| Source: HalifaxProj (inhibit) |
| Type: |
| mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status. mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation. mTor Inhibitors: -rapamycin (Sirolimus): classic natural product mTOR inhibitor -Curcumin -Resveratrol -Epigallocatechin Gallate (EGCG) -Honokiol |
| 318- | AgNPs, | Silver nanoparticles regulate autophagy through lysosome injury and cell hypoxia in prostate cancer cells |
| - | in-vitro, | Pca, | PC3 |
| 280- | ALA, | Alpha‐lipoic acid inhibits lung cancer growth via mTOR‐mediated autophagy inhibition |
| - | in-vivo, | Lung, | A549 |
| 265- | ALA, | Alpha-Lipoic Acid Reduces Cell Growth, Inhibits Autophagy, and Counteracts Prostate Cancer Cell Migration and Invasion: Evidence from In Vitro Studies |
| - | in-vitro, | Pca, | LNCaP | - | in-vitro, | Pca, | DU145 |
| 3396- | ART/DHA, | Progress on the study of the anticancer effects of artesunate |
| - | Review, | Var, | NA |
| 1076- | ART/DHA, | The Potential Mechanisms by which Artemisinin and Its Derivatives Induce Ferroptosis in the Treatment of Cancer |
| - | Review, | NA, | NA |
| 2047- | Buty, | Sodium butyrate inhibits migration and induces AMPK-mTOR pathway-dependent autophagy and ROS-mediated apoptosis via the miR-139-5p/Bmi-1 axis in human bladder cancer cells |
| - | in-vitro, | CRC, | T24/HTB-9 | - | in-vitro, | Nor, | SV-HUC-1 | - | in-vitro, | Bladder, | 5637 | - | in-vivo, | NA, | NA |
| 2017- | CAP, | Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease |
| - | Review, | Var, | NA |
| 1860- | dietFMD, | Chemo, | Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape |
| - | in-vitro, | BC, | SUM159 | - | in-vitro, | BC, | 4T1 |
| 2860- | FIS, | Fisetin induces autophagy in pancreatic cancer cells via endoplasmic reticulum stress- and mitochondrial stress-dependent pathways |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | PC, | Bxpc-3 | - | in-vitro, | Nor, | hTERT-HPNE | - | in-vivo, | NA, | NA |
| 292- | HCA, | Hydroxycitric Acid Inhibits Chronic Myelogenous Leukemia Growth through Activation of AMPK and mTOR Pathway |
| - | in-vitro, | AML, | K562 |
| 1918- | JG, | ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro |
| - | in-vitro, | Liver, | HepG2 | - | in-vivo, | NA, | NA |
| 5117- | JG, | https://pubmed.ncbi.nlm.nih.gov/31283929/ |
| - | vitro+vivo, | Liver, | NA |
| 8461- | Mg, | Effects of Salivary Mg on Head and Neck Carcinoma via TRPM7 |
| - | vitro+vivo, | SCC, | CAL27 | - | in-vitro, | Laryn, | FaDu |
| 4745- | SeNPs, | Chemo, | Translational Selenium Nanoparticles Promotes Clinical Non-small-cell Lung Cancer Chemotherapy via Activating Selenoprotein-driven Immune Manipulation |
| - | Study, | NSCLC, | NA |
| - | in-vitro, | CRC, | HCT116 |
| 2232- | SK, | Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis |
| - | in-vitro, | ESCC, | EC9706 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:0 prod#:% Target#:209 State#:% Dir#:2
wNotes=0 sortOrder:rid,rpid