UTF1 Cancer Research Results

UTF1, Undifferentiated Embryonic Cell Transcription Factor 1: Click to Expand ⟱
Source:
Type:

Undifferentiated Embryonic Cell Transcription Factor 1 (UTF1) — Nuclear transcriptional/chromatin regulator associated with embryonic stem-cell pluripotency, self-renewal, differentiation, and control of cell-cycle-associated gene expression. UTF1 expression is strongly linked to an undifferentiated cellular state and may also contribute to cancer stem-cell biology.

Typical modulation in Alzheimer’s disease: Insufficient evidence for a consistent disease-associated direction. UTF1 is not currently a well-established Alzheimer’s disease target.

Typical modulation in cancer: ↔ / context-dependent. UTF1 may function as either a tumor-promoting stemness factor or a tumor suppressor depending on cancer type and cellular context. Reduced UTF1 has been reported in breast cancer and associated with larger tumors and lymph-node metastasis, while UTF1 expression in other malignancies may be associated with an undifferentiated or stem-like phenotype. Avoid assigning a universal ↑ or ↓ cancer direction.

Recommended abbreviation: UTF1; gene/protein designation: UTF1.
Scientific Papers found: Click to Expand⟱
8506- MAG,    Magnolia officinalis Lignans induce apoptosis and epigenetic reprogramming via the miR-148a-3p/DNMT-1/UTF-1 axis in pancreatic cancer cells
- in-vitro, PC, Panc02 - in-vitro, PC, MIA PaCa-2
*Inflam↓, *antiOx↑, Ingr↝, tumCV↓, Apoptosis↑, ROS↑, MMP↓, Casp↑, selectivity↑, DNMT1↓, JAK2↓, STAT3↓, miR-148a↑, UTF1↑, IL6↓, survivin↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Ingr↝, 1,   UTF1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Casp↑, 1,   survivin↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

tumCV↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNMT1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

STAT3↓, 1,  

Migration(tgid=13) ⓘ

miR-148a↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↓, 1,   JAK2↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

IL6↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  
Total Targets: 2

Scientific Paper Hit Count for: UTF1, Undifferentiated Embryonic Cell Transcription Factor 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1845  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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