IFN-γ Cancer Research Results

IFN-γ, Interferon-γ: Click to Expand ⟱
Source:
Type:
Plays a key role in activation of cellular immunity and subsequently, stimulation of antitumor immune-response. Based on its cytostatic, pro-apoptotic and antiproliferative functions, IFN-γ is considered potentially useful for adjuvant immunotherapy for different types of cancer.
Moreover, it IFN-γ may inhibit angiogenesis in tumor tissue, induce regulatory T-cell apoptosis, and/or stimulate the activity of M1 proinflammatory macrophages to overcome tumor progression.
However, the current understanding of the roles of IFN-γ in the tumor microenvironment (TME) may be misleading in terms of its clinical application.

IFN-γ is often expressed in the tumor microenvironment, particularly in response to immune cell infiltration. Its expression can be influenced by the presence of tumor-infiltrating lymphocytes (TILs) and other immune cells.
High levels of IFN-γ are typically associated with a Th1 immune response, which is generally considered beneficial for anti-tumor immunity.

Tumor Suppression:
In many cases, IFN-γ has tumor-suppressive effects, as it can inhibit tumor cell proliferation and induce apoptosis in certain cancer types.
Scientific Papers found: Click to Expand⟱
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
741- Bor,    Boron Derivatives Inhibit the Proliferation of Breast Cancer Cells and Affect Tumor-Specific T Cell Activity In Vitro by Distinct Mechanisms
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
MOB1↓, PD-L1↑, p‑YAP/TEAD↝, IFN-γ↓, sFasL↑, Perforin↓, GranA↓, GranB/GZMB↓, GNLY↓, PD-1↑,
423- CUR,    Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TLR4↓, IRF3↓, IFN-γ↓, TRIF↓,
5487- EP,    High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas
- in-vivo, GBM, NA
OS↑, CellMemb↑, Imm↑, Inflam↓, necrosis↑, Pyro↑, eff↑, IL2↑, IL6↑, IL17↑, IFN-γ↓,
1004- HNK,  RAPA,    Honokiol downregulates PD-L1 expression and enhances antitumor effects of mTOR inhibitors in renal cancer cells
- in-vitro, RCC, NA
Apoptosis↑, TumCCA↑, ROS↑, PD-L1↓, IFN-γ↓,
8318- LIN,    Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity
- NA, BC, T47D - NA, CRC, SW-620 - NA, Liver, HepG2
TumCCA↑, IFN-γ↓, IL13↓, IL2↓, IL4↓, IL6↓, TNF-α↓, Th1 response?,
2914- LT,    Therapeutic Potential of Luteolin on Cancer
- Review, Var, NA
*antiOx↑, *IronCh↑, *toxicity↓, *BioAv↓, *BioAv↑, DNAdam↑, TumCP↓, DR5↑, P53↑, JNK↑, BAX↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, survivin↓, cycD1/CCND1↓, CycB/CCNB1↓, CDC2↓, P21↑, angioG↓, MMP2↓, AEG1↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, CXCR4↓, PI3K↓, Akt↓, ERK↓, TumAuto↑, LC3B-II↑, EMT↓, E-cadherin↑, N-cadherin↓, Wnt↓, ROS↑, NICD↓, p‑GSK‐3β↓, iNOS↓, COX2/PTGS2↓, NRF2↑, Ca+2↑, ChemoSen↑, ChemoSen↓, IFN-γ↓, RadioS↑, MDM2↓, NOTCH1↓, AR↓, TIMP1↑, TIMP2↑, ER Stress↑, CDK2↓, Telomerase↓, p‑NF-kB↑, p‑cMyc↑, hTERT/TERT↓, RAS↓, YAP/TEAD↓, TAZ↓, NF-kB↓, NRF2↓, HO-1↓, MDR1↓,
220- MFrot,  MF,    Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation
- in-vitro, Melanoma, B16-F10
OS↑, DCells↑, T-Cell↑, Apoptosis↑, IL1↑, IFN-γ↓, IL10↑, TumCG↓, ROS↑, TumCP↓, TumCCA↑, ChrMod↑, CXCL9↓, CXCL12↓, CD4+↑, CD8+↑,
39- QC,    A Comprehensive Analysis and Anti-Cancer Activities of Quercetin in ROS-Mediated Cancer and Cancer Stem Cells
- Analysis, NA, NA
ROS↑, GSH↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, MAPK↑, ERK↑, SOD↑, ATP↓, Casp↑, PI3K/Akt↓, mTOR↓, NOTCH1↓, Bcl-2↓, BAX↑, IFN-γ↓, TumCP↓, TumCCA↑, Akt↓, P70S6K↓, *Keap1↓, *GPx↑, *Catalase↑, *HO-1↑, *NRF2↑, NRF2↑, eff↑, HIF-1↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
1432- SFN,    Evaluation of biodistribution of sulforaphane after administration of oral broccoli sprout extract in melanoma patients with multiple atypical nevi
- Human, Melanoma, NA
other↑, decorin↑, *toxicity↓, IP-10/CXCL-10↓, MCP1/CCL2↓, CXCL9↓, MIP-1β↓, IFN-γ↓,
3290- SIL,    A review of therapeutic potentials of milk thistle (Silybum marianum L.) and its main constituent, silymarin, on cancer, and their related patents
- Analysis, Var, NA
hepatoP↑, chemoP↑, *lipid-P↓, *antiOx↑, tumCV↓, TumCMig↓, Apoptosis↑, ROS↑, GSH↓, Bcl-2↓, survivin↓, cycD1/CCND1↓, NOTCH1↓, BAX↑, NF-kB↓, COX2/PTGS2↓, LOX1↓, iNOS↓, TNF-α↓, IL1↓, Inflam↓, *toxicity↓, CXCR4↓, EGFR↓, ERK↓, MMP↓, Cyt‑c↑, TumCCA↑, RB1↑, P53↑, P21↑, p27/CDKN1B↑, cycE/CCNE↓, CDK4↓, p‑pRB↓, Hif1a↓, cMyc↓, IL1β↓, IFN-γ↓, PCNA↓, PSA↓, CYP1A1↓,
1049- SK,    Shikonin inhibits immune checkpoint PD-L1 expression on macrophage in sepsis by modulating PKM2
- in-vivo, NA, NA
TNF-α↓, IL6↓, IFN-γ↓, IL1β↓, PD-L1↓, p‑PKM2↓,
3112- VitC,    Antioxidative and Anti-Inflammatory Activity of Ascorbic Acid
- Review, Nor, NA
*ROS↓, *antiOx↑, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑, *AP-1↑, *Inflam↓, *CRP↓, IFN-γ↓,

