Risk Cancer Research Results

Risk, Risk: Click to Expand ⟱
Source:
Type:
Risk: by definition reduces risk of disease or cancer.
Down Target direction of risk indicates lower cancer risk.
ChemoPreventive also mean lower cancer risk. But for Chemopreventive an up arrow indicates more preventive. 
Cancer Risk Impact Score (CRIS)
CRIS scale:
–5 = very strong risk reduction
–4 = strong risk reduction
–3 = moderate risk reduction
–2 = modest risk reduction
–1 = weak / context-dependent
0 = neutral




CRIS Exposure / Compound Evidence Cancers Notes




-5 Exercise (overall)
VStrong Hum BC, CRC, Endo, PCa, Liv






-5 Aerobic + resistance VStrong Hum Broad inc + mort






-4 Aerobic exercise (mod–vig) VStrong Hum BC, CRC, Endo






-4 Resistance training (alone) Strong Hum BC, CRC






-3 High-intensity interval training Mod–Strong Hum BC, CRC






-2 NEAT / low-intensity activity Moderate Hum CRC






-5 Cruciferous vegetable pattern Strong Hum Lung, CRC, BC, PCa






-5 Sunlight exposure (physiologic) Strong Hum CRC, BC, PCa






-4 Fasting (metabolic pattern)
Strong Mech + Hum BC, CRC, PCa 






-4 Curcumin
Hum + Pre GI, BC, PCa






-4 Sulforaphane
Hum + Pre Lung, CRC, BC






-4 PEITC
Hum + Pre Lung, CRC, PCa






-4 EGCG (tea matrix)
Strong Hum GI, PCa, BC






-4 Lycopene
Strong Hum PCa






-4 Apigenin
Pre + Diet Hum BC, PCa, CRC 






-4 Luteolin
Pre + Diet Hum Lung, CRC, BC 






-4 Kaempferol
Diet Hum Ov, Panc, Lung






-4 Fisetin
Pre + Early Hum CRC, PCa, Mel






-4 Ellagic acid → Urolithin A
Hum (microbiome) CRC, PCa, BC






-3 Omega-3 (EPA/DHA)
Strong Hum CRC, BC






-3 Vitamin D3 (supp)
Obs + RCT CRC, BC






-3 Garlic (allicin)
Mod Hum GI






-3 Mushroom beta-glucans
Hum adjunct GI, BC






-3 Melatonin
Hum + Mech BC, PCa






-3 Coffee (whole)
Strong Hum Liv, Endo






-2 Quercetin
Limited Hum Lung, CRC






-2 Resveratrol
Limited Hum CRC, BC






-2 I3C / DIM
Mod Hum BC, Cerv






-2 Thymoquinone
Early Hum BC, CRC






-2 Beta-carotene (food)
Hum Lung






-1 Vitamin K2 (MK-4/7)
Limited Hum Liv, PCa






-1 Boron
Obs PCa, Lung






0 Vitamin C (oral)
Strong Hum —






0 Genistein (soy)
Strong Hum BC, PCa






0 Selenium (diet)
Mixed Hum PCa






0 Capsaicin
Mixed Gastric






+2 Vitamin E (alpha only)
Strong RCT PCa






+2 Green tea extract (high-dose)
Case reports Liv






+4 Beta-carotene (supplement)
Strong RCT Lung (smokers)






+5 Alcohol (ethanol)
Strong Hum BC, Liv, Eso







Evidence
Hum        human data
VStrong    very strong
Strong     strong
Mod        moderate
Obs        observational
Pre        preclinical
RCT        randomized controlled trial
Mech       mechanistic
Adjunct    adjunct clinical use


