PHB Cancer Research Results

PHB, prohibitin: Click to Expand ⟱
Source:
Type:

PHB1 and PHB2 form a conserved mitochondrial inner-membrane complex involved in mitochondrial structure, mitochondrial stress signaling, apoptosis, cell-cycle regulation, metabolism, and aging. Recent structural work describes the human prohibitin complex as linked to mitochondrial stress signaling, housekeeping, cell-cycle progression, apoptosis, and lifespan regulation.
Scientific Papers found: Click to Expand⟱
9154- MG, MIC-1,    Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells
- in-vitro, BC, NA
Ingr↝, *TumCG↓, Cyt‑c↑, P53↑, cl‑Casp7↑, survivin↓, Bcl-2↓, Bcl-xL↓, MMP↓, ROS↑, PHB↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

PHB↑, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,   Bcl-xL↓, 1,   cl‑Casp7↑, 1,   Cyt‑c↑, 1,   survivin↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: PHB, prohibitin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1505  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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