IL1RL1/ST2 Cancer Research Results

IL1RL1/ST2, Interleukin-1 Receptor-Like 1 / ST2: Click to Expand ⟱

Source:

Type:

IL1RL1 - Interleukin-1 Receptor-Like 1 / ST2

Abbreviation: IL1RL1, ST2, ST2L

Type: Cytokine receptor / IL-33 receptor

Function: IL1RL1 encodes ST2, the principal receptor for IL-33. Membrane-bound ST2L forms a signaling receptor complex with IL1RAP and transduces IL-33-dependent inflammatory and immune signals. A soluble isoform, sST2, lacks the signaling domain and functions as a decoy receptor that binds extracellular IL-33 and limits IL-33/ST2L signaling.

Cancer: ↕ Context-dependent. ST2-mediated IL-33 signaling can support either tumor-promoting or antitumor immune responses depending on cancer type, immune-cell composition, receptor isoform, and tumor microenvironment.

Scientific Papers found: Click to Expand⟱

8588-

FS,

Tam,

Dietary flaxseed and tamoxifen affect the inflammatory microenvironment in vivo in normal human breast tissue of postmenopausal women

BioAv↑, Dose↝, IL-1Ra↑, IL1R2↑, IL18↑, IL1RL1/ST2↑, MMP9↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Migration(tgid=13) ⓘ

MMP9↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL-1Ra↑, 1, IL18↑, 1, IL1R2↑, 1, IL1RL1/ST2↑, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1, Dose↝, 1, eff↑, 1,
Total Targets: 8

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: IL1RL1/ST2, Interleukin-1 Receptor-Like 1 / ST2

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells