COX2/PTGS2 Cancer Research Results

COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein: Click to Expand ⟱
Source: HalifaxProj(inhibit)
Type:
Cyclooxygenase-2 (COX-2) is an enzyme that plays a critical role in the conversion of arachidonic acid to prostaglandins, which are lipid compounds involved in various physiological processes, including inflammation, pain, and fever. COX-2 is an inducible enzyme, meaning its expression is typically low in normal tissues but can be upregulated in response to inflammatory stimuli, growth factors, and certain oncogenic signals.
-Cyclooxygenase-2 (COX-2), the rate-limiting enzyme in prostaglandin biosynthesis, plays a key role in inflammation and circulatory homeostasis.
-COX-2 is an inducible enzyme that is upregulated in response to pro-inflammatory signals, including cytokines (e.g., IL-1β, TNF-α) and growth factors.

COX-2 is often overexpressed in various tumors, including colorectal, breast, lung, and prostate cancers.
The prostaglandins produced by COX-2, particularly prostaglandin E2 (PGE2), have several effects that can facilitate cancer progression:
Cell Proliferation: PGE2 can promote the proliferation of cancer cells by activating signaling pathways such as the PI3K/Akt and MAPK pathways.
Nonselective NSAIDs, such as aspirin and ibuprofen, inhibit both COX-1 and COX-2. Epidemiological studies have suggested that regular use of NSAIDs may reduce the risk of certain cancers, particularly colorectal cancer.
Drugs specifically targeting COX-2, such as celecoxib, have been developed.

COX-2 and xanthine oxidase are ROS-producing pro-oxidant enzymes that contribute to inflammation. Elevated COX‑2 levels, often found in inflammatory conditions or certain types of cancers, can contribute to increased production of ROS.
Scientific Papers found: Click to Expand⟱
6461- 1,8-Cin,    1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases
- Review, AD, NA - Review, Var, NA
*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑,
5470- AF,    Exploring a Therapeutic Gold Mine: The Antifungal Potential of the Gold-Based Antirheumatic Drug Auranofin
- Review, Var, NA
TrxR↓, other↝, IL6↑, IL8↑, NK cell⇅, COX2/PTGS2↓, NOS2↓, NRF2↑, Prx↑, Half-Life↑, Dose↝, ROS↑, NF-kB↓,
4409- AgNPs,    Plant-based synthesis of gold and silver nanoparticles using Artocarpus heterophyllus aqueous leaf extract and its anticancer activities
- in-vitro, BC, MCF7
tumCV↓, TumCCA↑, cycD1/CCND1↓, COX2/PTGS2↓, HER2/EBBR2↓,
2559- AL,    Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time
- Human, Nor, NA
AntiAg↑, COX2/PTGS2↓, cardioP↑,
1253- aLinA,    The Antitumor Effects of α-Linolenic Acid
- Review, NA, NA
PPARγ↑, COX2/PTGS2↓, E6↓, E7↓, P53↑, p‑ERK↓, p38↓, lipid-P↑, ROS⇅, MPT↑, MMP↓, Cyt‑c↑, Casp↑, iNOS↓, NO↓, Casp3↑, Bcl-2↓, Hif1a↓, FASN↓, CRP↓, IL6↓, IL1β↓, IFN-γ↓, TNF-α↓, Twist↓, VEGF↓, MMP2↓, MMP9↓,
1159- And,    Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism
- Review, NA, NA
NRF2↑, COX2/PTGS2↓, IL6↓, IL8↓, IL1↓, iNOS↓, MPO↓, TNF-α↓, VEGF↓, Hif1a↓, p‑AMPK↑,
1078- And,    Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway
- in-vitro, BC, MDA-MB-231 - in-vitro, Nor, HUVECs - in-vivo, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, BT549 - in-vitro, BC, MDA-MB-361
TumCP↓, COX2/PTGS2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,
7907- Api,  IVT,    Anticancer Potential of Apigenin and Isovitexin with Focus on Oncogenic Metabolism in Cancer Stem Cells
- Review, Var, NA
ChemoSen↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, PI3K↓, MMP↓, TumMeta↓, MAPK↓, VEGF↓, MMP9↓, TGF-β↓, Inflam↓, COX2/PTGS2↓, IL6↓, NF-kB↓, TumCCA↑, P53↑, cycD1/CCND1↓, BAX↑, Casp↓, Bcl-2↓, CD133↓, Nanog↓, SOX2↓, Akt↓, TumCP↓, TumCMig↓, YAP/TEAD↓, CCN2/CTGF↓, CCN1/CYR61↓, SIRT3↓, SIRT6↓, PCNA↓, DNMT1↓, miR-34a↑,
211- Api,    Suppression of NF-κB and NF-κB-Regulated Gene Expression by Apigenin through IκBα and IKK Pathway in TRAMP Mice
- in-vivo, Pca, NA
IKKα↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Bcl-2↓, Bcl-xL↓, VEGF↓, PCNA↓, BAX↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
1149- Api,    Apigenin inhibits colonic inflammation and tumorigenesis by suppressing STAT3-NF-κB signaling
- vitro+vivo, IBD, NA
COX2/PTGS2↓, MPO↓, NF-kB↓, STAT3↓, Inflam↓,
1553- Api,    Role of Apigenin in Cancer Prevention via the Induction of Apoptosis and Autophagy
- Review, NA, NA
Dose∅, TumVol↓, Dose∅, COX2/PTGS2↓, Hif1a↓, TumCCA↑, P53↑, P21↑, Casp3↑, DNAdam↑, TumAuto↝,
1547- Api,    Apigenin: Molecular Mechanisms and Therapeutic Potential against Cancer Spreading
- Review, NA, NA
angioG↓, EMT↓, CSCs↓, TumCCA↑, Dose∅, ROS↑, MMP↓, Catalase↓, GSH↓, PI3K↓, Akt↓, NF-kB↓, OCT4↓, Nanog↓, SIRT3↓, SIRT6↓, eff↑, eff↑, Cyt‑c↑, Bax:Bcl2↑, p‑GSK‐3β↓, FOXO3↑, p‑STAT3↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MMPs↓, NRF2↓, HDAC↓, Telomerase↓, eff↑, eff↑, eff↑, eff↑, eff↑, XIAP↓, survivin↓, CK2↓, HSP90↓, Hif1a↓, FAK↓, EMT↓,
1543- Api,    Therapeutical properties of apigenin: a review on the experimental evidence and basic mechanisms
- Review, NA, NA
TNF-α↓, IL1β↓, IL6↓, IL10↓, COX2/PTGS2↓, iNOS↓, Inflam↓, Dose∅, Dose∅,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
3396- ART/DHA,    Progress on the study of the anticancer effects of artesunate
- Review, Var, NA
TumCP↓, TumCI↓, TumCMig↓, Apoptosis↑, Diff↑, TumAuto↑, angioG↓, TumCCA↑, ROS↑, AMPK↑, mTOR↑, ChemoSen↑, Tf↑, Ferroptosis↑, Ferritin↓, lipid-P↑, CDK1↑, CDK2↑, CDK4↑, CDK6↑, SIRT1↑, COX2/PTGS2↓, IL1β↓, survivin↓, DNAdam↑, RadioS↑,
562- ART/DHA,    Artesunate exerts an anti-immunosuppressive effect on cervical cancer by inhibiting PGE2 production and Foxp3 expression
- in-vivo, NA, HeLa
CD4+↓, CD25+↓, FoxP3+↓, Treg lymp↓, PGE2↓, FOXP3↓, COX2/PTGS2↓,
1079- ART/DHA,    Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2
- in-vitro, GC, BGC-823 - in-vitro, GC, HGC27 - in-vitro, GC, MGC803
TumCP↓, Apoptosis↑, COX2/PTGS2↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, MMP↓,
5396- Ash,    Withania Somnifera (Ashwagandha) and Withaferin A: Potential in Integrative Oncology
- Review, Var, NA
selectivity↑, ROS↑, Apoptosis↑, ChemoSen↑, RadioS↑, NF-kB↓, ER-α36↓, P53↑, *ROS∅, γH2AX↑, DNAdam↑, MMP↓, XIAP↓, IAP1↓, survivin↓, SOD↓, Dose↝, IL6↓, TNF-α↓, COX2/PTGS2↓, p‑Akt↓, NOTCH1↓, FOXO↑, Casp↑, MMP2↓, CSCs↓, *ROS↓, *SOD2↑, chemoP↑, ChemoSen↑, RadioS↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
1177- Ash,    Withaferin A downregulates COX-2/NF-κB signaling and modulates MMP-2/9 in experimental endometriosis
- in-vivo, EC, NA
TumVol↓, MMP2↓, MMP9↓, NF-kB↓, COX2/PTGS2↓, NO↓, IL1β↓, IL6↓,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
1299- BBR,    Effects of Berberine and Its Derivatives on Cancer: A Systems Pharmacology Review
- Review, NA, NA
TumCCA↑, TP53↑, COX2/PTGS2↓, Bax:Bcl2↑, ROS↑, VEGFR2/KDR/Flk1↓, Akt↓, ERK↓, MMP2↓, MMP9↓, IL8↑, P21↑, p27/CDKN1B↑, E-cadherin↓, Fibronectin↓, cMyc↓,
2699- BBR,    Plant Isoquinoline Alkaloid Berberine Exhibits Chromatin Remodeling by Modulation of Histone Deacetylase To Induce Growth Arrest and Apoptosis in the A549 Cell Line
- in-vitro, Lung, A549
