miR-195 Cancer Research Results

miR-195, miR-195: Click to Expand ⟱
Source:
Type:

miR-195 is commonly downregulated and acts as a tumour suppressor. Reduced miR-195 can release inhibition of cell-cycle, survival, angiogenesis, EMT, and drug-resistance genes.

MicroRNA-195 (miR-195; commonly miR-195-5p) is a small non-coding RNA belonging to the miR-15/16/195/424/497 family. It regulates gene expression by binding target messenger RNAs and promoting transcript degradation or translational repression. In many cancers, miR-195 ↓ is the more commonly reported pattern, and miR-195 generally functions as a tumour-suppressive microRNA. Restoration or miR-195 ↑ can inhibit cell-cycle progression, proliferation, migration, invasion, angiogenesis, epithelial-mesenchymal transition, and treatment resistance while promoting apoptosis in susceptible cancer models. Reported targets include CCND1, CCNE1, CDK4, CDK6, E2F3, BCL2, BCL2L2, BIRC5, VEGF, and FGF2/bFGF. Cancer review; Recent clinical review.



Scientific Papers found: Click to Expand⟱
6985- Form,    Formononetin relieves the facilitating effect of lncRNA AFAP1-AS1-miR-195/miR-545 axis on progression and chemo-resistance of triple-negative breast cancer
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, BT549
CDK4↓, Raf↓, miR-195↑, miR-545↑, ChemoSen↑, AFAP1-AS1↓,
8113- LA,    Analyzing of colorectal cancer related genes and microRNAs expression profiles in response to probiotics Lactobacillus acidophilus and Saccharomyces cerevisiae in colon cancer cell lines
- in-vitro, CRC, HT-29 - in-vitro, CRC, SW480
BAX↑, Casp3↑, Casp9↑, Bcl-2↓, MMP2↓, MMP9↓, miR-34a↑, miR-25-5p↑, miR-195↑, miR-27a-3p↑, Let-7↑, miR-106b↓, miR-17↓, miR-21↓, miR-155↓, miR-221↓, TumPF↓,
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

AFAP1-AS1↓, 1,   miR-106b↓, 1,   miR-122-5p↑, 1,   miR-195↑, 3,   miR-199↑, 1,   miR-326-5p↑, 1,   miR-545↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

Raf↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlutaM↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PKM2↓, 1,   PPP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Casp9↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

miR-25-5p↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↓, 1,   miR-21↑, 1,   miR-27a-3p↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK4↓, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 2,   miR-34a↑, 1,   PI3K↓, 1,  

Migration(tgid=13) ⓘ

miR-155↓, 1,   miR-206↑, 1,   miR-221↓, 1,   miR-221↑, 1,   miR-222↑, 1,   MMP2↓, 1,   MMP9↓, 1,   TumPF↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   miR-126↑, 1,   miR-17↓, 1,   miR-34b-5p↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,  
Total Targets: 46

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-195, miR-195
1 Formononetin
1 Lactobacillus
1 Licorice
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1554  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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