoptosis Induction
- in-vitro, Oral, NA
cl‑Casp3↑, survivin↓, Bcl-2↓, CD44↓, Wnt↓, β-catenin/ZEB1↑, EMT↓, Slug↓, Snail↓, CSCs↓, Apoptosis↑,

Showing Research Papers: 1 to 50 of 104
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 104

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ERCC4/XPF↓, 1,   Ku70/XRCC6↓, 1,   miR-339-5p↝, 1,   miR-375↑, 1,   NA↓, 1,   PSEN1/PS1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ATF3↑, 1,   Catalase↓, 2,   Copper↑, 1,   CYP1A1↓, 1,   frataxin↑, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 7,   GSH↑, 1,   GSR↓, 1,   GSR↑, 1,   GSTs↓, 2,   GSTs↑, 2,   H2O2↑, 1,   HO-1↓, 6,   HO-1↑, 6,   HO-2↓, 1,   lipid-P↑, 3,   MAD↓, 1,   MDA↑, 2,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 2,   NRF2↓, 6,   NRF2↑, 4,   p‑NRF2↓, 1,   mt-OXPHOS↓, 1,   PARK2↑, 1,   ROS↓, 2,   ROS↑, 32,   ROS⇅, 3,   ROS↝, 1,   ROS∅, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SIRT3↑, 2,   SOD↓, 3,   SOD↑, 2,   SOD1↑, 1,   SOD2↓, 1,   SOD2↑, 1,   Trx1↑, 1,   TrxR↓, 2,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 2,   ATP↓, 6,   CDC2↓, 4,   CDC25↓, 3,   EGF↓, 1,   ETC↓, 1,   Insulin↓, 1,   MEK↓, 1,   mitResp↓, 2,   MMP↓, 21,   MMP↑, 1,   MPT↑, 2,   mtDam↑, 3,   OCR↓, 2,   PINK1↑, 1,   XIAP↓, 15,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 2,   ACLY↓, 1,   AKT1↓, 1,   ALAT↓, 2,   ALAT↝, 1,   AMPK↑, 5,   ATG7↑, 1,   cMyc↓, 14,   ECAR↝, 1,   ERCC1↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 1,   GlutMet↓, 1,   Glycolysis↓, 5,   HK2↓, 4,   lactateProd↓, 1,   LDH↓, 2,   LDH↑, 1,   LDHA↓, 2,   LDL↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   NADPH↑, 1,   PDH↝, 1,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 2,   PFK↓, 1,   PFK1↓, 1,   PFK2↓, 1,   PKM2↓, 2,   POLD1↓, 1,   PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↓, 3,   SIRT1↑, 2,   SIRT2↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 30,   Akt↑, 1,   p‑Akt↓, 17,   APAF1↑, 4,   Apoptosis↓, 1,   Apoptosis↑, 28,   ASK1↑, 1,   BAD↑, 4,   Bak↑, 2,   BAX↑, 20,   Bax:Bcl2↑, 1,   Bcl-2↓, 27,   Bcl-xL↓, 6,   BID↓, 1,   BID↑, 2,   BIM↑, 3,   Casp1↓, 1,   Casp10↑, 1,   cl‑Casp12↝, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 31,   Casp3∅, 1,   cl‑Casp3↑, 6,   Casp6↑, 1,   Casp7↑, 9,   Casp8↑, 10,   Casp8∅, 1,   cl‑Casp8↑, 1,   Casp9↑, 18,   cl‑Casp9↑, 3,   proCasp9↓, 1,   cFLIP↓, 2,   Chk2↓, 1,   CK2↓, 1,   Cyt‑c↓, 2,   Cyt‑c↑, 20,   Diablo↑, 5,   DR4↑, 1,   DR5↑, 7,   Fas↑, 8,   FasL↑, 1,   HEY1↓, 2,   HGF/c-Met↓, 1,   Hippo↝, 1,   hTERT/TERT↓, 3,   iNOS↓, 6,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 3,   MAPK↑, 3,   Mcl-1↓, 11,   MDM2↓, 3,   MDM2↑, 2,   p‑MDM2↓, 1,   Myc↓, 4,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 5,   p38↓, 1,   p38↑, 3,   p‑p38↑, 1,   PUMA↑, 2,   survivin↓, 21,   Telomerase↓, 1,   TNFR 1↑, 1,   TRAIL↑, 2,   TRAILR↑, 1,   TRPV1↑, 1,   TumCD↑, 6,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   EZH2↓, 1,   H3↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 1,   miR-205↑, 1,   other↓, 2,   other↑, 1,   other↝, 1,   p‑pRB↓, 1,   tumCV↓, 8,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 9,   p‑CHOP/DDIT3↝, 1,   eIF2α↓, 1,   p‑eIF2α↑, 4,   p‑eIF2α↝, 1,   ER Stress↑, 6,   GRP78/BiP↑, 1,   HSP27↓, 3,   HSP70/HSPA5↓, 4,   HSP70/HSPA5↑, 1,   HSP90↓, 3,   IRE1↑, 1,   PERK↑, 1,   p‑PERK↝, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 2,   BNIP3↑, 1,   LC3A↑, 1,   LC3II↑, 4,   p62↓, 3,   TumAuto↑, 5,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   CYP1B1↑, 1,   DFF45↑, 2,   DNAdam↓, 1,   DNAdam↑, 5,   DNArepair↓, 1,   DNMT1↓, 3,   DNMT3A↓, 2,   DNMTs↓, 1,   MGMT↓, 1,   p16↑, 1,   P53↑, 16,   p‑P53↑, 1,   p53 Wildtype↑, 1,   PARP↑, 8,   cl‑PARP↑, 13,   PARP1↑, 1,   PCNA↓, 9,   RAD51↓, 1,   SIRT6↑, 1,   UHRF1↓, 1,   γH2AX↑, 3,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1/2/5/9↓, 1,   CDK2↓, 14,   CDK2↑, 1,   CDK4↓, 10,   Cyc↓, 2,   cycA1/CCNA1↓, 5,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 21,   cycE/CCNE↓, 4,   E2Fs↓, 2,   P21↑, 13,   RB1↓, 1,   p‑RB1↓, 2,   Securin↓, 1,   TumCCA↓, 2,   TumCCA↑, 19,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 3,   ALDH1A1↓, 4,   AXIN1↑, 1,   BMI1↓, 1,   CD133↓, 4,   CD34↓, 1,   CD44↓, 9,   CDK8↓, 2,   CDX2↓, 1,   cFos↓, 3,   cFos↑, 1,   CIP2A↓, 1,   cMET↓, 2,   CSCs↓, 21,   Diff↓, 1,   EMT↓, 71,   EpCAM↓, 1,   ERK↓, 7,   p‑ERK↓, 6,   ERK5↑, 1,   FOXO↑, 1,   FOXO3↓, 1,   FOXO3↑, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   Gli↓, 1,   Gli1↓, 9,   GSK‐3β↓, 7,   GSK‐3β↑, 3,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 2,   HDAC↓, 5,   HDAC1↓, 1,   HH↓, 7,   IGF-1↓, 2,   IGF-1R↓, 2,   IGFR↓, 1,   LRP6↓, 3,   p‑LRP6↓, 2,   mTOR↓, 19,   mTOR↑, 1,   p‑mTOR↓, 4,   mTORC2↓, 1,   Nanog↓, 7,   NOTCH↓, 9,   NOTCH1↓, 6,   NOTCH1↑, 1,   NOTCH3↓, 1,   OCT4↓, 9,   P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 26,   PI3K↑, 1,   p‑PI3K↓, 2,   PTCH1↓, 2,   PTCH2↓, 1,   PTEN↓, 1,   PTEN↑, 5,   RAS↓, 1,   Shh↓, 8,   Smo↓, 6,   SOX2↓, 4,   Src↓, 1,   p‑Src↓, 1,   STAT3↓, 18,   p‑STAT3↓, 5,   p‑STAT6↓, 1,   TCF↓, 3,   TCF↑, 1,   TOP1↓, 1,   TOP2↓, 2,   TumCG↓, 12,   Wnt↓, 17,   Wnt/(β-catenin)↓, 2,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AntiAg↓, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 8,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   Cdc42↓, 1,   CDK4/6↓, 1,   CEA↓, 1,   CLDN1↓, 3,   CLDN2↓, 1,   CLDN2↑, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   DLC1↑, 1,   E-cadherin↓, 9,   E-cadherin↑, 56,   EM↑, 1,   ER-α36↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   fascin↓, 1,   Fibronectin↓, 5,   GLI2↓, 5,   ITGA5↓, 1,   ITGB1↓, 2,   ITGB3↓, 1,   Ki-67↓, 5,   LEF1↓, 3,   MET↓, 2,   p‑MET↓, 1,   miR-139-5p↑, 1,   MMP-10↓, 2,   MMP1↓, 2,   MMP2↓, 35,   MMP2↝, 1,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 32,   MMP9↝, 1,   MMPs↓, 9,   N-cadherin↓, 42,   PKCδ↓, 3,   Rac1↓, 1,   RAGE↓, 1,   Rho↓, 2,   ROCK1↓, 3,   Sharpin↓, 1,   Slug↓, 34,   Smad1↓, 3,   SMAD2↓, 3,   p‑SMAD2↓, 4,   SMAD3↓, 5,   p‑SMAD3↓, 3,   p‑SMAD4↓, 1,   Snail↓, 104,   SOX4↓, 1,   TET1↑, 1,   TGF-β↓, 9,   TGF-β↑, 1,   TGF-β1↓, 2,   TIMP1↓, 1,   TIMP1↑, 1,   TIMP2↓, 1,   TIMP2↑, 1,   TSP-1↑, 2,   TumCA↓, 1,   TumCI?, 1,   TumCI↓, 38,   TumCMig↓, 32,   TumCP↓, 23,   TumCP↑, 1,   TumMeta↓, 26,   Twist↓, 22,   Tyro3↓, 1,   uPA↓, 6,   VCAM-1↓, 1,   Vim?, 1,   Vim↓, 59,   Vim↑, 1,   vinculin↓, 1,   Zeb1↓, 21,   Zeb1↑, 1,   ZEB2↓, 1,   ZO-1↑, 6,   α-SMA↓, 1,   β-catenin/ZEB1↓, 32,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 16,   ATF4↓, 1,   ATF4↑, 2,   p‑ATF4↝, 1,   EGFR↓, 13,   EGFR↑, 1,   p‑EGFR↓, 2,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 1,   Hif1a↓, 19,   NO↓, 1,   NO↝, 1,   PDGFR-BB↓, 1,   VEGF↓, 24,   VEGFR2/KDR/Flk1↓, 7,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   GLUT1↓, 1,   NHE1↓, 1,   P-gp/ABCB1↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX1↓, 2,   COX2/PTGS2↓, 21,   COX2/PTGS2↑, 1,   COX2/PTGS2↝, 1,   CRP↓, 1,   CXCL1↓, 1,   CXCR4↓, 4,   ICAM-1↓, 1,   IFN-γ↓, 1,   Igs↑, 1,   IKKα↓, 5,   IKKα↑, 1,   IL1↓, 2,   IL10↓, 3,   IL12↓, 2,   IL1β↓, 4,   IL2↑, 2,   IL6↓, 17,   IL8↓, 4,   Imm↑, 1,   Inflam↓, 7,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 3,   NF-kB↓, 30,   NF-kB↑, 1,   p‑NF-kB↓, 1,   NK cell↑, 2,   p50↓, 2,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 3,   PD-L1↓, 3,   PGE2↓, 5,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 7,   TNF-α∅, 1,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   AR↑, 1,   CDK6↓, 8,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 4,   BioAv↝, 2,   ChemoSen↑, 25,   Dose↑, 1,   Dose↝, 7,   Dose∅, 3,   eff↓, 3,   eff↑, 31,   eff↝, 1,   Half-Life↓, 1,   P450↓, 1,   RadioS↑, 9,   selectivity↑, 9,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 2,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 2,   AR↑, 1,   AST↓, 1,   AST↝, 1,   CEA↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 