NR1H4 Cancer Research Results

NR1H4, FXR, NR1H4 Nuclear Receptor Subfamily 1 Group H Member 4; Farnesoid X Receptor: Click to Expand ⟱

Source:

Type:

NR1H4 (Nuclear Receptor Subfamily 1 Group H Member 4; Farnesoid X Receptor, FXR) — Ligand-activated nuclear receptor and transcription factor that functions primarily as a bile-acid sensor. FXR regulates bile-acid synthesis and transport, cholesterol homeostasis, lipid and glucose metabolism, enterohepatic signaling, inflammation, and hepatic metabolic gene expression.

Typical modulation in cancer: Context-dependent. FXR can function as a tumor suppressor in some gastrointestinal and hepatic cancers by limiting inflammation, bile-acid toxicity, and proliferative signaling, whereas FXR activation may support survival or metabolic adaptation in selected tumor contexts. A universal ↑ or ↓ cancer direction should therefore not be assigned.

Typical mechanistic relationships: Bile acids → FXR activation → transcriptional regulation of genes involved in bile-acid synthesis/transport, cholesterol metabolism, lipid metabolism, and inflammatory signaling.

abbreviations: NR1H4; common name: FXR; aliases include BAR, RIP14, HRR1.

Scientific Papers found: Click to Expand⟱

9149-

WN,

Mechanistic examination of walnuts in prevention of breast cancer

in-vitro,

BC,

MCF7

Ingr↝, TumCP↓, NR1H4↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

NR1H4↑, 1,

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,
Total Targets: 3

Pathway results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: NR1H4, FXR, NR1H4 Nuclear Receptor Subfamily 1 Group H Member 4; Farnesoid X Receptor

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells