BioAv Cancer Research Results

BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
5272- 3BP,    The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells
- in-vitro, GBM, U87MG - in-vitro, Nor, HEK293
Glycolysis↓, ROS↑, GPx↓, eff↓, OXPHOS↓, HK2↓, ATP↓, ROS↑, ER Stress↑, BioAv↓, Cyt‑c↑, eff↑,
5464- AF,    Inhibition of Thioredoxin-Reductase by Auranofin as a Pro-Oxidant Anticancer Strategy for Glioblastoma: In Vitro and In Vivo Studies
- vitro+vivo, GBM, NA
TrxR↓, BioAv↓, ROS↑, eff↝, TET1?, BioAv↑,
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5439- AG,    Absorption enhancement study of astragaloside IV based on its transport mechanism in Caco-2 cells
- in-vitro, Colon, Caco-2
BioAv↑, BioAv↓,
5165- AL,    The human allicin-proteome: S-thioallylation of proteins by the garlic defence substance allicin and its biological effects
- in-vitro, AML, Jurkat - in-vitro, Nor, L929
necrosis↑, Thiols↓, GSH↓, ENO1↓, Zn2+↑, Glycolysis↓, ATP↓, BioAv↓,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
3387- ART/DHA,    Ferroptosis: A New Research Direction of Artemisinin and Its Derivatives in Anti-Cancer Treatment
- Review, Var, NA
BioAv↓, lipid-P↑, Ferroptosis↑, Iron↑, GPx4↓, GSH↓, P53↑, ER Stress↑, PERK↑, ATF4↑, GRP78/BiP↑, CHOP/DDIT3↑, ROS↑, NRF2↑,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
5394- Ash,    Safety and pharmacokinetics of Withaferin-A in advanced stage high grade osteosarcoma: A phase I trial
- Trial, OS, NA
toxicity↝, hepatoP↓, BioAv↓, Apoptosis↑, ROS↑, TumCCA↑,
3154- Ash,    Pharmacokinetics and bioequivalence of Withania somnifera (Ashwagandha) extracts – A double blind, crossover study in healthy adults
BioAv↑, BioAv↓,
5387- AsP,  PacT,    Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy
- in-vivo, Melanoma, B16-F10
Dose↝, TumCG↓, TumCP↓, BioAv↓, BioAv↑, other↑, Apoptosis↑, Bax:Bcl2↑, EPR↑, toxicity↝,
5448- ATV,    Beyond cardiovascular health: The pharmacotherapeutic potential of statins in oncology
- Review, Var, NA
Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, eff↑, HMGCR↓, LDL↓, cardioP↑, AntiTum↑, ChemoSen↑, RadioS↑, toxicity↓,
5445- ATV,    Atorvastatin
- NA, Nor, NA
*cardioP↑, *LDL↓, HMG-CoA↓, Half-Life↝, BioAv↓, Dose↝,
5570- B-Gluc,    Immunomodulation of Fungal β-Glucan in Host Defense Signaling by Dectin-1
- Review, Var, NA
Imm↑, BioAv↝, eff↑, AntiCan↑, Dectin1↝, Dose↝, BioAv↓,
5497- Ba,    Role of Intestinal Microbiota in Baicalin-Induced Drug Interaction and Its Pharmacokinetics
- Review, Var, NA
*Inflam↓, AntiCan↑, BioAv↝, BioAv⇅, BioAv↓, CYP3A2↓, P-gp/ABCB1↓,
5249- Ba,  BA,    Baicalein and baicalin in cancer therapy: Multifaceted mechanisms, preclinical evidence, and translational challenges
- Review, Var, NA
Apoptosis↑, Inflam↓, TumCCA↑, ChemoSen↑, RadioS↑, TumCG↓, toxicity↓, BioAv↓, Half-Life↓,
5251- Ba,    The Fascinating Effects of Baicalein on Cancer: A Review
- Review, Var, NA
AntiTum↑, TumCCA↓, ROS↓, MAPK↓, Akt↓, mTOR↓, Casp3↑, Casp9↑, TumCI↓, TumMeta↓, MMP2↓, MMP9↓, Securin↓, γH2AX↝, N-cadherin↓, Vim↓, Zeb1↓, ZEB2↓, TumCMig↓, TumCG↑, 12LOX↓, DR5↑, ROS↑, RadioS↑, ChemoSen↑, BioAv↓,
2603- Ba,    Baicalein inhibits prostate cancer cell growth and metastasis via the caveolin-1/AKT/mTOR pathway
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCG↓, Apoptosis↑, Cav1↓, p‑Akt↓, p‑mTOR↓, Bax:Bcl2↑, survivin↓, cl‑PARP↑, BioAv↓,
2597- Ba,    Baicalein – An Intriguing Therapeutic Phytochemical in Pancreatic Cancer
- Review, PC, NA
chemoP↑, ChemoSen↑, 12LOX?, Bcl-2↓, BAX↑, Mcl-1↓, ERK↓, Prx6↑, Dose↝, BioAv↓, eff↑,
2292- Ba,  BA,    Baicalin and baicalein in modulating tumor microenvironment for cancer treatment: A comprehensive review with future perspectives
- Review, Var, NA
AntiCan↑, *toxicity↓, BioAv↝, BioAv↓, *ROS↓, *TLR2↓, *NF-kB↓, *NRF2↑, *antiOx↑, *Inflam↓, HDAC1↓, HDAC8↓, Wnt↓, β-catenin/ZEB1↓, PD-L1↓, Sepsis↓, NF-kB↓, LOX1↓, COX2/PTGS2↓, VEGF↑, PI3K↓, Akt↓, mTOR↓, MMP2↓, MMP9↓, SIRT1↑, AMPK↑,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
5543- BBM,    Enhanced anti-metastatic and anti-tumorigenic efficacy of Berbamine loaded lipid nanoparticles in vivo
- in-vivo, Lung, B16-F10 - vitro+vivo, Lung, A549 - in-vitro, BC, MDA-MB-231
BioAv↓, Half-Life↓, eff↑, TumMeta↓, TumCP↓, TumCG↓, Apoptosis↑, TumCCA↑, MMP2↓, MMP9↓, VEGF↓, Bcl-2↓, eff↑, EPR↑,
2021- BBR,    Berberine: An Important Emphasis on Its Anticancer Effects through Modulation of Various Cell Signaling Pathways
- Review, NA, NA
*antiOx?, *Inflam↓, Apoptosis↑, TumCCA↑, BAX↑, eff↑, VEGF↓, PI3K↓, Akt↓, mTOR↓, Telomerase↓, β-catenin/ZEB1↓, Wnt↓, EGFR↓, AP-1↓, NF-kB↓, COX2/PTGS2↑, NRF2↓, RadioS↑, STAT3↓, ERK↓, AR↓, ROS↑, eff↑, selectivity↑, selectivity↑, BioAv↓, DNMT1↓, cMyc↓,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,
5642- BCA,    Interactions between the flavonoid biochanin A and P-glycoprotein substrates in rats: in vitro and in vivo
- vitro+vivo, Nor, NA
P-gp/ABCB1↓, BioAv↓,
5634- BCA,    Molecular Mechanisms of Biochanin A in AML Cells: Apoptosis Induction and Pathway-Specific Regulation in U937 and THP-1
- in-vitro, AML, U937 - in-vitro, AML, THP1
Apoptosis↑, Casp7↑, PARP1↑, Bcl-2↓, Myc↓, CHOP/DDIT3↑, P21↑, p62↑, TumCCA↑, TXNIP↑, ROS↑, *antiOx↑, *Inflam↓, *neuroP↑, AntiCan↑, TumCP↓, angioG↓, TumMeta↓, VEGF↓, MMPs↓, tumCV↓, DNAdam↑, CHOP/DDIT3↑, cMyc↓, BioAv↓, Half-Life↓, BioAv↑,
5591- BetA,    Advances and challenges in betulinic acid therapeutics and delivery systems for breast cancer prevention and treatment
- Review, BC, NA
BioAv↓, BioAv↑, selectivity↑, eff↑, angioG↓, *antiOx↑, *Inflam↓, MMP↓, Bcl-2↓, BAX↑, Casp9↑, Casp3↑, GRP78/BiP?, ER Stress↑, PERK↑, CHOP/DDIT3↑, ChemoSen↑, SESN2↑, ROS↑, MOMP↓, MAPK↑, Cyt‑c↑, AIF↑, STAT3↓, FAK↓, TIMP2↑, TumCMig↓, TumCI↓, Sp1/3/4↓, TumCCA↑, DNAdam↑,
5589- BetA,    Advancements in Betulinic Acid-Loaded Nanoformulations for Enhanced Anti-Tumor Therapy
- Review, Var, NA
BioAv↓, toxicity↝, BioAv↑, Half-Life↑,
5588- BetA,    Therapeutic applications of betulinic acid nanoformulations
- Review, Var, NA
BioAv↓, Half-Life↓, BioAv↑, Half-Life↑,
2731- BetA,    Betulinic Acid for Glioblastoma Treatment: Reality, Challenges and Perspectives
- Review, GBM, NA - Review, Park, NA - Review, AD, NA
BBB↑, *GSH↑, *Catalase↑, *motorD↑, *neuroP↑, *cognitive↑, *ROS↓, *antiOx↑, *Inflam↓, MMP↓, STAT3↓, NF-kB↓, Sp1/3/4↓, TOP1↓, EMT↓, Hif1a↓, VEGF↓, ChemoSen↑, RadioS↑, BioAv↓,
2735- BetA,    Betulinic acid as apoptosis activator: Molecular mechanisms, mathematical modeling and chemical modifications
- Review, Var, NA
mt-Apoptosis↑, Casp↑, p38↑, MAPK↓, JNK↓, VEGF↓, AIF↑, Cyt‑c↑, ROS↑, Ca+2↑, ATP↓, NF-kB↓, ATF3↓, TOP1↓, VEGF↓, survivin↓, Sp1/3/4↓, MMP↓, ChemoSen↑, selectivity↑, BioAv↓, BioAv↑, BioAv↑, BioAv↑, BioAv↑,
2748- BetA,    Betulinic Acid: Recent Advances in Chemical Modifications, Effective Delivery, and Molecular Mechanisms of a Promising Anticancer Therapy
- Review, Var, NA
Bcl-2↓, MMP↓, Cyt‑c↑, Casp↑, Diablo↑, AIF↑, angioG↓, BioAv↓, NF-kB↓,
5655- BNL,    Comparative pharmacokinetic studies of borneol in mouse plasma and brain by different administrations
- in-vivo, Nor, NA
*BioAv↝, BioAv↓, BioAv↑,
5660- BNL,    Recent Progress on the Synergistic Antitumor Effect of a Borneol-Modified Nanocarrier Drug Delivery System
- Review, Var, NA
TumMeta↓, BBB↑, EPR↑, toxicity↓, BioAv↑, ChemoSen↑, eff↑, other↑, P-gp/ABCB1↓, MDR1↓, ROS↑, TumCCA↑, other↝, BioAv↓, DNAdam↑, BioEnh↑,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
5731- Buty,    The Warburg Effect Dictates the Mechanism of Butyrate Mediated Histone Acetylation and Cell Proliferation
- in-vitro, CRC, HCT116 - in-vitro, CRC, HT29
HDAC↓, Warburg↓, TumCP⇅, HATs↑, BioAv↓, other↝, Risk↓,
5751- CA,    Potential Therapeutic Implications of Caffeic Acid in Cancer Signaling: Past, Present, and Future
- Review, Var, NA
*antiOx↑, *chemoPv↑, ROS↑, MMP2↓, MMP9↓, BioAv↓, eff↑, *Inflam↓, AMPK↑, lipid-P↑, eff↑, ChemoSen↑, *memory↑, *ROS↓,
5829- CAP,    Anti-cancer activity of capsaicin and its analogs in gynecological cancers
- Review, Var, NA
Pain↓, BioAv↓, toxicity↝, toxicity↓,
2015- CAP,  CUR,  urea,    Anti-cancer Activity of Sustained Release Capsaicin Formulations
- Review, Var, NA
AntiCan↑, TumCG↓, angioG↓, TumMeta↓, BioAv↓, BioAv↓, BioAv↑, selectivity↑, EPR↑, eff↓, ChemoSen↑, Dose∅, Half-Life∅, eff↑,
5894- CAR,    Targeting Gastrointestinal Cancers with Carvacrol: Mechanistic Insights and Therapeutic Potential
- Review, Var, NA
AntiCan↑, Apoptosis↑, Inflam↓, angioG↓, TumMeta↓, selectivity↑, BioAv↑, ChemoSen↑, Dose↝, TumCP↓, hepatoP↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, GSH↓, BAX↑, Casp7↑, Casp8↑, Cyt‑c↑, Fas↑, FADD↑, P53↑, Bcl-2↓, TumMeta↓, TumCMig↓, TumCI↓, E-cadherin↑, TIMP2↑, TIMP3↑, N-cadherin↓, ZEB2↓, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, selectivity↑, cl‑PARP↑, ERK↓, p38↑, OS↑, AFP↓, COX2/PTGS2↓, VEGF↓, PCNA↓, Ki-67↓, TNF-α↓, BioAv↓,
17- CBC/D,    CBC-1 as a Cynanbungeigenin C derivative inhibits the growth of colorectal cancer through targeting Hedgehog pathway component GLI 1
- in-vivo, CRC, NA
HH↓, Gli1↓, BioAv↓, TumCP↓,
5813- CBD,    Pharmacokinetics of Cannabidiol: A Systematic Review and Meta-Regression Analysis
- Review, Var, NA
Dose↝, BioAv↑, BioAv↓, BioAv↑,
5938- Cela,    Celastrol: A Review of Useful Strategies Overcoming its Limitation in Anticancer Application
- Review, Var, NA
AntiCan↑, BioAv↓, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, angioG↓, Inflam↓, antiOx↑, ChemoSen↑, HSP90↓, ROS↑, RadioS↑, P53↑, NLRP3↓,
5943- Cela,    Celastrol: A Spectrum of Treatment Opportunities in Chronic Diseases
- Review, Arthritis, NA - Review, IBD, NA - Review, AD, NA - Review, Park, NA
*other↝, *other↝, *CRP↓, *eff↝, *other↑, *CXCR4↓, *IL1β↓, *IL6↓, *IL17↓, *IL18↓, *TNF-α↓, *MMP9↓, *PGE2↓, *COX1↓, *COX2/PTGS2↓, *PI3K↓, *Akt↓, *other↑, TumCCA↑, Apoptosis↑, ROS↑, JNK↑, TumAuto↑, Hif1a↓, BNIP3↝, HSP90↓, Fas↑, FasL↑, ETC↓, VEGF↓, angioG↓, RadioS↑, *neuroP↑, *HSP70/HSPA5↑, *ROS↓, *MMP↑, *Cyt‑c↓, *Casp3↓, *Casp9↓, *MAPK↓, *Dose⇅, *HSPs↑, BioAv↓, Dose↝,
5947- Cela,    Recent advances in drug delivery of celastrol for enhancing efficiency and reducing the toxicity
- Review, Var, NA
BioAv↓, toxicity⇅, BioAv↑,
6004- CGA,    Dose-response plasma appearance of coffee chlorogenic and phenolic acids in adults
- Human, Nor, NA
*BioAv↝, *other↝, BioAv↓,
6009- CGA,    Chlorogenic Acid: An In-Depth Review of Its Effectiveness in Cancer Treatment
- Review, Var, NA
TumCCA↑, TumCI↓, TumMeta↓, angioG↓, ROS↑, ChemoSen↑, BioAv↓, Half-Life↓, PI3K↓, Akt↓, mTOR↓, Apoptosis↑, NOTCH↓, Hif1a↓, VEGF↓, Casp3↑, MMP↓, Ferroptosis↑, ATP↓,
6135- CHr,    Chrysin as a Multifunctional Therapeutic Flavonoid: Emerging Insights in Pathogenesis Management: A Narrative Review
- Review, Var, NA - Review, AD, NA
Inflam↓, angioG↓, Apoptosis↑, TumAuto↑, TumCCA↑, BioAv↓, Half-Life↓, BioAv↓, *ROS↓, *hepatoP↑, *RenoP↑, TET1↑, MMP9↓, cMyc↓, Ki-67↓, CBR1↓, ROS↑, ChemoSen↑, Bax:Bcl2↑, PUMA↑, NOTCH1↑, *AntiDiabetic↑, *neuroP↑, *GABA↑, *DNAdam↓, *BDNF↑, *memory↑, *AGEs↓, *Aβ↓, *cardioP↑, *AntiArt↑, eff↑, eff↑, *eff↑, RadioS↑, eff↑, ChemoSen↑, eff↑,
2780- CHr,    Anti-cancer Activity of Chrysin in Cancer Therapy: a Systematic Review
- Review, Var, NA
*antiOx↑, Inflam↓, *hepatoP↑, AntiCan↑, Cyt‑c↑, Casp3↑, XIAP↓, p‑Akt↓, PI3K↑, Apoptosis↑, COX2/PTGS2↓, FAK↓, AMPK↑, STAT3↑, MMP↓, DNAdam↑, BAX↑, Bak↑, Casp9↑, p38↑, MAPK↑, TumCCA↑, ChemoSen↑, HDAC8↓, Wnt↓, NF-kB↓, angioG↓, BioAv↓,

Showing Research Papers: 1 to 50 of 150
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 150

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ALDH1A3↓, 1,   p‑AMT/GCST/T-protein↑, 1,   ASAP2↓, 1,   CBR1↓, 1,   CDK7↓, 1,   DDIT4↑, 1,   LRIG1↑, 1,   miR-106b↓, 1,   miR-339-5p↝, 1,   NOD1↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ATF3↓, 1,   Catalase↓, 1,   Catalase↑, 1,   CYP1A1↓, 1,   Fenton↑, 1,   Ferroptosis↑, 8,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 5,   GSH↓, 13,   GSH↑, 1,   GSR↑, 1,   GSTA1↑, 2,   H2O2↓, 1,   H2O2↑, 1,   e-H2O2↓, 1,   i-H2O2∅, 1,   HO-1↓, 1,   HO-1↑, 3,   Iron↑, 2,   c-Iron↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↑, 6,   NAF1↓, 1,   NOX4↑, 1,   NQO1↑, 1,   NRF2↓, 5,   NRF2↑, 10,   OXPHOS↓, 1,   Prx4↑, 1,   Prx6↑, 1,   ROS↓, 5,   ROS↑, 74,   ROS⇅, 1,   ROS↝, 1,   SIRT3↓, 1,   SIRT3↑, 1,   SOD↑, 1,   SOD2↓, 1,   Thiols↓, 1,   Trx↓, 1,   TrxR↓, 6,   xCT/SLC7A11↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 1,   Zn2+↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 5,   ATP↓, 6,   mt-ATP↓, 1,   CDC25↓, 3,   ETC↓, 1,   mitResp↓, 1,   MMP↓, 25,   mtDam↑, 4,   OCR↓, 1,   Raf↓, 1,   c-Raf↓, 1,   XIAP↓, 7,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1,   12LOX↓, 1,   ACLY↓, 1,   ACSL4↑, 1,   AMPK↑, 8,   ATG7↑, 2,   Cav1↓, 1,   cMyc↓, 13,   CYP3A2↓, 1,   CYP3A4↓, 1,   ECAR↓, 1,   ENO1↓, 1,   FASN↓, 2,   GlucoseCon↓, 3,   Glycolysis↓, 14,   HK2↓, 5,   HMG-CoA↓, 1,   IDH1↓, 1,   lactateProd↓, 1,   LDH↑, 1,   LDL↓, 1,   PDK1 / PDPK1↓, 2,   PDK3↑, 1,   PKM2↓, 3,   PPARα↓, 1,   PPARγ↑, 2,   SIRT1↓, 2,   SIRT1↑, 6,   SIRT2↑, 1,   SREBP1/SREBF1↓, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Akt↓, 31,   Akt↑, 1,   p‑Akt↓, 10,   Apoptosis↑, 56,   mt-Apoptosis↑, 2,   BAD↓, 1,   BAD↑, 1,   Bak↑, 3,   BAX↓, 1,   BAX↑, 21,   Bax:Bcl2↑, 4,   Bcl-2↓, 23,   Bcl-2↑, 1,   Bcl-xL↓, 6,   BID↓, 1,   BIM↑, 1,   Casp↑, 13,   Casp12↑, 1,   Casp3↓, 2,   Casp3↑, 27,   cl‑Casp3↑, 5,   proCasp3↑, 1,   Casp7↑, 7,   cl‑Casp7↑, 1,   Casp8↑, 10,   cl‑Casp8↑, 1,   Casp9↑, 20,   cl‑Casp9↑, 3,   CBP↓, 1,   cFLIP↓, 2,   Chk2↓, 2,   Cyt‑c↑, 17,   Diablo↑, 1,   DR4↑, 2,   DR5↑, 6,   Endon↑, 1,   FADD↑, 1,   Fas↑, 3,   FasL↑, 2,   Ferroptosis↑, 8,   GSDME↑, 1,   hTERT/TERT↓, 2,   IAP1↓, 3,   IAP2/BIRC3↓, 1,   IAP2/BIRC3↑, 1,   iNOS↓, 4,   JNK↓, 2,   JNK↑, 5,   p‑JNK↑, 1,   MAPK↓, 15,   MAPK↑, 5,   Mcl-1↓, 8,   Mcl-1↑, 1,   MDM2↓, 2,   MOMP↓, 1,   MOMP↑, 1,   Myc↓, 2,   Necroptosis↑, 1,   necrosis↑, 1,   NOXA↑, 1,   p27/CDKN1B↑, 6,   p38↑, 5,   p‑p38↑, 1,   Paraptosis↑, 1,   PUMA↑, 3,   Pyro↑, 2,   RIP1↑, 1,   survivin↓, 13,   Telomerase↓, 3,   TRAIL↑, 1,   TRAIL⇅, 1,   TRAILR↑, 1,   TumCD↑, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   cSrc↓, 1,   EF-1α↓, 1,   FOXD3↑, 1,   SOX9?, 1,   Sp1/3/4↓, 5,   Sp1/3/4↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↑, 1,   EZH2↓, 1,   H3↑, 1,   ac‑H3↑, 1,   H4↑, 1,   HATs↓, 1,   HATs↑, 3,   miR-21↓, 4,   miR-218↑, 1,   miR-27a-3p↓, 1,   other↓, 1,   other↑, 2,   other↝, 6,   tumCV↓, 6,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   CHOP/DDIT3↑, 9,   cl‑CHOP/DDIT3↑, 1,   ER Stress↓, 1,   ER Stress↑, 12,   GRP78/BiP?, 1,   GRP78/BiP↑, 5,   HSP27↝, 1,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 5,   PERK↑, 2,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   Beclin-1/ATG6↑, 1,   BNIP3↝, 1,   LC3II↓, 1,   LC3II↑, 4,   p62↓, 1,   p62↑, 2,   SESN2↑, 2,   TumAuto↑, 12,   TumAuto↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 1,   BRCA1↓, 1,   CHK1↓, 2,   DNAdam↓, 2,   DNAdam↑, 15,   DNMT1↓, 5,   DNMT3A↓, 2,   DNMTs↓, 2,   G9a↓, 1,   NKX3.1↓, 1,   p16↑, 1,   P53?, 1,   P53↓, 1,   P53↑, 23,   PARP↑, 3,   cl‑PARP↓, 1,   cl‑PARP↑, 20,   PARP1↑, 1,   PCNA↓, 7,   TP53↑, 1,   UHRF1↓, 1,   γH2AX↓, 1,   γH2AX↑, 1,   γH2AX↝, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK1↑, 1,   CDK2↓, 9,   CDK4↓, 13,   cycA1/CCNA1↓, 1,   cycA1/CCNA1↑, 1,   CycB/CCNB1↓, 6,   cycD1/CCND1↓, 16,   cycD1/CCND1↑, 1,   cycE/CCNE↓, 6,   E2Fs↓, 1,   E2Fs↑, 1,   mitA↑, 1,   P21?, 1,   P21↑, 15,   RB1↑, 1,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA↓, 3,   TumCCA↑, 50,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   AR-FL↓, 1,   AR-V7↑, 1,   Axin2↑, 1,   CD133↓, 2,   CD44↓, 2,   p‑cDC2↓, 1,   CIP2A↓, 1,   cMET↓, 1,   CSCs↓, 13,   EMT↓, 19,   EMT↑, 1,   ERK↓, 17,   p‑ERK↓, 3,   FOXO3↑, 1,   Gli↓, 1,   Gli1↓, 4,   GSK‐3β↓, 4,   GSK‐3β↑, 1,   HDAC↓, 6,   HDAC1↓, 4,   HDAC10↓, 1,   HDAC2↓, 2,   HDAC3↓, 1,   HDAC4↓, 1,   HDAC8↓, 2,   HH↓, 4,   HMGCR↓, 1,   IGF-1↓, 2,   IGFBP1↑, 1,   IGFBP3↑, 1,   Let-7↑, 1,   miR-34a↑, 2,   mTOR↓, 22,   p‑mTOR↓, 3,   mTORC1↓, 2,   Nanog↓, 4,   Nestin↓, 1,   NOTCH↓, 7,   NOTCH1↓, 3,   NOTCH1↑, 2,   NOTCH3↓, 1,   OCT4↓, 3,   p300↓, 1,   PI3K↓, 25,   PI3K↑, 2,   p‑PI3K↓, 1,   PTCH1↓, 1,   PTEN↓, 1,   PTEN↑, 9,   RAS↓, 3,   Shh↓, 3,   SOX2↓, 2,   STAT1↓, 1,   STAT3↓, 24,   STAT3↑, 2,   p‑STAT3↓, 3,   STAT6↓, 1,   TOP1↓, 6,   TOP2↓, 1,   TOP2↑, 1,   TumCG↓, 19,   TumCG↑, 1,   Wnt↓, 17,   Zn2+↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 4,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 4,   CC(CDKs/cyclins)↓, 1,   CD31/PECAM-1↓, 2,   Cdc42↑, 1,   CXCL12↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 4,   FAK↓, 7,   FAK↑, 1,   p‑FAK↓, 2,   hnRNPA1↓, 1,   Ki-67↓, 5,   LAMs↓, 1,   MARK4↓, 1,   miR-200b↑, 1,   miR-203↑, 1,   miR-29b↓, 1,   MMP1↓, 4,   MMP13↓, 2,   MMP2↓, 24,   MMP3↓, 3,   MMP7↓, 3,   MMP9↓, 28,   MMP9↑, 3,   MMPs↓, 8,   MUC4↓, 1,   N-cadherin↓, 4,   PDGF↓, 2,   PKA↓, 2,   PKCδ↓, 2,   Rac1↓, 1,   Rho↓, 2,   RIP3↑, 1,   ROCK1↓, 3,   Slug↓, 1,   Snail↓, 1,   SOX4↓, 1,   SOX4↑, 1,   TET1?, 1,   TET1↑, 1,   TGF-β↓, 4,   TIMP1↑, 2,   TIMP2↑, 4,   TIMP3↑, 1,   TRIB3↑, 1,   TumCI↓, 21,   TumCMig↓, 13,   TumCP↓, 40,   TumCP↑, 1,   TumCP⇅, 1,   TumMeta↓, 33,   TumMeta↑, 2,   Twist↓, 3,   TXNIP↑, 1,   uPA↓, 6,   Vim↓, 5,   Zeb1↓, 3,   ZEB2↓, 2,   α-SMA↓, 2,   α-SMA↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 12,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 