HDAC↓, TumCCA↑, TNF-α↓, COX2/PTGS2↓, MMP2↓, MMP9↓, P21↑, P53↑, Casp↑, ac‑H3↑, ac‑H4↑, ROS↑, MMP↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5180- BBR,    Berberine Targets AP-2/hTERT, NF-κB/COX-2, HIF-1α/VEGF and Cytochrome-c/Caspase Signaling to Suppress Human Cancer Cell Growth
- in-vitro, NSCLC, NA
TumCMig↓, TumCP↓, Apoptosis↑, TFAP2A↓, hTERT/TERT↓, NF-kB↓, COX2/PTGS2↓, Hif1a↓, VEGF↓, Akt↓, p‑ERK↓, Cyt‑c↑, cl‑Casp↑, cl‑PARP↑, PI3K↓, Akt↓, Raf↓, MEK↓, ERK↓,
5176- BBR,    Berberine regulates AMP-activated protein kinase signaling pathways and inhibits colon tumorigenesis in mice
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
TumVol↓, Ki-67↓, COX2/PTGS2↓, AMPK↑, mTOR↓, NF-kB↓, cycD1/CCND1↓, survivin↓, P53↑, cl‑Casp3↑, TumCP↓, Inflam↓, COX2/PTGS2↓, ACC↑,
6513- BCP,    β-Caryophyllene oxide potentiates TNFα-induced apoptosis and inhibits invasion through down-modulation of NF-κB-regulated gene products
Apoptosis↑, TumCG↓, TumMeta↓, STAT3↓, PI3K↓, Akt↓, mTOR↓, ChemoSen↑, IAP1↓, IAP2/BIRC3↓, Bcl-2↓, Bcl-xL↓, survivin↓, COX2/PTGS2↓, cycD1/CCND1↓, cMyc↓, TumCI↓, MMP9↓, ICAM-1↓, angioG↓, VEGF↓, NF-kB↓,
6499- BCP,    JAK1/STAT3 regulatory effect of β-caryophyllene on MG-63 osteosarcoma cells via ROS-induced apoptotic mitochondrial pathway by DNA fragmentation
- in-vitro, OS, MG63
ROS↑, Apoptosis↑, TumCP↓, BAX↑, Casp3↑, Bcl-2↓, MMP↓, DNAdam↑, TNF-α↓, COX2/PTGS2↓, NF-kB↓, IL6↓, Inflam↓, JAK1↑, STAT3↑,
6501- BCP,    β-Caryophyllene promotes oxidative stress and apoptosis in KB cells through activation of mitochondrial-mediated pathway - An in-vitro and in-silico study
- in-vitro, Oral, KB
TumCG↓, Apoptosis↑, TumMeta↓, NF-kB↓, PI3K↓, Akt↓, ROS↑, MMP↓, DNAdam↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, PCNA↓, cycD1/CCND1↓, TNF-α↓, COX2/PTGS2↓, iNOS↓, IL6↓, VEGF↓,
2760- BetA,    A Review on Preparation of Betulinic Acid and Its Biological Activities
- Review, Var, NA - Review, Stroke, NA
AntiTum↑, Cyt‑c↑, Smad1↑, Sepsis↓, NF-kB↓, ICAM-1↓, MCP1/CCL2↓, MMP9↓, COX2/PTGS2↓, PGE2↓, ERK↓, p‑Akt↓, *ROS↓, *LDH↓, *hepatoP↑, *SOD↑, *Catalase↑, *GSH↑, *AST↓, *ALAT↓, *RenoP↑, *ROS↓, *α-SMA↓,
5686- BJ,  BRU,    A review of Brucea javanica: metabolites, pharmacology and clinical application
- Review, Var, NA
AntiTum↑, other↝, ChemoSen↑, QoL↑, chemoP↑, *Inflam↓, NF-kB↓, TumCP↓, TumCI↓, TumMeta↓, Hif1a↓, NRF2↓, STAT3↓, COX2/PTGS2↓, Casp3↑, Casp9↑, ROS↑, EGFR↓, NRF2↑,
5680- BML,    Anticancer properties of bromelain: State-of-the-art and recent trends
- Review, Var, NA
*Inflam↓, *Bacteria↓, *Pain↓, *Diar↓, *Wound Healing↑, ERK↓, JNK↓, XIAP↓, HSP27↓, β-catenin/ZEB1↓, HO-1↓, lipid-P↓, ACSL4↑, ROS↑, SOD↑, Catalase↓, GSH↓, MDA↓, Casp3↓, Casp9↑, DNAdam↑, Apoptosis↑, NF-kB↓, P53↑, MAPK↓, APAF1↑, Cyt‑c↓, CD44↓, Imm↑, ATG5↑, LC3I↑, Beclin-1/ATG6↑, IL2↓, IL4↓, IFN-γ↓, COX2/PTGS2↓, iNOS↓, ChemoSen↑, RadioS↑, Dose↝, other↓,
5677- BML,    Bromelain inhibits nuclear factor kappa-B translocation, driving human epidermoid carcinoma A431 and melanoma A375 cells through G(2)/M arrest to apoptosis
- in-vitro, Melanoma, A431 - in-vitro, Melanoma, A375
TumCP↓, Inflam↓, Akt↓, NF-kB↓, COX2/PTGS2↓, GSH↓, ROS↑, MMP↓, TumCCA↑, Apoptosis↑, ChemoSen↑,
5683- BML,    Bromelain inhibits COX-2 expression by blocking the activation of MAPK regulated NF-kappa B against skin tumor-initiation triggering mitochondrial death pathway
- in-vitro, NA, NA
COX2/PTGS2↓, MAPK↓, NF-kB↓, TumMeta↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MAPK↓, ERK↓, Akt↓, TumVol↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2768- Bos,    Boswellic acids as promising agents for the management of brain diseases
- Review, Var, NA - Review, AD, NA - Review, Park, NA
*neuroP↑, *ROS↓, *cognitive↓, TumCP↓, TumCMig↓, TumMeta↓, angioG↓, Apoptosis↑, *Inflam↓, IL1↓, IL2↓, IL4↓, IL6↓, TNF-α↓, P53↑, Akt↓, NF-kB↓, DNAdam↑, Casp↑, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, *SOD↑, *Catalase↑, *GPx↑, *NRF2↑,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Ki-67↓, CD31/PECAM-1↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
1169- Bos,    Boswellic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in Orthotopic Mouse Model By Downregulating Inflammatory, Proliferative, Invasive, and Angiogenic Biomarkers
- in-vivo, CRC, NA
TumCG↓, TumVol↓, Weight∅, ascitic↓, TumMeta↓, Ki-67↓, CD31/PECAM-1↓, NF-kB↓, COX2/PTGS2↓, Bcl-2↓, Bcl-xL↓, IAP1↓, survivin↓, cycD1/CCND1↓, ICAM-1↓, MMP9↓, CXCR4↓, VEGF↓,
1417- Bos,    Potential complementary and/or synergistic effects of curcumin and boswellic acids for management of osteoarthritis
- Review, Arthritis, NA
5LO↓, COX2/PTGS2↓, PGE2↓,
1420- Bos,    Acetyl-11-keto-β-boswellic acid inhibits proliferation and induces apoptosis of gastric cancer cells through the phosphatase and tensin homolog /Akt/ cyclooxygenase-2 signaling pathway
- vitro+vivo, GC, BGC-823
TumCP↓, TumCG↓, PTEN↑, BAX↑, Bcl-2↓, p‑Akt↓, COX2/PTGS2↓,
1416- Bos,    Anti-cancer properties of boswellic acids: mechanism of action as anti-cancerous agent
- Review, NA, NA
5LO↓, TumCCA↑, LC3B↓, PI3K↓, Akt↓, Glycolysis↓, AMPK↑, mTOR↓, Let-7↑, COX2/PTGS2↓, VEGF↓, CXCR4↓, MMP2↓, MMP9↓, HIF-1↓, angioG↓, TumCP↓, TumCMig↓, NF-kB↓,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,
5740- Buty,    A Review of Nutritional Regulation of Intestinal Butyrate Synthesis: Interactions Between Dietary Polysaccharides and Proteins
- Review, RCC, NA
*eff↓, Dose↝, eff↑, HDAC↓, ac‑H3↓, ac‑H4↓, *HCAR2↑, *Inflam↓, *ROS↓, *NRF2↑, *GSH↑, *CLDN1↑, *ZO-1↑, IL1β↓, IL6↓, COX2/PTGS2↓, eff↝, eff↑, other↝,
5739- Buty,    Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)
- Review, Var, NA
GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2/PTGS2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,

Showing Research Papers: 1 to 50 of 289
Page 1 of 6 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 289

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AApath↓, 1,   AKR1B10↓, 1,   ARG↓, 1,   ASAP2↓, 1,   CCN1/CYR61↓, 1,   CDK7↓, 1,   CTSK↓, 1,   CYP4A/CYP4A11/CYP4A22↓, 1,   IGF-2R↑, 1,   LRIG1↑, 1,   miR-106b↓, 1,   miR-134↑, 1,   MYCN↓, 1,   NA↓, 1,   NA↑, 1,   NEAT1↓, 1,   PGI2↓, 1,   PLA2↓, 1,   PSEN1/PS1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 3,   antiOx↑, 11,   ATF3↑, 1,   Catalase↓, 3,   Catalase↑, 3,   Copper↓, 1,   CYP1A1↓, 3,   CYP1A1↑, 1,   Ferroptosis↑, 5,   GPx↓, 1,   GPx↑, 5,   GPx4↓, 4,   GSH↓, 16,   GSH↑, 9,   GSR↑, 2,   GSTA1↑, 1,   GSTs↓, 2,   GSTs↑, 2,   GSTs↝, 1,   H2O2↑, 2,   HO-1↓, 3,   HO-1↑, 11,   HO-2↓, 1,   Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 5,   lipid-P↑, 9,   MDA↓, 4,   MDA↑, 1,   MFN2↑, 1,   MPO↓, 4,   NADH↓, 1,   NQO1↑, 2,   NRF2↓, 9,   NRF2↑, 24,   OXPHOS↓, 1,   OXPHOS↑, 1,   mt-OXPHOS↓, 1,   Prx↑, 1,   Prx4↑, 1,   ROS↓, 27,   ROS↑, 117,   ROS⇅, 6,   i-ROS↓, 1,   mt-ROS↑, 1,   SIRT3↓, 2,   SIRT3↑, 4,   SOD↓, 4,   SOD↑, 8,   SOD2↓, 1,   TBARS↑, 1,   Thiols↓, 1,   TrxR↓, 4,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 2,   IronCh↑, 1,   Tf↓, 1,   Tf↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 6,   ATP↓, 7,   ATP↑, 2,   mt-ATP↓, 1,   Bfl-1↓, 1,   CDC2↓, 5,   CDC25↓, 8,   EGF↓, 4,   ETC↓, 1,   FGFR1↓, 3,   Insulin↓, 1,   MEK↓, 6,   mitResp↓, 2,   mitResp↑, 2,   MKK4↓, 1,   MKK7↓, 1,   MKP5↑, 1,   MMP↓, 52,   MMP↑, 1,   MPT↑, 3,   mtDam↑, 8,   OCR↓, 2,   Raf↓, 6,   e-Raf↓, 1,   c-Raf↓, 1,   XIAP?, 1,   XIAP↓, 24,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↑, 4,   p‑ACC↑, 1,   ACSL4↑, 1,   AKT1↓, 1,   ALAT↓, 7,   ALAT↝, 1,   AMPK↑, 23,   AMPK↝, 1,   p‑AMPK↑, 2,   ATG7↑, 2,   CAIX/CA9↑, 1,   cMyc↓, 32,   cMyc↑, 1,   p‑cMyc↑, 1,   ECAR↓, 1,   ECAR↝, 1,   FASN↓, 3,   FASN↑, 1,   FGF21↓, 1,   G6PD↓, 1,   GLO-I↓, 1,   GLS↓, 1,   glucoNG↓, 1,   glucose↝, 1,   GlucoseCon↓, 6,   Glycolysis↓, 13,   HK2↓, 6,   IR↓, 1,   lactateProd↓, 7,   lactateProd↑, 1,   LDH↑, 1,   LDH↝, 1,   i-LDH↓, 1,   LDHA↓, 3,   lipidLev↓, 1,   lipoGen↓, 1,   NADPH↓, 2,   NADPH↑, 3,   PDK1 / PDPK1?, 2,   PDK1 / PDPK1↓, 6,   PDK3↑, 1,   PI3K/Akt↓, 3,   PI3k/Akt/mTOR↓, 1,   PKM2↓, 8,   PPARα↓, 1,   PPARα↑, 2,   cl‑PPARα↓, 1,   PPARγ↓, 1,   PPARγ↑, 10,   p‑S6K↓, 1,   SCD1↓, 1,   SHARP↑, 1,   SIRT1↓, 6,   SIRT1↑, 9,   SIRT2↓, 1,   SREBP1/SREBF1↓, 1,   SREBP2↓, 1,   STK11/LKB1↑, 1,   p‑STK11/LKB1↑, 1,   Warburg↓, 4,  

Cell Death(tgid=5) ⓘ

Akt↓, 89,   Akt↑, 1,   p‑Akt↓, 26,   APAF1↑, 4,   Apoptosis?, 1,   Apoptosis↓, 3,   Apoptosis↑, 91,   BAD↑, 4,   Bak↓, 1,   Bak↑, 4,   BAX↓, 2,   BAX↑, 54,   BAX⇅, 1,   Bax:Bcl2↑, 17,   Bcl-2↓, 68,   Bcl-2↑, 2,   Bcl-xL↓, 27,   BID↓, 1,   BID↑, 6,   p‑BID↓, 1,   cl‑BID↑, 1,   BIM↑, 3,   BMP2↓, 1,   Casp↓, 1,   Casp↑, 20,   cl‑Casp↑, 1,   Casp1↑, 1,   Casp10↑, 1,   Casp12↑, 1,   Casp3↓, 5,   Casp3↑, 81,   cl‑Casp3↑, 12,   cl‑Casp3⇅, 1,   proCasp3↑, 1,   Casp6↑, 1,   Casp7↑, 11,   Casp8↑, 22,   Casp8∅, 1,   cl‑Casp8↑, 2,   proCasp8↑, 1,   Casp9↓, 2,   Casp9↑, 54,   cl‑Casp9↑, 7,   proCasp9↑, 1,   CBP↓, 1,   cFLIP↓, 5,   Chk2↓, 2,   CK2↓, 4,   Cyt‑c↓, 4,   Cyt‑c↑, 51,   Diablo↑, 9,   DR4↑, 5,   DR5↓, 1,   DR5↑, 16,   Endon↑, 1,   FADD↑, 3,   Fas↑, 11,   FasL↓, 1,   FasL↑, 3,   Ferroptosis↑, 5,   GSDME↑, 1,   HEY1↓, 2,   hTERT/TERT↓, 5,   IAP1↓, 15,   IAP2/BIRC3↓, 7,   IAP2/BIRC3↑, 1,   iNOS↓, 39,   JNK↓, 8,   JNK↑, 11,   p‑JNK↓, 4,   JWA↑, 1,   MAPK↓, 19,   MAPK↑, 11,   MAPK↝, 3,   Mcl-1↓, 19,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MCT1↓, 2,   MDM2↓, 5,   MDM2↑, 1,   Myc↓, 5,   NICD↓, 1,   NOXA↑, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 17,   p38↓, 8,   p38↑, 15,   p‑p38↓, 2,   Paraptosis↑, 1,   Proteasome↓, 1,   PUMA↑, 5,   Pyro↑, 1,   RIP1↑, 1,   survivin↓, 44,   Telomerase↓, 11,   TNFR 1↑, 1,   TRAIL↑, 6,   TRAILR↑, 1,   TumCD↓, 1,   TumCD↑, 5,   TumCD∅, 1,   YAP/TEAD↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

cSrc↓, 4,   EF-1α↓, 1,   HCAR2↑, 1,   HER2/EBBR2↓, 10,   p70S6↓, 2,   PAK↓, 1,   RTK-RAS↓, 1,   Sp1/3/4↓, 5,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

BowelM↑, 1,   cJun↓, 7,   cJun↑, 1,   p‑cJun↓, 1,   EZH2↓, 3,   H3↑, 2,   ac‑H3↓, 1,   ac‑H3↑, 3,   H4↑, 2,   ac‑H4↓, 1,   ac‑H4↑, 3,   HATs↓, 9,   HATs↑, 2,   Matr↓, 1,   miR-145↑, 1,   miR-21↓, 2,   miR-21↑, 1,   other↓, 5,   other↑, 2,   other↝, 8,   other∅, 1,   PCAF↓, 1,   PhotoS↑, 2,   pRB↑, 1,   p‑pRB↓, 3,   sonoS↑, 1,   tumCV↓, 20,   tumCV∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 10,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 23,   GRP78/BiP↓, 2,   GRP78/BiP↑, 8,   HSF1↓, 1,   HSP27↓, 4,   HSP27↝, 1,   HSP70/HSPA5↓, 7,   HSP70/HSPA5↑, 2,   HSP70/HSPA5↝, 1,   HSP90↓, 6,   HSPs↓, 1,   HSPs↑, 1,   IRE1↑, 4,   PERK↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 3,   Beclin-1/ATG6↓, 2,   Beclin-1/ATG6↑, 6,   BNIP3↑, 1,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3B↓, 1,   LC3B-II↑, 2,   LC3I↑, 1,   LC3II↓, 1,   LC3II↑, 6,   p62↓, 2,   TumAuto↑, 18,   TumAuto↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CHK1↓, 2,   CYP1B1↑, 1,   DFF45↓, 2,   DFF45↑, 2,   DNAdam↓, 3,   DNAdam↑, 30,   DNArepair↑, 1,   DNMT1↓, 8,   DNMT3A↓, 1,   DNMTs↓, 5,   GADD45A↑, 1,   p16↑, 4,   P53?, 1,   P53↓, 3,   P53↑, 69,   p‑P53↓, 1,   p‑P53↑, 1,   PARP↓, 4,   PARP↑, 9,   cl‑PARP↓, 1,   cl‑PARP↑, 44,   PARP1↑, 1,   PCNA↓, 22,   SIRT6↓, 2,   SIRT6↑, 1,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 5,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 6,   CDK1↑, 4,   CDK1/2/5/9↓, 1,   CDK2↓, 32,   CDK2↑, 2,   CDK4↓, 38,   CDK4↑, 1,   p‑CDK4↓, 1,   Cyc↓, 1,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 17,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 67,   cycD1/CCND1↑, 1,   p‑cycD1/CCND1↓, 1,   CycD3↓, 2,   cycE/CCNE↓, 18,   cycE1↓, 1,   E2Fs↓, 4,   mitA↑, 1,   p19↑, 1,   P21?, 1,   P21↓, 4,   P21↑, 44,   RB1↑, 2,   p‑RB1↓, 6,   Securin↓, 2,   TFAP2A↓, 1,   TumCCA?, 2,   TumCCA↓, 5,   TumCCA↑, 96,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 6,   ALDH1A1↓, 2,   AR-V7?, 1,   CD133↓, 5,   CD24↓, 1,   CD34↓, 1,   CD44↓, 7,   CDK8↓, 2,   cFos↓, 7,   cMET↓, 3,   CREB2↓, 1,   CSCs↓, 23,   Diff↓, 2,   Diff↑, 1,   EMT↓, 44,   EMT↑, 1,   EP2↓, 2,   EP4/PTGER4↓, 1,   EpCAM↓, 1,   ERK↓, 38,   ERK↑, 3,   ERK↝, 1,   p‑ERK↓, 13,   p‑ERK↑, 1,   FGF↓, 4,   FGFR2↓, 1,   FOXM1↓, 1,   FOXO↑, 4,   FOXO1↓, 2,   FOXO1↑, 1,   FOXO3↓, 3,   FOXO3↑, 4,   Gli↓, 2,   Gli1↓, 5,   GSK‐3β↓, 8,   GSK‐3β↑, 3,   p‑GSK‐3β↓, 3,   HDAC↓, 23,   HDAC1↓, 4,   HDAC2↓, 2,   HDAC3↓, 2,   HDAC8↓, 2,   HH↓, 6,   Id1↓, 1,   IGF-1↓, 6,   IGF-1R↓, 2,   IGFBP3↑, 3,   Jun↓, 1,   Let-7↑, 3,   miR-194↑, 1,   miR-34a↑, 2,   mTOR↓, 44,   mTOR↑, 1,   mTOR↝, 2,   p‑mTOR↓, 5,   mTORC1↓, 5,   p‑mTORC1↓, 1,   mTORC2↓, 3,   n-MYC↓, 1,   Nanog↓, 7,   Nestin↓, 3,   NOTCH↓, 12,   NOTCH1↓, 12,   NOTCH1↑, 1,   NOTCH3↓, 2,   OCT4↓, 5,   p300↓, 2,   P70S6K↓, 2,   P90RSK↓, 1,   PI3K↓, 67,   PI3K↑, 1,   PI3K↝, 1,   p‑PI3K↓, 2,   PTEN↑, 23,   p‑PTEN↓, 1,   RAS↓, 12,   SCF↓, 1,   Shh↓, 7,   SHP1↓, 1,   SHP1↑, 1,   Smo↓, 3,   SOX2↓, 3,   Src↓, 2,   STAT↓, 3,   STAT1↓, 2,   STAT3↓, 55,   STAT3↑, 3,   p‑STAT3↓, 13,   p‑STAT3↑, 1,   STAT4↓, 2,   STAT5↓, 2,   STAT6↓, 1,   TAZ↓, 1,   TCF↓, 2,   TCF↑, 1,   TCF-4↓, 2,   TOP1↓, 4,   TOP2↓, 4,   TOP2↑, 2,   TumCG↓, 26,   TumCG↑, 1,   tyrosinase↓, 1,   Wnt↓, 35,   Wnt↑, 1,   Wnt↝, 1,   Wnt/(β-catenin)↓, 5,  

