CDK4 Cancer Research Results

CDK4, Cyclin-dependent kinase 4: Click to Expand ⟱
Source:
Type:
Cyclin-dependent kinase 4 (CDK4) is a key regulator of the cell cycle, particularly in the transition from the G1 phase to the S phase. Its expression and activity are often altered in various cancers, contributing to tumorigenesis.
CDK4 is frequently overexpressed in various cancers, and its expression levels can serve as a prognostic marker.
Scientific Papers found: Click to Expand⟱
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
2655- AL,    Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities
- Review, GC, NA
TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,
6396- ANE,  FEO,    Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis
- in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCMig↓, CSCs↓, ROS↑, MPT↑, Casp3↑, Casp9↑, DNAdam↑, cl‑PARP↑, Bax:Bcl2↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cMyc↓, P21↑, p27/CDKN1B↑, NF-kB↓, eff↑,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
3382- ART/DHA,    Repurposing Artemisinin and its Derivatives as Anticancer Drugs: A Chance or Challenge?
- Review, Var, NA
AntiCan↑, toxicity↑, Ferroptosis↑, ROS↑, TumCCA↑, BioAv↝, eff↝, Half-Life↓, Ferritin↓, GPx4↓, NADPH↓, GSH↓, BAX↑, Cyt‑c↑, cl‑Casp3↑, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, E-cadherin↑, MMP2↓, NF-kB↓, p16↑, CDK4↓, cycD1/CCND1↓, p62↓, LC3II↑, EMT↓, CSCs↓, Wnt↓, β-catenin/ZEB1↓, uPA↓, TumAuto↑, angioG↓, ChemoSen↑,
3383- ART/DHA,    Dihydroartemisinin: A Potential Natural Anticancer Drug
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, angioG↓, TumAuto↑, ER Stress↑, ROS↑, Ca+2↑, p38↑, HSP70/HSPA5↓, PPARγ↑, GLUT1↓, Glycolysis↓, PI3K↓, Akt↓, Hif1a↓, PKM2↓, lactateProd↓, GlucoseCon↓, EMT↓, Slug↓, Zeb1↓, ZEB2↓, Twist↓, Snail?, CAFs/TAFs↓, TGF-β↓, p‑STAT3↓, M2 MC↓, uPA↓, HH↓, AXL↓, VEGFR2/KDR/Flk1↓, JNK↑, Beclin-1/ATG6↑, GRP78/BiP↑, eff↑, eff↑, eff↑, eff↑, eff↑, eff↑, IL4↓, DR5↑, Cyt‑c↑, Fas↑, FADD↑, cl‑PARP↑, cycE/CCNE↓, CDK2↓, CDK4↓, Mcl-1↓, Ki-67↓, Bcl-2↓, CDK6↓, VEGF↓, COX2/PTGS2↓, MMP9↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
5395- Ash,    Withaferin A Targets Heat Shock Protein 90 in Pancreatic Cancer Cells
- vitro+vivo, PC, PANC1 - in-vitro, PC, MIA PaCa-2
TumCP↓, HSP90↓, Akt↓, CDK4↓, TumCG↓, Apoptosis↑, AntiCan↑,
3160- Ash,    Withaferin A: A Pleiotropic Anticancer Agent from the Indian Medicinal Plant Withania somnifera (L.) Dunal
- Review, Var, NA
TumCCA↑, H3↑, P21↑, cycA1/CCNA1↓, CycB/CCNB1↓, cycE/CCNE↓, CDC2↓, CHK1↓, Chk2↓, p38↑, MAPK↑, E6↓, E7↓, P53↑, Akt↓, FOXO3↑, ROS↑, γH2AX↑, MMP↓, mitResp↓, eff↑, TumCD↑, Mcl-1↓, ER Stress↑, ATF4↑, ATF3↑, CHOP/DDIT3↑, NOTCH↓, NF-kB↓, Bcl-2↓, STAT3↓, CDK1↓, β-catenin/ZEB1↓, N-cadherin↓, EMT↓, Cyt‑c↑, eff↑, CDK4↓, p‑RB1↓, PARP↑, cl‑Casp3↑, cl‑Casp9↑, NRF2↑, ER-α36↓, LDHA↓, lipid-P↑, AP-1↓, COX2/PTGS2↓, RenoP↑, PDGFR-BB↓, SIRT3↑, MMP2↓, MMP9↓, NADPH↑, NQO1↑, GSR↑, HO-1↑, *SOD2↑, *Prx↑, *Casp3?, eff↑, Snail↓, Slug↓, Vim↓, CSCs↓, HEY1↓, MMPs↓, VEGF↓, uPA↓, *toxicity↓, CDK2↓, CDK4↓, HSP90↓,
4809- ASTX,    Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression
- in-vitro, GC, AGS - in-vitro, GC, MKN45
tumCV↓, TumCP↓, TumCCA↑, p‑ERK↓, p27/CDKN1B↑, cycD1/CCND1↓, CDK4↓,
2474- Ba,    Anticancer properties of baicalein: a review
- Review, Var, NA - in-vitro, Nor, BV2
ROS⇅, ROS↑, ER Stress↑, Ca+2↑, Apoptosis↑, eff↑, DR5↑, 12LOX↓, Cyt‑c↑, Casp7↑, Casp9↑, Casp3↑, cl‑PARP↑, TumCCA↑, cycE/CCNE↑, CDK4↓, cycD1/CCND1↓, VEGF↓, cMyc↓, Hif1a↓, NF-kB↓, BioEnh↑, BioEnh↑, P450↓, *Hif1a↓, *iNOS↓, *COX2/PTGS2↓, *VEGF↓, *ROS↓, *PI3K↓, *Akt↓,
2626- Ba,    Molecular targets and therapeutic potential of baicalein: a review
- Review, Var, NA - Review, AD, NA - Review, Stroke, NA
AntiCan↓, *neuroP↑, *cardioP↑, *hepatoP↑, *RenoP↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, cycE/CCNE↑, BAX↑, Bcl-2↓, VEGF↓, Hif1a↓, cMyc↓, NF-kB↓, ROS↑, BNIP3↑, *neuroP↑, *cognitive↑, *NO↓, *iNOS↓, *COX2/PTGS2↓, *PGE2↓, *NRF2↑, *p‑AMPK↑, *Ferroptosis↓, *lipid-P↓, *ALAT↓, *AST↓, *Fas↓, *BAX↓, *Apoptosis↓,
2289- Ba,  Rad,    Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A
- in-vitro, ESCC, KYSE150
TumCP↓, TumCMig↓, Glycolysis↓, cycD1/CCND1↓, CDK4↓, ECAR↓, TumCCA↑, HK1↓, ALDH↓, ALDOA↓, PKM2↓, Hif1a↓,
2290- Ba,    Research Progress of Scutellaria baicalensis in the Treatment of Gastrointestinal Cancer
- Review, GI, NA
p‑mTOR↓, p‑Akt↓, p‑IKKα↓, NF-kB↓, PI3K↓, Akt↓, ROCK1↓, GSK‐3β↓, CycB/CCNB1↓, cycD1/CCND1↓, cycA1/CCNA1↑, CDK4↓, P53↑, P21↑, TumCCA↑, MMP2↓, MMP9↓, EMT↓, Hif1a↓, Shh↓, PD-L1↓, STAT3↓, IL1β↓, IL2↓, IL6↓, PKM2↓, HDAC10↓, P-gp/ABCB1↓, Bcl-xL↓, eff↓, BioAv↓, BioAv↑,
1379- BBR,    Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells
- in-vitro, lymphoma, NA
TumCP↓, CDK4↓, CDK6↓, cycD1/CCND1↓, TumCCA↑, MMP↓, Ca+2↑, ATP↓, mtDam↑, Apoptosis↑, ROS↑, JNK↑, eff↓,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2686- BBR,    Effects of resveratrol, curcumin, berberine and other nutraceuticals on aging, cancer development, cancer stem cells and microRNAs
- Review, Nor, NA
Inflam↓, IL6↓, MCP1/CCL2↓, COX2/PTGS2↓, PGE2↓, MMP2↓, MMP9↓, DNAdam↑, eff↝, Telomerase↓, Bcl-2↓, AMPK↑, ROS↑, MMP↓, ATP↓, p‑mTORC1↓, p‑S6K↓, ERK↓, PI3K↓, PTEN↑, Akt↓, Raf↓, MEK↓, Dose↓, Dose↑, selectivity↑, TumCCA↑, eff↑, EGFR↓, Glycolysis↓, Dose?, p27/CDKN1B↑, CDK2↓, CDK4↓, cycD1/CCND1↓, cycE/CCNE↓, Bax:Bcl2↑, Casp3↑, Casp9↑, VEGFR2/KDR/Flk1↓, ChemoSen↑, eff↑, eff↑, PGE2↓, JAK2↓, STAT3↓, CXCR4↓, CCR7↓, uPA↓, CSCs↓, EMT↓, Diff↓, CD133↓, Nestin↓, n-MYC↓, NOTCH↓, SOX2↓, Hif1a↓, VEGF↓, RadioS↑,
5178- BBR,    Berberine, a natural product, induces G1-phase cell cycle arrest and caspase-3-dependent apoptosis in human prostate carcinoma cells
- in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, P21↑, p27/CDKN1B↑, Apoptosis↑, Bax:Bcl2↑, MMP↓, Casp9↑, Casp3↑, PARP↑, DNAdam↑, selectivity↑, Cyt‑c↑,
5639- BCA,    Biochanin A Induces Apoptosis in MCF-7 Breast Cancer Cells through Mitochondrial Pathway and Pi3K/AKT Inhibition
- in-vitro, BC, NA
TumCP↓, ROS↑, Apoptosis↑, Bcl-2↓, p‑PI3K↓, p‑Akt↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑, CycD3↓, CycB/CCNB1↓, CDK1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, P53↑, tumCV↓, PI3K↓, Akt↓,
2765- BetA,    Unveiling Betulinic Acid as a Potent CDK4 Inhibitor for Cancer Therapeutics
- in-vitro, Lung, A549
CDK4↓,
5721- BF,    Bufalin Suppresses Triple-Negative Breast Cancer Stem Cell Growth by Inhibiting the Wnt/β-Catenin Signaling Pathway
- in-vitro, BC, NA
CSCs↓, TumCCA↑, cMyc↓, cycD1/CCND1↓, CDK4↓, MMP↓, Casp↑, CD133↓, CD44↓, ALDH1A1↓, Nanog↓, OCT4↓, SOX2↓, Wnt↓, β-catenin/ZEB1↓, EGFR↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
1427- Bos,    Acetyl-keto-β-boswellic acid inhibits cellular proliferation through a p21-dependent pathway in colon cancer cells
- in-vitro, CRC, HT-29 - in-vitro, CRC, HCT116 - in-vitro, CRC, LS174T
TumCG↓, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, P21↑,
1426- Bos,  CUR,  Chemo,    Novel evidence for curcumin and boswellic acid induced chemoprevention through regulation of miR-34a and miR-27a in colorectal cancer
- in-vivo, CRC, NA - in-vitro, CRC, HCT116 - in-vitro, CRC, RKO - in-vitro, CRC, SW480 - in-vitro, RCC, SW-620 - in-vitro, RCC, HT-29 - in-vitro, CRC, Caco-2
miR-34a↑, miR-27a-3p↓, TumCG↓, BAX↑, Bcl-2↓, PARP1↓, TumCCA↑, Apoptosis↑, cMyc↓, CDK4↓, CDK6↓, cycD1/CCND1↓, ChemoSen↑, miR-34a↑, miR-27a-3p↓,
1450- Bos,  Cisplatin,    3-Acetyl-11-keto-β-boswellic acid (AKBA) induced antiproliferative effect by suppressing Notch signaling pathway and synergistic interaction with cisplatin against prostate cancer cells
- in-vitro, Pca, DU145
ROS↑, MMP↓, Casp↑, Apoptosis↑, Bax:Bcl2↑, TumCCA?, cycD1/CCND1↓, CDK4↓, P21↑, p27/CDKN1B↑, NOTCH↓, ChemoSen↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5847- CAP,    An updated review on molecular mechanisms underlying the anticancer effects of capsaicin
- in-vitro, Liver, HepG2
HO-1↑, ROS↑, NRF2↑, *lipid-P↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *PGE2↓, *COX2/PTGS2↓, *iNOS↓, TumCP↓, TumCCA↑, cycE/CCNE↓, CDK4↓, MMP↓, P53↑, P21↑, BAX↑, SIRT1↑, angioG↓, P-gp/ABCB1↓, ChemoSen↑,
2016- CAP,    Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)
HSP90↓, ATPase↓, eff↑, HSP70/HSPA5↓, other↝, NF-kB↓, EGFR↓, CDK4↓, Src↓, VEGF↓, PI3K↓, Akt↓,
5761- CAPE,    Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of AMPK and Akt signaling networks
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCCA↑, AMPK↓, NF-kB↓, β-catenin/ZEB1↓, CREB↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓,
5887- CAR,  TV,    Antitumor Effects of Carvacrol and Thymol: A Systematic Review
- Review, Var, NA
Apoptosis↑, TumCCA↑, TumMeta↓, TumCP↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, eff↑, *Inflam↓, *antiOx↑, AXL↓, MDA↑, Casp3↑, Bcl-2↓, MMP2↓, MMP9↓, p‑JNK↑, BAX↑, MDA↓, TRPM7↓, MMP↓, Cyt‑c↑, Casp↑, cl‑PARP↑, ROS↑, CDK4↓, P21↑, F-actin↓, GSH↓, *SOD↑, *Catalase↑, *GPx↑, *GSR↑, *GSH↑, *lipid-P↓, *AST↓, *ALAT↓, *ALP↓, *LDH↓, DNAdam↑, AFP↓, VEGF↓, Weight↑, *chemoP↑, ROS↑,
5882- CAR,    Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells
- in-vitro, BC, MCF7
tumCV↓, TumCCA↑, pRB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, PI3K↓, p‑Akt↓, Apoptosis↑, Bcl-2↓, BAX↑,
5888- CAR,    Therapeutic application of carvacrol: A comprehensive review
- Review, Var, NA - Review, Stroke, NA - Review, Diabetic, NA - Review, Park, NA
*antiOx↑, *AntiCan↑, *AntiDiabetic↑, *cardioP↑, *Obesity↓, *hepatoP↑, *AntiAg↑, *Bacteria↓, *Imm↑, MMP2↓, MMP9↓, Apoptosis↓, MMP↓, ERK↓, PI3K↓, ALAT↓, *ROS↓, *Catalase↑, *SOD↑, *GPx↑, *AST↓, *LDH↓, *necrosis↓, ROS↑, TumCCA↑, CDK4↓, cycD1/CCND1↓, NOTCH↓, IL6↓, chemoP↑, *Pain↓, *neuroP↑, *TRPM7↓, *motorD↑, *NF-kB↓, *COX2/PTGS2↓, *MDA↓,
5944- Cela,    HSP90 inhibitor, celastrol, arrests human monocytic leukemia cell U937 at G0/G1 in thiol-containing agents reversible way
- in-vitro, AML, U937
TumCP↓, TumCCA↑, TumCD↑, HSP90↓, HSP70/HSPA5↑, cycD1/CCND1↓, CDK4↓, CDK6↓, ATPase↓,
5950- Cela,    Anticancer Inhibitors of Hsp90 Function: Beyond the Usual Suspects
- Review, Var, NA
ChemoSen↑, HSP90↓, Akt↓, CDK4↓,
6615- Cen,    Asiaticoside suppresses cell proliferation by inhibiting the NF-κB signaling pathway in colorectal cancer
- vitro+vivo, CRC, HCT116 - in-vitro, CRC, SW480 - in-vitro, CRC, LoVo
Dose↝, TumCP↓, selectivity↑, MMP↓, Apoptosis↑, TumCCA↑, NF-kB↓, CDK4↓, cycD1/CCND1↓, Casp9↑, Casp3↑, Bax:Bcl2↑, TumCG↓, ChemoSen↑, TNF-α↓, IL1β↓, P53↑, P21↑,
6652- Cen,    AA-PMe, a novel asiatic acid derivative, induces apoptosis and suppresses proliferation, migration, and invasion of gastric cancer cells
- in-vitro, GC, SGC-7901 - in-vitro, GC, HGC27
TumCP↓, selectivity↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, Apoptosis↑, Bcl-2↓, BAX↑, cMyc↓, Casp3↑, TumCMig↓, TumCI↓, MMP2↓, MMP9↓, tumCV↓,
6129- CHr,    A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases
- vitro+vivo, Melanoma, NA
ATP↓, TumCCA↑, CDK2↓, CDK4↓, TumW↓,
2784- CHr,    Chrysin targets aberrant molecular signatures and pathways in carcinogenesis (Review)
- Review, Var, NA
Apoptosis↑, TumCMig↓, *toxicity↝, ChemoSen↑, *BioAv↓, Dose↝, neuroP↑, *P450↓, *ROS↓, *HDL↑, *GSTs↑, *SOD↑, *Catalase↑, *MAPK↓, *NF-kB↓, *PTEN↑, *VEGF↑, ROS↑, MMP↓, Ca+2↑, selectivity↑, PCNA↓, Twist↓, EMT↓, CDKN1C/p57↑, p‑STAT3↑, MMP2↓, MMP9↓, eff↑, cycD1/CCND1↓, hTERT/TERT↓, CLDN1↓, TumVol↓, OS↑, COX2/PTGS2↓, eff↑, CDK2↓, CDK4↓, selectivity↑, TumCCA↑, E-cadherin↑, HK2↓, HDAC↓,
1145- CHr,    Chrysin inhibits propagation of HeLa cells by attenuating cell survival and inducing apoptotic pathways
- in-vitro, Cerv, HeLa
tumCV↓, BAX↑, BID↑, BOK↑, APAF1↑, TNF-α↑, FasL↑, Fas↑, FADD↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Mcl-1↓, NAIP↓, Bcl-2↓, CDK4↓, CycB/CCNB1↓, cycD1/CCND1↓, cycE1↓, TRAIL↑, p‑Akt↓, Akt↓, mTOR↓, PDK1 / PDPK1↓, BAD↓, GSK‐3β↑, AMPK↑, p27/CDKN1B↑, P53↑,
6140- Cin,  HCAs,    Cinnamaldehyde: Pharmacokinetics, anticancer properties and therapeutic potential (Review)
- Review, Var, NA
Dose↝, TumCP↓, TumCCA↑, Apoptosis↑, TumCMig↓, TumCI↓, angioG↓, *Inflam↓, *antiOx↑, *Bacteria↓, *AntiThr↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, AntiCan↑, ChemoSen↑, *BioAv↝, *BioAv↑, eff↑, CDK1↓, CDK2↓, CDK4↓, cJun↓, cFos↓, Apoptosis↑, PI3K↓, Akt↓, E-cadherin↑, MMP2↓, MMP9↓, TOP1↓, BRCA1↓, ROS↑, BAX↑, Bcl-2↓, XIAP↓, MMP↓, STAT3↓, mTOR↓, NF-kB↓, eff↑, toxicity↓, cardioP↑,
7425- CS,    Artichoke as a melanoma growth inhibitor
- in-vitro, Melanoma, NA
AntiCan↑, tumCV↓, PCNA↓, Casp3↑, P21↑, p27/CDKN1B↑, CDK4↓, survivin↓, TumCP↓, Apoptosis↑,
6201- Cuc,    Cucurbitacin B and Its Derivatives: A Review of Progress in Biological Activities
- Review, Var, NA - Review, AD, NA
*toxicity↑, *antiOx↑, *Inflam↓, *NLRP3↓, *NF-kB↓, *neuroP↑, *memory↑, *GABA↑, *cardioP↑, AntiTum↑, p‑FAK↓, ROS↑, TumMeta↑, TumCP↓, Apoptosis↑, P53↑, P21↑, TumCCA↑, p27/CDKN1B↑, CDK4↓, CDK2↓, cycD1/CCND1↓, cycE/CCNE↓, STAT3↓, ChemoSen↑, MMP2↓, MMP9↓, VEGF↓, TumCMig↓, angioG↓, NOTCH↓, EMT↓, toxicity↑, BioAv↑, EPR↑,
6216- CUR,    Role of Turmeric and Curcumin in Prevention and Treatment of Chronic Diseases: Lessons Learned from Clinical Trials
- Review, Var, NA
TumCG↓, angioG↓, EMT↓, TumCI↓, TumMeta↓, *GutMicro↑, *BioAv↓, *HO-1↑, *ROS↓, *COX2/PTGS2↓, *iNOS↓, PKCδ↓, EGFR↓, NF-kB↓, cJun↓, cFos↓, cMyc↓, Akt↓, PI3K↓, CDK4↓, *TNF-α↓, *CRP↓, *IL6↓, MMP9↓, VEGF↓, JAK↓, STAT↓, IL1↓, IL2↓, IL6↓, IL8↓, IL12↓, MCP1/CCL2↓, Apoptosis↑, ER Stress↑, 5LO↓, XO↓, *NRF2↑, *HO-1↑, *AChE↓, *neuroP↑, *glucose↓, *GLUT2↑, *GLUT3↑, *GLUT4↑, *GlucoseCon↑, *AMPK↑, *BMD↑, *MDA↓, *eff↑, eff↑, P53↑, BAX↑, DNAdam↑, Bcl-2↓, CSCs↓, ALDH↓, CD133↑,
6671- Deg,    A Novel Derivative of the Natural Agent Deguelin for Cancer Chemoprevention and Therapy
- in-vitro, Nor, BEAS-2B - in-vitro, Lung, H1299 - in-vitro, Lung, H460
HSP90↓, toxicity↝, eff↑, chemoPv↑, p53 Wildtype↓, CDK4↓, MAPK↓, Hif1a↓, selectivity↑, compI↓, TumCP↓, BioAv↑,
6801- EA,    A radiotherapeutic paradox: ellagic acid sensitizes tumors while attenuating radiation-induced myocardial injury
- vitro+vivo, BC, 4T1
TumCCA↑, CDK4↓, RadioS↑, TumCG↓, *radioP↑, *cardioP↑, *antiOx↑, *ROS↓, Dose↑, selectivity↑, BioAv↓,
1613- EA,    Ellagitannins in Cancer Chemoprevention and Therapy
- Review, Var, NA
ROS↑, angioG↓, ChemoSen↑, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, CDK2↓, CDK4↓, CDK6↓, cycD1/CCND1↓, cycE1↓, TumCG↓, VEGF↓, Hif1a↓, eff↑, COX2/PTGS2↓, TumCCA↑, selectivity↑, Wnt/(β-catenin)↓, *toxicity∅,
3238- EGCG,    Green tea catechin, epigallocatechin-3-gallate (EGCG): mechanisms, perspectives and clinical applications
- Review, Var, NA
Telomerase↓, DNMTs↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, CDK6↓, HATs↓, HDAC↓, selectivity↑, uPA↓, NF-kB↓, TNF-α↓, *ROS↓, *antiOx↑, Hif1a↓, VEGF↓, MMP2↓, MMP9↓, FAK↓, TIMP2↑, Mcl-1↓, survivin↓, XIAP↓, PCNA↓, p16↑, P21↑, p27/CDKN1B↑, pRB↑, P53↑, MDM2↑, ROS↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Diablo↑, BAX⇅, cl‑PPARα↓, PDGF↓, EGFR↓, FOXO↑, AP-1↓, JNK↓, COX2/PTGS2↓, angioG↓,
