LC3A Cancer Research Results

LC3A, Microtubule-associated protein 1 light chain 3 alpha: Click to Expand ⟱
Source:
Type:
LC3A is one of the isoforms of the LC3 family and plays a critical role in the autophagy pathway.

– Enhanced Autophagy and Tumor Survival: In some cancers, increased LC3A expression (and therefore autophagic activity) is associated with a cytoprotective response, helping tumor cells survive under stress conditions such as hypoxia, nutrient deprivation, or treatment-induced damage. This has been linked in some cases to more aggressive tumor behavior and resistance to therapies.
Scientific Papers found: Click to Expand⟱
2296- Ba,    The most recent progress of baicalein in its anti-neoplastic effects and mechanisms
- Review, Var, NA
CDK1↓, Cyc↓, p27/CDKN1B↑, P21↑, P53↑, TumCCA↑, TumCI↓, MMP2↓, MMP9↓, E-cadherin↑, N-cadherin↓, Vim↓, LC3A↑, p62↓, p‑mTOR↓, PD-L1↓, CAFs/TAFs↓, VEGF↓, ROCK1↓, Bcl-2↓, Bcl-xL↓, BAX↑, ROS↑, cl‑PARP↑, Casp3↑, Casp9↑, PTEN↑, MMP↓, Cyt‑c↑, Ca+2↑, PERK↑, IRE1↑, CHOP/DDIT3↑, Copper↑, Snail↓, Vim↓, Twist↓, GSH↓, NRF2↓, HO-1↓, GPx4↓, XIAP↓, survivin↓, DR5↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Copper↑, 1,   GPx4↓, 1,   GSH↓, 1,   HO-1↓, 1,   NRF2↓, 1,   ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,   XIAP↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   DR5↑, 1,   p27/CDKN1B↑, 1,   survivin↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   IRE1↑, 1,   PERK↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3A↑, 1,   p62↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   Cyc↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑mTOR↓, 1,   PTEN↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   CAFs/TAFs↓, 1,   E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   ROCK1↓, 1,   Snail↓, 1,   TumCI↓, 1,   Twist↓, 1,   Vim↓, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PD-L1↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PD-L1↓, 1,  
Total Targets: 44

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: LC3A, Microtubule-associated protein 1 light chain 3 alpha
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1282  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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