Ki-67 Cancer Research Results

Ki-67, Ki-67 protein: Click to Expand ⟱
Source:
Type: proliferation marker
A high Ki-67 proliferation index means many cells are dividing quickly and that the cancer is likely to grow and spread.
Markers of proliferation index (Ki-67)

• Ki-67 serves primarily as a proliferation marker: higher levels are generally indicative of aggressive disease and poorer outcomes across many cancer types.
• While Ki-67 itself is not considered a driver of tumorigenesis, its expression mirrors the high proliferative activity associated with protumoral behavior.
• It is widely used in clinical practice to aid in tumor grading, prognostication, and treatment planning.


Scientific Papers found: Click to Expand⟱
1333- AG,    Astragalus polysaccharide inhibits breast cancer cell migration and invasion by regulating epithelial-mesenchymal transition via the Wnt/β-catenin signaling pathway
- in-vitro, BC, NA
TumCMig↓, TumCI↓, Ki-67↓, TumCP↓, Snail↓, Vim↓, E-cadherin↑, Wnt↓, β-catenin/ZEB1↓,
378- AgNPs,    Antitumor efficacy of silver nanoparticles reduced with β-D-glucose as neoadjuvant therapy to prevent tumor relapse in a mouse model of breast cancer
- ex-vivo, BC, 4T1
TumVol↓, TumMeta↓, Ki-67↓,
383- AgNPs,    In vitro and in vivo evaluation of anti-tumorigenesis potential of nano silver for gastric cancer cells
- in-vitro, GC, MKN45
Ki-67↓, TumCP↓, CD34↓, BAX↑,
262- ALA,    Lipoic acid decreases breast cancer cell proliferation by inhibiting IGF-1R via furin downregulation
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TumCP↓, Akt↓, ERK↓, IGF-1R↓, Furin↓, Ki-67↓, AMPK↑, mTOR↓,
1351- And,  MEL,    Impact of Andrographolide and Melatonin Combinatorial Drug Therapy on Metastatic Colon Cancer Cells and Organoids
- in-vitro, CRC, T84 - in-vitro, CRC, COLO205 - in-vitro, CRC, HT-29 - in-vitro, CRC, DLD1
eff↑, Ki-67↓, Casp3↑, ER Stress↑, ROS↑, BAX↑, XBP-1↑, CHOP/DDIT3↑, eff↑,
6399- ANE,    Anethole attenuates lung cancer progression by regulating the proliferation and apoptosis through AKT and STAT3 signaling
- vitro+vivo, NSCLC, A549
TumCP↓, TumCG↓, Apoptosis↑, DNAdam↑, Casp3↑, PI3K↓, Akt↓, STAT3↓, Ki-67↓, cl‑Casp3↑,
584- Api,  Cisplatin,    Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms
- in-vivo, Var, NA
Beclin-1/ATG6↑, Casp3↑, Casp9↑, JNK↑, Mcl-1↓, Ki-67↓,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
557- ART/DHA,    Artemisinin and Its Derivatives in Cancer Care
- Review, Var, NA
*BioAv↓, *BioAv↑, Apoptosis↑, EGFR↓, CD31/PECAM-1↓, Ki-67↓, P53↓, TfR1/CD71↑, P-gp/ABCB1↓, PD-1↝,
1028- ASA,    Aspirin Suppressed PD-L1 Expression through Suppressing KAT5 and Subsequently Inhibited PD-1 and PD-L1 Signaling to Attenuate OC Development
- vitro+vivo, Ovarian, NA
TumCP↓, TumW↓, PD-L1↓, Ki-67↓, H3K27ac∅, eff↑,
2001- Ash,    Withania somnifera: from prevention to treatment of cancer
- Review, Var, NA
toxicity↓, TumW↓, Dose?, eff↝, Ki-67↓, survivin↓, XIAP↓, PERK↑, p‑RSK↑, CHOP/DDIT3↑, DR5↑, Dose↝, BG↓, DNMTs↓,
5384- AsP,  MEL,    Synergistic Anticancer Effect of Melatonin and Ascorbyl Palmitate Nanoformulation: A Promising Combination for Cancer Therapy
- in-vivo, Var, NA
AntiCan↑, TumCG↓, Apoptosis↑, DNAdam↑, TumCCA↑, IL6↓, STAT3↓, TumCP↓, Ki-67↓, TumCI↓, TumMeta↓, MMP9↓, eff↑, *Catalase↑, *SOD↑, *GSH↑, *MDA↓, *NO↓, *antiOx↑, *hepatoP↑, *RenoP↑,
5501- Ba,    Therapeutic effects and mechanisms of action of Baicalein on stomach cancer: a comprehensive systematic literature review
- Review, GC, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, BAX↑, TumAuto↑, ROS↑, NRF2↝, PI3K↓, Akt↓, NF-kB↓, TGF-β↓, SMAD4↓, GPx4↓, MMP↓, *HO-1↑, *GSTs↑, *antiOx↑, *AntiTum↑, *NRF2↑, ChemoSen↑, Akt↓, mTOR↓, FAK↓, Ki-67↓,
2291- Ba,  BA,    Baicalein and Baicalin Promote Melanoma Apoptosis and Senescence via Metabolic Inhibition
- in-vitro, Melanoma, SK-MEL-28 - in-vitro, Melanoma, A375
LDHA↓, ENO1↓, PKM2↓, GLUT1↓, GLUT3↓, HK2↓, PFK1↓, GPI↓, TPI↓, GlucoseCon↓, TumCG↓, TumCP↓, mTORC1↓, Hif1a↓, Ki-67↓,
2335- BBR,    Chemoproteomics reveals berberine directly binds to PKM2 to inhibit the progression of colorectal cancer
- in-vitro, CRC, HT29 - in-vitro, CRC, HCT116 - in-vivo, NA, NA
PKM2↓, Glycolysis↓, p‑STAT3↓, Bcl-2↓, cycD1/CCND1↓, TumCG↓, Ki-67↓, lactateProd↓, glucose↓,
1030- BBR,    Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5
- in-vitro, Lung, H460
PD-L1↓, TumCG↓, Ki-67↓, cl‑Casp3↑,
940- BBR,    Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression
- vitro+vivo, PC, PANC1 - in-vivo, PC, MIA PaCa-2
LDHA↓, lactateProd↓, AMPKα↓, TumVol↓, Ki-67↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
6509- BCP,    β­caryophyllene oxide induces apoptosis and inhibits proliferation of A549 lung cancer cells
- in-vitro, Lung, A549
tumCV↓, TumCP↓, Ki-67↓, PCNA↓, P21↓, P53↑, DNAdam↑, TumCCA↑, Apoptosis↑, Casp3↑, Casp7↑, Casp9↑, BAX↑, Bcl-2↓, GSH↑, GPx↑, 4-HNE↑, ROS↓, antiOx↑, lipid-P↓,
2741- BetA,    Betulinic acid triggers apoptosis and inhibits migration and invasion of gastric cancer cells by impairing EMT progress
- in-vitro, GC, SNU16 - in-vitro, GC, NCI-N87 - in-vivo, NA, NA
TumCG↓, TumCMig↓, TumCI↓, N-cadherin↓, E-cadherin↑, EMT↓, Ki-67↓, MMP2↓,
5726- BF,    Bufalin exerts antitumor effects in neuroblastoma via the induction of reactive oxygen species-mediated apoptosis by targeting the electron transport chain
- Review, neuroblastoma, SK-N-BE
Apoptosis↑, TumCP↓, TumCMig↓, MMP↓, ROS↑, ETC↓, Bcl-2↓, BAX↑, cl‑Casp3↑, cl‑PARP↑, eff↓, TumCG↓, Ki-67↓, PCNA↓,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Ki-67↓, CD31/PECAM-1↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
1169- Bos,    Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
- in-vivo, CRC, NA
TumCG↓, TumVol↓, Weight∅, ascitic↓, TumMeta↓, Ki-67↓, CD31/PECAM-1↓, NF-kB↓, COX2/PTGS2↓, Bcl-2↓, Bcl-xL↓, IAP1↓, survivin↓, cycD1/CCND1↓, ICAM-1↓, MMP9↓, CXCR4↓, VEGF↓,
6555- BSB,    Cyclodextrin Conjugated α-Bisabolol Suppresses FAK Phosphorylation and Induces Apoptosis in Pancreatic Cancer
- vitro+vivo, PC, NA
TumCP↓, TumCI↓, p‑FAK↓, TumVol↓, Ki-67↓,
5750- CA,    Exploration of the anticancer properties of Caffeic Acid in malignant mesothelioma cells
- in-vitro, MM, NA
eff↑, selectivity↑, Ki-67↓, PCNA↓, TumCP↓, p‑ERK↓, Akt↓, p27/CDKN1B↑, P21↑, TumCCA↑, Bax:Bcl2↑, cl‑Casp3↑, mt-Apoptosis↑,
5870- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen‐Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF7