Scientific Papers found: Click to Expand⟱
546- AL,    Effects of garlic intake on cancer: a systematic review of randomized clinical trials and cohort studies
- Review, NA, NA
Risk↓, TumVol↓,
545- AL,    Association and mechanism of garlic consumption with gastrointestinal cancer risk: A systematic review and meta‑analysis
Risk↓,
544- AL,    Garlic constituents for cancer prevention and therapy: From phytochemistry to novel formulations
Risk↓, ChemoSideEff↓, TumCG↓, NF-kB⇅,
547- AL,    Garlic and Cancer: A Critical Review of the Epidemiologic Literature
- Review, NA, NA
Risk↓,
548- AL,    Aged Garlic and Cancer: A Systematic Review
- Review, NA, NA
Risk↓,
4765- antiOx,  Chemo,    Antioxidants as precision weapons in war against cancer chemotherapy induced toxicity – Exploring the armoury of obscurity
- Review, Var, NA
chemoP↑, ChemoSen↑, OS↑, Dose↑, Risk↓, eff↓,
5403- ASA,    Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer
- Trial, CRC, NA
Risk↓, other↝,
5414- ASA,    Aspirin and cancer treatment: systematic reviews and meta-analyses of evidence: for and against
- Review, Var, NA
Risk↓, *toxicity↓, other↑, *COX1↓, TumCP↓, DNArepair↑, ChemoSen↑, other↓,
5412- ASA,    Clinical Pharmacology of Aspirin
- Review, NA, NA
*COX1↓, *COX2/PTGS2↓, *cardioP↑, *BioAv↑, *BioAv↝, *Half-Life↓, Risk↓, *other↑, *AntiAg↑,
5411- ASA,    Mechanistic Insights into a Classic Wonder Drug—Aspirin
- Review, Var, NA
*COX2/PTGS2↓, *COX1↓, *Inflam↓, *cardioP↑, Risk↓,
5410- ASA,    Low-Dose Aspirin and the Prevention of Colorectal Cancer in Inflammatory Bowel Disease: A Nationwide Cohort Study
- Study, CRC, NA
Risk↓, Dose↝, Risk↓,
5400- ASA,    Beyond COX-1: the effects of aspirin on platelet biology and potential mechanisms of chemoprevention
- Review, Nor, NA
Risk↓, *Inflam↓, *COX1↓, *AntiAg↑, *Half-Life↓, *BioAv↑,
5409- ASA,    Role of aspirin in cancer prevention
- Review, Var, NA
Imm↑, *Inflam↓, *AntiAg↑, *GutMicro↑, eff↑, TumMeta↓, angioG↓, Risk↓, Risk↓,
5404- ASA,    Low-Dose Aspirin and Prevention of Colorectal Cancer: Evidence From a Nationwide Registry-Based Cohort in Norway
- Study, CRC, NA
Risk↓, other↝, Dose↝, Risk↓, other↓, other↝, KRAS↓, other↓, other↓,
5405- ASA,    Exploring Aspirin’s Potential in Cancer Prevention: A Comprehensive Review of the Current Evidence
- Review, Var, NA
Risk↓, COX1↓, PGE2↓, Inflam↓, *AntiAg↓, PI3K↓, Akt↓, Risk↓,
5407- ASA,    Low-dose aspirin reduces the risk of colorectal cancer recurrence in patients with resected PI3K-altered localised disease, according to the ALASCCA trial.
- Trial, CRC, NA
Dose↝, Risk↓,
5427- ASTX,    Astaxanthin and Cancer Chemoprevention
- Review, Var, NA
chemoP↑, AntiCan↑, chemoPv↑, Risk↓, lipid-P↓, Pain↓, BioAv↑, Dose↝,
5447- ATV,    The Mevalonate Pathway, a Metabolic Target in Cancer Therapy
- Review, Var, NA
Risk↓, Dose↑, ChemoSen↑, chemoP↑, HMG-CoA↓, EMT↓, CSCs↓, HH↝, YAP/TEAD↝,
