CD36/FAT Cancer Research Results

CD36/FAT, cluster of differentiation 36/fatty acid translocase: Click to Expand ⟱

Source:

Type:

CD36 (Cluster of Differentiation 36; Fatty Acid Translocase, FAT) — Multifunctional transmembrane glycoprotein and scavenger receptor that mediates uptake of long-chain fatty acids, oxidized lipoproteins, and other lipid ligands. CD36 regulates fatty-acid transport and oxidation, lipid storage, macrophage lipid uptake, inflammatory signaling, angiogenesis, and cellular metabolic adaptation.

Typical modulation in cancer: Frequently ↑ and tumor-promoting in metabolically lipid-dependent cancers. Elevated CD36 can increase fatty-acid uptake and support tumor-cell survival, proliferation, epithelial-to-mesenchymal transition, migration, invasion, metastasis, and treatment resistance. CD36 has particularly strong evidence as a facilitator of metastatic lipid utilization. However, effects are tumor- and cell-type-dependent, and CD36 can have different functions in stromal, endothelial, and immune cells.

Typical modulation in Alzheimer’s disease: Context-dependent. CD36 participates in microglial recognition of amyloid-beta and can promote inflammatory and oxidative responses to Aβ. CD36 also contributes to lipid and oxidized-lipoprotein handling. Excessive CD36-mediated microglial activation may therefore contribute to neuroinflammation, although CD36 also participates in normal clearance and phagocytic processes.

Metabolic relevance: ↑ CD36 generally increases cellular long-chain fatty-acid uptake and can increase fatty-acid oxidation or lipid accumulation depending on tissue and metabolic state. CD36 is particularly important in skeletal muscle, adipose tissue, heart, intestine, macrophages, and metabolically adaptive cancer cells.

Recommended abbreviation: CD36; aliases: FAT, fatty acid translocase, SCARB3, GPIV, platelet

Scientific Papers found: Click to Expand⟱

8625-

MCT,

Medium-Chain Fatty Acids Selectively Sensitize Cancer Cells to Ferroptosis by Inducing CD36 and ACSL4

in-vitro,

lymphoma,

U937

in-vitro,

Lung,

A549

Ferroptosis↑, ACSL4↑, CD36/FAT↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,

Cell Death(tgid=5) ⓘ

Ferroptosis↑, 1,

Barriers & Transport(tgid=15) ⓘ

CD36/FAT↑, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: CD36/FAT, cluster of differentiation 36/fatty acid translocase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells