ALAT Cancer Research Results

ALAT, ALT, alanine aminotransferase: Click to Expand ⟱
Source:
Type: enzyme
(or ALT) -Used to be called serum glutamic-pyruvic transaminase (SGPT)
Most common in the liver.
An enzyme your body needs to break down proteins into energy.
It plays a crucial role in amino acid metabolism and is often measured in blood tests to assess liver function.
The catabolism of alanine by alanine aminotransferase 2 (ALT2) to pyruvate, was critical for the survival of non-small cell lung carcinoma (NSCLC) cells during glucose starvation. After knockdown of ALT2, cells were significantly more sensitive to glucose withdrawal compared to wildtype cells, which were rescued when supplemented with pyruvate.
Alanine aminotransferase (ALT) expression is highly elevated in the serum of patients with hepatocellular carcinoma.
A common example of dietary cancer therapy is the ketogenic diet, providing a fat-rich, low carbohydrate diet. The rationale is to reduce circulating glucose levels and induce ketosis.
Used as a clinical biomarker for Liver function.


Scientific Papers found: Click to Expand⟱
4390- AgNPs,    Therapeutic Potential of Cucumis melo (L.) Fruit Extract and Its Silver Nanopartciles Against DEN-Induced Hepatocellular Cancer in Rats
- in-vivo, Liver, NA
hepatoP↑, AST↓, ALAT↓, ALP↓,
5924- CA,    Carnosic acid impedes cell growth and enhances anticancer effects of carmustine and lomustine in melanoma
- vitro+vivo, Melanoma, B16-F10
TumCG↓, TumCCA↑, P21↑, eff↑, AST↓, ALAT↓,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
6254- CBC/D,    Cynanchum auriculatum Royle ex Wight., Cynanchum bungei Decne. and Cynanchum wilfordii (Maxim.) Hemsl.: Current Research and Prospects
- Review, Var, NA
*neuroP↑, *Imm↑, *Inflam↓, CSCs↓, HH↓, Gli↓, AST↓, ALAT↓, MDA↓, hepatoP↑, *NRF2↑, *HO-1↑, NF-kB?, GSK‐3β↓, β-catenin/ZEB1↓, COX2/PTGS2↓, MMP2↑, MMP9↓, BioAv↑,
2393- Cela,    Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect
- in-vivo, Sepsis, NA - in-vitro, Nor, RAW264.7
OS↑, PKM2↓, Glycolysis↓, Warburg↓, Inflam↓, HMGB1↓, ALAT↓, AST↓, TNF-α↓, IL1β↓, IL6↓,
6139- CHr,    Chrysin and its nanoformulations in cancer therapy: A systematic review of their radiosensitizing, phototherapy-enhancing potentials
- Review, Var, NA
RadioS↑, PhotoS↑, ROS↑, DNAdam↑, TumCCA↑, TumCD↑, selectivity↑, *ROS↓, *Inflam↓, *DNAdam↓, *antiOx↑, *lipid-P↓, *BioAv↑, eff↑, GSH↓, Catalase↓, ALAT↓, Ca+2↓, MDA↑,
2785- CHr,    Emerging cellular and molecular mechanisms underlying anticancer indications of chrysin
- Review, Var, NA
*NF-kB↓, *COX2/PTGS2↓, *iNOS↓, angioG↓, TOP1↓, HDAC↓, TNF-α↓, IL1β↓, cardioP↑, RenoP↑, neuroP↑, LDL↓, BioAv↑, eff↑, cycD1/CCND1↓, hTERT/TERT↓, MMP-10↓, Akt↓, STAT3↓, VEGF↓, EGFR↓, Snail↓, Slug↓, Vim↓, E-cadherin↑, eff↑, TET1↑, ROS↑, mTOR↓, PPARα↓, ER Stress↑, Ca+2↑, ERK↓, MMP↑, Cyt‑c↑, Casp3↑, HK2↓, NRF2↓, HO-1↓, MMP2↓, MMP9↓, Fibronectin↓, GRP78/BiP↑, XBP-1↓, p‑eIF2α↑, *AST↓, ALAT↓, ALP↓, LDH↓, COX2/PTGS2↑, Bcl-xL↓, IL6↓, PGE2↓, iNOS↓, DNAdam↑, UPR↑, Hif1a↓, EMT↓, Twist↓, lipid-P↑, CLDN1↓, PDK1 / PDPK1↓, IL10↓, TLR4↓, NOTCH1↑, PARP↑, Mcl-1↓, XIAP↓,
1607- EA,    Exploring the Potential of Ellagic Acid in Gastrointestinal Cancer Prevention: Recent Advances and Future Directions
- Review, GC, NA
STAT3↓, TumCP↓, Apoptosis↑, NF-kB↓, EMT↓, RadioS↑, antiOx↑, COX1↓, COX2/PTGS2↓, cMyc↓, Snail↓, Twist↓, MMP2↓, P90RSK↓, CDK8↓, PI3K↓, Akt↓, TumCCA↑, Casp8↑, PCNA↓, TGF-β↓, Shh↓, NOTCH↓, IL6↓, ALAT↓, ALP↓, AST↓, VEGF↓, P21↑, *toxicity∅, *Inflam↓, *cardioP↑, *neuroP↑, *hepatoP↑, ROS↑, *NRF2↓, *GSH↑,
6815- EMD,    NMR-based Metabolomic Techniques Identify the Toxicity of Emodin in HepG2 Cells
- in-vitro, Liver, HepG2
AntiCan↑, *hepatoP↑, *Inflam↓, *antiOx↑, *AntiBio↑, *toxicity↝, tumCV↓, TumCP↓, Apoptosis↑, ALAT↓, glucose↓, GSH↓, ATP↓,
6881- FA,    Potential Therapeutic Efficacy of Ferulic Acid and Its Derivatives in the Management of Cancers: A Comprehensive Analysis With Mechanistic Insight
- Review, Var, NA
ROS↑, TumCCA↑, TumCI↓, TumCMig↓, TumCP↓, BioAv↑, BioAv↑, TP53↑, CDK2↓, CDK4↓, CDK6↓, JAK2↓, STAT6↓, tyrosinase↓, p‑Akt↓, p‑PI3K↓, mTOR↓, Ki-67↓, Casp3↑, proCasp8↑, cl‑PARP↑, BAX↑, Bcl-2↓, Mcl-1↓, MMP9↓, cycD1/CCND1↓, cycE/CCNE↓, PINK1↑, PARK2↑, MMP↓, CycD3↓, TumAuto⇅, eff↑, eff↑, ALAT↓, AST↓, ALP↓, VEGF↓, MMPs↓, angioG↓,
1656- FA,    Ferulic Acid: A Natural Phenol That Inhibits Neoplastic Events through Modulation of Oncogenic Signaling
- Review, Var, NA
tyrosinase↓, CK2↓, TumCP↓, TumCMig↓, FGF↓, FGFR1↓, PI3K↓, Akt↓, VEGF↓, FGFR1↓, FGFR2↓, PDGF↓, ALAT↓, AST↓, TumCCA↑, CDK2↓, CDK4↓, CDK6↓, BAX↓, Bcl-2↓, MMP2↓, MMP9↓, P53↑, PARP↑, PUMA↑, NOXA↑, Casp3↑, Casp9↑, TIMP1↑, lipid-P↑, mtDam↑, EMT↓, Vim↓, E-cadherin↓, p‑STAT3↓, COX2/PTGS2↓, CDC25↓, RadioS↑, ROS↑, DNAdam↑, γH2AX↑, PTEN↑, LC3II↓, Beclin-1/ATG6↓, SOD↓, Catalase↓, GPx↓, Fas↑, *BioAv↓, cMyc↓, Beclin-1/ATG6↑, LC3‑Ⅱ/LC3‑Ⅰ↓,
4022- FulvicA,  Chemo,    Shilajit potentiates the effect of chemotherapeutic drugs and mitigates metastasis induced liver and kidney damages in osteosarcoma rats
- in-vivo, OS, NA
AST↓, ALAT↓, ALP↓, Bil↝, creat↓, uricA↓, ChemoSen↑, chemoP↑,
2525- H2,    Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis
- in-vivo, NA, NA
OS↓, cardioP↑, *AST↓, ALAT↓, *ROS↓, *MDA↓, *hepatoP↑, *Inflam↓, chemoP↑,
2524- H2,    Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy
- Trial, NA, NA
hepatoP↑, ALAT↓, AST↓, Dose↝, Dose↝,
8129- LF,    Study on the Therapeutic Benefit on Lactoferrin in Patients with Colorectal Cancer Receiving Chemotherapy
- Trial, CRC, NA
Dose↝, toxicity↓, INF-γ↝, other↑, *ROS↓, Imm↑, WBC↑, Neut↑, T-Cell↑, *antiOx↑, *GSH↑, *chemoP↑, *RenoP↑, *hepatoP↑, BUN↓, creat↓, ALAT↓, AST↓, RBC↑, PC↑, Mucositis↓, *AntiBio↑, *AntiViral↑, *AntiFungal↑, *Inflam↓,
200- MFrot,  MF,    Moderate intensity low frequency rotating magnetic field inhibits breast cancer growth in mice
- in-vivo, BC, MDA-MB-231 - in-vivo, BC, MCF7
ALAT↓, TumVol↓, TumCCA↑, TumCG↓, TumMeta↓, Imm↑, P53↑, ALAT↓, AST↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
7431- Poly,    Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression
- vitro+vivo, BC, 4T1
other↝, AntiTum↑, Dose↝, TumCG↓, ALAT↓, AST↓, hepatoP↑, COX2/PTGS2↓, MMP2↓, MMP9↓,
4488- Se,  Chit,  PEG,    Anticancer effect of selenium/chitosan/polyethylene glycol/allyl isothiocyanate nanocomposites against diethylnitrosamine-induced liver cancer in rats
- in-vivo, Liver, HepG2 - in-vivo, Nor, HL7702
tumCV↓, Apoptosis↑, *GSH↑, *VitC↑, *VitE↑, *SOD↑, *GPx↑, *GR↑, ALAT↓, ALP↓, AST↓, LDH↓, selectivity↑, eff↑,
3295- SIL,    Hepatoprotective effect of silymarin
- Review, NA, NA
*hepatoP↑, *ROS↓, *GSH↑, *BioAv↝, ERK↓, NF-kB↓, STAT3↓, COX2/PTGS2↓, Inflam↓, IronCh↑, lipid-P↓, ALAT↓, AST↓, TNF-α↓, *α-SMA↓, *SOD↑,
2116- TQ,  Cisplatin,    Oral administration of Nigella sativa oil ameliorates the effect of cisplatin on membrane enzymes, carbohydrate metabolism and oxidative damage in rat liver
- in-vivo, Nor, NA
*hepatoP↑, *antiOx↑, *ROS↓, ALAT↓, AST↓,
2113- TQ,    Potential role of Nigella sativa (NS) in abating oxidative stress-induced toxicity in rats: a possible protection mechanism
- in-vivo, Nor, NA
*antiOx↑, *RenoP↑, *hepatoP↑, *SOD↑, *GSH↑, *ROS↓, *lipid-P↓, ALAT↓, creat↓,
5021- UA,    Anticancer effect of ursolic acid via mitochondria-dependent pathways
- Review, Var, NA
Inflam↓, TNF-α↓, IL6↓, IL17↓, NF-kB↓, COX2/PTGS2↓, *AntiDiabetic↑, *hepatoP↑, ALAT↓, AST↓, TumCP↓, Apoptosis↑, TumCCA↑, TumAuto↑, tumCV↓, TumCMig↓, Glycolysis↓, ATP↓, lactateProd↓, HK2↓, PKA↓, COX2/PTGS2↓, mtDam↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, ROS↑, MMP↓, P53↑,