6389- Eug,    Molecular Insights into the Management of Eugenol's Anticancer Action Against Colon Cancer: A Detailed Review
- Review, Colon, NA
Apoptosis↓, TumCCA↓, Inflam↓, TumMeta↓, BioAv↑, eff↓, Half-Life↓, *ROS↓, *RNS↓, *SOD↓, *Catalase↑, *GSTs↑, *MAOA↓, *neuroP↑, *DNAdam↓, Apoptosis↑, ROS↑, selectivity↑, MMP↓, Cyt‑c↓, Casp3↑, Casp9↑, TumCD↑, BAX↑, BAD↑, APAF1↑, Bcl-2↓, Bcl-xL↓, P53↑, cl‑PARP↑, TumCCA↑, cycD1/CCND1↓, CycB/CCNB1↓, CDK2↓, CDK4↓, P21↑, p27/CDKN1B↑, NF-kB↓, COX2/PTGS2↓, PGE2↓, MAPK↓, PI3K↓, Akt↓, mTOR↓, MMPs↓, EMT↓, Snail↓, Slug↓, Zeb1↓, E-cadherin↑, ChemoSen↑,

Showing Research Papers: 1 to 50 of 134
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 134

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AFAP1-AS1↓, 1,   CD47↓, 1,   E2F4↑, 1,   FBXO5/EMI1↓, 1,   LIMK1↓, 1,   miR-124-3p↓, 1,   miR-195↑, 1,   miR-545↑, 1,   NA↑, 1,   PFS↑, 1,   TFE3↑, 1,   TRADD↑, 1,   URGCP/URG4↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   ATF3↑, 1,   Catalase↓, 1,   Catalase↑, 1,   compI↓, 3,   CYP1A1↓, 2,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 7,   GSH↑, 3,   GSR↑, 1,   GSTs↓, 1,   GSTs↑, 1,   GSTs↝, 1,   HK1↓, 1,   HO-1↓, 1,   HO-1↑, 9,   ICD↑, 1,   Keap1↓, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 2,   MDA↓, 2,   MDA↑, 2,   MPO↓, 1,   NADH↓, 1,   NOX4↓, 1,   NQO1↑, 3,   NRF2↓, 3,   NRF2↑, 12,   PARK2↑, 1,   Prx4↑, 1,   PYCR1↓, 1,   ROS↓, 10,   ROS↑, 58,   ROS⇅, 2,   i-ROS↓, 1,   i-ROS↑, 1,   mt-ROS↑, 1,   SIRT3↑, 3,   SOD↓, 4,   SOD↑, 3,   SOD1↑, 1,   SOD2↑, 2,   Trx↓, 1,   TrxR↓, 2,  

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1,   IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 4,   ATP↓, 6,   BOK↑, 2,   CDC2↓, 7,   CDC25↓, 7,   EGF↓, 2,   FGFR1↓, 3,   MEK↓, 2,   mitResp↓, 2,   MMP↓, 40,   MPT↑, 1,   mtDam↑, 9,   OCR↓, 1,   OCR↑, 1,   PGC-1α↑, 1,   PINK1↑, 1,   Raf↓, 3,   c-Raf↓, 1,   XIAP↓, 14,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ACC↑, 3,   AKT1↓, 2,   ALAT↓, 3,   ALDOA↓, 1,   AMP↑, 1,   AMPK↓, 2,   AMPK↑, 9,   AMPK↝, 1,   ATG7↑, 3,   CAIX/CA9↓, 1,   CAIX/CA9↑, 1,   cMyc↓, 24,   CREB↓, 1,   ECAR↓, 2,   FASN↓, 1,   glucoNG↓, 1,   GlucoseCon↓, 4,   Glycolysis↓, 8,   H2S↑, 1,   Histones↑, 1,   HK2↓, 3,   IDO1↓, 1,   lactateProd↓, 2,   LDH↓, 1,   LDHA↓, 1,   LDL↓, 1,   NADPH↓, 2,   NADPH↑, 2,   PCK1↓, 1,   PDK1 / PDPK1↓, 1,   PKM2↓, 5,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 4,   p‑S6K↓, 1,   SCD1↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   SREBP1/SREBF1↓, 1,   STK11/LKB1↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 49,   Akt↑, 1,   p‑Akt↓, 12,   APAF1↑, 3,   Apoptosis↓, 3,   Apoptosis↑, 51,   BAD↓, 1,   BAD↑, 4,   Bak↑, 4,   BAX↓, 2,   BAX↑, 40,   BAX⇅, 1,   Bax:Bcl2↑, 13,   Bcl-2↓, 44,   Bcl-xL↓, 9,   BID↓, 1,   BID↑, 5,   p‑BID↓, 1,   BIM↑, 4,   Casp↑, 12,   Casp1↓, 1,   Casp1↑, 1,   Casp10↓, 1,   Casp12↑, 1,   cl‑Casp12↑, 1,   Casp2↑, 1,   Casp3↓, 1,   Casp3↑, 52,   cl‑Casp3↑, 8,   Casp7↑, 7,   cl‑Casp7↑, 3,   Casp8↓, 1,   Casp8↑, 17,   cl‑Casp8↑, 3,   proCasp8↑, 1,   Casp9↑, 38,   cl‑Casp9↑, 6,   CBP↓, 1,   cFLIP↓, 1,   Chk2↓, 1,   Chk2↑, 3,   CK2↓, 5,   Cyt‑c↓, 1,   Cyt‑c↑, 38,   Diablo↑, 10,   DR4↑, 3,   DR5↑, 12,   FADD↑, 3,   Fas↑, 12,   FasL↑, 1,   Ferroptosis↑, 1,   HEY1↓, 1,   Hippo↓, 1,   hTERT/TERT↓, 4,   IAP1↓, 2,   IAP1↑, 1,   IAP2/BIRC3↓, 3,   cl‑IAP2/BIRC3↑, 1,   ICAD↑, 1,   iNOS↓, 3,   JNK↓, 3,   JNK↑, 10,   p‑JNK↓, 1,   p‑JNK↑, 1,   MAPK↓, 15,   MAPK↑, 6,   Mcl-1↓, 12,   Mcl-1↑, 1,   p‑Mcl-1↓, 1,   MDM2↓, 5,   MDM2↑, 1,   Myc↓, 2,   NAIP↓, 2,   NOXA↑, 2,   p27/CDKN1B↓, 3,   p27/CDKN1B↑, 32,   p38↓, 3,   p38↑, 9,   p‑p38↓, 1,   PUMA↑, 3,   survivin↓, 17,   Telomerase↓, 8,   TRAIL↑, 4,   TRAILR↑, 1,   TRPV1↑, 1,   TumCD↑, 5,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

EF-1α↓, 1,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   p70S6↓, 1,   Sp1/3/4↓, 5,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 7,   cJun↑, 2,   p‑cJun↑, 1,   EZH2↓, 3,   H3↑, 2,   p‑H3↓, 1,   ac‑H3↑, 1,   H4↑, 1,   ac‑H4↑, 1,   HATs↓, 2,   HATs↑, 2,   miR-27a-3p↓, 2,   miR-30a-5p↑, 1,   other↑, 1,   other↝, 1,   PCAF↓, 1,   pRB↓, 2,   pRB↑, 2,   p‑pRB↓, 2,   tumCV↓, 14,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 7,   cl‑CHOP/DDIT3↑, 1,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↓, 1,   ER Stress↑, 14,   GRP78/BiP↓, 1,   GRP78/BiP↑, 6,   HSF1↓, 1,   HSP27↓, 3,   HSP27↑, 1,   HSP27↝, 1,   HSP70/HSPA5↓, 7,   HSP70/HSPA5↑, 1,   HSP70/HSPA5↝, 1,   HSP90↓, 8,   HSPs↓, 1,   IRE1↑, 3,   PERK↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 2,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 6,   BNIP3↑, 2,   LC3‑Ⅱ/LC3‑Ⅰ↓, 1,   LC3II↓, 1,   LC3II↑, 6,   LC3s↑, 1,   p62↓, 1,   p62↑, 2,   TumAuto↑, 4,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 5,   ATR↑, 2,   BRCA1↓, 1,   BRCA1↑, 2,   p‑BRCA1↑, 1,   BRCA2↑, 1,   CHK1↓, 1,   CHK1↑, 3,   CYP1B1↑, 1,   DNAdam↑, 21,   DNArepair↑, 1,   DNMT1↓, 1,   DNMTs↓, 3,   p16↑, 3,   P53?, 1,   P53↓, 1,   P53↑, 43,   p‑P53↓, 1,   p‑P53↑, 2,   p53 Wildtype↓, 1,   PARP↑, 5,   cl‑PARP↑, 32,   PARP1↓, 1,   PARP1↑, 1,   PCNA↓, 11,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↑, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 8,   CDK2↓, 67,   CDK4↓, 135,   p‑CDK4↓, 1,   cycA1/CCNA1↓, 9,   cycA1/CCNA1↑, 2,   CycB/CCNB1↓, 16,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 95,   p‑cycD1/CCND1↓, 1,   CycD3↓, 5,   cycE/CCNE↓, 40,   cycE/CCNE↑, 3,   cycE1↓, 2,   E2Fs↓, 4,   mitA↓, 1,   P21?, 1,   P21↓, 2,   P21↑, 59,   RB1↓, 1,   RB1↑, 3,   p‑RB1↓, 7,   Securin↓, 1,   TumCCA?, 1,   TumCCA↓, 3,   TumCCA↑, 100,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 2,   ALDH1A1↓, 2,   CD133↓, 4,   CD133↑, 1,   CD44↓, 4,   cFos↓, 8,   cMET↓, 2,   CSCs↓, 14,   Diff↓, 1,   EMT↓, 27,   ERK↓, 16,   ERK↑, 1,   p‑ERK↓, 4,   FGF↓, 1,   FGFR2↓, 1,   FOXM1↓, 3,   FOXO↑, 2,   FOXO3↓, 1,   FOXO3↑, 2,   p‑FOXO3↓, 1,   Gli↓, 1,   Gli1↓, 1,   GSK‐3β↓, 4,   GSK‐3β↑, 2,   p‑GSK‐3β↓, 1,   HDAC↓, 10,   HDAC1↓, 2,   HDAC10↓, 1,   HDAC2↓, 1,   HDAC3↓, 1,   HH↓, 3,   IGF-1↓, 5,   IGF-1R↓, 1,   IGFBP3↑, 2,   Let-7↑, 1,   miR-34a↑, 4,   mTOR↓, 27,   mTOR↝, 1,   p‑mTOR↓, 4,   mTORC1↓, 6,   p‑mTORC1↓, 1,   mTORC2↓, 3,   n-MYC↓, 1,   Nanog↓, 5,   Nestin↓, 2,   NOTCH↓, 7,   NOTCH1↓, 2,   NOTCH3↓, 1,   OCT4↓, 5,   p300↓, 1,   P70S6K↓, 1,   PI3K↓, 40,   p‑PI3K↓, 2,   PTCH1↓, 1,   PTEN↓, 1,   PTEN↑, 6,   RAS↓, 6,   Shh↓, 2,   SOX2↓, 5,   Src↓, 1,   STAT↓, 2,   STAT1↓, 1,   STAT3↓, 23,   p‑STAT3↓, 7,   p‑STAT3↑, 1,   STAT5↓, 1,   STAT6↓, 3,   TCF↑, 1,   TCF↝, 1,   TCF-4↓, 2,   TOP1↓, 3,   TOP2↓, 4,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 22,   TumCG↑, 1,   tyrosinase↓, 2,   Wnt↓, 14,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   Akt2↓, 1,   AntiAg↑, 1,   AP-1↓, 9,   ATPase↓, 2,   AXL↓, 2,   CA↓, 1,   Ca+2↓, 1,   Ca+2↑, 16,   i-Ca+2↑, 1,   CAFs/TAFs↓, 1,   cal2↑, 1,   Cdc42↑, 1,   CDKN1C/p57↑, 1,   CLDN1↓, 1,   Cofilin↓, 1,   DLC1↑, 1,   E-cadherin↓, 3,   E-cadherin↑, 20,   ER-α36↓, 2,   F-actin↓, 1,   FAK↓, 4,   p‑FAK↓, 1,   Fibronectin↓, 2,   GIT1↓, 1,   ITGA5↓, 1,   ITGB4↓, 1,   Ki-67↓, 6,   KRAS↓, 1,   MALAT1↓, 1,   MARK4↓, 1,   MET↓, 1,   miR-200b↑, 1,   miR-203↑, 1,   MMP1↓, 3,   MMP13↓, 2,   MMP2↓, 37,   MMP3↓, 2,   MMP7↓, 8,   MMP9↓, 43,   MMP9↑, 1,   MMPs↓, 11,   N-cadherin↓, 10,   PAK1↑, 1,   PDGF↓, 5,   PKCδ↓, 4,   Rho↓, 1,   Rho↑, 1,   ROCK1↓, 1,   ROCK1↑, 1,   Slug↓, 7,   Smad1↑, 1,   Snail?, 1,   Snail↓, 9,   SOX4↓, 1,   SOX4↑, 1,   TET1↓, 1,   TGF-β↓, 5,   TIMP1↑, 2,   TIMP2↑, 2,   Treg lymp↓, 1,   TumCA↓, 1,   TumCI↓, 23,   TumCI↑, 1,   TumCMig↓, 25,   TumCMig↑, 1,   TumCP↓, 51,   TumCP↑, 1,   TumMeta↓, 25,   TumMeta↑, 2,   Twist↓, 10,   uPA↓, 16,   VCAM-1↓, 1,   Vim↓, 15,   Zeb1↓, 9,   ZEB2↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 17,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 33,   ATF4↓, 2,   ATF4↑, 6,   ATF4↝, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   eNOS↓, 1,   EPR↑, 1,   HIF-1↓, 2,   Hif1a↓, 22,   LOX1↓, 1,   NO↓, 2,   NO↑, 1,   PDGFR-BB↓, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 43,   VEGFR2/KDR/Flk1↓, 5,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 3,   GLUT1↑, 1,   GLUT3↑, 1,   NHE1↓, 1,   P-gp/ABCB1↓, 9,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↑, 1,   CCR7↓, 1,   CD4+↑, 1,   COX2/PTGS2↓, 37,   CXCL1↓, 1,   CXCR4↓, 6,   FOXP3↓, 2,   ICAM-1↓, 2,   IFN-γ↓, 1,   IKKα↓, 5,   p‑IKKα↓, 1,   IL1↓, 4,   IL10↓, 1,   IL10↑, 1,   IL12↓, 3,   IL1α↓, 1,   IL1β↓, 4,   IL2↓, 2,   IL2↑, 1,   IL4↓, 1,   IL4↑, 1,   IL6↓, 15,   IL6↑, 1,   IL8↓, 7,   Imm↑, 1,   Inflam↓, 10,   JAK↓, 1,   JAK1↓, 2,   JAK2↓, 7,   p‑JAK2↓, 1,   M2 MC↓, 1,   MCP1/CCL2↓, 3,   MIP2↓, 1,   NF-kB↓, 57,   NF-kB↑, 2,   p‑NF-kB↓, 1,   NK cell↑, 2,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   ac‑p65↓, 1,   PD-L1↓, 3,   PD-L1↑, 1,   PGE2↓, 12,   PSA↓, 8,   PSA∅, 1,   T-Cell↑, 1,   Th1 response↑, 1,   TLR4↓, 1,   TNF-α↓, 11,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,   XO↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 9,   CDK6↓, 38,   CDK6↑, 3,   GR↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 18,   BioAv↑, 16,   BioAv↝, 2,   BioEnh↑, 4,   ChemoSen↓, 1,   ChemoSen↑, 42,   Dose?, 1,   Dose↓, 1,   Dose↑, 5,   Dose↝, 13,   Dose∅, 1,   eff↓, 7,   eff↑, 69,   eff↝, 7,   Half-Life↓, 7,   Half-Life↝, 6,   MDR1↓, 1,   MRP1/ABCC1↓, 1,   P450↓, 1,   P450↝, 1,   RadioS↑, 15,   selectivity?, 1,   selectivity↑, 35,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 1,   AR↓, 9,   ascitic↓, 1,   AST↓, 2,   BMPs↑, 1,   BRCA1↓, 1,   BRCA1↑, 2,   p‑BRCA1↑, 1,   E6↓, 1,   E7↓, 1,   EGFR↓, 18,   p‑EGFR↓, 1,   EZH2↓, 3,   Ferritin↓, 1,   FOXM1↓, 3,   GutMicro↑, 2,   HER2/EBBR2↓, 4,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 4,   IL6↓, 15,   IL6↑, 1,   Ki-67↓, 6,   KRAS↓, 1,   LDH↓, 1,   Myc↓, 2,   PD-L1↓, 3,   PD-L1↑, 1,   PSA↓, 8,   PSA∅, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1,   AntiCan↑, 19,   AntiTum↑, 3,   cardioP↑, 4,   CardioT↓, 1,   chemoP↑, 7,   chemoPv↑, 7,   ChemoSideEff↓, 3,   hepatoP↑, 4,   neuroP↑, 4,   NP/CIPN↓, 2,   OS↑, 5,   QoL↑, 2,   radioP↑, 2,   RenoP↑, 3,   Risk↓, 2,   toxicity↓, 6,   toxicity↑, 2,   toxicity↝, 2,   toxicity∅, 2,   TumVol↓, 7,   TumW↓, 5,   Weight↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,  
Total Targets: 648

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

compII↑, 1,   Stroke↓, 1,   TPH1↓, 1,   β-HEX↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 26,   Catalase↑, 12,   Ferroptosis↓, 1,   GPx↓, 1,   GPx↑, 6,   GSH↑, 10,   GSR↑, 2,   GSTs↑, 2,   HDL↓, 1,   HDL↑, 1,   HO-1↑, 9,   Keap1↑, 1,   lipid-P↓, 8,   MDA↓, 7,   MPO↓, 2,   NQO1↑, 2,   Nrf1↑, 1,   NRF2↑, 13,   Prx↑, 1,   RNS↓, 1,   ROS?, 1,   ROS↓, 22,   SIRT3↑, 1,   SOD↓, 1,   SOD↑, 11,   SOD1↑, 1,   SOD2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 1,   compIII↑, 1,   MMP↑, 2,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC↓, 1,   ALAT↓, 5,   AMPK↑, 3,   p‑AMPK↑, 1,   p‑cMyc↑, 1,   FASN↓, 1,   glucose↓, 1,   GlucoseCon↑, 1,   GLUT2↑, 1,   LDH↓, 2,   LDHA↑, 1,   LDL↓, 2,   PPARγ↑, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 1,   Casp12↓, 1,   Casp3?, 1,   Casp3↓, 1,   cl‑Casp8↑, 1,   Cyt‑c↓, 1,   Fas↓, 1,   Ferroptosis↓, 1,   GranB/GZMB↓, 1,   IAP1↓, 1,   iNOS↓, 6,   p‑JNK↓, 1,   MAPK↓, 3,   MAPK↑, 1,   