IL2 Cancer Research Results

IL2, Interleukin-2: Click to Expand ⟱
Source:
Type:
The cytokine interleukin-2 (IL-2) can stimulate both effector immune cells and regulatory T (Treg) cells.

IL-2 is often expressed in various cancers, including melanoma, renal cell carcinoma, and certain hematological malignancies. Its expression can vary depending on the tumor type and the immune context.
Tumor-infiltrating lymphocytes (TILs), particularly activated T cells, are significant sources of IL-2 in the tumor microenvironment.

IL-2 is primarily known for its role in promoting anti-tumor immunity. It stimulates the proliferation and activation of T cells, enhancing their ability to recognize and kill tumor cells.
Scientific Papers found: Click to Expand⟱
5434- AG,    Recent Advances in the Mechanisms and Applications of Astragalus Polysaccharides in Liver Cancer Treatment: An Overview
- Review, Liver, NA
AntiCan↑, Apoptosis↑, TumCP↓, EMT↓, Imm↑, ChemoSen↑, BioAv↓, TumCG↓, IL2↑, IL12↑, TNF-α↑, P-gp/ABCB1↓, MDR1↓, QoL↑, Casp↑, DNAdam↑, Bcl-2↓, BAX↑, MMP↓, Cyt‑c↑, NOTCH1↓, GSK‐3β↓, TumCCA↑, GSH↓, ROS↑, lipid-P↑, c-Iron↑, GPx4↓, ACSL4↑, Ferroptosis↑, Wnt↓, β-catenin/ZEB1↓, cycD1/CCND1↓, Akt↓, PI3K↓, mTOR↓, CXCR4↓, Vim↓, PD-L1↓, eff↑, eff↑, ChemoSen↑, ChemoSen↑, chemoP↑,
5436- AG,    Therapeutic Effect of Astragalus Polysaccharides on Hepatocellular Carcinoma H22-Bearing Mice
- in-vivo, HCC, NA
TumCG↓, BAX↑, Bcl-2↓, IL2↑, IL6↑, TNF-α↑, toxicity↓,
5987- Chit,    Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine
- Review, Var, NA
other↝, other↝, *Weight↝, *toxicity↓, *Bacteria↓, *BioAv↑, DDS↑, *Wound Healing↑, *other↝, *Imm↑, eff↑, *BioAv↝, *BioAv↑, eff↑, NK cell↑, IL2↑, IFN-γ↑, IL10↑,
2781- CHr,  PBG,    Chrysin a promising anticancer agent: recent perspectives
- Review, Var, NA
PI3K↓, Akt↓, mTOR↓, MMP9↑, uPA↓, VEGF↓, AR↓, Casp↑, TumMeta↓, TumCCA↑, angioG↓, BioAv↓, *hepatoP↑, *neuroP↑, *SOD↑, *GPx↑, *ROS↓, *Inflam↓, *Catalase↑, *MDA↓, ROS↓, BBB↑, Half-Life↓, BioAv↑, ROS↑, eff↑, ROS↑, ROS↑, lipid-P↑, ER Stress↑, NOTCH1↑, NRF2↓, p‑FAK↓, Rho↓, PCNA↓, COX2/PTGS2↓, NF-kB↓, PDK1 / PDPK1↓, PDK3↑, GLUT1↓, Glycolysis↓, mt-ATP↓, Ki-67↓, cMyc↓, ROCK1↓, TOP1↓, TNF-α↓, IL1β↓, CycB/CCNB1↓, CDK2↓, EMT↓, STAT3↓, PD-L1↓, IL2↑,
