BAX Cancer Research Results

BAX, Apoptosis regulator BAX: Click to Expand ⟱

Source:

Type: Proapototic protein

BAX is a member of the Bcl-2 gene family.
Pro-apoptotic protein that forms heterodimers with anti-apoptotic BCL2 proteins; involved in various cellular activities and regulated by p53; mediates the release of cytochrome c from mitochondria.

Scientific Papers found: Click to Expand⟱

8330-

,

SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death

-

in-vitro,

GBM,

U87MG

tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,

6461-

1,8-Cin,

1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

-

Review,

AD,

NA

-

Review,

Var,

NA

*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑,

4774-

5-FU,

TQ,

CoQ10,

Exploring potential additive effects of 5-fluorouracil, thymoquinone, and coenzyme Q10 triple therapy on colon cancer cells in relation to glycolysis and redox status modulation

-

in-vitro,

CRC,

NA

AntiCan↑, TumCCA↑, Apoptosis↑, eff↑, Bcl-2↓, survivin↓, P21↑, p27/CDKN1B↑, BAX↑, Cyt‑c↑, Casp3↑, PI3K↓, Akt↓, mTOR↓, Hif1a↓, PTEN↑, AMPKα↑, PDH↑, LDHA↓, antiOx↓, ROS↑, AntiCan↑,

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5434-

AG,

Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview

-

Review,

Liver,

NA

AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,

5436-

AG,

Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice

-

in-vivo,

HCC,

NA

HCC H22-bearing mice

TumCG↓, BAX↑, Bcl-2↓, IL2↑, IL6↑, TNF-α↑, toxicity↓,

5238-

AgNPs,

β-Sitosterol-assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line

-

in-vitro,

HCC,

HepG2

TumCP↓, ROS↑, NRF2↑, BAX↑, P53↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓,

5976-

AgNPs,

Review on Harnessing Silver Nanoparticles for Therapeutic Innovations: A Comprehensive Review on Medical Applications, Safety, and Future Directions

-

Review,

Vit,

NA

*Bacteria↓, AntiCan↑, *Inflam↓, *Wound Healing↑, eff↑, ChemoSen↑, EGFR↓, ROS↑, P53↑, BAX↑, Casp3↑, toxicity↝,

4388-

AgNPs,

Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells

-

in-vitro,

Cerv,

NA

47.5 nm

tumCV↓, CSCs↓, selectivity↑, Apoptosis↑, ROS↑, LDH↓, Casp3↑, BAX↑, Bak↑, cMyc↑, MMP↓,

4417-

AgNPs,

Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways

-

in-vitro,

BC,

MDA-MB-231

ROS↑, MDA↑, COX2/PTGS2↑, IL1β↑, TNF-α↑, GSH↓, Cyt‑c↑, Casp3↑, BAX↑, Bcl-2↓, LDH↓, cycD1/CCND1↓, CDK2↓, TumCCA↑, mt-Apoptosis↑,

4416-

AgNPs,

Efficacy of curcumin-synthesized silver nanoparticles on MCF-7 breast cancer cells

-

in-vitro,

BC,

MCF7

TumCMig↓, Apoptosis↑, BAX↑, P53↑, Bcl-2↓,

4415-

AgNPs,

SDT,

CUR,

Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells

-

in-vitro,

BC,

MCF7

29.3 ± 5.6 nm

 48.23 µg/ml

SDT was performed using an US frequency of 1 MHz, intensity of 2 W/cm2, and a distance of 2 cm.

tumCV↓, BAX↑, Casp3↑, Bcl-2↓, eff↑, ROS↑, sonoS↑, eff↑, MMP↓, Cyt‑c↑,

4427-

AgNPs,

Silver nanoparticles induce apoptosis and G2/M arrest via PKCζ-dependent signaling in A549 lung cells

-

in-vitro,

Lung,

A549

tumCV↓, LDH↑, TumCCA↑, BAX↑, BID↑, Bcl-2↓, PKCδ↓,

4430-

AgNPs,

Evaluation of the Genotoxic and Oxidative Damage Potential of Silver Nanoparticles in Human NCM460 and HCT116 Cells

-

in-vitro,

Colon,

HCT116

20 nm

-

in-vitro,

Nor,

NCM460

*Bacteria↓, ROS↑, p‑p38↑, BAX↑, Bcl-2↓, BAX↑, P21↑, TumCD↑, toxicity↝,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

-

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

4584-

AgNPs,

Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells

-

in-vitro,

Pca,

DU145

selectivity↑, ROS↑, BAX↑, cl‑Casp3↑, p‑PARP↑, TumCCA↑, cycD1/CCND1↓, p27/CDKN1B↑, P21↑, AntiCan↑,

343-

AgNPs,

Silver nanoparticles of different sizes induce a mixed type of programmed cell death in human pancreatic ductal adenocarcinoma

-

in-vitro,

PC,

PANC1

 3.19 or 1.67 ug/mL

BAX↑, Bcl-2↓, P53↑, TumAuto↑,

335-

AgNPs,

PDT,

Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy

-

Review,

NA,

NA

ROS↑, GSH↓, GPx↑, Catalase↓, SOD↓, p38↑, BAX↑, Bcl-2↓,

324-

AgNPs,

CPT,

Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells

-

in-vitro,

Cerv,

HeLa

ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,

369-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

-

in-vitro,

Liver,

NA

ROS↑, GSH↓, DNAdam↑, lipid-P↝, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Casp9↑, Casp3↑, JNK↑,

363-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

ROS↑, lipid-P↑, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, JNK↑,

348-

AgNPs,

Induction of p53 mediated mitochondrial apoptosis and cell cycle arrest in human breast cancer cells by plant mediated synthesis of silver nanoparticles from Bergenia ligulata (Whole plant)

-

in-vitro,

BC,

MCF7

Apoptosis↑, ROS↑, MMP↓, P53↑, BAX↑, cl‑Casp3↑,

350-

AgNPs,

Cytotoxic and Apoptotic Effects of Green Synthesized Silver Nanoparticles via Reactive Oxygen Species-Mediated Mitochondrial Pathway in Human Breast Cancer Cells

-

in-vitro,

BC,

MCF7

 40ug/mL

ROS↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

397-

AgNPs,

GEM,

Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

-

in-vitro,

Ovarian,

A2780S

50 nM GEM, 50 nM AgNPs

6nm

P53↑, P21↑, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, MMP↓,

396-

AgNPs,

Systemic Evaluation of Mechanism of Cytotoxicity in Human Colon Cancer HCT-116 Cells of Silver Nanoparticles Synthesized Using Marine Algae Ulva lactuca Extract

-

in-vitro,

Colon,

HCT116

P53↑, BAX↑, P21↑, Bcl-2↓,

395-

AgNPs,

The apoptotic and genomic studies on A549 cell line induced by silver nitrate

-

in-vitro,

Lung,

A549

13.5uM@72hr

BAX↑, MMP↓,

393-

AgNPs,

Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity

-

in-vitro,

NA,

HCT116

mtDam↑, ROS↑, TumCCA↑, Casp3↑, BAX↑, Bcl-2↓, P53↑,

381-

AgNPs,

Silver Nanoparticles Exert Apoptotic Activity in Bladder Cancer 5637 Cells Through Alteration of Bax/Bcl-2 Genes Expression

-

in-vitro,

Bladder,

5637

 51.12 µg/mL

 more toxic with smaller NPs (this was 30nm)

ROS↑, BAX↑, Bcl-2↓, Casp3↑, Casp7↑, Apoptosis↑,

382-

AgNPs,

Investigation the apoptotic effect of silver nanoparticles (Ag-NPs) on MDA-MB 231 breast cancer epithelial cells via signaling pathways

-

in-vitro,

BC,

MDA-MB-231

Apoptosis↑, BAX↑, Bcl-2↓, P53↑, PTEN↑, hTERT/TERT↓, p‑ERK↓, cycD1/CCND1↓,

383-

AgNPs,

In vitro and in vivo evaluation of anti-tumorigenesis potential of nano silver for gastric cancer cells

-

in-vitro,

GC,

MKN45

 22.4 µg/mL

Ki-67↓, TumCP↓, CD34↓, BAX↑,

386-

AgNPs,

Tam,

Synergistic anticancer effects and reduced genotoxicity of silver nanoparticles and tamoxifen in breast cancer cells

-

in-vitro,

BC,

MCF7

35uM(AgNP)+20uM(Tam)

-

in-vitro,

BC,

MDA-MB-231

P53↑, BAX↑, Bcl-2↓, Casp3↑, DNAdam↑, TumCCA↑,

387-

AgNPs,

Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells

-

in-vitro,

Colon,

HT-29

33.45 μg/mL

Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1/ATG6↑, CHOP/DDIT3↑, LC3s↑, XBP-1↑,

388-

AgNPs,

Apoptotic efficacy of multifaceted biosynthesized silver nanoparticles on human adenocarcinoma cells

-

in-vitro,

BC,

MCF7

 5 and 10 µg/mL

ROS↑, Casp3↑, BAX↑, P53↑, Casp↑, Cyt‑c↑, MMP↓, DNAdam↑, Bcl-2↓, BAX↑,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

-

in-vitro,

Testi,

F9

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

7426-

AgNPs,

CS,

Silver Nanoparticles Formulation of Flower Head's Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

-

in-vitro,

Pca,

PC3

0.85 μg/mL

-

in-vitro,

Lung,

A549

 0.94 μg/mL

*antiOx↑, tumCV↓, eff↑, Dose↝, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,

5356-

AL,

Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects

-

Review,

GC,

NA

Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,

1290-

AL,

Effect of allicin on the expression of Bcl-2 and Bax protein in LM-8 cells

-

in-vitro,

OS,

LM8

5.0, 10.0 and 15.0 mg/L) for 24, 48 and 72

Bcl-2↓, BAX↑, Apoptosis↑, TumCG↓,

245-

AL,

Allicin: a promising modulator of apoptosis and survival signaling in cancer

-

Review,

Var,

NA

Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,

246-

AL,

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

-

in-vitro,

GC,

MGC803

 0-10ug/ml

Apoptosis↑, cl‑Casp3↑, p38↑, tumCV↓, BAX↑, Bcl-2↑,

248-

AL,

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

-

in-vitro,

GBM,

U87MG

Bcl-2↓, BAX↑, MAPK↑, ERK↑, ROS↑, p38↑, JNK↑,

249-

AL,

Allicin induces apoptosis of the MGC-803 human gastric carcinoma cell line through the p38 mitogen-activated protein kinase/caspase-3 signaling pathway

-

in-vitro,

GC,

MGC803

  0.1, 1 and 10 μg/ml

Casp3↑, p38↑, BAX↑, Bcl-2↓, p38↑, MAPK↑,

251-

AL,

Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway

-

in-vitro,

ESCC,

Eca109

 0-100ug/ml

-

in-vitro,

ESCC,

EC9706

-

in-vivo,

NA,

NA

5mg/kg/bw

mice

Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,

254-

AL,

Allicin and Cancer Hallmarks

-

Review,

Var,

NA

NRF2⇅, BAX↑, Bcl-2↓, Fas↑, MMP↓, Bax:Bcl2↑, Cyt‑c↑, Casp3↑, Casp12↑, GSH↓, TumCCA↑, ROS↑, antiOx↓,

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

-

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

235-

AL,

Allicin inhibits cell growth and induces apoptosis in U87MG human glioblastoma cells through an ERK-dependent pathway

-

in-vitro,

GBM,

U87MG

 90 μM

Apoptosis↑, Bcl-2↓, BAX↑, MAPK↑, p‑ERK↑, ROS↑, eff↓,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

-

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

2655-

AL,

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

-

Review,

GC,

NA

TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,

277-

ALA,

α-lipoic acid modulates prostate cancer cell growth and bone cell differentiation

-

in-vitro,

Pca,

22Rv1

 500 μM

-

in-vitro,

Pca,

C4-2B

ROS↑, Hif1a↑, JNK↑, Casp3↑, P21↑, BAX↑, Bcl-xL↓, cFos↓,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

-

Review,

NA,

NA

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

Showing Research Papers: 1 to 50 of 597
Page 1 of 12 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 597