ROS↑, cJun↑, p38↑, eff↓, TumCP↓, glucose↓, Apoptosis↑, BAX↑, PARP↑, Bcl-2↓, TumCG↑, Ki-67↓, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5874- CA,    Carnosic Acid Mediates Production of Reactive Oxygen Species to Regulate Mitogen-Activated Protein Kinase Pathway Phosphorylation and Induce Apoptosis in Human Breast Cancer Cells
- vitro+vivo, BC, T47D - in-vitro, BC, MCF10
AntiTum↓, ROS↑, cJun↑, p‑p38↑, Apoptosis↑, ROS↑, eff↑, TumCP↓, glucose↓, BAX↑, PARP↑, Bcl-2↓, eff↓, Ki-67↓, toxicity↝, STAT3↓, PI3K↓, Akt↓, mTOR↓,
5828- CAP,    Capsaicin: a novel radio-sensitizing agent for prostate cancer
- vitro+vivo, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
RadioS↑, NF-kB↓, TumCCA↑, TumCG↓, TumCP↓, DNAdam↑, γH2AX↑, Ki-67↓,
5846- CAP,    Capsaicin Alters the Expression of Genetic and Epigenetic Molecules In Hepatocellular Carcinoma Cell
- in-vitro, HCC, HepG2
Dose↝, miR-126↑, Ki-67↓, PI3K↓, mTOR↓, Akt↑, eff↑, Casp3↑,
1262- CAP,    Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway
- vitro+vivo, BC, NA
FBI-1↓, Ki-67↓, Bcl-2↓, survivin↓, BAX↑, Casp3↑, TumCP↓, Apoptosis↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
5920- Cats,    Treatment with Uncaria tomentosa Promotes Apoptosis in B16-BL6 Mouse Melanoma Cells and Inhibits the Growth of B16-BL6 Tumours
- in-vivo, Melanoma, B16-BL6
eff↑, Ki-67↓, TumCP↓, Apoptosis↑, TumCG↓,
6643- Cen,    Asiaticoside inhibits epithelial-mesenchymal transition and stem cell-like properties of pancreatic cancer PANC-1 cells by blocking the activation of p65 and p38MAPK
- vitro+vivo, PC, PANC1
tumCV↓, Ki-67↓, PCNA↓, N-cadherin↓, Vim↓, SOX2↓, OCT4↓, p65↓, MAPK↓, CD44↓, CD133↓, E-cadherin↑, TumVol↓, TumCP↓, EMT↓, CSCsMark↓,
6007- CGA,    A Comprehensive View on the Impact of Chlorogenic Acids on Colorectal Cancer
- Review, CRC, NA
antiOx↑, TumCCA↑, Apoptosis↑, Wnt↝, PI3K↝, MAPK↝, ROS↓, BioAv↝, P53↑, P21↑, CDK1↑, Ki-67↓, Ca+2↑, p‑Akt↓, mTOR↓, GSH↑, NRF2↑, HO-1↑, COX2/PTGS2↓, TNF-α↓, IL1β↓, IL6↓,
7174- CHA,    Inhibition of SUV39H1 reduces tumor angiogenesis via Notch1 in oral squamous cell carcinoma
- vitro+vivo, OS, OS-RC-2
SUV39H↓, TumCG↓, NOTCH1↓, CD31/PECAM-1↓, VEGF↓, toxicity↓, Ki-67↓, angioG↓,
7159- CHA,    ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
- vitro+vivo, GC, HGC27 - in-vitro, GC, AGS - in-vitro, GC, BGC-823 - in-vitro, GC, SGC-7901 - in-vitro, Nor, HEK293
TumCP↓, TumCCA↑, Casp↑, Apoptosis↑, TrxR1↓, ROS↑, eff↓, eff↑, PI3K↓, Akt↓, TumCG↓, cl‑PARP↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, Bcl-2↓, Bcl-xL↓, Mcl-1↓, XIAP↓, survivin↓, TumVol↓, TumW↓, Weight∅, toxicity↓, Ki-67↓, other↝,
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, eff↑, eff↑, *eff↑, RadioS↑, eff↑, ChemoSen↑, eff↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
6160- Cin,    Cinnamaldehyde induces apoptosis and enhances anti-colorectal cancer activity via covalent binding to HSPD1
- vitro+vivo, CRC, HCT116
AntiTum↑, Apoptosis↑, PI3K↓, Akt↓, TumCG↓, TumCCA↑, HSP60/HSPD1↓, Ki-67↓, ChemoSen↑,
1584- Citrate,    Anticancer effects of high-dose extracellular citrate treatment in pancreatic cancer cells under different glucose concentrations
- in-vitro, PC, MIA PaCa-2 - in-vitro, PC, PANC1
tumCV↓, i-Ca+2↓, TumCMig↓, CD133↓, pH↑, eff↑, Ki-67↓, eff↑,
6309- Cro,    Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway
- in-vitro, CRC, HCT116
tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,
2270- dietMet,    Methionine-restricted diet inhibits growth of MCF10AT1-derived mammary tumors by increasing cell cycle inhibitors in athymic nude mice
- in-vivo, Var, NA
Weight↓, TumVol↓, P21↑, p27/CDKN1B↑, *adiP↑, *glucose↓, *IGF-1↓, *FGF21↑, *OS↑, Ki-67↓, Casp3↑, cycD1/CCND1↓,
6273- DL,    D-Limonene Exhibits Antiproliferative Activity Against Human Colorectal Adenocarcinoma (Caco-2) Cells via Regulation of Inflammatory and Apoptotic Pathways
- in-vitro, Colon, Caco-2 - in-vitro, Nor, HEK293 - in-vitro, Colon, HCT116
ROS↑, antiOx↓, GSH↓, Casp3↑, BAX↑, P53↑, LDH↑, TNF-α↑, IL1β↑, MMP2↓, MMP9↓, Ki-67↓, Bcl-2↓, selectivity↑,
1621- EA,    The multifaceted mechanisms of ellagic acid in the treatment of tumors: State-of-the-art
- Review, Var, NA
AntiCan↑, Apoptosis↑, TumCP↓, TumMeta↓, TumCI↓, TumAuto↑, VEGFR2/KDR/Flk1↓, MAPK↓, PI3K↓, Akt↓, PD-1↓, NOTCH↓, PCNA↓, Ki-67↓, cycD1/CCND1↓, CDK2↑, CDK6↓, Bcl-2↓, cl‑PARP↑, BAX↑, Casp3↑, DR4↑, DR5↑, Snail↓, MMP2↓, MMP9↓, TGF-β↑, PKCδ↓, β-catenin/ZEB1↓, SIRT1↓, HO-1↓, ROS↑, CHOP/DDIT3↑, Cyt‑c↑, MMP↓, OCR↓, AMPK↑, Hif1a↓, NF-kB↓, E-cadherin↑, Vim↓, EMT↓, LC3II↑, CIP2A↓, GLUT1↓, PDH↝, MAD↓, LDH↓, GSTs↑, NOTCH↓, survivin↓, XIAP↓, ER Stress↑, ChemoSideEff↓, ChemoSen↑,
3215- EGCG,    Epigallocatechin gallate modulates ferroptosis through downregulation of tsRNA-13502 in non-small cell lung cancer
- in-vitro, NSCLC, A549 - in-vitro, NSCLC, H1299
TumCP↓, Ki-67↓, GPx4↓, ACSL4↑, Iron↑, MDA↑, ROS↑, Ferroptosis↑, eff↑, NRF2↑, HO-1↑,
26- EGCG,  QC,  docx,    Green tea and quercetin sensitize PC-3 xenograft prostate tumors to docetaxel chemotherapy
- vitro+vivo, Pca, PC3
BAD↓, cl‑PARP↑, Casp7↑, IκB↓, Ki-67↓, VEGF↓, EGFR↓, FGF↓, TGF-β↓, TNF-α↓, SCF↓, Bax:Bcl2↑, NF-kB↓, chemoP↑, ChemoSen↑, TumVol↓,
686- EGCG,    Prevention effect of EGCG in rat's lung cancer induced by benzopyrene
- in-vivo, Lung, NA
NF-kB↓, p50↓, Ki-67↓,
680- EGCG,    Cancer preventive and therapeutic effects of EGCG, the major polyphenol in green tea
- Review, NA, NA
NF-kB↓, STAT3↓, PI3K↓, HGF/c-Met↓, Akt↓, ERK↓, MAPK↓, AR↓, Casp↑, Ki-67↓, PARP↑, Bcl-2↓, BAX↑, PCNA↓, p27/CDKN1B↑, P21↑,
6819- EMD,    Recent advances in the therapeutic potential of emodin for human health
- Review, Nor, NA
AntiCan↑, *AntiDiabetic↑, *neuroP↑, *Inflam↓, *antiOx↑, *BioAv↓, *BioAv↑, *SOD↑, *GPx↑, *GSH↑, *NRF2↑, *ROS↓, *lipid-P↓, *Cyt‑c↓, *BAX↓, *Bcl-2↓, *iNOS↓, *NO↓, *IL6↓, *IL10↓, *IL17↓, *IFN-γ↓, *NF-kB↓, *LC3II↓, *Akt↓, *Beclin-1/ATG6↓, *AMPK↓, *TNF-α↓, *PGE2↓, *Apoptosis↓, *Casp3↓, *Casp9↓, *P53↓, *P21↓, *NAD↓, *ATP↓, *CHOP/DDIT3↓, *GADD34↓, *ATF4↓, tumCV↓, Apoptosis↑, TumCG↓, TumCI↓, TumMeta↓, CSCs↓, NOTCH1↓, STAT3↓, eff↑, miR-34a↓, *neuroP↑, *BDNF↓, *hepatoP↑, *ALAT↓, *AST↓, TG/TAG↓, ROS↑, Slug↓, EMT↓, Glycolysis↓, ChemoSen↑, P-gp/ABCB1↓, Ki-67↓, PCNA↓, ER Stress↑, TRIB3↑, NF-kB↑, TumMeta↑, *Imm↓, *toxicity↝,
6385- Eug,    Anticancer potential of eugenol in hepatocellular carcinoma through modulation of oxidative stress, inflammation, apoptosis, and proliferation mechanisms
- in-vivo, HCC, HepG2
tumCV↓, TumCMig↓, *ALAT↓, *AST↓, *ALP↓, *Bil↓, *CEA↓, *lipid-P↓, *TNF-α↓, *IL1β↓, NF-kB↓, CXCR3↓, HRAS↓, KRAS↓, Ki-67↓, *GSH↑, *GPx↑, *SOD↑, *NRF2↑, P53↑, BAX↑, DR4↑, DR5↑,

Showing Research Papers: 1 to 50 of 129
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 129

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

CBR1↓, 1,   compII↓, 1,   compV↓, 1,   CXCR3↓, 1,   ENL↑, 1,   ERCC3↑, 1,   HSP60/HSPD1↓, 1,   IGF-2R↑, 1,   Ingr↑, 1,   miR-106b↓, 1,   miR-107↑, 1,   miR-224↓, 1,   miR-422a↑, 1,   MMP16↓, 1,   OGFr↑, 1,   PGE3↑, 1,   PGI2↓, 1,   PTN↓, 1,   SUV39H↓, 1,   XRCC1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1,   antiOx↓, 1,   antiOx↑, 5,   Catalase↓, 1,   compI↓, 2,   CYP1A1↓, 1,   Ferroptosis↑, 6,   GPx↑, 1,   GPx4↓, 7,   GSH↓, 11,   GSH↑, 2,   GSTs↑, 1,   H2O2↓, 1,   H2O2↑, 1,   HK1↓, 1,   HO-1↓, 1,   HO-1↑, 4,   ICD↑, 1,   Iron↑, 1,   Iron↝, 1,   i-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 4,   MAD↓, 1,   MDA↑, 4,   NQO1?, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 4,   NRF2↝, 1,   PARK2↑, 1,   PYCR1↓, 1,   ROS↓, 5,   ROS↑, 51,   mt-ROS↑, 2,   SOD↓, 2,   SOD↑, 2,   SOD1↑, 1,   SOD2↑, 2,   Trx1↑, 1,   TrxR↓, 1,   TrxR1↓, 1,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

TfR1/CD71↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 4,   mt-ATP↓, 1,   CDC2↓, 2,   CDC25↓, 3,   CDC25↝, 1,   compIII↓, 1,   ETC↓, 2,   FGFR1↓, 1,   MMP↓, 18,   mtDam↑, 4,   OCR↓, 1,   PINK1↑, 1,   XIAP↓, 6,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 1,   ACSL4↑, 1,   ALAT↓, 1,   AMPK↓, 1,   AMPK↑, 4,   CAIX/CA9↓, 1,   cMyc↓, 8,   ENO1↓, 1,   FABP4↑, 1,   FAO↑, 1,   FASN↓, 2,   FBI-1↓, 1,   FGF21↓, 1,   glucose↓, 3,   GlucoseCon↓, 5,   GlutMet↓, 1,   Glycolysis↓, 9,   GPI↓, 1,   HK2↓, 6,   lactateProd↓, 7,   LDH↓, 3,   LDH↑, 1,   LDHA↓, 3,   PCK1↓, 1,   PDH↝, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PFK↓, 2,   PFK1↓, 1,   PI3K/Akt↓, 2,   PKM2↓, 6,   POLD1↓, 1,   PPARα↑, 1,   PPARγ↓, 1,   PPARγ↑, 2,   PPP↓, 1,   p‑S6↓, 1,   SIRT1↓, 2,   SIRT1↑, 1,   TPI↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 39,   Akt↑, 1,   p‑Akt↓, 5,   Apoptosis↓, 2,   Apoptosis↑, 48,   mt-Apoptosis↑, 1,   BAD↓, 1,   BAD↑, 1,   Bak↑, 1,   BAX↑, 32,   Bax:Bcl2↑, 6,   Bcl-2↓, 34,   Bcl-xL↓, 7,   BIM↑, 1,   Casp↑, 7,   proCasp↑, 1,   cl‑Casp12↑, 1,   Casp3↓, 1,   Casp3↑, 30,   cl‑Casp3↑, 12,   Casp7↑, 6,   Casp8↑, 3,   cl‑Casp8↑, 1,   proCasp8↑, 1,   Casp9↑, 11,   cl‑Casp9↑, 2,   CBP↓, 1,   cFLIP↓, 1,   Chk2↑, 1,   p‑Chk2↑, 1,   CK2↓, 1,   Cyt‑c↑, 12,   Diablo↑, 4,   DR4↑, 3,   DR5↑, 6,   FADD↑, 2,   Fas↑, 3,   Ferroptosis↑, 6,   GSDMD↑, 1,   HGF/c-Met↓, 2,   hTERT/TERT↓, 1,   IAP1↓, 2,   IAP2/BIRC3↓, 1,   iNOS↓, 2,   JNK↓, 1,   JNK↑, 7,   MAPK↓, 6,   MAPK↑, 1,   MAPK↝, 1,   p‑MAPK↓, 1,   p‑MAPK↑, 2,   Mcl-1↓, 6,   MDM2↓, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 3,   p38↑, 4,   p‑p38↓, 1,   p‑p38↑, 3,   PUMA↑, 1,   Pyro↑, 1,   p‑RSK↑, 1,   survivin↓, 14,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↑, 2,   TUNEL↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↓, 1,   cSrc↓, 2,   p‑HER2/EBBR2↓, 1,   Sp1/3/4↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 2,   EZH2↓, 1,   p‑H3↓, 1,   ac‑H3↑, 2,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 1,   miR-21↓, 1,   miR-30a-5p↑, 1,   other↑, 1,   other↝, 3,   SD↑, 1,   tumCV↓, 17,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 5,   p‑eIF2α↑, 1,   ER Stress↑, 6,   GRP78/BiP↑, 1,   HSP70/HSPA5↓, 1,   PERK↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 4,   LC3B↑, 1,   LC3B-II↓, 1,   LC3II↑, 3,   LC3s↑, 1,   p62↓, 1,   p62↑, 3,   TumAuto↑, 8,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   CHK1↑, 1,   CHK1↝, 1,   p‑CHK1↑, 1,   DNAdam↑, 10,   DNArepair↓, 1,   DNMT1↓, 1,   DNMTs↓, 2,   NKX3.1↓, 1,   P53↓, 2,   P53↑, 21,   PARP↑, 4,   cl‑PARP↑, 13,   PARP1↑, 1,   PCNA↓, 24,   PCNA↑, 1,   TP53↑, 1,   γH2AX↑, 4,   p‑γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   CDK1↑, 1,   CDK1↝, 1,   CDK2↓, 7,   CDK2↑, 1,   CDK4↓, 6,   cycA1/CCNA1↓, 2,   CycB/CCNB1↓, 5,   CycB/CCNB1↝, 1,   cycD1/CCND1↓, 22,   CycD3↓, 1,   cycE/CCNE↓, 3,   P21↓, 3,   P21↑, 13,   RB1↓, 1,   TumCCA↑, 46,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   AXIN1↑, 2,   CD133↓, 4,   CD34↓, 2,   CD44↓, 2,   CDK8↓, 1,   cFos↓, 1,   CIP2A↓, 1,   cMET↓, 1,   CSCs↓, 7,   CSCsMark↓, 1,   Diff↑, 1,   EMT?, 1,   EMT↓, 19,   EpCAM↓, 1,   ERK↓, 8,   ERK↑, 2,   p‑ERK↓, 5,   FGF↓, 1,   FOXM1↓, 1,   FOXO1↓, 1,   p‑FOXO3↓, 1,   FOXO4↓, 1,   Gli1↓, 5,   GSK‐3β↑, 2,   H3K27ac∅, 1,   HDAC↓, 5,   HDAC1↓, 2,   HDAC2↓, 1,   HDAC3↓, 1,   HH?, 1,   HH↓, 6,   HRAS↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   IGFBP3↓, 1,   Jun↓, 1,   p‑MAP2K1/MEK1↓, 1,   MCM2↓, 1,   miR-34a↓, 1,   miR-34a↑, 2,   mTOR↓, 20,   p‑mTOR↓, 1,   mTORC1↓, 2,   mTORC2↓, 1,   Nanog↓, 1,   NOTCH↓, 5,   NOTCH1↓, 2,   NOTCH1↑, 2,   OCT4↓, 2,   p300↓, 1,   PI3K↓, 28,   PI3K↝, 1,   p‑PI3K↓, 2,   PTEN↑, 7,   RAS↓, 1,   SCF↓, 1,   Shh↓, 1,   SHP1↓, 1,   SOX2↓, 2,   STAT3↓, 19,   STAT3↑, 2,   p‑STAT3↓, 5,   STAT6↓, 2,   TOP1↓, 1,   TOP2↓, 2,   TumCG↓, 42,   TumCG↑, 1,   TumCG∅, 1,   tyrosinase↓, 1,   Wnt↓, 6,   Wnt↝, 1,  

