chemoPv Cancer Research Results

chemoPv, ChemoPreventive: Click to Expand ⟱
Source:
Type:
Chemopreventive: An agent that lowers the probability of cancer development or delays progression from premalignant states.
Mechanisms
-Reduce DNA damage / mutagenesis
-Enhance detoxification or repair
-Modulate hormones or inflammation
-Promote differentiation or apoptosis of abnormal cells


Scientific Papers found: Click to Expand⟱
7981- AAS/EEAA,    Chemopreventive Potential of Oils Extracted from Seeds of Three Annona Species
- Review, Var, NA
other↝, chemoPv↑,
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
7400- Amla,    Amla (Emblica officinalis Gaertn), a wonder berry in the treatment and prevention of cancer
- Review, Var, NA
radioP↑, ChemoSen↑, chemoPv↑, *ROS↓, antiOx↑, Inflam↓, Imm↑, *hepatoP↑, *cardioP↑, *lipid-P↓, TumCCA↑, Chk2↑, CDK1↓, CycB/CCNB1↓, CDC25↓, TumMeta↓,
6595- Anamu,    Dibenzyl trisulfide binds to and competitively inhibits the cytochrome P450 1A1 active site without impacting the expression of aryl hydrocarbon receptor
- in-vivo, Nor, NA
CYP1A1↓, CYP1B1↓, chemoPv↑,
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
2639- Api,    Plant flavone apigenin: An emerging anticancer agent
- Review, Var, NA
*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2596- Api,  LT,    Natural Nrf2 Inhibitors: A Review of Their Potential for Cancer Treatment
- Review, Var, NA
NRF2↓, chemoPv↑, ChemoSen↑,
2584- Api,  Chemo,    The versatility of apigenin: Especially as a chemopreventive agent for cancer
- Review, Var, NA
ChemoSen↑, RadioS↑, eff↝, DR5↑, selectivity↑, angioG↓, selectivity↑, chemoP↑, MAPK↓, PI3K↓, Akt↓, mTOR↓, Wnt↓, β-catenin/ZEB1↓, GLUT1↓, radioP↑, BioAv↓, chemoPv↑,
5427- ASTX,    Astaxanthin and Cancer Chemoprevention
- Review, Var, NA
chemoP↑, AntiCan↑, chemoPv↑, Risk↓, lipid-P↓, Pain↓, BioAv↑, Dose↝,
147- ATG,  EGCG,  CUR,    Increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells
- in-vitro, Pca, LNCaP - in-vitro, Pca, MCF7
Bax:Bcl2↑, NF-kB↓, PI3K/Akt↓, STAT3↓, chemoPv↑, TumCP↓, TumCCA↑, TumCMig↓,
5179- BBR,    Regulation of Cell Signaling Pathways by Berberine in Different Cancers: Searching for Missing Pieces of an Incomplete Jig-Saw Puzzle for an Effective Cancer Therapy
- Review, Var, NA
AMPK↑, Casp3↑, cl‑PARP↑, Mcl-1↓, cFLIP↓, β-catenin/ZEB1↓, Wnt↓, STAT3↓, mTOR↓, Hif1a↓, NF-kB↓, SIRT1↑, DNMT1↓, DNMT3A↓, miR-29b↓, IGFBP1↑, eff↑, chemoPv↑, BioAv↓,
5631- BCA,    Perspectives Regarding the Role of Biochanin A in Humans
- Review, Var, NA - Review, AD, NA
*BioAv↓, *Inflam↓, AntiCan↑, *neuroP↑, chemoPv↑, Dose↝, *SOD↑, *MDA↓, *BAX↓, *HSP70/HSPA5↑, *AntiDiabetic↑, *Insulin↑, *TNF-α↓, *IL1β↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *MMP9↓, *ROS↓, *PGE2↓, *BACE/β-secretase↓, *BioAv↑, P-gp/ABCB1⇅,
5632- BCA,    Pharmacokinetics and bioavailability of the isoflavone biochanin A in rats
- in-vivo, Var, NA
chemoPv↑, *BioAv↓,
6512- BCP,    Beta-Caryophyllene Exhibits Anti-Proliferative Effects through Apoptosis Induction and Cell Cycle Modulation in Multiple Myeloma Cells
- in-vitro, MM, NA
CB2 / CNR2↑, BAX↑, Bcl-2↓, Casp3↑, TumCP↓, Apoptosis↑, Akt↓, Wnt↓, β-catenin/ZEB1↓, TumCCA↑, Inflam↓, chemoPv↑, neuroP↑, *BioAv↝, CB2 / CNR2↑, tumCV↓,
5582- BetA,    Targeting mitochondrial apoptosis by betulinic acid in human cancers
- Review, Var, NA
Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,
2736- BetA,  Chemo,    Multifunctional Roles of Betulinic Acid in Cancer Chemoprevention: Spotlight on JAK/STAT, VEGF, EGF/EGFR, TRAIL/TRAIL-R, AKT/mTOR and Non-Coding RNAs in the Inhibition of Carcinogenesis and Metastasis
- Review, Var, NA
chemoPv↑, p‑STAT3↓, JAK1↓, JAK2↓, VEGF↓, EGFR↓, Cyt‑c↑, Diablo↑, AMPK↑, mTOR↓, Sp1/3/4↓, DNAdam↑, Gli1↓, GLI2↓, PTCH1↓, MMP2↓, MMP9↓, miR-21↓, SOD2↓, ROS↑, Apoptosis↑,
2759- BetA,    Chemopreventive and Chemotherapeutic Potential of Betulin and Betulinic Acid: Mechanistic Insights From In Vitro, In Vivo and Clinical Studies
- Review, Var, NA
chemoPv↑, ChemoSen↑, *Inflam↓, *NRF2↑, *NF-kB↓, *COX2/PTGS2↓, ROS↑, MMP↓, Sp1/3/4↓, VEGF↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
5705- Brut,    A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)
- in-vivo, CRC, NA
Risk↓, TumMeta↓, Apoptosis↑, COX2/PTGS2↓, iNOS↓, IL1β↓, IL6↓, IL10↓, P53↑, P21↓, survivin↓, chemoPv↑, *Inflam↓,
5745- Buty,    Microbial Oncotarget: Bacterial-Produced Butyrate, Chemoprevention and Warburg Effect
- Review, Var, NA
selectivity↑, HDAC↓, TumCP↓, Apoptosis↑, Warburg↓, chemoPv↑,
5868- CA,    Carnosic acid inhibits the proliferation and migration capacity of human colorectal cancer cells
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29 - in-vitro, CRC, LoVo
Apoptosis↑, TumCMig↓, uPA↓, MMPs↓, COX2/PTGS2↓, TumCA↓, MMP9↓, MMP2↓, chemoPv↑,
5779- Calc,    Calcium supplementation for the prevention of colorectal adenomas: A systematic review and meta-analysis of randomized controlled trials
- Study, CRC, NA
chemoPv↑,
5842- CAP,    Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses
- Review, Nor, NA - Review, Diabetic, NA
*Pain↓, *TRPV1↑, AMPK↑, ROS↑, TumCP↑, Apoptosis↑, TumCCA↑, Casp3↑, BAX↑, Bak↑, cl‑PARP↑, Bcl-2↓, RNS↑, *glucose↓, *Insulin↑, *BP↓, *AntiAg↑, ER Stress↑, Hif1a↓, chemoPv↑,
5833- CAP,    Capsaicin: From Plants to a Cancer-Suppressing Agent
- Review, Var, NA
chemoPv↑, TumCCA↑, Apoptosis↑, ROS↑, MMP↓, Ca+2↑, JNK↑, Casp3↑, NADH↓, CDK2↓, CDK4↓, CDK6↓, P53↑,
5861- CAP,    Anticancer Properties of Capsaicin Against Human Cancer
- Review, Var, NA
*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,
5198- CAP,    Capsaicin induces apoptosis by generating reactive oxygen species and disrupting mitochondrial transmembrane potential in human colon cancer cell lines
- in-vitro, CRC, LoVo - in-vitro, CRC, Colo320
tumCV↓, DNAdam↑, Apoptosis↑, ROS↑, MMP↑, Casp3↑, chemoPv↑,
2652- CAP,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, AntiCan↑, ROS↑, TumCG↓, ROS↑, MMP↑, Apoptosis↑, TumCCA↑, JNK↑, SOD↓, Catalase↓, GPx↓, other↓, SIRT1↓, NADPH↑, FOXO3↑,
2019- CAP,    Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer
- Review, Var, NA
chemoPv↑, Ca+2↑, antiOx↑, *ROS↓, *MMP∅, *Cyt‑c∅, *Casp3∅, *eff↑, *Inflam↓, *NF-kB↓, *COX2/PTGS2↓, iNOS↓, TRPV1↑, i-Ca+2?, MMP↓, Cyt‑c↑, Bax:Bcl2↑, P53↑, JNK↑, PI3K↓, Akt↓, mTOR↓, LC3II↑, ATG5↑, p62↑, Fap1↓, Casp3↑, Apoptosis↑, ROS↑, MMP9↓, eff↑, eff↓, eff↑, selectivity↑, eff↑, ChemoSen↑,
5772- CAPE,    The Pluripotent Activities of Caffeic Acid Phenethyl Ester
- Review, Var, NA
*Bacteria↓, *AntiCan↑, *Imm↑, *Wound Healing↑, *NF-kB↓, *5LO↓, *AntiDiabetic↑, ChemoSen↑, selectivity↑, chemoPv↑,
5898- CAR,    Carvacrol-induced apoptosis via tumor suppressor gene activation and oxidative stress modulation in a rat model of breast cancer
- in-vivo, BC, NA
*lipid-P↓, *MDA↓, *antiOx↑, *Inflam↑, RenoP↑, hepatoP↑, *ALAT↓, AST↓, creat↓, chemoPv↑, Cyt‑c↑, FADD↑, P53↑,
5954- CEL,    The molecular mechanisms of celecoxib in tumor development
- Review, Var, NA
TumCP↓, TumCMig↓, TumCI↓, COX2/PTGS2↓, p‑NF-kB↓, Akt↓, MMP2↓, MMP9↓, Apoptosis↑, mitResp↑, ER Stress↑, TumAuto↑, ChemoSen↑, Inflam↓, PGE2↓, chemoPv↑, toxicity↓, Risk↓, PI3K↓, RadioS↑, TumCMig↓, TumCI↓, cJun↓, Sp1/3/4↓, ROS↑, MMP↓, MPT↑, Ca+2↑, Glycolysis↓, ATP↓, CSCs↓, Wnt/(β-catenin)↓, EMT↓, toxicity↝,
2653- Cela,    Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence
- Review, Var, NA
chemoPv↑, Catalase↑, ROS↑, HSP90↓, Sp1/3/4↓, AMPK↑, P53↑, JNK↑, ER Stress↑, MMP↓, TumCCA↑, TumAuto↑, Hif1a↑, Akt↑, other↓, Prx↓,
6072- CHL,    Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout
- in-vivo, Var, NA
AntiCan↑, AntiTum↑, chemoPv↑,
6078- CHL,    Update on the bioavailability and chemopreventative mechanisms of dietary chlorophyll derivatives
- Review, Nor, NA
*BioAv↑, chemoPv↑, *ROS↓, eff↑,
6082- CHOC,    Potential for preventive effects of cocoa and cocoa polyphenols in cancer
- Review, Var, NA
*ROS↓, Apoptosis↑, Inflam↓, TumCP↓, angioG↓, TumMeta↓, *Ca+2↓, *MMP∅, CYP1A1↑, PGE2↓, TumCCA↑, chemoPv↑,
6126- CHr,    Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis
- in-vitro, Melanoma, NA
tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,
2796- CHr,    Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice
- in-vivo, Lung, NA
PCNA↓, COX2/PTGS2↓, NF-kB↓, chemoPv↑, *SOD↑, *Catalase↓, *GR↓, *GPx↓, *lipid-P↓, *COX2/PTGS2↓, *NF-kB↓, *ROS↓,
2786- CHr,    Chemopreventive and therapeutic potential of chrysin in cancer: mechanistic perspectives
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, TumCI↓, TumMeta↑, *toxicity↓, selectivity↑, chemoPv↑, *GSTs↑, *NADPH↑, *GSH↑, HDAC8↓, Hif1a↓, *ROS↓, *NF-kB↓, SCF↓, cl‑PARP↑, survivin↓, XIAP↓, Casp3↑, Casp9↑, GSH↓, ChemoSen↑, Fenton↑, P21↑, P53↑, cycD1/CCND1↓, CDK2↓, STAT3↓, VEGF↓, Akt↓, NRF2↓,
6144- Cin,    The Cinnamon-Derived Dietary Factor Cinnamic Aldehyde Activates the Nrf2-Dependent Antioxidant Response in Human Epithelial Colon Cells
- in-vitro, Colon, HCT116
Nrf1↑, HO-1↑, chemoPv↑,
4762- CoQ10,    The role of coenzyme Q10 as a preventive and therapeutic agent for the treatment of cancers
- Review, Var, NA
*AntiCan↓, *ROS↓, chemoPv↑, TumCCA↑, Apoptosis↑, TumCP↓, angioG↓, MMPs↓, ChemoSen∅,
6373- CPLE,    Anticancer Activity of Phytochemicals of the Papaya Plant Assessed: A Narrative Review
- Review, Var, NA
chemoPv↑, TumCP↓, angioG↓, TumMeta↓, ROS↑, Dose↝,
5801- CRMs,  Chemo,    Caloric Restriction Enhances Chemotherapy Efficacy and Reshapes Stress Responses in Sarcoma
- in-vivo, sarcoma, NA
TumCG↓, *hepatoP↑, *ROS↓, *OS↑, ChemoSen↑, chemoPv↑, selectivity↑, *DNAdam↓,
6527- CRV,    Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events
- in-vivo, Melanoma, NA
AntiTum↑, P450↓, GSR↑, GSTs↑, GSH↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓, p53 Wildtype↓, chemoPv↑, Apoptosis↑,
7411- CS,    Long Term Exposure to Polyphenols of Artichoke (Cynara scolymus L.) Exerts Induction of Senescence Driven Growth Arrest in the MDA-MB231 Human Breast Cancer Cell Line
- in-vitro, BC, MDA-MB-231 - in-vitro, CRC, HCT116
AntiCan↑, chemoPv↑, Apoptosis↑, TumCI↓, Casp↑, p16↑, P21↑, TumCCA↑, ROS↓, eff↓, TumCD↑, TumCG↓, cellSen↑, *ROS↓,
6195- Cuc,    Cucurbitacins as Potent Chemo-Preventive Agents: Mechanistic Insight and Recent Trends
- Review, Var, NA
TumCG↓, Apoptosis↑, TumCCA↑, TumMeta↓, angioG↓, chemoPv↑, BioAv↓, Half-Life↝, cycD1/CCND1↓, cycE/CCNE↓, Casp3↑, cl‑PARP↑, JNK↑, Akt↓, ERK↓, survivin↓, XIAP↓, Bcl-2↓, Mcl-1↓, ROS↑, NRF2↓, FAK↓, MMP9↓, VEGF↓, VEGFR2/KDR/Flk1↓, *NF-kB↓, TLR4↝, NLRP3↑, Pyro↑, GSH↓,
161- CUR,  MeSA,    Enhanced apoptotic effects by the combination of curcumin and methylseleninic acid: potential role of Mcl-1 and FAK
- in-vitro, BC, MDA-MB-231 - in-vitro, Pca, DU145
Mcl-1↑, Mcl-1↓, MPT↑, AIF↑, chemoPv↑, Apoptosis↑, ROS↑, FAK↓, STAT3↓, NF-kB↓,
128- CUR,  RES,    Evaluation of biophysical as well as biochemical potential of curcumin and resveratrol during prostate cancer
- in-vivo, Pca, NA
lipid-P↓, chemoPv↑, GSH↑, SOD↑, GSTs↑, glucose↓,
11- CUR,    Curcumin inhibits hypoxia-induced epithelial‑mesenchymal transition in pancreatic cancer cells via suppression of the hedgehog signaling pathway
- in-vitro, PC, PANC1
HH↓, Shh↓, Smo↓, Gli1↓, N-cadherin↓, E-cadherin↑, Vim↓, TumCP↓, TumCMig↓, TumCI↓, EMT↓, chemoPv↑,
165- CUR,    Curcumin interrupts the interaction between the androgen receptor and Wnt/β-catenin signaling pathway in LNCaP prostate cancer cells
- in-vitro, Pca, LNCaP
AR↓, β-catenin/ZEB1↓, p‑Akt↓, GSK‐3β↓, p‑β-catenin/ZEB1↑, cycD1/CCND1↓, cMyc↓, chemoPv↑, TumCP↓,

Showing Research Papers: 1 to 50 of 129
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 129

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

2/16-OHE1↑, 2,   ACE/ACE1↓, 1,   HOTAIR↓, 1,   IGF-2R↑, 1,   mal↓, 1,   miR-106b↓, 2,   miR-10a-5p↝, 1,   MYCN↓, 1,   NA↓, 1,   Nausea↓, 1,   PGI2↓, 1,   SCFAs↑, 1,   Vomit↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   Catalase↓, 1,   Catalase↑, 2,   compI↓, 1,   CYP1A1↓, 2,   CYP1A1↑, 1,   Fenton↑, 1,   GCLM↑, 1,   GPx↓, 1,   GSH↓, 8,   GSH↑, 3,   GSH/GSSG↓, 2,   GSR↑, 1,   GSSG↓, 1,   GSTA1↓, 1,   GSTs↑, 2,   H2O2↓, 1,   H2O2↑, 1,   HO-1↑, 1,   lipid-P?, 1,   lipid-P↓, 2,   lipid-P↑, 1,   MDA↑, 1,   Mets↑, 1,   NADH↓, 1,   NQO1↑, 3,   Nrf1↑, 2,   NRF2↓, 4,   NRF2↑, 3,   Prx↓, 2,   RNS↑, 1,   ROS↓, 4,   ROS↑, 36,   ROS⇅, 2,   mt-ROS↑, 3,   selenoP↑, 1,   SOD↓, 2,   SOD↑, 2,   SOD2↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

Tf↓, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 3,   ATP↓, 1,   BCR↓, 1,   CDC16↓, 1,   CDC25↓, 1,   mitResp↓, 1,   mitResp↑, 1,   MMP↓, 19,   MMP↑, 2,   MPT↑, 3,   mtDam↑, 4,   OCR↓, 1,   XIAP↓, 4,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AKT1↓, 1,   AMPK↑, 6,   ATG7↑, 1,   cMyc↓, 4,   FASN↓, 1,   glucose↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   lactateProd↓, 1,   LDHA↓, 1,   NADPH↑, 2,   PI3K/Akt↓, 2,   PKM2↓, 1,   PPARα↓, 1,   SIRT1↓, 2,   SIRT1↑, 2,   Warburg↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 23,   Akt↑, 1,   p‑Akt↓, 5,   APAF1↑, 3,   Apoptosis↓, 1,   Apoptosis↑, 50,   BAD↓, 1,   Bak↑, 1,   BAX↑, 14,   Bax:Bcl2↑, 9,   Bcl-2↓, 16,   Bcl-xL↓, 2,   BID↑, 3,   Casp↑, 2,   cl‑Casp↑, 1,   Casp12↑, 2,   Casp3↑, 25,   cl‑Casp3↑, 3,   cl‑Casp7↑, 1,   Casp8↑, 7,   cl‑Casp8↑, 1,   Casp9↑, 14,   cl‑Casp9↑, 3,   CBP↑, 1,   cFLIP↓, 1,   Chk2↑, 1,   CK2↓, 3,   Cyt‑c↑, 19,   Diablo↑, 1,   DR4↑, 3,   DR5↑, 4,   FADD↑, 2,   Fap1↓, 1,   Fas↑, 1,   FasL↑, 2,   Hippo↝, 1,   IAP1↓, 1,   IAP2/BIRC3↑, 1,   cl‑IAP2/BIRC3↑, 1,   iNOS↓, 4,   JNK↓, 1,   JNK↑, 6,   p‑JNK↓, 2,   MAPK↓, 6,   Mcl-1↓, 6,   Mcl-1↑, 1,   MOMP↑, 1,   Necroptosis↑, 1,   necrosis↑, 1,   p27/CDKN1B↑, 3,   p38↑, 2,   p‑p38↓, 1,   PUMA↑, 1,   Pyro↑, 1,   survivin↓, 7,   Telomerase↓, 2,   TRAIL↑, 1,   TRPV1↑, 2,   TumCD↑, 4,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↓, 1,   CDC7↓, 1,   HER2/EBBR2↓, 3,   Sp1/3/4↓, 4,   TSC2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 1,   cJun↑, 1,   miR-21↓, 3,   miR-27a-3p↓, 1,   other↓, 2,   other↑, 1,   other↝, 2,   pRB↑, 1,   p‑pRB↓, 1,   tumCV↓, 10,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   CHOP/DDIT3↑, 1,   ER Stress↑, 8,   GRP78/BiP↑, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 2,   HSP90↑, 1,   HSPs↓, 1,   NQO2↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   Beclin-1/ATG6↓, 1,   Beclin-1/ATG6↑, 3,   LC3II↑, 3,   p62↑, 2,   TumAuto↑, 8,  

DNA Damage & Repair(tgid=10) ⓘ

BRCA1↑, 1,   CUL4B↑, 1,   CYP1B1↓, 1,   DNAdam↑, 4,   DNArepair↓, 1,   DNMT1↓, 2,   DNMT3A↓, 1,   NKX3.1↑, 1,   p16↑, 1,   P53↓, 1,   P53↑, 16,   p53 Wildtype↓, 2,   PARP↑, 1,   cl‑PARP↑, 13,   PCNA↓, 4,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 3,   CDK1↑, 1,   CDK2↓, 6,   CDK4↓, 7,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 3,   cycD1/CCND1↓, 14,   CycD3↓, 1,   cycE/CCNE↓, 5,   cycF↓, 1,   E2Fs↓, 1,   P21↓, 2,   P21↑, 8,   RB1↑, 1,   p‑RB1↓, 1,   TumCCA↑, 32,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

cDC2↓, 1,   cMET↓, 1,   CSCs↓, 4,   Diff↑, 1,   EMT↓, 7,   EP300↑, 1,   ERK↓, 5,   p‑ERK↓, 5,   FGF↓, 1,   FOXO3↓, 1,   FOXO3↑, 2,   Gli↓, 1,   Gli1↓, 3,   GSK‐3β↓, 2,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 1,   HDAC↓, 6,   HDAC1↓, 1,   HDAC3↓, 1,   HDAC8↓, 1,   HH↓, 2,   IGF-1↓, 3,   IGF-1↑, 1,   IGFBP1↑, 1,   IGFBP3↑, 1,   Let-7↑, 1,   miR-34a↑, 3,   miR-34a↝, 1,   mTOR↓, 9,   NF2↑, 1,   NOTCH↓, 1,   PI3K↓, 18,   PTCH1↓, 2,   PTEN↑, 5,   RAS↓, 2,   SCF↓, 1,   Shh↓, 2,   Smo↓, 1,   p‑Src↓, 1,   STAT↓, 1,   STAT3↓, 11,   p‑STAT3↓, 4,   p‑STAT3↑, 1,   TOP1↓, 2,   TOP2↑, 1,   TumCG↓, 15,   Wnt↓, 8,   Wnt/(β-catenin)↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,   AP-1↓, 3,   Ca+2↓, 1,   Ca+2↑, 10,   i-Ca+2?, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 1,   CDK4/6↓, 1,   CXCL12↓, 1,   E-cadherin↑, 5,   ER-α36↝, 1,   FAK↓, 4,   p‑FAK↓, 2,   GLI2↓, 1,   ITGB4↓, 1,   Ki-67↓, 3,   MET↑, 1,   miR-148a↓, 1,   miR-155↝, 1,   miR-19b↓, 2,   miR-200b↑, 2,   miR-29b↓, 1,   MMP1↓, 1,   MMP2↓, 12,   MMP9↓, 15,   MMPs↓, 6,   MSH2↑, 1,   MUC4↓, 3,   N-cadherin↓, 3,   PDGF↓, 2,   PRNP↑, 1,   Rac1↓, 1,   RAGE↓, 1,   Rho↝, 1,   Slug↓, 1,   Snail↓, 2,   TIMP1↑, 2,   TIMP2↑, 3,   TSC1↑, 1,   TumCA↓, 1,   TumCI↓, 15,   TumCMig↓, 12,   TumCP↓, 29,   TumCP↑, 1,   TumMeta↓, 17,   TumMeta↑, 2,   Twist↓, 3,   uPA↓, 5,   VEGFR1↓, 1,   Vim↓, 3,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 14,   p‑β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 24,   EGFR↓, 7,   Hif1a↓, 14,   Hif1a↑, 1,   NO↝, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 20,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

AQPs↓, 1,   BBB↓, 1,   BBB↑, 2,   GLUT1↓, 3,   GLUT4↓, 1,   P-gp/ABCB1↓, 2,   P-gp/ABCB1⇅, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CB2 / CNR2↑, 2,   cellSen↑, 1,   COX2/PTGS2↓, 16,   CXCR2↓, 2,   CXCR4↓, 5,   HMGB1↓, 1,   ICAM-1↓, 1,   IKKα↓, 3,   IL10↓, 1,   IL10↑, 1,   IL1α↓, 1,   IL1β↓, 2,   IL6↓, 3,   IL8↓, 1,   Imm↑, 2,   Inflam↓, 10,   IκB↓, 1,   JAK↓, 1,   JAK1↓, 1,   JAK2↓, 2,   MCP1/CCL2↓, 1,   MIP2↓, 1,   NF-kB↓, 22,   NF-kB↑, 1,   p‑NF-kB↓, 1,   p‑p65↓, 1,   PD-L1↓, 1,   PGE2↓, 4,   PSA↓, 3,   TLR4↝, 1,   TNF-α↓, 4,   TNF-α↑, 2,  

Cellular Microenvironment(tgid=17) ⓘ

NOX↓, 1,   pH↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,   NLRP3↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 7,   CDK6↓, 4,   COMT↓, 2,   ER(estro)↓, 1,   Estro↝, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 7,   BioAv↑, 8,   BioEnh↑, 1,   ChemoSen↓, 1,   ChemoSen↑, 24,   ChemoSen∅, 1,   Dose↑, 1,   Dose↝, 11,   eff↓, 6,   eff↑, 24,   eff↝, 3,   Half-Life↓, 1,   Half-Life↝, 1,   MRP1/ABCC1↓, 2,   P450↓, 1,   RadioS↑, 7,   selectivity↑, 20,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 7,   ascitic↓, 1,   AST↓, 1,   BRCA1↑, 1,   creat↓, 1,   EGFR↓, 7,   GutMicro↑, 1,   HER2/EBBR2↓, 3,   IL6↓, 3,   Ki-67↓, 3,   PD-L1↓, 1,   PSA↓, 3,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 18,   AntiDiabetic↑, 1,   AntiTum↑, 4,   cardioP↑, 2,   chemoP↑, 4,   chemoPv↑, 129,   ChemoSideEff↓, 1,   hepatoP↑, 3,   memory↑, 1,   neuroP↑, 4,   OS↑, 1,   Pain↓, 1,   PRAS40↓, 1,   QoL↑, 2,   radioP↑, 3,   RenoP↑, 3,   Risk↓, 7,   TGFβR1↑, 1,   toxicity↓, 5,   toxicity↝, 3,   TumVol↓, 3,   TumW↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiViral↑, 1,  
Total Targets: 417

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   Stroke↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 13,   Catalase↓, 1,   Catalase↑, 1,   GPx↓, 1,   GPx↑, 1,   GSH↑, 5,   GSTA1↑, 1,   GSTs↑, 2,   HO-1↑, 1,   lipid-P↓, 4,   MDA↓, 3,   NQO1↑, 2,   NRF2↑, 5,   RNS↓, 1,   ROS?, 1,   ROS↓, 21,   selenoP↑, 1,   SOD↑, 3,   TrxR↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Insulin↑, 2,   MMP∅, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   glucose↓, 1,   LDL↓, 1,   NADPH↑, 1,   PKM2↓, 1,  

Cell Death(tgid=5) ⓘ

BAX↓, 1,   Casp3↓, 1,   Casp3∅, 1,   Casp9↓, 1,   Cyt‑c∅, 1,   iNOS↓, 2,   JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   p38↓, 1,   TRPV1↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,   P53↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

EMT↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 2,   AP-1↓, 1,   Ca+2↓, 1,   Ca+2↝, 1,   MMP9↓, 1,   PKCδ↓, 1,   TGF-β↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX1↓, 1,   COX2/PTGS2↓, 7,   IL1β↓, 1,   IL2↑, 1,   IL4↑, 1,   IL6↓, 1,   Imm↑, 2,   Inflam↓, 15,   Inflam↑, 1,   NF-kB↓, 8,   PGE2↓, 1,   TNF-α↓, 4,  

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 6,   BioAv↑, 6,   BioAv↝, 6,   Dose↑, 1,   Dose↝, 3,   eff↑, 5,   Half-Life↝, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   BP↓, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1,   AntiCan↓, 1,   AntiCan↑, 2,   AntiDiabetic↓, 1,   AntiDiabetic↑, 4,   cardioP↑, 2,   chemoP↑, 1,   chemoPv↑, 1,   hepatoP↑, 5,   neuroP↑, 3,   Obesity↓, 1,   OS↑, 1,   Pain↓, 1,   radioP↑, 1,   toxicity↓, 5,   toxicity↝, 1,   Wound Healing↑, 3,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 3,  
Total Targets: 97

Scientific Paper Hit Count for: chemoPv, ChemoPreventive
7 Curcumin
6 Chemotherapy
6 Capsaicin
6 Quercetin
5 Phenethyl isothiocyanate
5 Sulforaphane (mainly Broccoli)
4 Apigenin (mainly Parsley)
4 Nimbolide
4 Thymoquinone
3 EGCG (Epigallocatechin Gallate)
3 Betulinic acid
3 Chrysin
3 Resveratrol
3 D-limonene
2 Arctigenin
2 Biochanin A
2 Chlorophyllin
2 Genistein (soy isoflavone)
2 Fisetin
2 Formononetin
2 Grapeseed extract
2 Hibiscus sabdariffa
2 Indole-3-carbinol
2 Inositol
2 Vitexin
2 Licochalcone A
2 α-Santalol/Sandalwood oil
1 Annona atemoya Seed Extract
1 Allicin (mainly Garlic)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Luteolin
1 Astaxanthin
1 Berberine
1 Beta-Caryophyllene
1 Boswellia (frankincense)
1 Bruteridin(bergamot juice)
1 Butyrate
1 Carnosic acid
1 Calcium
1 Caffeic Acid Phenethyl Ester (CAPE)
1 Carvacrol
1 Celecoxib
1 Celastrol
1 Chocolate
1 Cinnamon
1 Coenzyme Q10
1 Carica papaya leaf extract
1 Calorie Restriction Mimetics
1 Carvone
1 Cynara scolymus/Globe Artichoke/Artichoke Extract
1 Cucurbitacin
1 methylseleninic acid
1 Deguelin
1 Diclofenac
1 Dandelion Root
1 Ginkgo biloba-EGb 761
1 5-fluorouracil
1 Eugenol
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Honokiol
1 Hops (Humulus lupulus)
1 Hyperoside
1 Inulin Prebiotic
1 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
1 isoflavones
1 Isovitexin
1 Juglone
1 Kaempferol
1 Lasiodin
1 SDG/lignans
1 Methyl salicylate / Sweet Birch oil
1 Aspirin
1 Oleuropein
1 Psoralidin
1 Rutin
1 buckwheat sprouts
1 Selenium
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenite (Sodium)
1 Sutherlandioside D
1 Ursolic acid
1 Vitamin C (Ascorbic Acid)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1417  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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