Showing Research Papers: 1 to 15 of 15

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

IL13↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   CYP1A1↓, 1,   GSH↓, 4,   HO-1↓, 2,   HO-1↑, 1,   lipid-P↓, 1,   lipid-P↑, 1,   MDA↓, 1,   NRF2↓, 1,   NRF2↑, 2,   ROS↑, 7,   ROS⇅, 1,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   CDC2↓, 1,   MMP↓, 3,   MPT↑, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   cMyc↓, 2,   p‑cMyc↑, 1,   FASN↓, 1,   PI3K/Akt↓, 1,   p‑PKM2↓, 1,   PPARγ↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 3,   APAF1↑, 1,   Apoptosis↑, 5,   BAX↑, 4,   Bcl-2↓, 4,   Casp↑, 2,   Casp10↑, 1,   Casp3↓, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   Casp8↑, 1,   cl‑Casp8↑, 1,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↓, 1,   Cyt‑c↑, 2,   DR5↑, 2,   Fas↑, 1,   GranA↓, 1,   GranB/GZMB↓, 1,   hTERT/TERT↓, 1,   iNOS↓, 6,   JNK↓, 1,   JNK↑, 1,   MAPK↓, 1,   MAPK↑, 1,   MDM2↓, 1,   necrosis↑, 1,   NICD↓, 1,   p27/CDKN1B↑, 1,   p38↓, 1,   Perforin↓, 1,   Pyro↑, 1,   sFasL↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TNFR 1↑, 1,   TRAILR↑, 1,   YAP/TEAD↓, 1,   p‑YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   other↓, 2,   other↑, 1,   p‑pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ER Stress↑, 1,   HSP27↓, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3B-II↑, 1,   LC3I↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 2,   P53↑, 5,   cl‑PARP↑, 2,   PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 3,   cycE/CCNE↓, 1,   P21↑, 2,   RB1↑, 1,   TumCCA↑, 6,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD44↓, 1,   CSCs↓, 1,   EMT↓, 2,   ERK↓, 3,   ERK↑, 1,   p‑ERK↓, 1,   GSK‐3β↓, 1,   p‑GSK‐3β↓, 1,   mTOR↓, 2,   NOTCH1↓, 4,   P70S6K↓, 1,   PI3K↓, 2,   RAS↓, 1,   STAT3↓, 1,   TAZ↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AEG1↓, 1,   Ca+2↑, 1,   Ca+2↝, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   decorin↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   LEF1↓, 1,   MMP2↓, 3,   MMP7↓, 1,   MMP9↓, 2,   MMPs↓, 1,   MOB1↓, 1,   N-cadherin↓, 1,   RAGE↓, 1,   Slug↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TIMP2↑, 1,   TSP-1↑, 1,   TumCMig↓, 1,   TumCP↓, 3,   Twist↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   EGFR↓, 2,   HIF-1↓, 1,   Hif1a↓, 2,   LOX1↓, 1,   NO↓, 1,   VEGF↓, 3,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CellMemb↑, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 6,   CRP↓, 1,   CXCL9↓, 2,   CXCR4↓, 2,   DCells↑, 1,   GNLY↓, 1,   IFN-γ↓, 15,   IKKα↓, 1,   IL1↓, 1,   IL1↑, 1,   IL10↑, 1,   IL17↑, 1,   IL1β↓, 3,   IL2↓, 2,   IL2↑, 1,   IL4↓, 2,   IL6↓, 5,   IL6↑, 1,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 3,   IP-10/CXCL-10↓, 1,   MCP1/CCL2↓, 1,   MIP-1β↓, 1,   NF-kB↓, 4,   p‑NF-kB↑, 1,   PD-1↑, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 1,   T-Cell↑, 1,   Th1 response?, 1,   TLR4↓, 1,   TNF-α↓, 6,   TRIF↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↓, 1,   ChemoSen↑, 2,   Dose↝, 1,   eff↑, 2,   MDR1↓, 1,   P450↓, 1,   RadioS↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   CRP↓, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 2,   hTERT/TERT↓, 1,   IL6↓, 5,   IL6↑, 1,   PD-L1↓, 2,   PD-L1↑, 1,   PSA↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   hepatoP↑, 1,   OS↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,   IRF3↓, 1,  
Total Targets: 208

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   Catalase↑, 2,   GPx↑, 2,   HO-1↑, 1,   Keap1↓, 1,   lipid-P↓, 1,   NRF2↑, 3,   ROS↓, 2,   SOD↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Migration(tgid=13) ⓘ

AP-1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CRP↓, 1,   Inflam↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

CRP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

Pain↓, 1,   toxicity↓, 3,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,   Diar↓, 1,  
Total Targets: 21

Scientific Paper Hit Count for: IFN-γ, Interferon-γ
2 Quercetin
1 alpha Linolenic acid
1 Bromelain
1 Boron
1 Curcumin
1 Electrical Pulses
1 Honokiol
1 Rapamycin
1 Linalool
1 Luteolin
1 Magnetic Field Rotating
1 Magnetic Fields
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:442  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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