AntiP Cancer Research Results

AntiP, antiparasitic: Click to Expand ⟱
Source:
Type:

Antiparasitic Activity - Activity Against Parasitic Organisms

Type: Therapeutic effect / antimicrobial functional outcome

Function: Antiparasitic activity refers to the ability of a compound, extract, drug, or intervention to inhibit the growth, survival, replication, development, or infectivity of parasitic organisms. Depending on the study, this may include protozoa, helminths, or ectoparasites.

Favorable Direction: ↑ Antiparasitic activity = greater inhibition or killing of parasites and is generally favorable.

Unfavorable Direction: ↓ Antiparasitic activity = reduced effectiveness against parasites.
Scientific Papers found: Click to Expand⟱
8022- IVM,    Antibiotic ivermectin preferentially targets renal cancer through inducing mitochondrial dysfunction and oxidative damage
- vitro+vivo, RCC, NA
AntiP↑, TumCP↓, Apoptosis↑, selectivity↑, TumCG↓, MMP↓, mitResp↓, ATP↓, ROS↑, eff↓,
8021- IVM,    The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells
- vitro+vivo, AML, HL-60 - NA, lymphoma, U937 - NA, Pca, DU145
AntiP↑, TumCD↑, selectivity↑, TumCG↓, i-Chl↑, ROS↑, ChemoSen↑,
8020- IVM,    Ivermectin induces PAK1-mediated cytostatic autophagy in breast cancer
- vitro+vivo, BC, NA
AntiP↑, TumAuto↑, Akt↓, mTOR↓, PAK1↓, selectivity↑,
8206- LCA,    Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways
- in-vivo, GC, BGC-823
ROS?, Casp3↑, cl‑PARP↑, eff↓, ERK↑, JNK↑, MAPK↑, AntiP↑, AntiTum↑, TumCP↓, selectivity↑, GSH/GSSG↓, MDA↑, lipid-P↑, PI3K↓, Akt↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSH/GSSG↓, 1,   lipid-P↑, 1,   MDA↑, 1,   ROS?, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   mitResp↓, 1,   MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   Apoptosis↑, 1,   Casp3↑, 1,   JNK↑, 1,   MAPK↑, 1,   TumCD↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1,   mTOR↓, 1,   PI3K↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

i-Chl↑, 1,   PAK1↓, 1,   TumCP↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   eff↓, 2,   selectivity↑, 4,  

Functional Outcomes(tgid=23) ⓘ

AntiP↑, 4,   AntiTum↑, 1,  
Total Targets: 28

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: AntiP, antiparasitic
3 Ivermectin
1 Licochalcone A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1749  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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