Showing Research Papers: 1 to 23 of 23

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 23

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Mucositis↓, 1,   PC↑, 1,   RBC↑, 1,   WBC↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Bil↝, 1,   Catalase↓, 2,   GPx↓, 1,   GSH↓, 2,   HO-1↓, 1,   lipid-P↓, 1,   lipid-P↑, 2,   MDA↓, 1,   MDA↑, 1,   NRF2↓, 1,   PARK2↑, 1,   ROS↑, 7,   SOD↓, 1,   uricA↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 2,   CDC25↓, 1,   FGFR1↓, 2,   MMP↓, 3,   MMP↑, 1,   mtDam↑, 3,   PINK1↑, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 24,   BUN↓, 1,   cMyc↓, 2,   glucose↓, 1,   Glycolysis↓, 2,   HK2↓, 2,   lactateProd↓, 1,   LDH↓, 2,   LDL↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 1,   PPARα↓, 1,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 2,   Apoptosis↓, 1,   Apoptosis↑, 5,   BAX↓, 1,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Bcl-xL↓, 1,   Casp3↑, 5,   Casp8↑, 2,   proCasp8↑, 1,   Casp9↑, 2,   CK2↓, 1,   Cyt‑c↑, 1,   Fas↑, 1,   hTERT/TERT↓, 1,   iNOS↓, 1,   Mcl-1↓, 2,   NOXA↑, 1,   PUMA↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   PhotoS↑, 1,   tumCV↓, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