43,   angioG↑, 1,   ATF4↑, 1,   ATF4↝, 1,   EGFR↓, 7,   EGR1↑, 1,   EPR↑, 5,   HIF-1↓, 1,   Hif1a↓, 20,   Hif1a↝, 1,   LOX1↓, 1,   NO↓, 1,   p‑PDGFR-BB↓, 1,   TAMS↝, 1,   VEGF↓, 36,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 3,   ZBTB10↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 8,   GLUT1↓, 2,   GLUT4↓, 1,   NHE1↓, 1,   P-gp/ABCB1↓, 10,   P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↓, 1,   COX2/PTGS2↓, 23,   COX2/PTGS2↑, 1,   CRP↓, 1,   CXCR4↓, 3,   Dectin1↝, 1,   ICAM-1↓, 1,   IKKα↓, 2,   p‑IKKα↓, 1,   IL1↓, 3,   IL1↑, 1,   IL10↓, 1,   IL10↑, 1,   IL12↑, 1,   IL1α↓, 1,   IL1β↓, 5,   IL2↓, 2,   IL2↑, 3,   IL4↑, 1,   IL6↓, 11,   IL8↓, 4,   Imm↑, 3,   INF-γ↓, 1,   Inflam↓, 17,   IκB↓, 1,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 3,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 50,   NK cell↑, 1,   p65↓, 3,   p‑p65↓, 1,   PD-L1↓, 5,   PGE2↓, 7,   PSA↓, 6,   TLR4↝, 1,   TNF-α↓, 13,   TNF-α↑, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,   NLRP3↑, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 9,   CDK6↓, 3,   FKBP5↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 166,   BioAv↑, 73,   BioAv⇅, 1,   BioAv↝, 8,   BioEnh↑, 2,   chemoR↓, 1,   ChemoSen↑, 64,   Dose↑, 6,   Dose↝, 20,   Dose∅, 1,   eff↓, 10,   eff↑, 57,   eff↝, 4,   Half-Life↓, 21,   Half-Life↑, 4,   Half-Life↝, 22,   Half-Life∅, 1,   MDR1↓, 4,   MRP1/ABCC1↓, 1,   MRP1/ABCC1↑, 1,   P450↓, 1,   RadioS↑, 27,   RadioS↝, 1,   selectivity↑, 28,   selectivity↝, 1,   selectivity∅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   AR↓, 9,   ascitic↓, 1,   BRCA1↓, 1,   CRP↓, 1,   EGFR↓, 7,   EZH2↓, 1,   GutMicro↑, 5,   GutMicro↝, 1,   hTERT/TERT↓, 2,   IL6↓, 11,   Ki-67↓, 5,   LDH↑, 1,   Myc↓, 2,   PD-L1↓, 5,   PSA↓, 6,   TP53↑, 1,   TRIB3↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 26,   AntiDiabetic↑, 1,   AntiTum↑, 6,   cachexia↓, 1,   cardioP↑, 4,   chemoP↑, 11,   chemoPv↑, 7,   ChemoSideEff↓, 1,   hepatoP↓, 2,   hepatoP↑, 3,   memory↑, 2,   neuroP↑, 3,   OS↑, 2,   Pain↓, 1,   QoL↑, 1,   radioP↑, 3,   RenoP↑, 1,   Risk↓, 2,   toxicity↓, 9,   toxicity↑, 1,   toxicity⇅, 2,   toxicity↝, 6,   toxicity∅, 1,   TumVol↓, 5,   UBE2C↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Dectin1↝, 1,   Sepsis↓, 1,  
Total Targets: 539

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1,   antiOx↓, 3,   antiOx↑, 24,   ARE↑, 1,   Catalase↑, 7,   GPx↑, 5,   GSH↑, 2,   GSR↑, 1,   GSTA1↓, 1,   H2O2↓, 1,   HO-1↑, 2,   lipid-P↓, 4,   MDA↓, 4,   NRF2↑, 5,   ROS↓, 25,   SOD↑, 7,   SOD1↑, 1,   TAC↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   LDH↓, 2,   LDL↓, 1,   PPARγ↑, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Casp3↓, 1,   Casp9↓, 1,   Cyt‑c↓, 1,   iNOS↓, 1,   MAPK↓, 1,   MAPK↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 2,   other↝, 3,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,   