5487- EP,    High-frequency irreversible electroporation improves survival and immune cell infiltration in rodents with malignant gliomas
- in-vivo, GBM, NA
OS↑, CellMemb↑, Imm↑, Inflam↓, necrosis↑, Pyro↑, eff↑, IL2↑, IL6↑, IL17↑, IFN-γ↓,
2919- LT,    Luteolin as a potential therapeutic candidate for lung cancer: Emerging preclinical evidence
- Review, Var, NA
RadioS↑, ChemoSen↑, chemoP↑, *lipid-P↓, *Catalase↑, *SOD↑, *GPx↑, *GSTs↑, *GSH↑, *TNF-α↓, *IL1β↓, *Casp3↓, *IL10↑, NRF2↓, HO-1↓, NQO1↓, GSH↓, MET↓, p‑MET↓, p‑Akt↓, HGF/c-Met↓, NF-kB↓, Bcl-2↓, SOD2↓, Casp8↑, Casp3↑, PARP↑, MAPK↓, NLRP3↓, ASC↓, Casp1↓, IL6↓, IKKα↓, p‑p65↓, p‑p38↑, MMP2↓, ICAM-1↓, EGFR↑, p‑PI3K↓, E-cadherin↓, ZO-1↑, N-cadherin↓, CLDN1↓, β-catenin/ZEB1↓, Snail↓, Vim↑, ITGB1↓, FAK↓, p‑Src↓, Rac1↓, Cdc42↓, Rho↓, PCNA↓, Tyro3↓, AXL↓, CEA↓, NSE↓, SOD↓, Catalase↓, GPx↓, GSR↓, GSTs↓, GSH↓, VitE↓, VitC↓, CYP1A1↓, cFos↑, AR↓, AIF↑, p‑STAT6↓, p‑MDM2↓, NOTCH1↓, VEGF↓, H3↓, H4↓, HDAC↓, SIRT1↓, ROS↑, DR5↑, Cyt‑c↑, p‑JNK↑, PTEN↓, mTOR↓, CD34↓, FasL↑, Fas↑, XIAP↓, p‑eIF2α↑, CHOP/DDIT3↑, LC3II↑, PD-1↓, STAT3↓, IL2↑, EMT↓, cachexia↓, BioAv↑, *Half-Life↝, *eff↑,
3277- Lyco,    Recent trends and advances in the epidemiology, synergism, and delivery system of lycopene as an anti-cancer agent
- Review, Var, NA
antiOx↑, TumCP↓, Apoptosis↑, TumMeta↑, ChemoSen↑, BioAv↓, Dose↝, BioAv↓, BioAv↑, SOD↑, Catalase↑, GPx↑, IL2↑, IL4↑, IL1↑, TNF-α↑, GSH↑, GPx↑, GSTA1↑, GSR↑, PPARγ↑, Casp3↑, NF-kB↓, COX2/PTGS2↓, Bcl-2↑, BAX↓, P53↓, CHK1↓, Chk2↓, γH2AX↓, DNAdam↓, ROS↓, P21↑, PCNA↓, β-catenin/ZEB1↓, PGE2↓, ERK↓, cMyc↓, cycE/CCNE↓, JAK1↓, STAT3↓, SIRT1↑, cl‑PARP↑, cycD1/CCND1↓, TNF-α↓, IL6↓, p65↓, MMP2↓, MMP9↓, Wnt↓,
5602- NaHCO3,  immuno,    Immunotherapy Enhancement by Targeting Extracellular Tumor pH in Triple-Negative Breast Cancer Mouse Model
- in-vivo, BC, 4T1