13,   EGFR↑, 1,   p‑EGFR↓, 2,   EZH2↓, 1,   GutMicro↑, 1,   HER2/EBBR2↓, 2,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 3,   IL6↓, 17,   Ki-67↓, 5,   LDH↓, 2,   LDH↑, 1,   Myc↓, 4,   NOS2↓, 1,   NSE↓, 1,   PD-L1↓, 3,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 5,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 1,   cachexia↓, 1,   cardioP↑, 3,   chemoP↑, 3,   chemoPv↑, 2,   ChemoSideEff↓, 2,   neuroP↑, 1,   OS↑, 1,   QoL↑, 1,   RenoP↑, 2,   Risk↓, 4,   Symptoms∅, 1,   toxicity↓, 2,   TumVol↓, 3,   TumW↓, 3,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 551

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 7,   Catalase↑, 3,   GPx↑, 1,   GSH↑, 3,   GSR↑, 1,   GSTs↑, 3,   HO-1↑, 1,   Keap1↓, 1,   lipid-P↓, 4,   NRF2↓, 1,   NRF2↑, 5,   Prx↑, 1,   RNS↓, 1,   ROS↓, 10,   SOD↓, 1,   SOD↑, 2,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Cell Death(tgid=5) ⓘ

Casp3?, 1,   Casp3↓, 1,   iNOS↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL10↑, 1,   IL1β↓, 1,   Inflam↓, 4,   NF-kB↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   MAOA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 1,   eff↑, 1,   Half-Life↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AST↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 2,   chemoPv↑, 1,   hepatoP↑, 2,   neuroP↑, 5,   toxicity↓, 5,   toxicity∅, 1,  
Total Targets: 46

Scientific Paper Hit Count for: Snail, Snail
7 Sulforaphane (mainly Broccoli)
7 Quercetin
6 Resveratrol
6 EGCG (Epigallocatechin Gallate)
6 Honokiol
5 Apigenin (mainly Parsley)
4 Ellagic acid
4 Luteolin
3 Curcumin
3 Cyclopamine
3 Eugenol
3 Fisetin
3 HydroxyTyrosol
3 Urolithin
2 Alpha-Lipoic-Acid
2 Ashwagandha(Withaferin A)
2 Baicalein
2 Berberine
2 Chrysin
2 Ginkgetin
2 Piperine
2 Pterostilbene
1 1,8-Cineole
1 Astragalus
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Cisplatin
1 Betulinic acid
1 Butyrate
1 Caffeic acid
1 Capsaicin
1 Cannabidiol
1 Chlorogenic acid
1 Citric Acid
1 Genistein (soy isoflavone)
1 Sorafenib (brand name Nexavar)
1 Fucoidan
1 Ginger/6-Shogaol/Gingerol
1 Hydroxycinnamic-acid
1 Isobavachalcone
1 Inositol
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 Juglone
1 Kaempferol
1 Magnolol
1 5-fluorouracil
1 Metformin
1 Naringin
1 Phenethyl isothiocyanate
1 Piperlongumine
1 isoflavones
1 Rosmarinic acid
1 Rauwolfia serpentina/Indian Snakeroot
1 salinomycin
1 Sanguinarine
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Taurine
1 Thymoquinone
1 Vitamin D3
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:376  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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