PAI-1/SERPINE1 Cancer Research Results

PAI-1/SERPINE1, plasminogen activator inhibitor-1: Click to Expand ⟱
Source:
Type:

PAI-1 (plasminogen activator inhibitor-1; SERPINE1) is a secreted serine-protease inhibitor that primarily inhibits tissue-type and urokinase-type plasminogen activators (tPA/PLAT and uPA/PLAU), thereby regulating plasmin generation, fibrinolysis and extracellular-matrix remodeling. In many cancers, PAI-1 is overexpressed by tumour cells and stromal cells and can promote tumour-cell survival, migration, invasion, angiogenesis, epithelial–mesenchymal transition, metastasis and resistance to therapy through both protease-dependent and signalling functions involving interactions with vitronectin, integrins and LRP1. High tumour or circulating PAI-1 is associated with poor prognosis in several malignancies, particularly breast cancer. The typical cancer-associated direction is therefore generally up, while the desired anticancer modulation is commonly down or functional inhibition. PAI-1 is also strongly associated with cellular senescence and is frequently used as a component of the senescence-associated secretory phenotype (SASP), although elevated PAI-1 alone is not sufficient to establish cellular senescence. PAI-1 is kept separate from PAI-2/SERPINB2 and from its upstream plasminogen activators uPA and tPA.

In cancer, PAI-1 is commonly upregulated and is associated with invasion, angiogenesis, metastasis, treatment resistance, and poor prognosis, although its biology is context-dependent.
Scientific Papers found: Click to Expand⟱
9203- BITC,    Benzyl isothiocyanate inhibits tumor growth and lung metastasis of 4T1 murine mammary carcinoma cells in a BALB/c mouse xenograft model
- vitro+vivo, BC, 4T1
AntiTum↑, Dose↝, TumVol↓, TumW↓, PCNA↓, Bcl-2↓, CD31/PECAM-1↓, VEGF↓, BAX↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp9↑, cl‑PARP↑, TumNum↓, TumMeta↓, MMP2↓, MMP9↓, TIMP1↓, uPA↓, TIMP2↑, PAI-1/SERPINE1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

BAX↑, 1,   Bcl-2↓, 1,   cl‑Casp3↑, 1,   cl‑Casp7↑, 1,   cl‑Casp9↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   PCNA↓, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   MMP9↓, 1,   PAI-1/SERPINE1↑, 1,   TIMP1↓, 1,   TIMP2↑, 1,   TumMeta↓, 1,   uPA↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

CD31/PECAM-1↓, 1,   VEGF↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,   TumNum↓, 1,   TumVol↓, 1,   TumW↓, 1,  
Total Targets: 21

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: PAI-1/SERPINE1, plasminogen activator inhibitor-1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1612  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page