HSPs↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   HDAC3↓, 1,   IGF-1↓, 1,   IGFBP3↑, 1,   neuroG↑, 1,   PI3K↓, 1,   STAT↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   Ca+2↝, 1,   Ki-67↓, 1,   MMP9↓, 1,   TIMP1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 2,   CRP↓, 1,   CXCR4↓, 1,   IL17↓, 1,   IL18↓, 1,   IL1β↓, 1,   IL6↓, 1,   IL8↓, 1,   Inflam↓, 28,   Inflam↑, 1,   NF-kB↓, 5,   PGE2↓, 1,   TLR2↓, 1,   TNF-α↓, 2,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↑, 1,   BDNF↑, 2,   GABA↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 2,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 3,   BioAv↑, 3,   BioAv↝, 4,   Dose↑, 3,   Dose⇅, 1,   Dose↝, 3,   eff↑, 1,   eff↝, 1,   Half-Life↓, 1,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   CRP↓, 1,   GutMicro↝, 1,   IL6↓, 1,   Ki-67↓, 1,   LDH↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiArt↑, 2,   AntiCan↑, 3,   AntiDiabetic↑, 4,   AntiP↑, 1,   AntiTum↑, 1,   cardioP↑, 10,   chemoP↑, 1,   chemoPv↑, 2,   cognitive↑, 3,   hepatoP↑, 5,   memory↑, 4,   motorD↑, 1,   neuroP↓, 1,   neuroP↑, 13,   radioP↑, 1,   RenoP↑, 1,   toxicity↓, 5,   toxicity↑, 2,   toxicity↝, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 2,   Bacteria↓, 4,  
Total Targets: 113

Scientific Paper Hit Count for: BioAv, bioavailability
14 Curcumin
7 Baicalein
6 Betulinic acid
5 EGCG (Epigallocatechin Gallate)
5 Fisetin
4 Honokiol
4 Piperlongumine
4 Resveratrol
4 Thymoquinone
3 Berberine
3 borneol
3 Capsaicin
3 Celastrol
3 Chrysin
3 Gambogic Acid
3 Kaempferol
3 Quercetin
3 Aflavin-3,3′-digallate
2 Astragalus
2 Artemisinin
2 Ashwagandha(Withaferin A)
2 Atorvastatin
2 Baicalin
2 Biochanin A
2 Chlorogenic acid
2 Propolis -bee glue
2 Camptothecin
2 Cucurbitacin
2 Silymarin (Milk Thistle) silibinin
2 Fenbendazole
2 Glabrescione B
2 HydroxyTyrosol
2 Luteolin
2 Lycopene
2 Magnolol
2 Sulforaphane (mainly Broccoli)
2 Shikonin
1 3-bromopyruvate
1 Auranofin
1 Allicin (mainly Garlic)
1 Apigenin (mainly Parsley)
1 Chemotherapy
1 Ascorbyl Palmitate
1 Paclitaxel/Taxol
1 beta-glucans
1 Berbamine
1 Boswellia (frankincense)
1 Butyrate
1 Caffeic acid
1 urea
1 Carvacrol
1 Cynanbungeigenin C (CBC) and D (CBD)
1 Cannabidiol
1 irinotecan
1 Crocetin
1 Dichloroacetophenone(2,2-)
1 Disulfiram
1 Copper and Cu NanoParticles
1 Ellagic acid
1 Emodin
1 Evodiamine
1 Gallic acid
1 Garcinol
1 Genistein (soy isoflavone)
1 Ginkgetin
1 Arsenic trioxide
1 HydroxyCitric Acid
1 Isoliquiritigenin
1 isoorientin
1 Ivermectin
1 Lapachol
1 Licochalcone A
1 Lemongrass Extract/Citral
1 SDG/lignans
1 Folic Acid, Vit B9
1 Naringin
1 Oleuropein
1 Oleocanthal
1 Psoralidin
1 Parthenolide
1 Pterostilbene
1 enzalutamide
1 salinomycin
1 Spermidine
1 Selenite (Sodium)
1 Tomatine
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:792  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

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