Cal1 Cancer Research Results

Cal1, CAPN1, Calpain 1; μ-Calpain: Click to Expand ⟱
Source:
Type:

CAPN1 (Calpain 1; μ-Calpain) — Calcium-dependent cysteine protease of the conventional calpain family. CAPN1 participates in limited proteolysis of cytoskeletal, adhesion, signaling, and regulatory proteins and thereby influences cell migration, invasion, adhesion, survival, and tissue remodeling.

Typical modulation in cancer: Frequently ↑ or activated and often tumor-promoting. Increased CAPN1 activity can promote cytoskeletal remodeling, focal-adhesion turnover, migration, invasion, epithelial-mesenchymal transition, and metastatic behavior. Effects can vary by tumor type and substrate context.

Typical mechanistic relationship: Intracellular Ca2+ ↑ → CAPN1 activation → regulated proteolysis of cytoskeletal and adhesion-associated proteins → focal-adhesion turnover / actin remodeling ↑ → migration and invasion ↑.

Additional functions: CAPN1 can also regulate apoptosis, autophagy, membrane repair, signal transduction, and proteolytic processing of numerous cellular proteins.
Scientific Papers found: Click to Expand⟱
9219- AITC,    Sensitivity of allyl isothiocyanate to induce apoptosis via ER stress and the mitochondrial pathway upon ROS production in colorectal adenocarcinoma cells
- in-vitro, CRC, HT-29
TumCG↓, TumNum↓, tumCV↓, TumCCA↑, Casp9↑, Casp3↑, MMP↓, Cyt‑c↑, AIF↑, Endon↑, Ca+2↝, ER Stress↑, Cal1↑, ATF6↑, GRP78/BiP↑, GRP94↑, CHOP/DDIT3↑, CASP4↑, ROS↑,
9235- AITC,    Anticancer Activity, Mechanism, and Delivery of Allyl Isothiocyanate
- Review, Var, NA
tumCV↓, Apoptosis↑, TumCCA↑, CDK1↓, cycA1/CCNA1↓, CycB/CCNB1↓, DNAdam↑, p‑Akt↓, p‑mTOR↓, Casp3↑, Casp9↑, ROS↑, MMP↓, selectivity↑, TumAuto↑, Beclin-1/ATG6↑, HATs↓, HDAC↓, HMTs↓, p‑ERK↑, P21↑, CDC25↓, CDK1↓, FasL↑, TRAIL↑, MAPK↑, ATF6↑, GRP94↑, GRP78/BiP↑, Cal1↑, cal2↑, CHOP/DDIT3↑, BAX↑, Endoglin↑, AIF↑, APAF1↑, Cyt‑c↑, TIMP1↑, GSTs↑, GGT/CD224↑, NRF2↓, BioAv↓, BioAv↑, Risk↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GSTs↑, 1,   NRF2↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,  

Cell Death(tgid=5) ⓘ

AIF↑, 2,   APAF1↑, 1,   Apoptosis↑, 1,   BAX↑, 1,   Casp3↑, 2,   CASP4↑, 1,   Casp9↑, 2,   Cyt‑c↑, 2,   Endon↑, 1,   FasL↑, 1,   TRAIL↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   p‑ERK↑, 1,   MAPK↑, 1,   p‑mTOR↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

HATs↓, 1,   HDAC↓, 1,   HMTs↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2,   CHOP/DDIT3↑, 2,   ER Stress↑, 1,   GRP78/BiP↑, 2,   GRP94↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 2,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   P21↑, 1,   TumCCA↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

Ca+2↝, 1,   Cal1↑, 2,   cal2↑, 1,   TIMP1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Endoglin↑, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Cellular Microenvironment(tgid=17) ⓘ

GGT/CD224↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

Risk↓, 1,   TumNum↓, 1,  
Total Targets: 49

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Cal1, CAPN1, Calpain 1; μ-Calpain
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:1929  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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