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

8-oxo-dG↑, 1, AKR1B10↓, 1, p‑AMT/GCST/T-protein↑, 1, ANAPC2↑, 1, AntiBio↓, 1, ATF1↓, 1, ATG13↑, 1, ATG16L1↑, 1, ATGL/PNPLA2↓, 1, AURKB↑, 1, BMP7/OP1↓, 1, CASP4↑, 1, CCN1/CYR61↓, 1, i-Cer↑, 1, compV↓, 1, CXCR3↓, 1, DR6↑, 1, EDEM↑, 1, ERCC3↑, 1, ERCC4/XPF↓, 1, FBXO5/EMI1↓, 1, FEN1↓, 1, FFA/NEFA↓, 1, GALNT10↓, 1, HSL/LIPE↓, 1, p‑HSL/LIPE↑, 1, HSP60/HSPD1↓, 1, HSP60/HSPD1↑, 1, IL7↓, 1, Ingr↝, 1, IRF1↑, 1, Ku70/XRCC6↓, 1, LATS1↓, 1, LIFR/CD118↓, 1, LIMK1↓, 1, miR-106b↓, 1, miR-107↑, 1, miR-122-5p↑, 1, miR-195↑, 1, miR-224↓, 1, miR-375↓, 1, miR-422a↑, 1, miR-590-3p↑, 1, MMP16↓, 1, MTA1↓, 1, MYCN↓, 1, NA↓, 1, NA↑, 1, NOD1↓, 1, OGFr↑, 2, PDE3B↓, 1, PTN↓, 1, Rictor↓, 1, RSK2/RPS6KA3/p90RSK2↓, 1, RUBCN↓, 1, SALL4↓, 1, TFE3↑, 1, THEM4/CTMP↑, 1, TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 3, ULK1/ATG1↑, 1, URGCP/URG4↓, 1, WEE1↑, 2, XRCC1↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↓, 5, antiOx↑, 9, antiOx⇅, 3, ARE↑, 1, Catalase↓, 10, Catalase↑, 8, compI↓, 2, Copper↑, 1, CYP1A1↓, 4, CYP1A1↑, 1, Fenton↑, 2, Ferroptosis↑, 8, frataxin↑, 1, GPx↓, 3, GPx↑, 5, GPx4↓, 10, GPx4↑, 1, GSH↓, 44, GSH↑, 7, GSH/GSSG↓, 3, GSR↑, 1, GSS↑, 1, GSSG↓, 1, GSTA1↑, 1, GSTs↓, 1, GSTs↑, 4, H2O2↑, 8, HK1↓, 1, HO-1↓, 6, HO-1↑, 11, HO-1↝, 1, ICD↑, 3, Iron↑, 2, i-Iron↑, 1, c-Iron↑, 1, Keap1↓, 1, lipid-P↓, 10, lipid-P↑, 11, lipid-P↝, 1, MAD↓, 1, MDA↓, 4, MDA↑, 10, MFN2↑, 1, NADPH/NADP+↓, 1, NAF1↓, 1, NOX4↑, 1, NQO1?, 1, NQO1↓, 1, NQO1↑, 1, Nrf1↑, 1, NRF2↓, 16, NRF2↑, 20, NRF2⇅, 1, NRF2↝, 1, p‑NRF2↓, 1, OXPHOS↓, 3, PARK2↑, 3, Prx↓, 1, Prx6↑, 1, PrxII↓, 1, PYCR1↓, 1, RNS↑, 1, ROS?, 3, ROS↓, 19, ROS↑, 297, ROS⇅, 6, ROS∅, 1, i-ROS↓, 1, i-ROS↑, 4, mt-ROS↑, 7, SAM-e↝, 1, SIRT3↓, 3, SIRT3↑, 1, SOD?, 1, SOD↓, 14, SOD↑, 10, SOD1↓, 1, SOD1↑, 2, SOD2↓, 3, SOD2↑, 5, TAC?, 1, TAC↓, 1, TBARS↑, 2, Thiols↓, 3, Trx1↑, 1, Trx2↓, 1, TrxR↓, 5, TrxR1↓, 2, xCT/SLC7A11↓, 4,

Metal & Cofactor Biology(tgid=2) ⓘ

Ferritin↓, 1, FTH1↓, 1, IronCh↑, 2, NCOA4↑, 1, Tf↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1, ADP:ATP↑, 1, AIF↑, 21, AIF↝, 1, ATP↓, 12, ATP∅, 1, e-ATP↑, 1, BCR↓, 1, BOK↑, 2, CDC2↓, 9, CDC2↑, 1, CDC25↓, 13, CDC25↑, 1, p‑CDC25↑, 1, compIII↓, 1, compIII↑, 1, EGF↓, 6, ETC↓, 3, FGFR1↓, 2, MEK↓, 5, p‑MEK↓, 2, p‑MEK↑, 1, mitResp↓, 2, mitResp↑, 2, MKK4↓, 1, MKK7↓, 1, MMP↓, 167, MMP↝, 1, MPT↑, 3, mtDam↑, 25, OCR↓, 5, p‑p42↑, 1, PHB↓, 1, PINK1↑, 3, Raf↓, 7, e-Raf↓, 1, XIAP↓, 22,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX?, 1, 12LOX↓, 5, Ac-histone H3↑, 1, ACC↑, 3, Acetyl-CoA↓, 1, ACLY↓, 2, ACSL4↑, 1, AKT1↓, 4, ALAT↓, 1, ALAT↝, 1, ALAT∅, 1, ALDOA↓, 1, AMPK?, 1, AMPK↓, 1, AMPK↑, 17, p‑AMPK↑, 3, ATG7↑, 3, CAIX/CA9↓, 1, CAIX/CA9↑, 1, cMyc↓, 31, cMyc↑, 3, p‑cMyc↑, 1, p‑CREB↓, 1, CYP3A4↓, 1, ENO1↓, 1, ERCC1↓, 1, FASN↓, 4, FBI-1↓, 1, GLO-I↓, 1, glucose↓, 2, GlucoseCon↓, 6, GlutMet↓, 1, Glycolysis↓, 18, H2S↑, 1, HK2↓, 13, HMG-CoA↓, 1, lactateProd↓, 8, lactateProd↑, 1, LDH?, 1, LDH↓, 8, LDH↑, 7, LDH↝, 1, i-LDH↓, 1, LDHA↓, 7, LDL↓, 3, MCT4↓, 1, NAD↝, 1, NADPH↓, 2, PCK1↓, 1, PDH↑, 1, PDH↝, 1, PDK1 / PDPK1↓, 7, PDKs↓, 1, PFK↓, 2, PFKP↓, 1, PI3K/Akt↓, 9, PI3K/Akt↑, 1, PI3K/Akt↝, 1, PI3k/Akt/mTOR↝, 1, PIK3CA↓, 1, PKM2↓, 7, PPARα↓, 1, PPARγ↓, 2, PPARγ↑, 2, Pyruv↓, 1, p‑S6↓, 1, p‑S6K↓, 1, SIRT1↓, 3, SIRT1↑, 6, SREBP1/SREBF1↓, 2, SREBP2↓, 1, TCA?, 1, TCA↓, 2, TS↓, 1, Warburg↓, 3,

Cell Death(tgid=5) ⓘ

Akt↓, 140, Akt↑, 3, p‑Akt↓, 55, APAF1↑, 12, Apoptosis?, 1, Apoptosis↓, 10, Apoptosis↑, 318, mt-Apoptosis↑, 6, ASK1↑, 2, p‑ASK1↑, 1, BAD↓, 5, BAD↑, 25, Bak↓, 1, Bak↑, 24, BAX↑, 603, Bax:Bcl2↓, 1, Bax:Bcl2↑, 19, Bcl-2↓, 452, Bcl-2↑, 6, Bcl-2∅, 1, cl‑Bcl-2↑, 1, Bcl-xL↓, 56, Bcl-xL↑, 1, BID↓, 1, BID↑, 15, p‑BID↓, 1, cl‑BID↑, 2, BIM↓, 1, BIM↑, 13, Casp↓, 2, Casp↑, 36, Casp↝, 1, cl‑Casp↑, 1, cl‑Casp1↑, 1, Casp10↓, 1, Casp10↑, 2, Casp12↑, 6, Casp12↝, 1, cl‑Casp12↑, 2, Casp2↑, 2, Casp3?, 2, Casp3↓, 6, Casp3↑, 279, cl‑Casp3↑, 77, cl‑Casp3⇅, 1, proCasp3↓, 1, proCasp3↑, 2, Casp6↑, 2, Casp7↑, 25, cl‑Casp7↑, 5, Casp8↓, 2, Casp8↑, 54, cl‑Casp8↑, 14, proCasp8↑, 4, pro‑Casp8↑, 1, Casp9↓, 1, Casp9↑, 178, p‑Casp9↑, 1, cl‑Casp9↑, 29, proCasp9↓, 1, proCasp9↑, 3, cFLIP↓, 7, Chk2↑, 1, p‑Chk2↑, 1, Cupro↑, 1, Cyt‑c↓, 1, Cyt‑c↑, 173, Cyt‑c↝, 1, Diablo↑, 6, DR4↑, 11, DR5↑, 34, FADD↑, 7, Fas↓, 2, Fas↑, 35, FasL↓, 1, FasL↑, 17, FasL⇅, 1, Ferroptosis↑, 8, GSDMD↑, 2, cl‑GSDMD↑, 1, GSDME↑, 1, GSDME-N↑, 2, HEY1↓, 1, HGF/c-Met↓, 3, Hippo↓, 1, hTERT/TERT↓, 10, IAP1↓, 5, IAP2/BIRC3↓, 2, ICAD↓, 1, iNOS↓, 15, JNK↓, 6, JNK↑, 30, p‑JNK↑, 7, cl‑JNK↑, 1, MAPK?, 1, MAPK↓, 35, MAPK↑, 25, MAPK↝, 2, p‑MAPK↓, 3, p‑MAPK↑, 1, Mcl-1↓, 32, p‑Mcl-1↓, 1, cl‑Mcl-1↑, 1, MDM2↓, 13, miR-497↑, 1, miR-548ah-5p↑, 1, MKP1↓, 1, MKP2↓, 1, MLKL↑, 2, p‑MLKL↓, 1, MOMP↓, 1, MOMP↑, 4, Myc↓, 4, NAIP↓, 2, Necroptosis↑, 3, necrosis↑, 2, NICD↓, 1, NOXA↑, 5, p27/CDKN1B↓, 1, p27/CDKN1B↑, 35, p38↓, 5, p38↑, 30, p‑p38↓, 5, p‑p38↑, 9, Paraptosis↑, 1, Proteasome↓, 2, PUMA↑, 8, PUMA⇅, 1, Pyro↑, 7, RIP1↓, 1, RIP1↑, 1, survivin↓, 66, survivin↝, 1, Telomerase↓, 10, TNFR 1↑, 2, TRAIL↑, 9, TRAILR↑, 2, TRPV1↑, 1, TumCD?, 1, TumCD↓, 2, TumCD↑, 19, TUNEL↑, 2, YAP/TEAD↓, 6,

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1, CaMKII ↓, 2, cSrc↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 11, p‑HER2/EBBR2↓, 1, miR-25-5p↑, 1, p70S6↓, 1, RET↓, 1, RTK-RAS↓, 1, Sp1/3/4↓, 8, TSC2↑, 3, p‑TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1, cJun↓, 7, cJun↑, 5, p‑cJun↑, 1, EZH2↓, 1, H3↓, 3, p‑H3↓, 1, ac‑H3↑, 3, ac‑H4↑, 2, HATs↓, 2, HATs↑, 1, KCNQ1OT1↓, 1, miR-21↓, 4, miR-21↑, 1, miR-27a-3p↓, 2, miR-27a-3p↑, 1, miR-30a-5p↑, 1, other?, 1, other↓, 4, other↑, 2, other↝, 6, PhotoS↑, 2, pRB↓, 2, pRB↑, 1, p‑pRB↓, 2, Shc↓, 1, sonoS↑, 2, TET3↑, 1, tumCV?, 1, tumCV↓, 93, tumCV↑, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 2, ATFs↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 31, CRT↑, 1, eIF2α↓, 2, eIF2α↑, 8, p‑eIF2α↓, 1, p‑eIF2α↑, 3, ER Stress↓, 2, ER Stress↑, 40, GRP78/BiP?, 1, GRP78/BiP↓, 3, GRP78/BiP↑, 12, GRP94↑, 1, HSP27↓, 3, HSP27↑, 1, HSP27↝, 1, HSP70/HSPA5↓, 3, HSP70/HSPA5↑, 4, HSP70/HSPA5↝, 1, HSP72↓, 1, HSP90↓, 7, HSP90↑, 2, IRE1↑, 4, PERK↑, 10, p‑PERK↑, 1, UPR↑, 7, XBP-1↑, 4,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 4, ATG5↑, 9, Beclin-1/ATG6↑, 20, BNIP3?, 1, BNIP3↓, 1, BNIP3↑, 5, LC3‑Ⅱ/LC3‑Ⅰ↑, 4, LC3A↑, 1, LC3B↑, 1, LC3B-II↑, 3, LC3I↓, 1, LC3I↑, 1, LC3II↑, 17, LC3s↑, 3, MitoP↑, 1, p62↓, 7, p62↑, 4, SESN2↑, 2, TumAuto↑, 43, TumAuto⇅, 1, TumAuto↝, 1,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 4, p‑ATM↑, 1, BRCA1↓, 1, BRCA1↑, 1, p‑BRCA1↑, 1, CHK1↑, 2, p‑CHK1↑, 2, DFF45↓, 2, DFF45↑, 1, DNA-PK↑, 1, DNAdam↓, 1, DNAdam↑, 65, DNArepair↓, 5, DNArepair↑, 1, DNMT1↓, 11, DNMT3A↓, 5, DNMTs↓, 5, GADD45A↑, 3, MGMT↓, 1, p16↑, 2, P53?, 1, P53↓, 3, P53↑, 166, P53⇅, 1, P53↝, 1, p‑P53↑, 9, p53 Wildtype↓, 1, PARP↓, 5, PARP↑, 27, p‑PARP↑, 4, cl‑PARP↓, 3, cl‑PARP↑, 97, PARP1↓, 1, PARP1↑, 3, cl‑PARP1↑, 4, PCLAF↓, 1, PCNA↓, 34, PCNA↑, 1, RAD51↓, 1, RAD51↑, 1, SIRT6↓, 1, SMG1↑, 1, TP53↑, 1, γH2AX↑, 10, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 25, CDK1↑, 2, p‑CDK1↓, 1, CDK1/2/5/9↓, 1, CDK2↓, 35, CDK2↑, 3, p‑CDK2↓, 2, CDK4↓, 40, CDK4↑, 1, CDK4↝, 1, p‑CDK4↓, 1, Cyc↓, 4, cycA1/CCNA1↓, 12, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 36, CycB/CCNB1↑, 3, cycD1/CCND1↓, 97, cycD1/CCND1↑, 4, p‑cycD1/CCND1↓, 1, CycD3↓, 5, cycE/CCNE↓, 20, cycE/CCNE↑, 2, cycE1↓, 2, cycF↓, 1, cycF↑, 1, E2Fs↓, 3, mitA↓, 1, p19↑, 1, P21?, 1, P21↓, 5, P21↑, 89, PLK1↓, 1, RB1↓, 2, RB1↑, 3, cl‑RB1↓, 1, Securin↓, 1, TAp63α↑, 1, TumCCA?, 1, TumCCA↓, 8, TumCCA↑, 229,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, p‑4E-BP1↓, 2, ALDH↓, 3, ALDH1A1↓, 4, BMI1↓, 1, BRAF↝, 1, CD133↓, 4, CD133↑, 1, CD24↓, 2, CD34↓, 1, CD44↓, 9, cDC2↓, 3, p‑cDC2↑, 1, CEBPA↑, 1, cFos↓, 8, CIP2A↓, 1, cMET↓, 3, p‑cMET↑, 2, CSCs↓, 26, CTNNB1↓, 1, Diff↑, 2, EIF4E↓, 1, EMT?, 1, EMT↓, 50, EMT↑, 3, EpCAM↓, 3, ERK↓, 59, ERK↑, 13, p‑ERK↓, 19, p‑ERK↑, 4, FGF↓, 3, FOXM1↓, 1, FOXO1↓, 2, FOXO1↑, 3, FOXO3↓, 1, FOXO3↑, 2, FOXO3↝, 1, p‑FOXO3↓, 1, Gli1↓, 10, GSK‐3β↓, 9, GSK‐3β↑, 8, p‑GSK‐3β↓, 4, HDAC↓, 20, HDAC1↓, 7, HDAC10↑, 1, HDAC2↓, 4, HDAC3↓, 4, HDAC4↓, 1, HDAC8↓, 1, HH↓, 7, HMGCR↓, 1, HRAS↓, 3, IGF-1↓, 9, p‑IGF-1↓, 1, IGF-1R↓, 3, IGF-2↓, 1, IGFBP3↑, 4, IGFBP7↑, 1, IGFR↓, 2, Jun↓, 1, Let-7↑, 3, MAP2K1/MEK1↓, 1, p‑MAP2K1/MEK1↓, 1, MCM2↓, 1, miR-34a↓, 1, miR-34a↑, 8, Mst1↑, 1, mTOR↓, 66, mTOR↑, 2, mTOR↝, 1, p‑mTOR↓, 23, mTORC1↓, 7, mTORC2↓, 3, Nanog↓, 9, Nanog↑, 1, Nestin↓, 1, NOTCH↓, 11, NOTCH⇅, 1, NOTCH1↓, 13, NOTCH1↑, 1, NOTCH2↓, 1, NOTCH3↓, 2, NRAS↓, 1, OCT4↓, 9, OCT4↑, 1, P70S6K↓, 7, p‑P70S6K↓, 3, p‑P90RSK↑, 1, PDGFRA↓, 1, PI3K↓, 110, PI3K↑, 1, p‑PI3K↓, 13, p‑PI3K↑, 1, circ‑PLEKHM3↑, 1, PTCH1↓, 3, PTEN↑, 25, PTEN↝, 1, RAS↓, 10, RAS↑, 1, SAL↑, 1, Shh↓, 8, SHP1↑, 1, Smo↓, 6, SOX2↓, 7, Src↓, 1, Src↑, 1, STAT↓, 4, STAT3↓, 61, STAT3↑, 4, p‑STAT3↓, 13, p‑STAT3↑, 1, STAT4↑, 1, STAT5↓, 1, STAT6↓, 2, Sufu↑, 1, TAZ↓, 1, TCF↑, 1, TCF↝, 1, TCF-4↓, 1, TOP1↓, 3, TOP1↝, 1, TOP2↓, 6, TRPM7↓, 2, TumCG?, 1, TumCG↓, 97, TumCG↑, 4, tyrosinase↓, 1, Wnt?, 1, Wnt↓, 33, Wnt/(β-catenin)↓, 4, ZFX↓, 1,

Migration(tgid=13) ⓘ

5LO↓, 2, AEG1↓, 1, Akt2↓, 1, AntiAg?, 1, AntiAg↓, 1, AntiAg↑, 1, AP-1↓, 10, AXL↓, 1, Ca+2↓, 2, Ca+2↑, 39, Ca+2↝, 1, i-Ca+2↑, 2, CAFs/TAFs↓, 1, cal2↑, 2, CCN2/CTGF↓, 2, CD31/PECAM-1↓, 3, Cdc42↑, 1, CEA↓, 1, CLDN2↓, 2, COL1↓, 1, COL3A1↓, 1, CXCL12↓, 1, E-cadherin↓, 6, E-cadherin↑, 45, ER-α36↓, 3, F-actin↓, 1, FAK↓, 16, Fibronectin↓, 3, GLI2↓, 3, HLA↑, 1, hnRNPA1↓, 1, ITGB1↓, 2, ITGB3↓, 1, Ki-67↓, 32, KRAS↓, 2, LAMs↓, 1, LEF1↓, 1, LRP1↓, 1, MALAT1↓, 1, MARK4↓, 1, MET↓, 3, miR-133a-3p↑, 1, miR-139-5p↑, 2, miR-155↓, 3, miR-221↓, 1, miR-29b↑, 1, miR-320a↓, 1, miR-340↓, 1, miR-384↑, 1, MMP-10↓, 1, MMP1↓, 5, MMP13↓, 4, MMP2↓, 72, MMP3↓, 8, MMP7↓, 8, MMP9↓, 87, MMPs↓, 27, MRGPRF↓, 1, N-cadherin↓, 28, NFAT↑, 1, p‑p44↓, 1, p‑p44↑, 1, PAK1↓, 1, PAK1↑, 1, PDGF↓, 3, p‑PKA↓, 1, PKCδ↓, 11, RAGE↓, 2, RECK↑, 1, Rho↓, 2, RIP3↑, 3, p‑RIP3↑, 2, ROCK1↓, 2, Slug↓, 5, SMAD2↓, 1, p‑SMAD2↓, 2, SMAD3↓, 1, SMAD3↑, 1, p‑SMAD3↓, 2, SMAD4↓, 2, SMAD4↑, 1, p‑SMAD4↓, 1, Snail↓, 20, SOX4↑, 1, TET1↑, 3, TGF-β↓, 16, TGF-β↑, 2, TIMP1↓, 2, TIMP1↑, 10, TIMP2↓, 3, TIMP2↑, 14, TIMP3↑, 1, Treg lymp↓, 1, TSC1↑, 1, TSP-1↑, 4, TumCA↓, 2, TumCI?, 1, TumCI↓, 76, TumCI↑, 1, TumCMig↓, 79, TumCMig↑, 1, TumCP?, 2, TumCP↓, 183, TumCP↑, 5, TumMeta↓, 53, TumMeta↑, 3, TumPF↓, 2, Twist↓, 15, uPA↓, 20, uPAR↓, 2, VCAM-1↓, 1, VEGFR1↓, 2, Vim↓, 33, Zeb1↓, 7, ZEB2↓, 2, ZO-1↑, 1, α-tubulin↓, 1, β-catenin/ZEB1↓, 35, β-catenin/ZEB1↑, 1, cl‑β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 65, angioG↑, 2, ATF4↓, 1, ATF4↑, 10, ECM/TCF↓, 1, EGFR↓, 30, EGFR↑, 1, p‑EGFR↓, 2, Endoglin↑, 1, eNOS↓, 2, EPR↑, 3, HIF-1↓, 4, Hif1a↓, 46, Hif1a↑, 1, LOX1↓, 2, miR-17↓, 1, NO↓, 4, NO↑, 1, VEGF↓, 81, VEGFR2/KDR/Flk1↓, 15,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, BBB∅, 1, CellMemb↓, 1, GLUT1↓, 7, GLUT1↑, 1, GLUT3↑, 1, GLUT4↓, 2, P-gp/ABCB1↓, 16,

Immune & Inflammatory Signaling(tgid=16) ⓘ

ANXA1↓, 1, B2M↓, 1, CB2 / CNR2↑, 3, CD25+↑, 1, CD4+↓, 1, CD4+↑, 3, COX2/PTGS2↓, 56, COX2/PTGS2↑, 2, CRP↓, 1, CXCR2↓, 2, CXCR4↓, 11, FOXP3↓, 2, FOXP3↑, 1, HMGB1↓, 2, HMGB1↑, 1, ICAM-1↓, 2, IFN-γ↓, 4, IFN-γ↑, 3, IKKα↓, 7, IKKα↑, 2, p‑IKKα↓, 1, IL1↓, 5, IL10↓, 4, IL10↑, 1, IL12↓, 1, IL12↑, 2, IL1α↓, 1, IL1β↓, 12, IL1β↑, 3, IL2↓, 2, IL2↑, 3, IL6↓, 36, IL6↑, 1, IL8↓, 10, Imm↑, 9, Imm↝, 2, Inflam↓, 25, Inflam↝, 1, IκB↑, 2, p‑IκB↓, 1, p‑IκB↑, 1, JAK↓, 5, JAK1↓, 3, JAK1↑, 1, JAK2↓, 8, p‑JAK2↓, 1, LTA/TNF-β↓, 1, M2 MC↓, 1, MCP1/CCL2↓, 2, MDSCs↓, 1, NF-kB?, 1, NF-kB↓, 132, NF-kB↑, 6, p‑NF-kB↓, 2, p‑NF-kB↑, 2, NK cell↑, 3, p65↓, 6, p‑p65↑, 1, PD-1↓, 1, PD-L1↓, 7, PD-L1↑, 1, PGE2↓, 5, PSA↓, 8, RANTES↓, 1, SOCS1↑, 1, T-Cell↑, 3, Th1 response↑, 1, TLR4↓, 4, TNF-α↓, 36, TNF-α↑, 9,

Protein Aggregation(tgid=19) ⓘ

BACE/β-secretase↓, 1, NLRP3↓, 1, PP2A↑, 1, XO↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 14, CDK6↓, 19, CDK6↑, 3, ER(estro)↓, 1, ERα/ESR1↓, 1, ERβ/ESR2↑, 1, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 4, BioAv↓, 26, BioAv↑, 29, BioAv↝, 7, BioAv∅, 1, BioEnh↑, 1, ChemoSen?, 1, ChemoSen↓, 2, ChemoSen↑, 110, ChemoSen↝, 1, CYP1A2↓, 1, DDS↑, 1, Dose?, 1, Dose↓, 2, Dose↑, 5, Dose↝, 38, Dose∅, 7, eff↓, 71, eff↑, 158, eff↝, 8, eff∅, 1, Half-Life↓, 7, Half-Life↝, 5, Half-Life∅, 3, MDR1↓, 5, MRP1/ABCC1↓, 2, P450↓, 4, RadioS↑, 32, selectivity?, 2, selectivity↓, 1, selectivity↑, 78, selectivity∅, 1, TET2↓, 1, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 2, ALAT↓, 1, ALAT↝, 1, ALAT∅, 1, ALP↓, 1, ALP↝, 1, AR↓, 14, AST↓, 1, AST↝, 1, AST∅, 1, B2M↓, 1, BMPs↑, 1, BRAF↝, 1, BRCA1↓, 1, BRCA1↑, 1, p‑BRCA1↑, 1, CEA↓, 1, CRP↓, 1, E6↓, 3, E7↓, 3, EGFR↓, 30, EGFR↑, 1, p‑EGFR↓, 2, ERα/ESR1↓, 1, EZH2↓, 1, Ferritin↓, 1, FOXM1↓, 1, GutMicro↑, 3, HER2/EBBR2↓, 11, p‑HER2/EBBR2↓, 1, hTERT/TERT↓, 10, IL6↓, 36, IL6↑, 1, Ki-67↓, 32, KRAS↓, 2, LDH?, 1, LDH↓, 8, LDH↑, 7, LDH↝, 1, i-LDH↓, 1, Maspin↑, 2, Myc↓, 4, PD-L1↓, 7, PD-L1↑, 1, PSA↓, 8, RAGE↓, 2, TP53↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, AntiCan↓, 2, AntiCan↑, 50, AntiCan∅, 1, antiNeop↑, 3, AntiTum↓, 1, AntiTum↑, 23, cardioP↑, 7, CardioT↓, 1, CardioT↑, 1, chemoP↑, 22, chemoPv↑, 13, ChemoSideEff↓, 5, ChemoSideEff∅, 1, hepatoP↓, 1, hepatoP↑, 11, NDRG1↑, 1, neuroP↑, 5, NKG2D↑, 1, OS↑, 8, Pain↓, 2, Pin1↓, 3, PRAS40↑, 1, QoL↑, 2, QoL∅, 1, radioP↑, 4, Remission↑, 1, RenoP↑, 7, Risk↓, 9, toxicity?, 1, toxicity↓, 14, toxicity↑, 4, toxicity↝, 7, toxicity∅, 2, TumVol↓, 26, TumVol↑, 1, TumW↓, 14, Weight↑, 2, Weight∅, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, Bacteria↓, 2, CD8+↑, 2,
Total Targets: 1075

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1, AntiBio↑, 7, CD19↑, 1, colonLen↑, 1, CYP2D6↓, 1, diuretic↑, 2, Mucositis↓, 1, PLA2↓, 1, Stroke↓, 1, TRPA1↑, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx?, 1, antiOx↓, 4, antiOx↑, 58, Bil↓, 1, Catalase↑, 31, Ferroptosis↓, 1, GPx↑, 25, GSH↑, 26, GSR↑, 7, GSTA1↑, 2, GSTs↑, 8, H2O2↓, 4, HDL↑, 2, HO-1↓, 1, HO-1↑, 10, Iron↓, 1, Keap1↓, 2, Keap1↑, 1, lipid-P↓, 23, MDA↓, 14, MDA↑, 1, NADH↓, 1, NQO1↑, 1, NRF2↑, 26, RNS↓, 3, ROS↓, 56, ROS↑, 2, ROS∅, 1, SOD↓, 1, SOD↑, 33, SOD1↑, 2, SOD2↑, 2, TAC↑, 1, TBARS↓, 1, Trx↑, 1, uricA↓, 1, VitC↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2, Insulin↑, 1, MMP↑, 2, PGC-1α↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 8, AMPK↑, 4, p‑AMPK↑, 1, BUN↓, 1, CREB↑, 1, glucose↓, 3, glucose↑, 1, glucose↝, 2, GlucoseCon↑, 1, GLUT2↑, 2, H2S↑, 1, HMG-CoA↓, 1, LDH↓, 3, LDHA↑, 1, LDL↓, 1, lipidLev↓, 1, NAD↑, 1, NADPH↓, 1, NADPH↑, 1, PPARα↑, 2, PPARγ↓, 1, PPARγ↑, 1, SIRT1↑, 4, SREBP1/SREBF1↓, 1,

Cell Death(tgid=5) ⓘ

Akt↓, 1, Akt↑, 3, Apoptosis↓, 2, BAX↓, 4, Bcl-2↑, 1, Casp1↓, 1, Casp3↓, 6, Casp9↓, 3, Cyt‑c↓, 2, Fas↓, 3, FasL↓, 1, Ferroptosis↓, 1, HGF/c-Met↑, 1, iNOS↓, 11, JNK↓, 1, JNK↑, 1, MAPK↓, 3, p38↓, 1, TRPV1↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 4, cJun↓, 1, other↓, 3, other↑, 2, other↝, 2,

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 1, ER Stress↓, 1, GRP78/BiP↑, 1, GRP94↑, 1, HSP70/HSPA5↑, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3, p16↓, 1, P53↓, 3, PCNA↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1, CDK4↓, 1, cycD1/CCND1↓, 1, cycE/CCNE↓, 1, E2Fs↑, 1, P21↓, 1, RB1↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ERK↑, 1, p‑ERK↑, 1, GSK‐3β↓, 2, HDAC↓, 2, HDAC3↓, 1, IGF-1↑, 1, IGF-1R↓, 1, mTOR↑, 1, PDGFRB↓, 1, PI3K↓, 1, PI3K↑, 3, RAS↓, 1, STAT3↓, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 2, AP-1↓, 2, Ca+2↓, 1, CEA↓, 1, Ki-67↓, 1, MMP13↓, 2, MMP2↓, 1, PAI-1/SERPINE1↓, 1, PKCδ↑, 1, p‑Rac1↓, 1, TXNIP↓, 1, ZO-1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1, ATF4↓, 1, Hif1a↓, 1, NO↓, 6, NO↑, 1, PDGFR-BB↓, 2,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, GastroP↑, 4, GLUT3↑, 1, GLUT4↑, 1, P-gp/ABCB1↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2, COX1↓, 2, COX2/PTGS2↓, 15, CRP↓, 2, IFN-γ↓, 1, IKKα↓, 1, IKKα↑, 1, IL10↓, 3, IL10↑, 1, IL18↓, 1, IL1β↓, 8, IL2↓, 2, IL4↓, 1, IL5↓, 1, IL6↓, 11, IL6↑, 1, IL8↓, 3, Imm↑, 4, Inflam↓, 62, Inflam↑, 1, IκB?, 1, JAK↓, 2, NF-kB?, 1, NF-kB↓, 12, NF-kB↑, 1, NK cell↑, 1, PGE2↓, 7, PGE2↑, 1, PSA∅, 1, TLR4↓, 3, TNF-α↓, 17,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↑, 1, AChE↓, 10, BChE↓, 4, BDNF↑, 2, GABA↑, 1, MAOA↓, 1, NGF↑, 1, tau↓, 2, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 2, Aβ↓, 5, BACE/β-secretase↓, 2, NLRP3↓, 1,