Migration(tgid=13) ⓘ

5LO↓, 15,   AEG1↓, 1,   AntiAg↓, 1,   AntiAg↑, 3,   AP-1↓, 14,   ARG1/2↑, 1,   ATPase↓, 1,   AXL↓, 1,   BACH1↓, 1,   CA↓, 6,   Ca+2↓, 1,   Ca+2↑, 17,   Ca+2↝, 2,   CAFs/TAFs↓, 1,   CC(CDKs/cyclins)↓, 1,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 5,   Cdc42↑, 1,   CDK4/6↓, 1,   CDKN1C/p57↑, 1,   CEA↓, 2,   CLDN1↓, 1,   CLDN2↓, 1,   Cofilin↓, 1,   COL1↓, 1,   COL3A1↓, 1,   CXCL12↓, 1,   DLC1↑, 1,   E-cadherin↓, 7,   E-cadherin↑, 27,   EFEMP↓, 1,   ER-α36↓, 2,   F-actin↓, 1,   FAK↓, 14,   p‑FAK↓, 2,   p‑FAK↑, 1,   fascin↓, 1,   Fibronectin↓, 4,   GLI2↓, 2,   HLA↑, 1,   ITGA5↓, 1,   Ki-67↓, 14,   LAMs↓, 1,   LEF1↓, 1,   MALAT1↓, 2,   MET↓, 1,   miR-19b↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   miR-203↑, 1,   MMP-10↓, 1,   MMP1↓, 5,   MMP13↓, 3,   MMP2↓, 70,   MMP2↑, 1,   MMP3↓, 4,   MMP7↓, 15,   MMP9↓, 100,   MMP9↑, 1,   MMP9:TIMP1↓, 1,   MMPs↓, 29,   MUC4↓, 4,   N-cadherin↓, 17,   PDGF↓, 6,   PKA↓, 2,   PKCδ↓, 7,   Rac1↓, 1,   RAGE↓, 1,   RECK↑, 1,   Rho↓, 3,   RIP3↑, 1,   ROCK1↓, 4,   ROCK1↑, 1,   Slug↓, 7,   Smad1↓, 1,   Smad1↑, 1,   SMAD3↓, 2,   Snail?, 1,   Snail↓, 21,   SOX4↓, 1,   SOX4↑, 1,   SPARC↓, 1,   TET1↑, 1,   TGF-β↓, 19,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 6,   TIMP2↑, 9,   TIMP3↑, 1,   Treg lymp↓, 2,   TSP-1↑, 3,   TumCA↓, 4,   TumCI↓, 35,   TumCMig↓, 33,   TumCP↓, 69,   TumMeta↓, 48,   TumMeta↑, 2,   Twist↓, 15,   uPA↓, 24,   uPAR↓, 2,   VCAM-1↓, 3,   Vim↓, 23,   Zeb1↓, 12,   ZEB2↓, 3,   α-SMA↓, 2,   α-tubulin↓, 1,   α-tubulin↑, 1,   β-catenin/ZEB1↓, 42,   β-catenin/ZEB1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 62,   ATF4↓, 2,   ATF4↑, 5,   ATF4↝, 1,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 1,   Endoglin↑, 1,   eNOS↓, 1,   HIF-1↓, 5,   Hif1a↓, 43,   LOX1↓, 3,   miR-210↓, 1,   NO↓, 11,   NO↑, 1,   NO↝, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   PHDs↓, 1,   TXA2↓, 1,   VEGF↓, 96,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 10,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 3,   CTR1↑, 1,   GLUT1↓, 7,   GLUT1↑, 1,   GLUT3↑, 1,   NHE1↓, 2,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1,   CD25+↓, 1,   CD4+↓, 2,   CD4+↑, 1,   COX1↓, 8,   COX1↑, 1,   COX2/PTGS2↓, 294,   CRP↓, 6,   CXCc↓, 1,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 17,   CXCR4↑, 1,   FOXP3↓, 3,   FoxP3+↓, 1,   GM-CSF↓, 2,   HCAR2↑, 1,   HMGB1↓, 2,   ICAM-1↓, 7,   IFN-γ↓, 6,   IKKα↓, 7,   p‑IKKα↓, 1,   IL1↓, 10,   IL1↑, 1,   IL10↓, 9,   IL10↑, 2,   IL12↓, 3,   IL17↓, 2,   IL18↓, 1,   IL1α↓, 1,   IL1β↓, 27,   IL1β↑, 1,   IL2↓, 4,   IL2↑, 4,   IL22↓, 1,   IL23↓, 1,   IL4↓, 3,   IL4↑, 2,   IL5↓, 1,   IL6↓, 64,   IL6↑, 1,   IL8↓, 14,   IL8↑, 2,   Imm↑, 7,   Inflam↓, 46,   IκB↓, 2,   IκB↑, 1,   p‑IκB↓, 2,   JAK↓, 5,   JAK1↓, 3,   JAK1↑, 1,   JAK2↓, 11,   p‑JAK2↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 6,   MDSCs↓, 1,   MIP2↓, 1,   mPGES-1↓, 2,   MyD88↓, 1,   NF-kB?, 1,   NF-kB↓, 171,   NF-kB↑, 5,   p‑NF-kB↓, 4,   p‑NF-kB↑, 1,   NK cell↑, 6,   NK cell⇅, 1,   p50↓, 2,   p65↓, 9,   p‑p65↓, 1,   ac‑p65↓, 1,   ac‑p65↑, 1,   PD-1↓, 2,   PD-L1↓, 7,   PGD2↓, 1,   PGE1↓, 2,   PGE2↓, 48,   PGE2↑, 1,   PSA↓, 6,   PSA∅, 1,   Resistin↓, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR2↓, 1,   TLR4↓, 4,   TNF-α↓, 58,   TNF-α↑, 5,   TRAF1↓, 1,  

