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| SYK (Spleen Associated Tyrosine Kinase) — Non-receptor cytoplasmic tyrosine kinase that transduces signals from immune receptors and other cell-surface receptors. SYK is especially important in B-cell receptor, Fc receptor, integrin, and C-type lectin receptor signaling and regulates proliferation, differentiation, phagocytosis, inflammatory responses, adhesion, and survival. Typical modulation in cancer: Context-dependent. SYK can promote survival and proliferation in several hematologic malignancies, particularly B-cell cancers, where SYK inhibition can be therapeutically beneficial. In some epithelial cancers, including breast cancer, SYK has also been reported to have tumor-suppressive functions, so a universal ↑ or ↓ cancer direction should not be assigned. Typical mechanistic relationship: Activated immunoreceptor / ITAM-containing receptor → SYK recruitment and phosphorylation → downstream PI3K/AKT, PLCγ, MAPK, NF-kB, and cytoskeletal signaling → proliferation, survival, immune activation, adhesion, and migration. Immune relevance: SYK is a major signaling kinase in B cells, macrophages, neutrophils, mast cells, and other hematopoietic cells and contributes to innate and adaptive immune responses. |
| 9305- | MushMait, | Structure of a β-glucan from Grifola frondosa and its antitumor effect by activating Dectin-1/Syk/NF-κB signaling |
| - | vitro+vivo, | sarcoma, | NA |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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