p‑eIF2α↑, 1,   ER Stress↑, 2,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   TumAuto↑, 1,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 3,   P53↑, 3,   PARP↑, 2,   cl‑PARP↑, 1,   PCNA↓, 1,   TP53↑, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 3,   cycD1/CCND1↓, 3,   CycD3↓, 1,   cycE/CCNE↓, 1,   P21↑, 2,   TumCCA↑, 9,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CDK8↓, 1,   CSCs↓, 1,   EMT↓, 3,   ERK↓, 3,   p‑ERK↑, 1,   FGF↓, 1,   FGFR2↓, 1,   FOXO3↓, 1,   Gli↓, 1,   GSK‐3β↓, 2,   HDAC↓, 2,   HH↓, 1,   mTOR↓, 2,   NOTCH↓, 2,   NOTCH1↑, 1,   P90RSK↓, 1,   PI3K↓, 3,   p‑PI3K↓, 1,   PTEN↑, 2,   p‑PTEN↓, 1,   Shh↓, 1,   STAT3↓, 3,   p‑STAT3↓, 1,   STAT6↓, 1,   TOP1↓, 1,   TumCG↓, 3,   tyrosinase↓, 2,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   Ca+2↑, 1,   CLDN1↓, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   p‑FAK↑, 1,   Fibronectin↓, 1,   Ki-67↓, 1,   MMP-10↓, 1,   MMP2↓, 5,   MMP2↑, 1,   MMP9↓, 6,   MMPs↓, 2,   PDGF↓, 1,   PKA↓, 1,   Slug↓, 1,   Snail↓, 2,   TET1↑, 1,   TGF-β↓, 1,   TIMP1↑, 1,   TumCI↓, 1,   TumCMig↓, 3,   TumCP↓, 5,   TumMeta↓, 2,   Twist↓, 2,   Vim↓, 2,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   EGFR↓, 1,   Hif1a↓, 1,   VEGF↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 8,   COX2/PTGS2↑, 1,   HMGB1↓, 1,   IL10↓, 1,   IL10↑, 1,   IL17↓, 1,   IL1β↓, 2,   IL2↑, 1,   IL6↓, 5,   Imm↑, 2,   INF-γ↝, 1,   Inflam↓, 3,   JAK2↓, 1,   Neut↑, 1,   NF-kB?, 1,   NF-kB↓, 4,   PGE2↓, 1,   T-Cell↑, 1,   TLR4↓, 1,   TNF-α↓, 4,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 4,   ChemoSen↑, 1,   Dose?, 1,   Dose↝, 4,   eff↑, 9,   eff∅, 1,   RadioS↑, 3,   selectivity↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 24,   ALP↓, 7,   AST↓, 17,   Bil↝, 1,   creat↓, 3,   EGFR↓, 1,   hTERT/TERT↓, 1,   IL6↓, 5,   Ki-67↓, 1,   LDH↓, 2,   TP53↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiTum↑, 1,   cardioP↑, 2,   chemoP↑, 3,   ChemoSideEff↓, 1,   hepatoP↑, 4,   neuroP↑, 1,   OS↓, 1,   OS↑, 1,   RenoP↑, 1,   toxicity↓, 1,   TumVol↓, 1,  
Total Targets: 203

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 1,   GPx↑, 2,   GSH↑, 5,   HO-1↑, 1,   lipid-P↓, 2,   MDA↓, 2,   NRF2↓, 1,   NRF2↑, 1,   ROS↓, 7,   SOD↑, 4,   VitC↑, 1,   VitE↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

LDH↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,   necrosis↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TRPM7↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   α-SMA↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   Imm↑, 2,   Inflam↓, 6,   NF-kB↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   BioAv↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AST↓, 3,   LDH↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiDiabetic↑, 2,   cardioP↑, 2,   chemoP↑, 1,   hepatoP↑, 9,   motorD↑, 1,   neuroP↑, 3,   Obesity↓, 1,   Pain↓, 1,   RenoP↑, 2,   toxicity↝, 1,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 1,  
Total Targets: 46

Scientific Paper Hit Count for: ALAT, ALT, alanine aminotransferase
2 Chrysin
2 Ferulic acid
2 Hydrogen Gas
2 Thymoquinone
1 Silver-NanoParticles
1 Carnosic acid
1 Carvacrol
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Celastrol
1 Ellagic acid
1 Emodin
1 Shilajit/Fulvic Acid
1 Chemotherapy
1 Lactoferrin/Talactoferrin
1 Magnetic Field Rotating
1 Magnetic Fields
1 Propolis -bee glue
1 Polyphenols
1 Selenium
1 chitosan
1 polyethylene glycol
1 Silymarin (Milk Thistle) silibinin
1 Cisplatin
1 Ursolic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:554  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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