necrosis↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↑, 1,   other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   HSP27↓, 1,   HSP70/HSPA5↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,   LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,   p16↓, 1,   P53↓, 1,   PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,   P21↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1,   ERK↓, 2,   ERK↑, 1,   GSK‐3β↓, 2,   mTOR↓, 1,   PI3K↓, 1,   PI3K↑, 1,   PTEN↑, 1,   STAT3↓, 1,   TRPM7↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 4,   APP↓, 1,   Ca+2↓, 1,   Ca+2↝, 1,   Ki-67↓, 1,   MMP2↑, 1,   MMP9↓, 2,   PKCδ↓, 1,   Rho↓, 1,   ROCK1↓, 1,   TGF-β↓, 1,   TGF-β↑, 1,   TIMP1↓, 1,   α-SMA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   ATF4↓, 1,   Hif1a↓, 1,   NO↓, 1,   VEGF↓, 2,   VEGF↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   GLUT3↑, 1,   GLUT4↑, 1,   IBI↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 9,   CRP↓, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IFN-γ↑, 1,   IL10↓, 2,   IL10↑, 1,   IL17↓, 2,   IL1β↓, 5,   IL22↓, 1,   IL23↓, 1,   IL4↓, 1,   IL5↓, 1,   IL6↓, 7,   IL8↓, 2,   Imm↑, 2,   Inflam↓, 24,   LPS↓, 1,   MCP1/CCL2↓, 2,   NF-kB↓, 10,   PGE2↓, 4,   TLR4↓, 2,   TNF-α↓, 7,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,   AChE↓, 2,   GABA↑, 1,   MAOA↓, 1,   tau↓, 2,  

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 5,   BACE/β-secretase↓, 1,   NLRP3↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv?, 1,   BioAv↓, 11,   BioAv↑, 2,   BioAv↝, 2,   Dose↑, 1,   Dose↝, 4,   eff↑, 2,   Half-Life↑, 1,   Half-Life∅, 1,   P450↓, 1,   P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 5,   ALP↓, 1,   AST↓, 6,   BMD↑, 1,   BP↓, 1,   creat↓, 1,   CRP↓, 1,   GutMicro↑, 5,   IL6↓, 7,   Ki-67↓, 1,   LDH↓, 2,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 2,   AntiArt↑, 1,   AntiCan↑, 4,   AntiDiabetic↑, 4,   AntiP↑, 1,   antiPs↑, 1,   cardioP↑, 10,   chemoP↑, 2,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 8,   memory↑, 5,   motorD↑, 1,   neuroP↑, 20,   Obesity↓, 4,   Pain↓, 2,   radioP↑, 1,   RenoP↑, 2,   Risk↓, 1,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 4,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,   Bacteria↓, 4,   Sepsis↓, 2,  
Total Targets: 205

Scientific Paper Hit Count for: CDK4, Cyclin-dependent kinase 4
13 Fisetin
7 Ferulic acid
6 Honokiol
4 Baicalein
4 Berberine
4 Boswellia (frankincense)
4 Capsaicin
4 Sulforaphane (mainly Broccoli)
4 Lycopene
3 Artemisinin
3 Carvacrol
3 Chrysin
3 Garcinol
3 Luteolin
3 Magnolol
3 Silymarin (Milk Thistle) silibinin
3 Thymoquinone
2 Allicin (mainly Garlic)
2 Apigenin (mainly Parsley)
2 Ashwagandha(Withaferin A)
2 Curcumin
2 Celastrol
2 Centella asiatica / Gotu kola → asiaticoside
2 Ellagic acid
2 Gallic acid
2 HydroxyTyrosol
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 Kaempferol
2 lambertianic acid
2 Propolis -bee glue
2 Piperlongumine
2 Shikonin
1 Anethole/trans-Anethole
1 Fennel Oil/Foeniculum vulgare
1 Astaxanthin
1 Radiotherapy/Radiation
1 Biochanin A
1 Betulinic acid
1 Bufalin/Huachansu
1 Chemotherapy
1 Cisplatin
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Thymol-Thymus vulgaris
1 Cinnamon
1 Hydroxycinnamic-acid
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 Deguelin
1 EGCG (Epigallocatechin Gallate)
1 Eugenol
1 Formononetin
1 Fucoidan
1 Hydrogen Gas
1 Indole-3-carbinol
1 Inulin Prebiotic
1 isoorientin
1 Ivermectin
1 Juglone
1 Licochalcone A
1 Licorice
1 Linalool
1 Melatonin
1 Metformin
1 Nimbolide
1 Orlistat
1 Quercetin
1 Resveratrol
1 Rosmarinic acid
1 Aflavin-3,3′-digallate
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:894  State#:%  Dir#:1
  wNotes=0  sortOrder:rid,rpid

 

Home Page