5449- ATV,    Pleiotropic effects of statins: A focus on cancer
- NA, Var, NA
lipid-P↓, TumCG↓, Apoptosis↑, ChemoSen↑, RAS↓, HMG-CoA↓, HMGCR↓, LDL↓, toxicity↓, Risk↓, P21↑, HDAC↓, Bcl-2↓, BAX↑, BIM↑, Casp↑, cl‑PARP↑, MMP↓, ROS↑, angioG↓, TumMeta↓, PTEN↑, eff↑, OS↑, Remission↑,
5562- betaCar,    Association of Dietary α-Carotene and β-Carotene Intake with Low Cognitive Performance in Older Adults: A Cross-Sectional Study from the National Health and Nutrition Examination Survey
- Study, AD, NA
*cognitive↑, Risk↓,
5628- Bif,  immuno,    Bifidobacterium modulation of tumor immunotherapy and its mechanism
- Review, Var, NA
Imm↑, Risk↓, GutMicro↑, AntiTum↑, OS↑, selectivity↑, eff↑,
3518- Bor,    Boron Report
- Review, Var, NA - Review, AD, NA
Risk↓, serineP↓, PSA↓, TumVol↓, IGF-1↓, *Mag↑, *Calcium↑, *VitD↑, *COX2/PTGS2↓, *5LO↓, *PGE2↓, *NF-kB↓, *cognitive↑,
3512- Bor,    Activation of the EIF2α/ATF4 and ATF6 Pathways in DU-145 Cells by Boric Acid at the Concentration Reported in Men at the US Mean Boron Intake
- in-vitro, Pca, DU145
TumCP↓, eIF2α↑, ATF4↑, ATF6↑, GADD34↑, CHOP/DDIT3↓, GRP78/BiP↑, GRP94↑, Risk↓, *BMD↑, Ca+2↓, *Half-Life↝, IRE1∅, chemoP↑,
696- Bor,    Nothing Boring About Boron
- Review, Var, NA
*hs-CRP↓, *TNF-α↓, *SOD↑, *Catalase↑, *GPx↑, *cognitive↑, *memory↑, *Risk↓, *SAM-e↑, *NAD↝, *ATP↝, *Ca+2↝, HDAC↓, TumVol↓, IGF-1↓, PSA↓, Cyc↓, TumCMig↓, *serineP↓, HIF-1↓, *ChemoSideEff↓, *VitD↑, *Mag↑, *eff↑, Risk↓, *Inflam↓, *neuroP↑, *Calcium↑, *BMD↑, *chemoP↑, AntiCan↑, *Dose↑, *Dose↝, *BMPs↑, *testos↑, angioG↓, Apoptosis↑, *selectivity↑, *chemoPv↑,
701- Bor,    Dietary boron intake and prostate cancer risk
- Analysis, NA, NA
Risk↓,
702- Bor,  GEN,  SeMet,  Rad,    Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)
- Analysis, NA, NA
Risk↓, TumCMig↓, Bcl-2↓,
754- Bor,  HRT,    Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women
- Analysis, NA, NA
Risk↓,
747- Bor,    Growing Evidence for Human Health Benefits of Boron
- Review, NA, NA
TumCG↓, Risk↓,
737- Bor,    Boric Acid Activation of eIF2α and Nrf2 Is PERK Dependent: a Mechanism that Explains How Boron Prevents DNA Damage and Enhances Antioxidant Statu
- in-vitro, Pca, DU145
Risk↓, p‑eIF2α↑, ATF4↑, GADD34↑,
712- Bor,    Boron concentrations in selected foods from borate-producing regions in Turkey
- Analysis, NA, NA
Risk↓,
713- Bor,    Effects of dietary boron on cervical cytopathology and on micronucleus frequency in exfoliated buccal cells
- Analysis, NA, NA
Risk↓,
714- Bor,    Dietary Boron and Hormone Replacement Therapy as Risk Factors for Lung Cancer in Women
- Analysis, NA, NA
Risk↓,
4620- Bor,  BTZ,    Boron Compounds in the Breast Cancer Cells Chemoprevention and Chemotherapy
- Review, Var, NA - Review, Arthritis, NA - Review, Pca, NA
Risk↓, *memory↑, *Dose↑, Risk↓, other↝, *testos↑, other↝, Risk↓, TumCP↓, Apoptosis↑, eff↑,
4619- Bor,    Using Boron Supplementation in Cancer Prevention and Treatment: A Review Article
