METTL7A Cancer Research Results

METTL7A, TMT1A, Thiol Methyltransferase 1A: Click to Expand ⟱
Source:
Type:

TMT1A (Thiol Methyltransferase 1A; METTL7A) — Methyltransferase-family enzyme with reported mRNA m6A methyltransferase and thiol S-methyltransferase activity. TMT1A/METTL7A is associated with the endoplasmic reticulum and lipid droplets and can influence RNA stability, lipid/cholesterol metabolism, drug metabolism, and cellular signaling.

Typical modulation in cancer: Context-dependent. METTL7A can act as a tumor suppressor in some cancers but can also promote treatment resistance or tumor-supportive signaling in others. In colorectal cancer, METTL7A is reduced and functions as a tumor suppressor by binding SREBP1/SCAP, limiting SREBP1 nuclear translocation, reducing cholesterol synthesis, and suppressing tumor progression. In contrast, increased METTL7A has been linked to resistance to thiol-containing HDAC inhibitors and to tumor-promoting DDR1/STAT3/CXCL5 signaling in some breast cancer models.
Scientific Papers found: Click to Expand⟱
8639- MBZ,    Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vitro, Liver, HepG2 - in-vitro, AML, K562
ENOX2↓, MMP2↓, TumCI↓, RASSF1A↑, WFDC10A↑, METTL7A↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ENOX2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

METTL7A↑, 1,   RASSF1A↑, 1,  

Migration(tgid=13) ⓘ

MMP2↓, 1,   TumCI↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

WFDC10A↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: METTL7A, TMT1A, Thiol Methyltransferase 1A
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1878  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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