eff↑, TumCG↓, OS↑, e-pH↑, IFN-γ↑, IL2↑, IL12↑, Dose↝, PD-L1↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1508- SFN,    Nrf2 targeting by sulforaphane: A potential therapy for cancer treatment
- Review, Var, NA
*BioAv↑, HDAC↓, TumCCA↓, eff↓, Wnt↓, β-catenin/ZEB1↓, Casp12?, Bcl-2↓, cl‑PARP↑, Bax:Bcl2↑, IAP1↓, Casp3↑, Casp9↑, Telomerase↓, hTERT/TERT↓, ROS?, DNMTs↓, angioG↓, VEGF↓, Hif1a↓, cMYB↓, MMP1↓, MMP2↓, MMP9↓, ERK↑, E-cadherin↑, CD44↓, MMP2↓, eff↑, IL2↑, IFN-γ↑, IL1β↓, IL6↓, TNF-α↓, NF-kB↓, ERK↓, NRF2↑, RadioS↑, ChemoSideEff↓,
3288- SIL,    Silymarin in cancer therapy: Mechanisms of action, protective roles in chemotherapy-induced toxicity, and nanoformulations
- Review, Var, NA
Inflam↓, lipid-P↓, TumMeta↓, angioG↓, chemoP↑, EMT↓, HDAC↓, HATs↑, MMPs↓, uPA↓, PI3K↓, Akt↓, VEGF↓, CD31/PECAM-1↓, Hif1a↓, VEGFR2/KDR/Flk1↓, Raf↓, MEK↓, ERK↓, BIM↓, BAX↑, Bcl-2↓, Bcl-xL↓, Casp↑, MAPK↓, P53↑, LC3II↑, mTOR↓, YAP/TEAD↓, *BioAv↓, MMP↓, Cyt‑c↑, PCNA↓, cMyc↓, cycD1/CCND1↓, β-catenin/ZEB1↓, survivin↓, APAF1↑, Casp3↑, MDSCs↓, IL10↓, IL2↑, IFN-γ↑, hepatoP↑, cardioP↑, GSH↑, neuroP↑,
1688- SSE,    Potential Role of Selenium in the Treatment of Cancer and Viral Infections
- Review, Var, NA
IL2↑, INF-γ↑, Th1 response↑, Th2↑, Dose↑, AntiCan∅, Risk↑, chemoP↑, Hif1a↓, VEGF↓, selectivity↑, *GADD45A↑, NRF2↓, *NRF2↑, ChemoSen↑, angioG↓, PrxI↓, ChemoSideEff↓, eff↑,
3427- TQ,    Chemopreventive and Anticancer Effects of Thymoquinone: Cellular and Molecular Targets
ROS⇅, Fas↑, DR5↑, TRAIL↑, Casp3↑, Casp8↑, Casp9↑, P53↑, mTOR↓, Bcl-2↓, BID↓, CXCR4↓, JNK↑, p38↑, MAPK↑, LC3II↑, ATG7↑, Beclin-1/ATG6↑, AMPK↑, PPARγ↑, eIF2α↓, P70S6K↓, VEGF↓, ERK↓, NF-kB↓, XIAP↓, survivin↓, p65↓, DLC1↑, FOXO↑, TET2↑, CYP1B1↑, UHRF1↓, DNMT1↓, HDAC1↓, IL2↑, IL1↓, IL6↓, IL10↓, IL12↓, TNF-α↓, iNOS↓, COX2/PTGS2↓, 5LO↓, AP-1↓, PI3K↓, Akt↓, cMET↓, VEGFR2/KDR/Flk1↓, CXCL1↓, ITGA5↓, Wnt↓, β-catenin/ZEB1↓, GSK‐3β↓, Myc↓, cycD1/CCND1↓, N-cadherin↓, Snail↓, Slug↓, Vim↓, Twist↓, Zeb1↓, MMP2↓, MMP7↓, MMP9↓, JAK2↓, STAT3↓, NOTCH↓, cycA1/CCNA1↓, CDK2↓, CDK4↓, CDK6↓, CDC2↓, CDC25↓, Mcl-1↓, E2Fs↓, p16↑, p27/CDKN1B↑, P21↑, ChemoSen↑,

Showing Research Papers: 1 to 13 of 13

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↓, 1,   Catalase↑, 1,   CYP1A1↓, 1,   Ferroptosis↑, 1,   GPx↓, 1,   GPx↑, 2,   GPx4↓, 1,   GSH↓, 3,   GSH↑, 2,   GSR↓, 1,   GSR↑, 1,   GSTA1↑, 1,   GSTs↓, 1,   HO-1↓, 1,   c-Iron↑, 1,   lipid-P↓, 1,   lipid-P↑, 2,   NQO1↓, 1,   NRF2↓, 3,   NRF2↑, 1,   PrxI↓, 1,   ROS?, 1,   ROS↓, 2,   ROS↑, 5,   ROS⇅, 1,   SOD↓, 1,   SOD↑, 1,   SOD2↓, 1,   VitC↓, 1,   VitE↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↑, 1,   mt-ATP↓, 1,   CDC2↓, 1,   CDC25↓, 1,   MEK↓, 1,   MMP↓, 2,   mtDam↑, 1,   Raf↓, 1,   XIAP↓, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACSL4↑, 1,   ALAT↓, 1,   AMPK↑, 1,   ATG7↑, 1,   cMyc↓, 3,   Glycolysis↓, 1,   PDK1 / PDPK1↓, 1,   PDK3↑, 1,   PPARγ↑, 2,   SIRT1↓, 1,   SIRT1↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 5,   p‑Akt↓, 2,   APAF1↑, 1,   Apoptosis↑, 3,   BAX↓, 1,   BAX↑, 3,   Bax:Bcl2↑, 2,   Bcl-2↓, 6,   Bcl-2↑, 1,   Bcl-xL↓, 1,   BID↓, 1,   BIM↓, 1,   Casp↑, 3,   Casp1↓, 1,   Casp12?, 1,   Casp3↑, 6,   Casp8↑, 2,   Casp9↑, 2,   Chk2↓, 1,   Cyt‑c↑, 3,   DR5↑, 2,   Fas↑, 2,   FasL↑, 1,   Ferroptosis↑, 1,   HGF/c-Met↓, 1,   hTERT/TERT↓, 1,   IAP1↓, 1,   iNOS↓, 1,   JNK↑, 1,   p‑JNK↑, 1,   MAPK↓, 2,   MAPK↑, 1,   Mcl-1↓, 1,   p‑MDM2↓, 1,   Myc↓, 1,   necrosis↑, 1,   p27/CDKN1B↑, 1,   p38↑, 1,   p‑p38↑, 1,   Pyro↑, 1,   survivin↓, 2,   Telomerase↓, 1,   TRAIL↑, 1,   YAP/TEAD↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

H3↓, 1,   H4↓, 1,   HATs↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 1,   eIF2α↓, 1,   p‑eIF2α↑, 1,   ER Stress↑, 2,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 3,  

DNA Damage & Repair(tgid=10) ⓘ

CHK1↓, 1,   CYP1B1↑, 1,   DNAdam↓, 1,   DNAdam↑, 1,   DNMT1↓, 1,   DNMTs↓, 1,   p16↑, 1,   P53↓, 1,   P53↑, 2,   PARP↑, 1,   cl‑PARP↑, 2,   PCNA↓, 4,   UHRF1↓, 1,   γH2AX↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 2,   CDK4↓, 1,   cycA1/CCNA1↓, 1,   CycB/CCNB1↓, 1,   cycD1/CCND1↓, 4,   cycE/CCNE↓, 1,   E2Fs↓, 1,   P21↑, 2,   TumCCA↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD34↓, 1,   CD44↓, 1,   cFos↑, 1,   cMET↓, 1,   cMYB↓, 1,   EMT↓, 4,   ERK↓, 4,   ERK↑, 1,   p‑ERK↑, 1,   FOXO↑, 1,   FOXO3↓, 1,   GSK‐3β↓, 3,   HDAC↓, 4,   HDAC1↓, 1,   mTOR↓, 5,   NOTCH↓, 1,   NOTCH1↓, 2,   NOTCH1↑, 1,   P70S6K↓, 1,   PI3K↓, 4,   p‑PI3K↓, 1,   PTEN↓, 1,   PTEN↑, 1,   p‑PTEN↓, 1,   p‑Src↓, 1,   STAT3↓, 4,   p‑STAT6↓, 1,   TOP1↓, 1,   TumCG↓, 3,   Wnt↓, 4,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AP-1↓, 1,   AXL↓, 1,   CD31/PECAM-1↓, 1,   Cdc42↓, 1,   CEA↓, 1,   CLDN1↓, 1,   DLC1↑, 1,   E-cadherin↓, 1,   E-cadherin↑, 1,   FAK↓, 1,   p‑FAK↓, 1,   p‑FAK↑, 1,   ITGA5↓, 1,   ITGB1↓, 1,   Ki-67↓, 1,   MET↓, 1,   p‑MET↓, 1,   MMP1↓, 1,   MMP2↓, 5,   MMP7↓, 1,   MMP9↓, 3,   MMP9↑, 1,   MMPs↓, 2,   N-cadherin↓, 2,   Rac1↓, 1,   Rho↓, 2,   ROCK1↓, 1,   Slug↓, 1,   Snail↓, 2,   TumCP↓, 2,   TumMeta↓, 3,   TumMeta↑, 1,   Twist↓, 1,   Tyro3↓, 1,   uPA↓, 2,   Vim↓, 2,   Vim↑, 1,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 6,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 5,   EGFR↑, 1,   Hif1a↓, 3,   VEGF↓, 7,   VEGFR2/KDR/Flk1↓, 2,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   CellMemb↑, 1,   GLUT1↓, 1,   P-gp/ABCB1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   COX2/PTGS2↓, 4,   CXCL1↓, 1,   CXCR4↓, 2,   ICAM-1↓, 1,   IFN-γ↓, 1,   IFN-γ↑, 4,   IKKα↓, 1,   IL1↓, 1,   IL1↑, 1,   IL10↓, 2,   IL10↑, 2,   IL12↓, 1,   IL12↑, 2,   IL17↑, 1,   IL1β↓, 2,   IL2↑, 13,   IL4↑, 1,   IL6↓, 4,   IL6↑, 2,   Imm↑, 2,   INF-γ↑, 1,   Inflam↓, 2,   JAK1↓, 1,   JAK2↓, 1,   MDSCs↓, 1,   NF-kB↓, 6,   NK cell↑, 1,   p65↓, 2,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 3,   PGE2↓, 1,   Th1 response↑, 1,   Th2↑, 1,   TNF-α↓, 4,   TNF-α↑, 3,  

Cellular Microenvironment(tgid=17) ⓘ

e-pH↑, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 2,   CDK6↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 3,   ChemoSen↑, 7,   DDS↑, 1,   Dose?, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 1,   eff↑, 11,   eff∅, 1,   Half-Life↓, 1,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 1,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AR↓, 2,   AST↓, 1,   CEA↓, 1,   EGFR↑, 1,   hTERT/TERT↓, 1,   IL6↓, 4,   IL6↑, 2,   Ki-67↓, 1,   Myc↓, 1,   NSE↓, 1,   PD-L1↓, 3,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   AntiCan∅, 1,   cachexia↓, 1,   cardioP↑, 1,   chemoP↑, 4,   ChemoSideEff↓, 3,   hepatoP↑, 1,   neuroP↑, 1,   OS↑, 2,   QoL↑, 1,   Risk↑, 1,   toxicity↓, 1,  
Total Targets: 290

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↑, 2,   GPx↑, 2,   GSH↑, 1,   GSTs↑, 1,   lipid-P↓, 1,   MDA↓, 1,   NRF2↑, 1,   ROS↓, 1,   SOD↑, 2,  

Cell Death(tgid=5) ⓘ

Casp3↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

GADD45A↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL10↑, 1,   IL1β↓, 1,   Imm↑, 1,   Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   BioAv↑, 3,   BioAv↝, 1,   eff↑, 1,   Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

hepatoP↑, 1,   neuroP↑, 1,   toxicity↓, 1,   Weight↝, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 28

Scientific Paper Hit Count for: IL2, Interleukin-2
2 Astragalus
2 Propolis -bee glue
1 chitosan
1 Chrysin
1 Electrical Pulses
1 Luteolin
1 Lycopene
1 Bicarbonate(Sodium)
1 immunotherapy
1 Sulforaphane (mainly Broccoli)
1 Silymarin (Milk Thistle) silibinin
1 Selenite (Sodium)
1 Thymoquinone
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:366  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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