- Review, Var, NA
Dose↝, Risk↓, *antiOx↓, *Inflam↓, ChemoSen↑, AntiCan↑, *PCNA↓, *ROS↓, other↝,
5707- Brut,    Targeting Redox Homeostasis and Cell Survival Signaling with a Flavonoid-Rich Extract of Bergamot Juice in In Vitro and In Vivo Colorectal Cancer Models
- in-vitro, CRC, HCT116
Risk↓, TumCG↓, Apoptosis↑, TumCCA↑, ROS↑, MMP↓, DNAdam↑, TumMeta↓, TumCP↓,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5731- Buty,    The Warburg Effect Dictates the Mechanism of Butyrate Mediated Histone Acetylation and Cell Proliferation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
HDAC↓, Warburg↓, TumCP⇅, HATs↑, BioAv↓, other↝, Risk↓,
5778- Calc,  VitD3,    Colorectal cancer risk and dietary intake of calcium, vitamin D, and dairy products: a meta-analysis of 26,335 cases from 60 observational studies
- Study, CRC, NA
Risk↓, eff↝, Risk↓,
5777- Calc,    Calcium intake and colorectal cancer risk: dose-response meta-analysis of prospective observational studies
- Study, CRC, NA
Risk↓,
5775- Calc,    Calcium Intake and Risk of Colorectal Cancer in the NIH-AARP Diet and Health Study
- Study, CRC, NA
Risk↓, Dose↓, eff↝,
5776- Calc,    Calcium
- Review, Var, NA
Risk∅, Risk↓, Risk↓, Risk↓,
5932- CAR,    Carvacrol attenuates mucosal barrier impairment and tumorigenesis by regulating gut microbiome
- in-vivo, IBD, NA - in-vivo, Park, NA
*GutMicro↑, Risk↓, *Inflam↓, *antiOx↓, *ZO-1↑, *iNOS↓, *IL6↓, *NO↓, *PGE2↓, *memory↑, *TLR4↓, *NF-kB↓, *IBI↑, *CLDN3↑, *CLDN1↑, *MUC1↑, *OCLN↑, *iNOS↑, *COX2/PTGS2↓, *IFN-γ↓, IL1β↓, ADAM10?,
5966- CEL,    Determine whether administering celecoxib during radiotherapy can reduce the risk of recurrence of triple-negative breast cancer. Pilot study
- Trial, BC, NA
Risk↓, eff↑,
5955- CEL,    COX-2 independent induction of cell cycle arrest and apoptosis in colon cancer cells by the selective COX-2 inhibitor celecoxib
- in-vitro, Colon, NA
Risk↓, COX2/PTGS2↓, TumCCA↓,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
6096- Chol,    Plasma methionine, choline, betaine, and dimethylglycine in relation to colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)
- Study, CRC, NA
Risk↓, other↑,
7432- Chy,    A Cytogenetic Study on the Efficacy of Chyawanprash Awaleha as an Antioxidant in Oral Premalignant Cancer
- Trial, Oral, NA
Dose↝, Risk↓,
4766- CoQ10,    Activities of Vitamin Q10in Animal Models and a Serious Deficiency in Patients with Cancer
- Review, Var, NA
Risk↓,
4768- CoQ10,    Role of coenzymes in cancer metabolism
- Review, Var, NA
Risk↓, *ROS↓, AntiCan↑, TumMeta↓, ROS↑, TumCG↓, Apoptosis↑, TumMeta↓, Wnt↓, β-catenin/ZEB1↓, TumCG↓, selectivity↑, RadioS↑, ChemoSen↑, H2O2↓, MMP2↓, cardioP↑, ChemoSen∅, Dose↝,
4769- CoQ10,    CoQ10 Is Key for Cellular Energy and Cancer Support
- Review, Var, NA
Risk↓, TumCG↓, angioG↓, TumCD↑, *toxicity↓, *BioAv↑, MMPs↓, Inflam↓, chemoP↑, cardioP↑, *ROS↓, *toxicity↝, Dose?,

