ATP Cancer Research Results

ATP, Adenosine triphosphate: Click to Expand ⟱
Source:
Type:
Adenosine triphosphate (ATP) is the source of energy for use and storage at the cellular level.
Cellular ATP levels are critical for cell survival, and several reports have shown that reductions in cellular ATP levels can lead to apoptosis and other types of cell death in cancer cells, depending on the level of depletion.
Adenosine triphosphate (ATP) is one of the main biochemical components of the tumor microenvironment (TME), where it can promote tumor progression or tumor suppression depending on its concentration and on the specific ecto-nucleotidases and receptors expressed by immune and cancer cells.

Cancer cells, unlike normal cells, derive as much as 60% of their ATP from glycolysis via the “Warburg effect”, and the remaining 40% is derived from mitochondrial oxidative phosphorylation.
Scientific Papers found: Click to Expand⟱
1577- Citrate,    Citric acid promotes SPARC release in pancreatic cancer cells and inhibits the progression of pancreatic tumors in mice on a high-fat diet
- in-vivo, PC, NA - in-vitro, PC, PANC1 - in-vitro, PC, PATU-8988 - in-vitro, PC, MIA PaCa-2
Apoptosis↑, TumCP↓, TumCG↑, SPARC↑, Glycolysis↓, OCR↓, pol-M1↑, pol-M2 MC↓, Weight∅, ATP↓, ECAR↓, mitResp↓, i-ATP↑, p65↓, i-Ca+2↑, eff↓,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1/ATG6↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
2512- H2,    Hydrogen Attenuates Allergic Inflammation by Reversing Energy Metabolic Pathway Switch
- in-vivo, Asthma, NA
selectivity↑, lactateProd↓, ATP↑, HK2↓, PFK↓, Hif1a↓, PGC-1α↑, Glycolysis↓, OXPHOS↑, Dose↝,
7503- H2S,    Hydrogen Sulfide, an Endogenous Stimulator of Mitochondrial Function in Cancer Cells
- Review, Var, NA
DNArepair↑, CBS↑, 3MST/MPST↑, ETC↑, ATP↑, Glycolysis↑, ACLY↑,
7816- ISQ,    Isoquercitrin Induces Endoplasmic Reticulum Stress and Immunogenic Cell Death in Gastric Cancer Cells
- in-vitro, GC, AGS - in-vitro, GC, HGC27
TumCP↑, Bcl-2↓, BAX↑, cl‑Casp3↑, Casp12↑, MMP↓, CRT↑, e-ATP↑, HMGB1↑, HSP70/HSPA5↑, HSP90↑, ER Stress↑,
538- MF,    The extremely low frequency electromagnetic stimulation selective for cancer cells elicits growth arrest through a metabolic shift
- in-vitro, BC, MDA-MB-231 - in-vitro, Melanoma, MSTO-211H
TumCG↓, Ca+2↑, COX2/PTGS2↓, ATP↑, MMP↑, ROS↑, OXPHOS↑, mitResp↑,
493- MF,    Extremely low-frequency electromagnetic field induces acetylation of heat shock proteins and enhances protein folding
- in-vitro, NA, HEK293 - in-vitro, Liver, AML12
ATP↑, HSP70/HSPA5↓, HSP90↓,
993- RES,    Resveratrol reverses the Warburg effect by targeting the pyruvate dehydrogenase complex in colon cancer cells
- in-vitro, CRC, Caco-2 - in-vivo, Nor, HCEC 1CT
TumCG↓, Glycolysis↓, PPP↓, ATP↑, PDH↑, Ca+2↝, TumCP↓, lactateProd↓, OCR↑, ECAR↓, *ECAR∅, *other?, cycE/CCNE↑, cycA1/CCNA1↑, TumCCA↑, cycD1/CCND1↑, OXPHOS↑,
3001- RosA,    Therapeutic Potential of Rosmarinic Acid: A Comprehensive Review
- Review, Var, NA
TumCP↓, Apoptosis↑, TumMeta↓, Inflam↓, *antiOx↑, *AntiAge↑, *ROS↓, BioAv↑, Dose↝, NRF2↑, P-gp/ABCB1↑, ATP↑, MMPs↓, cl‑PARP↓, Hif1a↓, GlucoseCon↓, lactateProd↓, Warburg↓, TNF-α↓, COX2/PTGS2↓, IL6↓, HDAC2↓, GSH↑, ROS↓, ChemoSen↑, *BG↓, *IL1β↓, *TNF-α↓, *IL6↓, *p‑JNK↓, *p38↓, *Catalase↑, *SOD↑, *GSTs↑, *VitC↑, *VitE↑, *GSH↑, *GutMicro↑, *cardioP↑, *ROS↓, *MMP↓, *lipid-P↓, *NRF2↑, *hepatoP↑, *neuroP↑, *P450↑, *HO-1↑, *AntiAge↑, *motorD↓,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

3MST/MPST↑, 1,   CBS↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

GSH↑, 1,   HO-1↓, 1,   NRF2↑, 1,   OXPHOS↑, 4,   ROS↓, 1,   ROS↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↓, 1,   ATP↑, 7,   e-ATP↑, 1,   i-ATP↑, 1,   ETC↑, 1,   Insulin↓, 1,   mitResp↓, 1,   mitResp↑, 1,   MMP↓, 1,   MMP↑, 1,   OCR↓, 1,   OCR↑, 1,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACLY↑, 1,   ECAR↓, 2,   GlucoseCon↓, 1,   Glycolysis↓, 4,   Glycolysis↑, 1,   HK2↓, 1,   lactateProd↓, 3,   PDH↑, 1,   PFK↓, 1,   PPP↓, 1,   SIRT1↑, 1,   Warburg↓, 2,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 1,   Bcl-2↓, 1,   Casp12↑, 1,   cl‑Casp3↑, 1,   MAPK↓, 1,   TumCD↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CRT↑, 1,   ER Stress↑, 1,   HSP70/HSPA5↓, 1,   HSP70/HSPA5↑, 1,   HSP90↓, 1,   HSP90↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1,   Beclin-1/ATG6↑, 1,   LAMP2↑, 1,   p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNArepair↑, 1,   P53↑, 1,   cl‑PARP↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycA1/CCNA1↑, 1,   cycD1/CCND1↑, 1,   cycE/CCNE↑, 1,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

HDAC↓, 1,   HDAC2↓, 1,   IGF-1↓, 1,   STAT5↓, 1,   TumCG↓, 2,   TumCG↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↑, 1,   Ca+2↝, 1,   i-Ca+2↑, 1,   MMPs↓, 1,   SPARC↑, 1,   Treg lymp↓, 1,   TumCP↓, 3,   TumCP↑, 1,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 2,  

Barriers & Transport(tgid=15) ⓘ

P-gp/ABCB1↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   HMGB1↑, 1,   IL6↓, 1,   Inflam↓, 1,   pol-M1↑, 1,   M2 MC↓, 1,   pol-M2 MC↓, 1,   p65↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen↑, 2,   Dose↝, 3,   eff↓, 1,   eff↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   GutMicro↑, 2,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

ChemoSideEff↓, 1,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 96

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GSH↑, 1,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 1,   NRF2↑, 1,   ROS↓, 2,   SOD↑, 1,   VitC↑, 1,   VitE↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ECAR∅, 1,  

Cell Death(tgid=5) ⓘ

p‑JNK↓, 1,   p38↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other?, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL1β↓, 1,   IL6↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

P450↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

BG↓, 1,   GutMicro↑, 1,   IL6↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 2,   cardioP↑, 1,   hepatoP↑, 1,   motorD↓, 1,   neuroP↑, 1,  
Total Targets: 28

Scientific Paper Hit Count for: ATP, Adenosine triphosphate
2 Magnetic Fields
1 Citric Acid
1 diet FMD Fasting Mimicking Diet
1 Chemotherapy
1 Hydrogen Gas
1 hydrogen sulfide
1 isoquercitrin
1 Resveratrol
1 Rosmarinic acid
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:21  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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