TfR1/CD71 Cancer Research Results

TfR1/CD71, Transferrin receptor protein 1,: Click to Expand ⟱
Source:
Type: gene/protein
Also called CD71
A protein that in humans is encoded by the TFRC gene. A protein that mediates iron uptake from transferrin into cells.
Transferrin receptor, which can control iron metabolism, is frequently expressed in tumor cells.
As is well known, TfR1 binds to iron-loaded transferrin and plays a pivotal role in cellular uptake of iron as well as ferritin sequesters and stores the cellular iron.


Scientific Papers found: Click to Expand⟱
1069- AL,    Allicin promotes autophagy and ferroptosis in esophageal squamous cell carcinoma by activating AMPK/mTOR signaling
- vitro+vivo, ESCC, TE1 - vitro+vivo, ESCC, KYSE-510 - in-vitro, Nor, Het-1A
TumCP↓, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, p‑AMPK↑, mTOR↓, TumAuto↑, NCOA4↑, MDA↑, Iron↑, TumW↓, TumVol↓, ATG5↑, ATG7↑, TfR1/CD71↓, FTH1↓, ROS↑, Iron↑, Ferroptosis↑, *toxicity↓,
576- ART/DHA,    Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell Proteome
- Analysis, NA, NA
GSTP1/GSTπ↓, TfR1/CD71↓,
5132- ART/DHA,    Dihydroartemisinin Exerts Its Anticancer Activity through Depleting Cellular Iron via Transferrin Receptor-1
- in-vitro, Liver, HepG2 - in-vitro, BC, MCF7
Iron↓, TfR1/CD71↓, ROS↑,
2426- GamB,    Anti-cancer natural products isolated from chinese medicinal herbs
- Review, Var, NA
TfR1/CD71↓, MMP2↓, MMP9↓, ChemoSen↑,
222- MFrot,  MF,    LF-MF inhibits iron metabolism and suppresses lung cancer through activation of P53-miR-34a-E2F1/E2F3 pathway
- in-vitro, Lung, A549
TumCG↓, OS↑, miR-34a↑, E2Fs↓, P53↑, TfR1/CD71↓, Ferritin↓,

Showing Research Papers: 1 to 5 of 5

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 5

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GSTP1/GSTπ↓, 1,   Iron↓, 1,   Iron↑, 2,   MDA↑, 1,   ROS↑, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   FTH1↓, 1,   NCOA4↑, 1,   TfR1/CD71↓, 5,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

p‑AMPK↑, 1,   ATG7↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,   p62↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

E2Fs↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

miR-34a↑, 1,   mTOR↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

Ferritin↓, 1,  

Functional Outcomes(tgid=23) ⓘ

OS↑, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 30

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: TfR1/CD71, Transferrin receptor protein 1,
2 Artemisinin
1 Allicin (mainly Garlic)
1 Gambogic Acid
1 Magnetic Field Rotating
1 Magnetic Fields
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:465  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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