Showing Research Papers: 1 to 50 of 185
Page 1 of 4 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 185

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

6IL↑, 1,   8-oxo-dG↑, 1,   ADCY4↑, 1,   APG↓, 1,   Buty↑, 1,   Ingr↑, 1,   JAG1↑, 1,   miR-590-3p↑, 1,   MYCN↓, 1,   NEU1↑, 1,   SCFAs↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 6,   ARE↑, 1,   Catalase↑, 2,   CYP1A1↑, 1,   CYP2E1↑, 1,   Ferroptosis↑, 2,   GPx↑, 1,   GSH↓, 3,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   HO-1↓, 1,   HO-1↑, 2,   lipid-P↓, 2,   NRF2↓, 4,   NRF2↑, 2,   NRF2↝, 1,   OXPHOS↑, 1,   OXPHOS↝, 1,   ROS↓, 7,   ROS↑, 30,   selenoP↑, 1,   SOD↑, 3,   SOD2↓, 1,   Trx↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

selm↑, 1,   selm↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 3,   EGF↓, 1,   Insulin↓, 1,   mitResp↑, 1,   MMP↓, 14,   MPT↑, 1,   mtDam↑, 1,   OCR↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 5,   cAMP↓, 1,   cMyc↓, 1,   CYP3A4↓, 1,   FASN↓, 1,   glucose↓, 2,   GLUT2↓, 1,   Glycolysis↓, 4,   HMG-CoA↓, 3,   lactateProd↑, 1,   LDL↓, 1,   PKM2↓, 1,   PPARα↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,   Warburg↓, 3,  

Cell Death(tgid=5) ⓘ

Akt↓, 12,   p‑Akt↓, 4,   Apoptosis↑, 31,   BAX↑, 9,   Bcl-2↓, 8,   BIM↑, 1,   BMP2↓, 1,   Casp↑, 5,   Casp3↑, 9,   cl‑Casp3↑, 3,   pro‑Casp3↑, 1,   Casp7↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 2,   Casp9↑, 4,   cl‑Casp9↑, 1,   Cyt‑c↑, 10,   DR4↑, 3,   DR5↑, 2,   FADD↑, 1,   Fas↑, 4,   FasL↑, 2,   Ferroptosis↑, 2,   GADD34↑, 2,   hTERT/TERT↓, 1,   iNOS↓, 3,   JNK↑, 2,   MAPK↓, 1,   MAPK↑, 1,   MCT1↓, 1,   MDM2↓, 1,   Myc↓, 1,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 2,   p38↑, 1,   PUMA↑, 1,   survivin↓, 3,   Telomerase↓, 1,   TRAIL↑, 1,   TumCD↑, 2,   YAP/TEAD↓, 1,   YAP/TEAD↝, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,   Sp1/3/4↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 1,   EZH2↓, 1,   H3↓, 1,   HATs↑, 1,   miR-21↓, 1,   other↓, 5,   other↑, 7,   other↝, 11,   other∅, 1,   pRB↓, 1,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   GRP94↑, 1,   IRE1↑, 1,   IRE1∅, 1,   UPR↑, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↓, 1,   TumAuto↑, 6,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 8,   DNArepair↑, 1,   DNMT1↓, 1,   DNMTs↓, 2,   P53↑, 9,   PARP↓, 1,   PARP↑, 2,   cl‑PARP↑, 5,   PCNA↓, 3,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 2,   CDK2↑, 1,   CDK4↓, 2,   Cyc↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 2,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 5,   cycE/CCNE↓, 3,   cycE/CCNE↑, 1,   P21↓, 2,   P21↑, 5,   p‑RB1↓, 1,   cl‑RB1↓, 1,   TumCCA↓, 1,   TumCCA↑, 22,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMI1↓, 1,   cMET↓, 1,   CSCs↓, 3,   EMT↓, 4,   EMT↝, 1,   EP300↓, 1,   ERK↓, 2,   ERK↑, 2,   p‑ERK↓, 2,   FOXM1↓, 1,   GH↓, 1,   GSK‐3β↑, 1,   HDAC↓, 7,   HH↝, 1,   HMGCR↓, 1,   IGF-1↓, 6,   IGFBP1↑, 1,   miR-194↑, 1,   mTOR↓, 6,   mTOR↑, 1,   mTORC1↓, 1,   NOTCH↓, 1,   NOTCH3↑, 1,   PI3K↓, 6,   PI3K↑, 1,   PTEN↑, 3,   RAS↓, 1,   STAT↓, 1,   STAT3↓, 3,   SUZ12↓, 1,   TumCG↓, 24,   Wnt↓, 6,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

Akt2↓, 1,   AntiAg↑, 1,   AP-1↓, 2,   Ca+2↓, 1,   Ca+2↑, 1,   CC(CDKs/cyclins)↓, 1,   CLDN2↑, 1,   E-cadherin↑, 1,   FAK↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   Ki-67↓, 2,   KRAS↓, 1,   MMP2↓, 5,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 5,   pax↓, 1,   PKCδ↓, 1,   Rho↓, 1,   serineP↓, 1,   Snail↓, 1,   TET1↑, 1,   TumCA↓, 1,   TumCI↓, 9,   TumCMig↓, 11,   TumCP↓, 32,   TumCP⇅, 1,   TumMeta↓, 17,   UroPA↓, 1,   VEGFR1↓, 1,   Vim↓, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 6,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 14,   ATF4↑, 2,   ECM/TCF↓, 1,   EGFR↓, 2,   HIF-1↓, 3,   Hif1a↓, 5,   VEGF↓, 7,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 2,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 10,   CRP↓, 1,   IL10↓, 1,   IL1β↓, 4,   IL6↓, 2,   Imm↑, 7,   Inflam↓, 11,   JAK1↓, 2,   JAK1↑, 1,   Neut↑, 1,   NF-kB↓, 13,   NF-kB⇅, 1,   p‑NF-kB↓, 1,   NK cell↑, 3,   PGE2↓, 3,   PSA↓, 5,   SOCS-3↓, 1,   TNF-α↓, 2,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

ADAM10?, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

CDK6↓, 1,   DHT↓, 1,   SXR↑, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 2,   BioAv↑, 6,   BioAv↝, 1,   chemoR↓, 1,   ChemoSen↑, 32,   ChemoSen∅, 1,   CYP1A2↑, 1,   CYP2A3/CYP2A6↓, 1,   Dose?, 2,   Dose↓, 4,   Dose↑, 6,   Dose⇅, 1,   Dose↝, 33,   Dose∅, 3,   eff↓, 4,   eff↑, 36,   eff↝, 10,   eff∅, 3,   Half-Life↝, 1,   MRP1/ABCC1↓, 1,   P450↓, 1,   P450↝, 1,   RadioS↑, 9,   selectivity↑, 14,  

Clinical Biomarkers(tgid=22) ⓘ

BloodF↓, 1,   BMD↑, 2,   CRP↓, 1,   EGFR↓, 2,   EZH2↓, 1,   FOXM1↓, 1,   GutMicro↑, 4,   Hcy/homoC↓, 1,   HER2/EBBR2↓, 1,   hTERT/TERT↓, 1,   IL6↓, 2,   Ki-67↓, 2,   KRAS↓, 1,   Myc↓, 1,   PSA↓, 5,   SUZ12↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 24,   AntiCan∅, 1,   antiNeop↑, 1,   AntiTum↑, 6,   cardioP↑, 3,   chemoP↑, 14,   chemoPv↑, 7,   ChemoSideEff↓, 3,   cognitive↑, 1,   memory↑, 1,   neuroP↑, 1,   OS↓, 1,   OS↑, 12,   Pain↓, 1,   QoL↑, 4,   radioP↑, 5,   Remission↑, 1,   RenoP↑, 1,   Risk↓, 204,   Risk↑, 2,   Risk∅, 2,   toxicity↓, 5,   toxicity↝, 3,   toxicity∅, 2,   TumVol↓, 4,   TumW↓, 2,  

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,  
Total Targets: 337

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   AntiBio↑, 2,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 4,   antiOx↑, 13,   Catalase↑, 2,   GPx↓, 1,   GPx↑, 5,   GPx1↑, 1,   GSH↑, 1,   H2O2↓, 1,   lipid-P↓, 3,   MDA↓, 2,   NQO1↑, 1,   NRF2↓, 2,   NRF2↑, 2,   ROS↓, 20,   SAM-e↑, 1,   selenoP↑, 8,   SOD↑, 3,   SOD1↑, 1,   SOD2↑, 2,   TAC↑, 2,   TrxR↑, 1,   TrxR1↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↝, 1,   Insulin↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   AMPK↑, 2,   CRM↑, 2,   glucose↓, 2,   glyC↓, 1,   LDL↓, 4,   NAD↝, 1,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,   Casp9↓, 1,   iNOS↓, 1,   iNOS↑, 1,   JNK↓, 1,   MAPK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 2,   other↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

NQO2↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 2,   DNArepair↑, 1,   P53↓, 1,   PCNA↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↓, 1,   AntiAg↑, 4,   Ca+2↝, 1,   CLDN1↑, 1,   MUC1↑, 1,   serineP↓, 1,   TGF-β↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   ZO-1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   NO↓, 1,  

Barriers & Transport(tgid=15) ⓘ

CLDN3↑, 1,   IBI↑, 1,   OCLN↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 6,   COX2/PTGS2↓, 5,   CRP↓, 3,   IFN-γ↓, 1,   IL1↓, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 2,   Imm↑, 3,   Inflam↓, 19,   MCP1/CCL2↓, 1,   NF-kB↓, 3,   PGE2↓, 2,   TLR4↓, 1,   TNF-α↓, 6,   VitD↑, 4,  

Cellular Microenvironment(tgid=17) ⓘ

pH↝, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,   GABA↓, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

testos↑, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 14,   BioAv↝, 2,   Dose↓, 1,   Dose↑, 2,   Dose↝, 11,   eff↑, 4,   Half-Life↓, 3,   Half-Life↝, 3,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BMD↑, 3,   BMPs↑, 1,   BP↓, 1,   Calcium↑, 2,   CRP↓, 3,   GutMicro↑, 7,   hs-CRP↓, 1,   IL6↓, 2,   Mag↑, 2,   VitD↑, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 6,   AntiTum↓, 1,   cardioP↑, 11,   chemoP↑, 2,   chemoPv↑, 2,   ChemoSideEff↓, 1,   cognitive↑, 7,   hepatoP↑, 2,   memory↑, 5,   Mood↑, 1,   neuroP↑, 7,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   QoL↑, 2,   radioP↑, 2,   Risk↓, 2,   Strength↑, 1,   toxicity↓, 11,   toxicity↑, 2,   toxicity⇅, 1,   toxicity↝, 4,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 2,   AntiViral↑, 2,   Bacteria↓, 1,  
Total Targets: 139

Scientific Paper Hit Count for: Risk, Risk
19 Selenium
13 Boron
11 Aspirin
11 Lycopene
11 Selenite (Sodium)
9 Magnesium
6 Vitamin D3
5 Allicin (mainly Garlic)
5 Calcium
5 Vitamin K2
5 diet Plant based
5 Exercise
5 Kaempferol
5 Phenethyl isothiocyanate
4 Chemotherapy
4 Coenzyme Q10
4 isoflavones
4 Selenium NanoParticles
3 Radiotherapy/Radiation
3 Celecoxib
3 diet Fermented Foods
3 diet FMD Fasting Mimicking Diet
3 diet Short Term Fasting
3 Folic Acid, Vit B9
3 iodine
3 Sulforaphane (mainly Broccoli)
3 Metformin
2 Anti-oxidants
2 Atorvastatin
2 Genistein (soy isoflavone)
2 Hormone replacement therapy
2 Bruteridin(bergamot juice)
2 EGCG (Epigallocatechin Gallate)
2 Flaxseed/Linseed
2 Indole-3-carbinol
2 Inulin Prebiotic
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Lutein
2 Melatonin
2 Vitamin C (Ascorbic Acid)
1 Astaxanthin
1 beta-carotene(VitA)
1 Bifidobacterium
1 immunotherapy
1 selenomethionine
1 Bortezomib
1 Butyrate
1 Carvacrol
1 Choline
1 Chyawanprash
1 Dipyridamole
1 Ginkgo biloba-EGb 761
1 Vitamin B12
1 Fisetin
1 flavonoids
1 Germanium Organic/Ge-132 / propagermanium (organogermanium)
1 Grapeseed extract
1 Inositol
1 Lactobacillus
1 Lecithin
1 Lactoferrin/Talactoferrin
1 SDG/lignans
1 Oleuropein
1 Quercetin
1 Rutin
1 buckwheat sprouts
1 chitosan
1 Spermidine
1 Whole Body Vibration
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:785  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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