CAXII/CA12 Cancer Research Results

CAXII/CA12, (Carbonic Anhydrase XII: Click to Expand ⟱
Source:
Type:

CA12 (Carbonic Anhydrase XII; CA XII) — Membrane-associated zinc metalloenzyme that catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. CA12 contributes to extracellular and intracellular pH regulation, bicarbonate transport, cellular adaptation to hypoxia, and maintenance of the tumor microenvironment.

Typical modulation in cancer: Frequently ↑ in multiple solid tumors and in some therapy-resistant cancer-cell populations. Elevated CA12 can support pH homeostasis, tumor-cell survival, migration, invasion, metastasis, and chemoresistance. However, prognostic significance varies by cancer type; for example, higher CA12 expression can correlate with more favorable luminal breast cancer phenotypes while being associated with poorer outcomes in some other malignancies.

Typical modulation in Alzheimer’s disease: No well-established Alzheimer’s disease-associated direction. CA12 is primarily relevant to epithelial ion/pH homeostasis and cancer biology.
Scientific Papers found: Click to Expand⟱
8554- Matr,    Matrine injection inhibits pancreatic cancer growth via modulating carbonic anhydrases- a network pharmacology-based study with in vitro validation
- in-vitro, PC, Capan1 - in-vitro, PC, MIA PaCa-2
TumCP↓, TumCCA↑, Apoptosis↑, CAIX/CA9↓, CAXII/CA12↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis(tgid=4) ⓘ

CAIX/CA9↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

CAXII/CA12↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: CAXII/CA12, (Carbonic Anhydrase XII
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1863  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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