8-oxo-dG Cancer Research Results

8-oxo-dG, 8-oxo-2′-Deoxyguanosine: Click to Expand ⟱
Source:
Type: Biomarker

8-oxo-2′-Deoxyguanosine

Abbreviation: 8-oxo-dG, 8-oxodG, 8-OHdG

Alternative Names: 8-Oxo-7,8-dihydro-2′-deoxyguanosine, 8-Hydroxy-2′-deoxyguanosine

Type: Oxidative DNA damage biomarker / oxidized DNA nucleoside / DNA lesion

Function: 8-oxo-dG is formed when reactive oxygen species oxidize guanine residues in DNA or the deoxyguanosine nucleotide pool. It is one of the most widely used biomarkers of oxidative DNA damage and can be measured in cellular DNA, tissue, blood, urine, and other biological samples.

Cancer: ↑ 8-oxo-dG generally indicates increased oxidative DNA damage and is associated with mutagenesis, genomic instability, carcinogen exposure, and cancer development or progression.

Favorable Direction in Cancer Prevention: ↓ 8-oxo-dG is generally favorable because it indicates reduced oxidative DNA damage.

Anticancer Treatment Interpretation: Context-dependent. ↑ 8-oxo-dG within treated cancer cells or tumor tissue can indicate successful induction of oxidative DNA damage by an anticancer treatment, whereas chronic systemic or normal-tissue 8-oxo-dG ↑ is generally unfavorable.

Pathway Relationship: ROS ↑ → guanine oxidation ↑ → 8-oxo-dG ↑ → oxidative DNA damage/mutagenic lesions ↑.

Repair Relationship: OGG1 and associated base-excision-repair pathways remove oxidized guanine lesions from DNA. Increased urinary 8-oxo-dG can therefore reflect both oxidative damage and subsequent repair/excretion.

Interpretation Note: Tissue DNA 8-oxo-dG and urinary 8-oxo-dG should not be interpreted identically. Tissue 8-oxo-dG reflects retained oxidative DNA lesions, whereas urinary 8-oxo-dG can reflect whole-body oxidative damage and repair/excretion.
Scientific Papers found: Click to Expand⟱
8420- Lyco,    Anticancer activity of lycopene in HT-29 colon cancer cell line
- in-vitro, CRC, HT-29
Risk↓, Dose↝, TumCP↓, Casp3↑, BAX↑, cl‑PARP↑, 8-oxo-dG↑, γH2AX↑, Cyt‑c↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

8-oxo-dG↑, 1,  

Cell Death(tgid=5) ⓘ

BAX↑, 1,   Casp3↑, 1,   Cyt‑c↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↑, 1,   γH2AX↑, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,  
Total Targets: 9

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: 8-oxo-dG, 8-oxo-2′-Deoxyguanosine
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1830  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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