Cellular Microenvironment(tgid=17) ⓘ

pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,   NLRP3↓, 3,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 10,   CDK6↓, 17,   CDK6↑, 1,   CYP19?, 1,   ER(estro)↓, 1,   GR↑, 1,   Irisin↓, 1,   Leptin↓, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 27,   BioAv↑, 24,   BioAv↝, 15,   BioEnh↑, 2,   ChemoSen↓, 2,   ChemoSen↑, 86,   ChemoSen⇅, 1,   Dose?, 4,   Dose↓, 1,   Dose↑, 10,   Dose⇅, 1,   Dose↝, 29,   Dose∅, 12,   eff↓, 13,   eff↑, 110,   eff↝, 9,   eff∅, 1,   Half-Life↓, 10,   Half-Life↑, 2,   Half-Life↝, 10,   MDR1↓, 6,   MRP1/ABCC1↓, 3,   P450↓, 3,   P450↝, 1,   RadioS↑, 41,   selectivity?, 1,   selectivity↑, 34,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 7,   ALAT↝, 1,   ALP↓, 2,   ALP↝, 1,   AR↓, 10,   ascitic↓, 2,   AST↓, 7,   AST↝, 1,   BMD↑, 1,   BRCA1↑, 1,   BRCA1↝, 1,   p‑BRCA1↑, 1,   CA125↓, 1,   CEA↓, 2,   CRP↓, 6,   CYFRA21-1↓, 1,   E6↓, 2,   E7↓, 2,   EGFR↓, 36,   EGFR↑, 1,   p‑EGFR↓, 1,   EZH2↓, 3,   Ferritin↓, 2,   FOXM1↓, 1,   GutMicro↑, 4,   GutMicro↝, 1,   HER2/EBBR2↓, 10,   hTERT/TERT↓, 5,   IL6↓, 64,   IL6↑, 1,   Ki-67↓, 14,   LDH↑, 1,   LDH↝, 1,   i-LDH↓, 1,   Myc↓, 5,   NOS2↓, 3,   PD-L1↓, 7,   PSA↓, 6,   PSA∅, 1,   RAGE↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 2,   AntiCan↑, 27,   antiNeop↑, 2,   AntiTum↑, 8,   cachexia↓, 1,   cardioP↑, 8,   CardioT↑, 1,   chemoP↑, 20,   chemoPv↑, 16,   chemoPv⇅, 1,   ChemoSideEff↓, 5,   hepatoP↑, 8,   neuroP↑, 3,   NP/CIPN↓, 1,   Obesity↓, 1,   OS↑, 10,   Pain↓, 1,   QoL↑, 5,   radioP↑, 4,   RenoP↑, 5,   Risk↓, 10,   Symptoms∅, 1,   toxicity↓, 7,   toxicity↑, 1,   toxicity↝, 7,   toxicity∅, 1,   TumVol↓, 13,   TumW↓, 4,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 2,  
Total Targets: 853

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

12-HETE↓, 1,   15-LOX/ALOX15↓, 1,   5-HETE↓, 1,   AntiBio↑, 6,   Eic↓, 1,   Mucositis↓, 1,   Stress↓, 1,   Stroke↓, 2,   TRPA1↑, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 41,   Catalase↓, 1,   Catalase↑, 25,   GPx↓, 1,   GPx↑, 16,   GPx1↑, 1,   GSH↑, 21,   GSR↑, 2,   GSTs↑, 9,   H2O2↓, 1,   HDL↑, 1,   HO-1↓, 2,   HO-1↑, 8,   Keap1↓, 1,   Keap1↑, 1,   Keap1↝, 1,   lipid-P↓, 18,   MDA↓, 8,   MDA↑, 1,   MPO↑, 1,   NRF2↓, 1,   NRF2↑, 16,   Prx↑, 1,   RNS↓, 2,   ROS↓, 52,   ROS↝, 1,   ROS∅, 1,   mt-ROS?, 1,   SOD↓, 1,   SOD↑, 25,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 3,   TBARS↓, 1,   uricA↓, 1,   VitC↑, 1,   VitE↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↓, 1,   IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1,   ATP↑, 2,   Insulin↑, 1,   MMP↓, 1,   MMP↑, 2,   PGC-1α↝, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↑, 1,   Acetyl-CoA↓, 1,   ALAT?, 1,   ALAT↓, 4,   AMPK↑, 2,   p‑cMyc↑, 1,   cPLA2↓, 1,   p‑CREB↑, 1,   cytoP450↓, 1,   FAO↑, 1,   FASN↓, 1,   glucose↓, 2,   LDH↓, 2,   LDL↓, 2,   NAD↑, 1,   NADPH↑, 1,   PPARγ↓, 1,   SIRT1↑, 4,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,   Apoptosis↓, 1,   BAX↓, 1,   Bcl-2↑, 1,   Casp3?, 1,   Casp3↓, 4,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 3,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   p38↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

HCAR2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   p16↓, 1,   P53↓, 2,   PARP1↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 2,   GSK‐3β↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   PI3K↓, 1,   PI3K↑, 1,   PTEN↑, 1,   RAS↓, 1,   VGSC↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 3,   AntiAg↑, 7,   Ca+2↝, 1,   CLDN1↑, 1,   MMP13↓, 1,   TIMP1↓, 1,   VCAM-1↓, 1,   ZO-1↑, 1,   α-SMA↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   angioG↑, 1,   NO↓, 4,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↓, 1,   BBB↑, 2,   GastroP↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 5,   COX2/PTGS2↑, 1,   CRP↓, 1,   HCAR2↑, 1,   IFN-γ↓, 1,   IL1↓, 2,   IL10↑, 2,   IL12↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 8,   IL2↓, 1,   IL4↓, 1,   IL6↓, 12,   IL6↑, 1,   IL8↓, 2,   Imm↑, 4,   Inflam↓, 53,   pol-M2 MC↑, 1,   NF-kB↓, 12,   PGE2↓, 2,   TLR2↓, 1,   TNF-α↓, 16,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1,   AChE↓, 3,   ADAM10↑, 1,   BChE↓, 1,   BDNF↑, 1,   EndoR↑, 1,   MAOA↓, 2,   monoA↑, 1,   NGF↑, 1,   tau↓, 2,   p‑tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 7,   BACE/β-secretase↓, 3,   PP2A↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,   testos↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20,   BioAv↑, 20,   BioAv⇅, 1,   BioAv↝, 9,   Dose↝, 2,   eff↓, 1,   eff↑, 9,   Half-Life↝, 2,   P450↓, 1,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT?, 1,   ALAT↓, 4,   ALP↓, 1,   AST↓, 5,   BG↓, 1,   BP↓, 1,   creat↓, 1,   CRP↓, 1,   GutMicro↑, 3,   GutMicro↝, 1,   IL6↓, 12,   IL6↑, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 3,   antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 7,   AntiDiabetic↑, 3,   antiPs↑, 2,   AntiTum↓, 1,   AntiTum↑, 1,   cardioP↑, 14,   chemoP↑, 5,   chemoPv↑, 7,   cognitive↓, 2,   cognitive↑, 4,   hepatoP↑, 12,   memory↑, 5,   motorD↓, 1,   motorD↑, 1,   neuroP↑, 28,   Obesity↓, 5,   OS↑, 1,   Pain↓, 5,   radioP↑, 6,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 19,   toxicity↝, 4,   toxicity∅, 2,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1,   AntiFungal↑, 2,   AntiViral↑, 3,   Bacteria↓, 4,   CD8+↑, 1,   Diar↓, 1,  
Total Targets: 223

Scientific Paper Hit Count for: COX2/PTGS2, cycloocygenase-2 (Cox-2) mRNA and Cox-2 protein
16 Curcumin
14 Resveratrol
14 Thymoquinone
13 Fisetin
11 Celecoxib
11 Quercetin
7 Apigenin (mainly Parsley)
7 Berberine
7 Boswellia (frankincense)
7 Lycopene
6 Artemisinin
6 Chrysin
6 Eugenol
6 Honokiol
6 Silymarin (Milk Thistle) silibinin
5 Propolis -bee glue
5 Diclofenac
5 Ellagic acid
5 EGCG (Epigallocatechin Gallate)
5 Garcinol
5 Sulforaphane (mainly Broccoli)
4 Cisplatin
4 Kaempferol
4 Licorice
4 Rosmarinic acid
3 Ashwagandha(Withaferin A)
3 Beta-Caryophyllene
3 Bromelain
3 Butyrate
3 Caffeic Acid Phenethyl Ester (CAPE)
3 Carvacrol
3 Chlorogenic acid
3 Radiotherapy/Radiation
3 Ginger/6-Shogaol/Gingerol
3 Gambogic Acid
3 Grapeseed extract
3 Isoliquiritigenin
3 lambertianic acid
3 Phenethyl isothiocyanate
3 Piperine
3 Shikonin
2 Andrographis
2 Caffeic acid
2 Chocolate
2 CUSP9
2 D-limonene
2 Echinacea
2 Formononetin
2 Hydroxycinnamic-acid
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Naringin
2 Oleuropein
2 Urolithin
2 Vitamin C (Ascorbic Acid)
1 1,8-Cineole
1 Auranofin
1 Silver-NanoParticles
1 Allicin (mainly Garlic)
1 alpha Linolenic acid
1 Isovitexin
1 Baicalein
1 Baicalin
1 Betulinic acid
1 Brucea javanica
1 brusatol
1 Bruteridin(bergamot juice)
1 α-Bisabolol / Chamomile oil
1 Carnosic acid
1 Thymol-Thymus vulgaris
1 Cynanbungeigenin C (CBC) and D (CBD)
1 cannabidiolic acid
1 Cinnamon
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Oxygen, Hyperbaric
1 Docetaxel
1 Dandelion Root
1 Evodiamine
1 Exercise
1 Ferulic acid
1 Bortezomib
1 Paclitaxel/Taxol
1 Genistein (soy isoflavone)
1 Geraniol
1 Ginkgetin
1 Proanthocyanidins
1 Hydrogen Gas
1 Inositol
1 iodine
1 isoorientin
1 Lasiodin
1 Licochalcone A
1 Lemongrass Extract/Citral
1 Luteolin
1 5-fluorouracil
1 Chemotherapy
1 Magnolol
1 Melatonin
1 Metformin
1 Magnetic Fields
1 Myricetin
1 Nimbolide
1 Oleocanthal
1 Alpha-Lipoic-Acid
1 Piperlongumine
1 Polyphenols
1 Pterostilbene
1 Perilla
1 Germacranolide sesquiterpene lactone
1 Rutin
1 buckwheat sprouts
1 Salvia officinalis
1 Sanguinarine
1 acetaminophen
1 Aflavin-3,3′-digallate
1 Turmerones
1 Ursolic acid
1 Aspirin
1 Wogonin
1 xanthohumol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:66  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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