Erlin1 Cancer Research Results

Erlin1, ER lipid raft associated 1: Click to Expand ⟱
Source:
Type:

ERLIN1 (ER Lipid Raft Associated 1; Erlin-1) — Endoplasmic-reticulum membrane protein of the SPFH family that forms complexes with ERLIN2 and participates in ER-associated protein degradation (ERAD), including degradation of inositol 1,4,5-trisphosphate receptors (IP3R). ERLIN1 also regulates intracellular calcium signaling, cholesterol binding, SREBP signaling, and lipid homeostasis.

Typical modulation in cancer: ↑ ERLIN1 may be tumor-promoting in some cancers. In colorectal cancer, ERLIN1 is upregulated in tumor tissue; ERLIN1 knockdown suppresses proliferation and migration and increases apoptosis, whereas ERLIN1 overexpression promotes tumor-cell growth and migration. Thus, ERLIN1 ↓ is generally interpreted as anticancer in this context.

Typical modulation in Alzheimer’s disease: No well-established Alzheimer’s disease-associated direction. ERLIN1 may have indirect relevance through ER protein quality control, calcium homeostasis, lipid metabolism, and ER stress.
Scientific Papers found: Click to Expand⟱
8547- Matr,    Matrine in cancer therapy: antitumor mechanisms and nano-delivery strategies
- Review, Var, NA
*Ingr↝, *AntiTum↑, Apoptosis↑, TumAuto↑, Ferroptosis↑, TumCP↓, TumCMig↓, TumCI↓, JPT1/HN1↓, Erlin1↑, LINC01116↓, miR-592↑, ERK↓, JAK↓, STAT3↓, miR-182-5p↓, PI3K↓, Akt↓, Wnt↓, β-catenin/ZEB1↓, Sharpin↓, ROS↓, AMPK↑, mTOR↓, Snail↓, Vim↓, N-cadherin↓, MMP2↓, MMP9↓, E-cadherin↑, PTEN↑, miR-10b-5p↓, GPx4↓, lipid-P↑, Iron↑, Piezo1↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Ferroptosis↑, 1,   GPx4↓, 1,   Iron↑, 1,   lipid-P↑, 1,   ROS↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   Ferroptosis↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

JPT1/HN1↓, 1,   LINC01116↓, 1,   miR-10b-5p↓, 1,   miR-182-5p↓, 1,   miR-592↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

Erlin1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↓, 1,   mTOR↓, 1,   PI3K↓, 1,   Piezo1↑, 1,   PTEN↑, 1,   STAT3↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   Sharpin↓, 1,   Snail↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumCP↓, 1,   Vim↓, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

JAK↓, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

Ingr↝, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiTum↑, 1,  
Total Targets: 2

Scientific Paper Hit Count for: Erlin1, ER lipid raft associated 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1852  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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