GLS Cancer Research Results

GLS, Glutaminase: Click to Expand ⟱

Source:

Type:

GLS - Glutaminase

Abbreviation: GLS, GLS1, Kidney-Type Glutaminase

Alternative Names: KGA, GAC

Type: Mitochondrial metabolic enzyme / glutamine metabolism enzyme / glutaminolysis regulator

Function: GLS catalyzes the conversion of glutamine to glutamate and ammonia, providing the first major enzymatic step of glutaminolysis. Glutamate can subsequently be converted to α-ketoglutarate to replenish the TCA cycle and can also support glutathione synthesis, amino-acid metabolism, nucleotide synthesis, lipid synthesis, and cellular redox control.

Cancer: ↑ GLS expression and activity are increased in many cancers and support glutamine-dependent proliferation, energy production, anabolic metabolism, redox homeostasis, survival, and treatment resistance.

Favorable Direction in Cancer: ↓ GLS expression or activity is generally favorable in glutamine-dependent cancers and can reduce glutaminolysis, TCA-cycle replenishment, glutathione production, and cancer-cell survival.

Pathway Relationship: GLS ↑ → glutaminolysis ↑ → glutamate ↑ → α-ketoglutarate/TCA-cycle anaplerosis ↑ and glutathione synthesis ↑.

Interpretation Note: GLS should be distinguished from GLS2. GLS generally has a stronger tumor-promoting association, whereas GLS2 can function as either a tumor promoter or tumor suppressor depending on cancer type.

Scientific Papers found: Click to Expand⟱

975-

Est,

Estrogen inhibits autophagy and promotes growth of endometrial cancer by promoting glutamine metabolism

vitro+vivo,

UEC,

GLS↑, cMyc↑, GlutMet↑, tumCV↑, TumAuto↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↑, 1, GLS↑, 1, GlutMet↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↓, 1,
Total Targets: 5

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: GLS, Glutaminase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells