Na+ Cancer Research Results

Na+, Sodium ion: Click to Expand ⟱
Source:
Type:
Na+, Sodium Ion -Na⁺ influx enhances metastatic potential.
-VGSC activation → Na⁺ influx
-Na⁺ entry alters cell membrane potential.(Vm)
-in cancer: VGSC expression: ↑ upregulated
-in cancer: Na⁺ influx: ↑ increased
Na⁺ gradients support several transporters:
Transporter	             Effect
Na⁺/H⁺ exchanger (NHE1)	     extracellular acidification
Na⁺/Ca²⁺ exchanger	     Ca²⁺ signaling
Na⁺/glucose cotransporter    metabolic adaptation
-Sodium channel blockers can reduce metastasis in models.
Scientific Papers found: Click to Expand⟱
7387- MF,    Effects of Sinusoidal Magnetic Field Observed on Cell Proliferation, Ion Concentration, and Osmolarity in Two Human Cancer Cell Lines
- in-vitro, AML, HL-60 - in-vitro, adrenal, SK-HEP-1
Dose↝, TumCG↓, Na+↑, K+↑,
5608- NaHCO3,    Sodium Bicarbonate Nanoparticles for Amplified Cancer Immunotherapy by Inducing Pyroptosis and Regulating Lactic Acid Metabolism
- Study, Var, NA
TumCG↓, TumMeta↓, e-pH↑, Pyro↑, Imm↑, Na+↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

K+↑, 1,  

Cell Death(tgid=5) ⓘ

Pyro↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,  

Migration(tgid=13) ⓘ

Na+↑, 2,   TumMeta↓, 1,  

Barriers & Transport(tgid=15) ⓘ

Na+↑, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Na+, Sodium ion
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1452  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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