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 24, BioAv↑, 26, BioAv↝, 12, BioEnh↑, 1, Dose↝, 6, Dose∅, 1, eff↓, 1, eff↑, 12, Half-Life↑, 1, Half-Life↝, 5, P450↓, 3, selectivity↑, 2,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8, ALP↓, 5, AST↓, 8, Bil↓, 1, BMD↑, 1, BP↓, 3, CEA↓, 1, creat↓, 1, CRP↓, 2, GutMicro↑, 4, IL6↓, 11, IL6↑, 1, Ki-67↓, 1, LDH↓, 3, NOS2↓, 1, PSA∅, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, antiAll↑, 2, AntiArt↑, 5, AntiCan↑, 12, antiCG↑, 1, antiD↓, 1, AntiDiabetic↑, 14, AntiP↓, 1, AntiP↑, 3, AntiTum↓, 1, AntiTum↑, 3, cardioP↑, 23, CardioT↓, 1, chemoP↑, 6, chemoPv↑, 3, cognitive↑, 5, hepatoP↓, 1, hepatoP↑, 23, memory↑, 2, motorD↑, 2, neuroP?, 1, neuroP↓, 1, neuroP↑, 34, Obesity↓, 3, Pain↓, 3, radioP↑, 2, RenoP↑, 7, Risk↓, 1, toxicity?, 1, toxicity↓, 15, toxicity↑, 3, toxicity↝, 1, toxicity∅, 6, Wound Healing↑, 4,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 4, AntiViral↑, 6, Bacteria↓, 14, CD8+↑, 1, Diar↓, 3, Sepsis↓, 2,
Total Targets: 267

Scientific Paper Hit Count for: BAX, Apoptosis regulator BAX

30 Silver-NanoParticles
25 Quercetin
23 Curcumin
16 Thymoquinone
15 Baicalein
14 Apigenin (mainly Parsley)
14 Luteolin
12 Allicin (mainly Garlic)
10 Betulinic acid
10 Fisetin
9 Ashwagandha(Withaferin A)
9 Sulforaphane (mainly Broccoli)
9 Propolis -bee glue
9 EGCG (Epigallocatechin Gallate)
9 Emodin
8 Berberine
8 Eugenol
8 Graviola
8 Juglone
7 Cisplatin
7 Carvacrol
7 D-limonene
7 Garcinol
7 Isobavachalcone
7 Kaempferol
7 Licochalcone A
7 Lycopene
7 Phenethyl isothiocyanate
7 Resveratrol
7 Silymarin (Milk Thistle) silibinin
6 Artemisinin
6 Capsaicin
6 Ellagic acid
6 Ferulic acid
6 Licorice
5 5-fluorouracil
5 Alpha-Lipoic-Acid
5 Beta-Caryophyllene
5 Chrysin
5 Formononetin
5 Gambogic Acid
5 Geraniol
5 Magnetic Fields
5 Hibiscus sabdariffa
5 Honokiol
5 Hyperoside
5 Ivermectin
5 Nimbolide
4 Astragalus
4 Andrographis
4 Melatonin
4 Isovitexin
4 Radiotherapy/Radiation
4 Boron
4 Boswellia (frankincense)
4 Carnosic acid
4 chitosan
4 Cinnamon
4 Paclitaxel/Taxol
4 Evodiamine
4 Gallic acid
4 Indole-3-carbinol
4 Isoliquiritigenin
4 isoorientin
4 Magnolol
4 Rosmarinic acid
4 Shikonin
3 Gemcitabine (Gemzar)
3 Cynara scolymus/Globe Artichoke/Artichoke Extract
3 Astaxanthin
3 Chemotherapy
3 Caffeic acid
3 Thymol-Thymus vulgaris
3 Chlorogenic acid
3 Docetaxel
3 Dandelion Root
3 Eurycomanone
3 HydroxyTyrosol
3 isoquercitrin
3 Oleuropein
3 Aflavin-3,3′-digallate
3 Urolithin
2 Photodynamic Therapy
2 tamoxifen
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 immunotherapy
2 beta-glucans
2 Berbamine
2 Bufalin/Huachansu
2 α-Bisabolol / Chamomile oil
2 Hydroxycinnamic-acid
2 Crocetin
2 Carvone
2 Polyphenols
2 Cynaropicrin
2 Ginkgolic acids
2 Ginger/6-Shogaol/Gingerol
2 Ginkgetin
2 Gossypol/AT-101
2 Rutin
2 Vitamin C (Ascorbic Acid)
2 Lactobacillus
2 Laetrile B17 Amygdalin
2 low dose naltrexone
2 Lemongrass Extract/Citral
2 Lutein
2 Naringin
2 Propyl gallate
2 Piperine
2 Piperlongumine
2 Plumbagin
2 Parthenolide
2 Pterostilbene
2 Rauwolfia serpentina/Indian Snakeroot
2 salinomycin
2 Selenium
2 Selenite (Sodium)
2 Ursolic acid
1 1,8-Cineole
1 Coenzyme Q10
1 SonoDynamic Therapy UltraSound
1 Camptothecin
1 DTS(dibenzyl trisulphide) from Anamu
1 Anethole/trans-Anethole
1 Angelica archangelica / Garden Angelica
1 Metformin
1 Aspirin
1 Ascorbyl Palmitate
1 Trastuzumab
1 Atorvastatin
1 Aloe anthraquinones
1 epirubicin
1 Biochanin A
1 Brucea javanica
1 Bromelain
1 borneol
1 Butyrate
1 Cat’s Claw
1 Celastrol
1 Centella asiatica / Gotu kola → asiaticoside
1 chaetocin
1 Prebiotic
1 Chlorophyllin
1 Citric Acid
1 Copper and Cu NanoParticles
1 Dichloroacetate
1 Date Fruit Extract
1 Disulfiram
1 Electrical Pulses
1 Fenbendazole
1 olaparib/LYNPARZA
1 carboplatin
1 Ginkgolide B
1 Ginseng
1 γ-linolenic acid (Borage Oil)
1 Gold NanoParticles
1 HydroxyCitric Acid
1 Helleborus niger extracts – Christmas Rose
1 iodine
1 itraconazole
1 doxorubicin
1 lambertianic acid
1 Lapachol
1 SDG/lignans
1 Magnetic Field Rotating
1 Marjoram (Origanum majorana)
1 Phenylbutyrate
1 sericin
1 Psoralidin
1 buckwheat sprouts
1 Sanguinarine
1 α-Santalol/Sandalwood oil
1 Scoulerine
1 polyethylene glycol
1 Auranofin
1 Salvia miltiorrhiza
1 Terpinen-4-ol / Tea Tree Oil
1 triptolide
1 Vitamin D3
1 Vitamin K2
1 VitK3,menadione
1 Vitexin
1 Zerumbone

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:26  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

Home Page