Migration(tgid=13) ⓘ

AntiAg↓, 1,   AP-1↓, 2,   AXL↓, 1,   Ca+2↑, 4,   i-Ca+2↓, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   CD31/PECAM-1↓, 9,   CLDN2↓, 1,   CXCL12↓, 1,   E-cadherin↑, 16,   FAK↓, 6,   p‑FAK↓, 2,   Fibronectin↓, 1,   Furin↓, 1,   GLI2↓, 2,   GLI3↑, 1,   ITGA5↓, 1,   ITGB1↓, 2,   Ki-67↓, 129,   KRAS↓, 1,   MALAT1↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-19b↓, 1,   miR-29b↑, 1,   miR-340↓, 1,   miR-384↑, 1,   MMP13↓, 2,   MMP2↓, 12,   MMP3↓, 2,   MMP7↓, 3,   MMP9↓, 25,   MMP9↑, 1,   MMPs↓, 5,   MUC4↓, 1,   N-cadherin↓, 10,   pax↓, 1,   PKCδ↓, 2,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 4,   SMAD2↓, 2,   SMAD3↓, 2,   SMAD4↓, 1,   Snail?, 1,   Snail↓, 5,   TET1↑, 1,   TGF-β↓, 7,   TGF-β↑, 2,   TIMP1↑, 1,   TIMP2↑, 1,   TIMP3↑, 1,   TRIB3↑, 1,   TSP-1↑, 1,   TumCI↓, 27,   TumCMig?, 1,   TumCMig↓, 19,   TumCMig↑, 1,   TumCP?, 1,   TumCP↓, 56,   TumMeta↓, 19,   TumMeta↑, 1,   TumPF↓, 2,   Twist↓, 4,   uPA↓, 4,   Vim?, 1,   Vim↓, 8,   Zeb1↓, 3,   ZEB2↓, 2,   β-catenin/ZEB1↓, 10,   cl‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 19,   ATF4↑, 1,   EGFR↓, 11,   p‑EGFR↓, 1,   eNOS↓, 1,   EPR↑, 1,   HIF-1↓, 1,   Hif1a↓, 9,   LymphAG↓, 1,   miR-126↑, 1,   NO↓, 1,   NO↑, 1,   VEGF↓, 22,   VEGFR2/KDR/Flk1↓, 6,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT1↓, 5,   GLUT3↓, 1,   P-gp/ABCB1↓, 4,   SLC12A5↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 15,   CRP↓, 1,   CXCR4↓, 3,   HMGB1↓, 1,   ICAM-1↓, 1,   IKKα↓, 1,   IL10↓, 1,   IL1β↓, 5,   IL1β↑, 1,   IL2↑, 1,   IL4↓, 1,   IL6↓, 7,   IL8↓, 2,   Inflam↓, 11,   IκB↓, 1,   JAK1↓, 2,   JAK2↓, 6,   M2 MC↓, 1,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 31,   NF-kB↑, 1,   p50↓, 1,   p65↓, 2,   PD-1↓, 2,   PD-1↝, 1,   PD-L1↓, 3,   PGE2↓, 1,   PSA↓, 1,   Th1 response↑, 1,   TNF-α↓, 9,   TNF-α↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 4,   CDK6↓, 6,   COMT↓, 2,   DHT↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 9,   BioAv↝, 4,   ChemoSen↑, 26,   Dose?, 1,   Dose↝, 22,   Dose∅, 1,   eff↓, 9,   eff↑, 49,   eff↝, 2,   Half-Life↓, 3,   MRP1/ABCC1↓, 1,   RadioS↑, 9,   selectivity↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 1,   ALP↓, 1,   AR↓, 4,   ascitic↓, 1,   AST↓, 1,   BG↓, 1,   BMPs↑, 1,   CA125↓, 1,   CRP↓, 1,   EGFR↓, 11,   p‑EGFR↓, 1,   EZH2↓, 1,   FOXM1↓, 1,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 7,   Ki-67↓, 129,   KRAS↓, 1,   LDH↓, 3,   LDH↑, 1,   PD-L1↓, 3,   PSA↓, 1,   TG/TAG↓, 1,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 9,   antiNeop↑, 1,   AntiTum↓, 1,   AntiTum↑, 6,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 5,   chemoPv↑, 3,   ChemoSideEff↓, 2,   hepatoP↑, 4,   K17↓, 1,   neuroP↑, 2,   OS↑, 7,   radioP↑, 1,   RenoP↑, 1,   Risk↓, 2,   Strength↑, 1,   toxicity↓, 7,   toxicity↝, 2,   TumVol↓, 17,   TumW↓, 8,   Weight↓, 1,   Weight∅, 3,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 521

