CD59 Cancer Research Results

CD59, MAC-IP, CD59 Molecule; MAC-Inhibitory Protein: Click to Expand ⟱
Source:
Type:

CD59 (CD59 Molecule; MAC-Inhibitory Protein) — Glycosylphosphatidylinositol (GPI)-anchored cell-surface complement regulatory protein that protects cells from complement-mediated lysis by inhibiting formation of the terminal membrane attack complex (MAC; C5b-9). CD59 binds components of the assembling MAC and prevents effective C9 incorporation and polymerization.

Typical modulation in cancer: Frequently ↑ and generally unfavorable. Increased CD59 expression can protect tumor cells from complement-dependent cytotoxicity, promote immune evasion, and reduce the effectiveness of complement-dependent antitumor immune responses and some antibody-based therapies.

Typical modulation in Alzheimer’s disease: Context-dependent. CD59 contributes to protection of neurons and other cells from excessive terminal complement activation. Reduced local complement regulation may increase susceptibility to complement-mediated membrane injury, whereas excessive complement activation is implicated in neuroinflammatory and synaptic pathology.

Typical mechanistic relationship: CD59 ↑ → C5b-9/MAC formation ↓ → complement-mediated membrane injury and cell lysis ↓. In cancer cells, CD59 ↑ → complement-dependent tumor-cell killing ↓ → immune escape ↑.

Aliases: MAC-IP, MACIF, MIRL, protectin.
Scientific Papers found: Click to Expand⟱
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Bax:Bcl2↑, 1,   Casp↑, 1,   Cyt‑c↑, 1,   Fas?, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

JAK3↓, 1,   STAT3↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP1↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   COL1↓, 1,   E-cadherin↑, 1,   EMT↓, 1,   MMP2↓, 1,   MMP9↓, 2,   TIMP2↓, 1,   Vim↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD59↑, 1,   COX2/PTGS2↓, 1,   IFN-γ↓, 1,   IL1β↓, 1,   IL2↓, 1,   IL4↑, 1,   PGE2↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   MDR1↓, 1,   RadioS↑, 1,   Synergy↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,  
Total Targets: 35

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 1,   Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   hepatoP↑, 1,   RenoP↑, 1,  
Total Targets: 6

Scientific Paper Hit Count for: CD59, MAC-IP, CD59 Molecule; MAC-Inhibitory Protein
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1910  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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