miR-122-5p Cancer Research Results

miR-122-5p, miR-122-5p: Click to Expand ⟱
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Type:

miR-122-5p - MicroRNA-122-5p

Abbreviation: miR-122-5p

Type: MicroRNA

Function: Liver-enriched regulatory microRNA involved in lipid metabolism, hepatocyte differentiation, proliferation, apoptosis, migration, and tumor suppression. miR-122-5p regulates numerous cancer-related genes and signaling pathways and is particularly important in hepatocellular carcinoma.

Cancer: ↓ Frequently decreased, particularly in hepatocellular carcinoma, where miR-122-5p generally functions as a tumor suppressor. Reduced miR-122-5p can promote proliferation, invasion, metastasis, and loss of differentiation, while restoration of miR-122-5p can suppress tumor progression.
Scientific Papers found: Click to Expand⟱
7266- Gink,    Ginkgo biloba derivative ginkgetin inhibits breast cancer growth by regulating the miRNA-122-5p/GALNT10 axis
- vitro+vivo, BC, MDA-MB-231 - in-vitro, BC, MDA-MB-453 - in-vitro, BC, MCF7
Casp3↑, BAX↑, Cyt‑c↑, Bcl-2↓, TumCP↓, TumCMig↓, Apoptosis↑, miR-122-5p↑, GALNT10↓, TumCG↓,
8281- LE,    A Licorice Roots Extract Induces Apoptosis and Cell Cycle Arrest and Improves Metabolism via Regulating MiRNAs in Liver Cancer Cells
- in-vitro, Liver, NA
Apoptosis↑, TumCCA↑, Let-7↑, miR-34b-5p↑, miR-122-5p↑, miR-126↑, miR-195↑, miR-199↑, miR-206↑, miR-326-5p↑, Hif1a↓, PI3K↓, cMyc↓, AMPK↑, P53↑, Glycolysis↓, HK2↓, LDHA↓, PKM2↓, PPP↓, G6PD↓, GlutaM↓, GLS↓, miR-21↑, miR-221↑, miR-222↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

GALNT10↓, 1,   miR-122-5p↑, 2,   miR-195↑, 1,   miR-199↑, 1,   miR-326-5p↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,   cMyc↓, 1,   G6PD↓, 1,   GLS↓, 1,   GlutaM↓, 1,   Glycolysis↓, 1,   HK2↓, 1,   LDHA↓, 1,   PKM2↓, 1,   PPP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp3↑, 1,   Cyt‑c↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-21↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Let-7↑, 1,   PI3K↓, 1,   TumCG↓, 1,  

Migration(tgid=13) ⓘ

miR-206↑, 1,   miR-221↑, 1,   miR-222↑, 1,   TumCMig↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1,   miR-126↑, 1,   miR-34b-5p↑, 1,  
Total Targets: 34

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: miR-122-5p, miR-122-5p
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1616  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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