TRIF Cancer Research Results

TRIF, Toll/IL-1 receptor domain-containing adaptor-inducing interferon-β: Click to Expand ⟱
Source:
Type:
TRIF (Toll/IL-1 receptor domain-containing adaptor-inducing interferon-β) is a protein that plays a crucial role in the innate immune response, particularly in the activation of interferons and the production of pro-inflammatory cytokines.

Research has shown that TRIF is involved in the regulation of cancer development and progression. Here are some ways in which TRIF is linked to cancer:

• Tumor suppression: TRIF has been shown to have tumor-suppressive effects in certain types of cancer, such as breast, lung, and colon cancer. It does this by activating interferons and other anti-tumor immune responses.
Downregulated in: Breast, Lung, CRC
Upregulated in: Melanoma, GBM
Scientific Papers found: Click to Expand⟱
423- CUR,    Inhibition of TLR4/TRIF/IRF3 Signaling Pathway by Curcumin in Breast Cancer Cells
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
TLR4↓, IRF3↓, IFN-γ↓, TRIF↓,
3556- TQ,    Thymoquinone alleviates the experimentally induced Alzheimer’s disease inflammation by modulation of TLRs signaling
- in-vivo, AD, NA
*Inflam↓, *memory↑, *cognitive↑, *Aβ↓, *TNF-α↓, *IL1β↓, *TLR2↓, *NF-kB↓, *IRF3↓, TLR4↓, MyD88↓, TRIF↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

IFN-γ↓, 1,   MyD88↓, 1,   TLR4↓, 2,   TRIF↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

IRF3↓, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   TLR2↓, 1,   TNF-α↓, 1,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   memory↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

IRF3↓, 1,  
Total Targets: 9

Scientific Paper Hit Count for: TRIF, Toll/IL-1 receptor domain-containing adaptor-inducing interferon-β
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:661  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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