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 11,   Bil↓, 1,   Catalase↑, 6,   GPx↑, 7,   GSH↑, 8,   GSR↑, 2,   GSTs↑, 2,   H2O2↓, 1,   HO-1↑, 3,   Keap1↓, 1,   lipid-P↓, 5,   MDA↓, 3,   NRF2↑, 7,   ROS↓, 11,   SOD↑, 10,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

adiP↑, 1,   ALAT↓, 3,   AMPK↓, 1,   CREB↑, 1,   FGF21↑, 1,   glucose↓, 1,   LDH↓, 2,   NAD↓, 1,   NAD↑, 1,   PPARγ↓, 1,   PPARγ↑, 1,   SIRT1↑, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Apoptosis↓, 2,   BAX↓, 1,   Bax:Bcl2↓, 1,   Bcl-2↓, 1,   Casp3↓, 1,   cl‑Casp8↑, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   GADD34↓, 1,   iNOS↓, 2,   MAPK↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3II↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↓, 1,   RB1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   IGF-1↓, 1,   IGF-1↑, 1,  

Migration(tgid=13) ⓘ

CEA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↓, 1,   NO↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   CRP↓, 1,   IFN-γ↓, 1,   IL10↓, 1,   IL17↓, 2,   IL1β↓, 3,   IL22↓, 1,   IL6↓, 4,   Imm↓, 1,   Inflam↓, 10,   Inflam↑, 1,   NF-kB↓, 2,   PGE2↓, 2,   TLR2↓, 1,   TLR4↓, 1,   TNF-α↓, 5,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↑, 1,   BDNF↓, 1,   BDNF↑, 2,   GABA↑, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 7,   BioAv↑, 3,   BioAv↝, 2,   eff↑, 2,   Half-Life↓, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 3,   ALP↓, 2,   AST↓, 3,   Bil↓, 1,   CEA↓, 1,   CRP↓, 1,   IL6↓, 4,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 3,   AntiTum↑, 1,   cardioP↑, 8,   chemoP↑, 2,   hepatoP↑, 6,   memory↑, 2,   neuroP↑, 10,   OS↑, 1,   radioP↑, 1,   RenoP↑, 3,   toxicity↓, 6,   toxicity↝, 1,   toxicity∅, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   Bacteria↓, 3,  
Total Targets: 114

Scientific Paper Hit Count for: Ki-67, Ki-67 protein
5 EGCG (Epigallocatechin Gallate)
5 Quercetin
5 Thymoquinone
4 Berberine
4 itraconazole
4 Luteolin
4 Resveratrol
3 Capsaicin
3 Formononetin
3 doxorubicin
3 SDG/lignans
3 Linalool
2 Silver-NanoParticles
2 Melatonin
2 Cisplatin
2 Artemisinin
2 Baicalein
2 Boswellia (frankincense)
2 Carnosic acid
2 chaetocin
2 Chrysin
2 Docetaxel
2 Eugenol
2 Ferulic acid
2 Fisetin
2 Flaxseed/Linseed
2 Garcinol
2 Grapeseed extract
2 Hydrogen Gas
2 Ivermectin
2 Kaempferol
2 Magnolol
2 Phenethyl isothiocyanate
2 Piperlongumine
2 Sulforaphane (mainly Broccoli)
2 Gemcitabine (Gemzar)
1 Astragalus
1 Alpha-Lipoic-Acid
1 Andrographis
1 Anethole/trans-Anethole
1 Apigenin (mainly Parsley)
1 Aspirin
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Baicalin
1 Beta-Caryophyllene
1 Betulinic acid
1 Bufalin/Huachansu
1 α-Bisabolol / Chamomile oil
1 Caffeic acid
1 Carvacrol
1 Cat’s Claw
1 Centella asiatica / Gotu kola → asiaticoside
1 Chlorogenic acid
1 Propolis -bee glue
1 Cinnamon
1 Citric Acid
1 Crocetin
1 diet Methionine-Restricted Diet
1 D-limonene
1 Ellagic acid
1 Emodin
1 Fennel Oil/Foeniculum vulgare
1 Bortezomib
1 Gallic acid
1 Ginger/6-Shogaol/Gingerol
1 γ-linolenic acid (Borage Oil)
1 Hyperthermia
1 Inositol
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 isoorientin
1 Juglone
1 low dose naltrexone
1 Lycopene
1 Mushroom Chaga
1 Marjoram (Origanum majorana)
1 Piperine
1 Psoralidin
1 Pterostilbene
1 Rosmarinic acid
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Terpinen-4-ol / Tea Tree Oil
1 Aflavin-3,3′-digallate
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Xylitol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:425  State#:%  Dir#:1
wNotes=0 sortOrder:rid,rpid

 

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