CRM Cancer Research Results

CRM, Calorie restriction mimetics (CRMs): Click to Expand ⟱
Source:
Type:
Calorie restriction mimetics (CRMs) are compounds that appear to mimic some of the biochemical effects of caloric restriction without the need to actually reduce caloric intake.

-Resveratrol:Known for activating sirtuins (e.g., SIRT1)
-Curcumin
-Quercetin
-EGCG
-Spermidine
-Fisetin
-Berberine
-Pterostilbene
-Hydroxytyrosol
-Sulforaphane
-Cinnamaldehyde
-Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN)
-Alpha-Ketoglutarate (AKG)
-Rapamycin (Sirolimus
Scientific Papers found: Click to Expand⟱
5780- CRMs,  HCAs,  RES,  Sper,  ASA  Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential
- Review, Var, NA
*OS↑, *AntiAge↑, *cardioP↑, *neuroP↑, AntiCan↑, *TNF-α↓, *Weight↓, *BP↓, *Inflam↓, *Insulin↓, *ROS↓, *AMPK↑, *mTOR↓, *SIRT1↑, CRM↑,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
CRM↑, ChemoSen↑, RadioS↑, eff↑, eff↑, IGF-1↓, TumCG↓, AMPK↑, eff↑, ChemoSen↑, RadioS↑, ROS↑, DNAdam↑, eff↑, HO-1↓,
1625- HCA,    In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase
- Review, Nor, NA
CRM↑, ACLY↓, TumAuto↑, Inflam↓, TumCG↓, toxicity∅, lipoGen↓, *ROS↓, *OCR↓,
4895- Sper,    Spermidine as a target for cancer therapy
- Review, Var, NA - Review, AD, NA
TumAuto↑, Apoptosis↑, OS↑, CRM↑, TumCG⇅, cardioP↑, cognitive↑, *Dose⇅,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

HO-1↓, 1,   ROS↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↓, 1,   AMPK↑, 1,   CRM↑, 4,   lipoGen↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   TumCG↓, 2,   TumCG⇅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 2,   eff↑, 4,   RadioS↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   cardioP↑, 1,   cognitive↑, 1,   OS↑, 1,   toxicity∅, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↓, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   SIRT1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

mTOR↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose⇅, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BP↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   cardioP↑, 1,   neuroP↑, 1,   OS↑, 1,   Weight↓, 1,  
Total Targets: 15

Scientific Paper Hit Count for: CRM, Calorie restriction mimetics (CRMs)
2 Spermidine
1 Calorie Restriction Mimetics
1 Hydroxycinnamic-acid
1 Resveratrol
1 Aspirin
1 diet Short Term Fasting
1 diet FMD Fasting Mimicking Diet
1 HydroxyCitric Acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1128  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page