Casp8 Cancer Research Results

Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase: Click to Expand ⟱
Source: CGL-Driver Genes
Type: TSG
Caspase-8 is a unique member of caspases with a dual role in cell death and survival. Caspase-8 expression is often lost in some tumors, but increased in others, indicating a potential pro-survival function in cancer.
Caspase-8 (Casp8) acts as an initiator in cell apoptosis signaling. However, the role of Casp8 in tuning the tumor immune microenvironment remains controversial due to the complicated crosstalk between immune-tolerogenic apoptotic cell death and immunogenic cell death cascades.
Scientific Papers found: Click to Expand⟱
334- AgNPs,    Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53
- in-vitro, Colon, HCT116
Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,
346- AgNPs,  RSQ,    Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment
- in-vivo, Melanoma, SK-MEL-28 - in-vivo, Melanoma, WM35
ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,
7426- AgNPs,  CS,    Silver Nanoparticles Formulation of Flower Head's Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation
- in-vitro, Pca, PC3 - in-vitro, Lung, A549
*antiOx↑, tumCV↓, eff↑, Dose↝, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,
5356- AL,    Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects
- Review, GC, NA
Apoptosis↑, TumCP↓, MAPK↓, PI3K↓, Akt↓, NF-kB↓, AntiCan↑, ChemoSen↑, TumCCA↑, Apoptosis↑, BioAv↑, selectivity↑, TGF-β↓, ROS↑, DNAdam↑, p‑P53↑, P21↑, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, MMP↓, NF-kB↑, BAX↑, Bcl-2↓, ER Stress↑, Casp↑, AIF↑, Fas↑, Casp8↑, Cyt‑c↑, cl‑PARP↑, Ca+2↑, *NRF2↑, *chemoP↑, *GutMicro↑, CycB/CCNB1↑, H2S↑, HIF-1↓, RadioS↑,
245- AL,    Allicin: a promising modulator of apoptosis and survival signaling in cancer
- Review, Var, NA
Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,
239- AL,    Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways
- in-vitro, GC, SGC-7901
Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,
234- AL,    Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy
- in-vitro, HCC, Hep3B
ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,
5168- AL,    Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells
- in-vitro, Var, NA
TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,
2655- AL,    Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities
- Review, GC, NA
TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,
2660- AL,    Allicin: A review of its important pharmacological activities
- Review, AD, NA - Review, Var, NA - Review, Park, NA - Review, Stroke, NA
*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,
7399- Amla,    Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)
- Review, Var, NA
*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,
7407- Amla,    Functional and Nutraceutical Significance of Amla (Phyllanthus emblica L.): A Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *GSH↑, *GPx↑, *SOD↑, *Catalase↑, *lipid-P↓, *ROS↓, *cardioP↑, *AntiDiabetic↑, *neuroP↑, *GastroP↑, *COX2/PTGS2↓, *MDA↓, *BAX↓, *TG/TAG↓, *HDL↑, *LDL↓, *HMG-CoA↓, *Dose↝, *CRP↓, DNAdam↑, Casp3↑, Casp7↑, Casp8↑, Fas↑, TumCI↓, selectivity↑,
581- Api,  Cisplatin,    The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy
- in-vitro, Pca, CD44+
Bcl-2↓, survivin↓, Casp8↑, P53↑, Sharpin↓, APAF1↑, p‑Akt↓, NF-kB↓, P21↑, Cyc↓, CDK2↓, CDK4/6↓, Snail↓, ChemoSen↑,
176- Api,    Induction of caspase-dependent extrinsic apoptosis by apigenin through inhibition of signal transducer and activator of transcription 3 (STAT3) signalling in HER2-overexpressing BT-474 breast cancer cells
- in-vitro, BC, BT474
cl‑Casp8↑, cl‑Casp3↑, p‑JAK1↓, p‑JAK2↓, p‑STAT3↓, P53↑, VEGF↓, Hif1a↓, MMP9↓, TumCG↓, TumCCA↑, cl‑PARP↑,
179- Api,    Apigenin induces caspase-dependent apoptosis by inhibiting signal transducer and activator of transcription 3 signaling in HER2-overexpressing SKBR3 breast cancer cells
- in-vitro, BC, SkBr3
cl‑Casp8↑, cl‑Casp3↑, VEGF↓, TumCG↓, TumCCA↑, cl‑PARP↑, p‑STAT3↓, p‑JAK2↓,
180- Api,    Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells
- in-vitro, BC, MDA-MB-231
cl‑Casp8↑, cl‑Casp3↑, cl‑PARP↑, BAX∅, Bcl-2∅, Bcl-xL∅, p‑STAT3↓, P53↑, P21↑, p‑JAK2↓, VEGF↓,
240- Api,    The flavonoid apigenin reduces prostate cancer CD44(+) stem cell survival and migration through PI3K/Akt/NF-κB signaling
- in-vitro, Pca, PC3 - in-vitro, Pca, CD44+
P21↑, p27/CDKN1B↑, Casp3↑, Casp8↑, Slug↓, Snail↓, NF-kB↓, PI3K↓, Akt↓,
416- Api,    In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma
- vitro+vivo, NA, NA
Bax:Bcl2↑, P53↑, ROS↑, Casp9↑, Casp8↑, cl‑PARP1↑, p‑ERK⇅, p‑JNK↓, p‑p38↑, p‑Akt↓, cJun↓, NF-kB↓, EGFR↓, TumCCA↑,
2634- Api,    Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells
- in-vitro, CRC, HCT116
TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP/DDIT3↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
1563- Api,  MET,    Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells
- in-vitro, Nor, HDFa - in-vitro, PC, AsPC-1 - in-vitro, PC, MIA PaCa-2 - in-vitro, Pca, DU145 - in-vitro, Pca, LNCaP - in-vivo, NA, NA
selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,
3391- ART/DHA,    Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug
- Review, Var, NA
TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,
566- ART/DHA,  2DG,    Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells
- in-vitro, Lung, A549 - in-vitro, Lung, PC9
GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,
2321- ART/DHA,    Dihydroartemisinin mediating PKM2-caspase-8/3-GSDME axis for pyroptosis in esophageal squamous cell carcinoma
- in-vitro, ESCC, Eca109 - in-vitro, ESCC, EC9706
Pyro↑, PKM2↓, Casp8↑, Casp3↑, Warburg↓, TumCCA↑, Apoptosis↑,
1364- Ash,    Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress
- in-vitro, Bladder, J82
cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑, ROS↑, MMP↓, DNAdam↑, eff↓,
5389- AsP,  Tras,    ASCORBYL PALMITATE ENHANCES ANTI-PROLIFERATIVE EFFECT OF TRASTUZUMAB IN HER2-POSITIVE BREAST CANCER CELLS
tumCV↓, eff↑, P53↑, BAX↑, Casp3↑, Casp8↑, Bcl-2↓, Apoptosis↑, p‑p38↓, ERK↓, PI3K↓,
5250- Ba,    Exploring baicalein: A natural flavonoid for enhancing cancer prevention and treatment
- Review, Var, NA
Apoptosis↑, TumAuto↑, DNAdam↑, *antiOx↑, Inflam↓, PGE2↓, TumCCA↑, TumCMig↓, TumCI↓, angioG↓, selectivity↑, ChemoSen↑, HIF-1↓, cMyc↓, NF-kB↓, VEGF↓, P53↑, MMP2↓, CSCs↓, Bcl-xL↓, XIAP↓, survivin↓, tumCV↓, Casp3↑, Casp8↑, Bax:Bcl2↑, Akt↓, mTOR↓, PCNA↓, MMP↓, ROS↑, PARP↑, Casp9↑, BioAv↑, eff↑, P-gp/ABCB1↓, BioAv↑, selectivity↑,
1526- Ba,    Baicalein induces apoptosis through ROS-mediated mitochondrial dysfunction pathway in HL-60 cells
- in-vitro, AML, HL-60
Apoptosis↑, cl‑PARP↑, DNAdam↑, cl‑BID↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9?, H2O2↑, ROS↑,
1524- Ba,    Baicalein Induces Caspase‐dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
DR5↑, FADD↑, FasL↑, Casp8↑, cFLIP↓, Casp3↑, Casp9↑, cl‑PARP↑, MMP↓, BID↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑, Apoptosis↑, TumCCA↑, DR5↑, FasL↑, DR4∅, cFLIP↓, FADD↑, MMPs↓,
1521- Ba,    Baicalein induces apoptosis via ROS-dependent activation of caspases in human bladder cancer 5637 cells
- in-vitro, Bladder, 5637
TumCG↓, Apoptosis↑, IAP1↓, IAP2/BIRC3↓, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, MMP↓, Casp8↑, BID↑, ROS?, eff↓, DR4↑, DR5↑, FasL↑, TRAIL↑,
2476- Ba,    Baicalein Induces Caspase-dependent Apoptosis Associated with the Generation of ROS and the Activation of AMPK in Human Lung Carcinoma A549 Cells
- in-vitro, Lung, A549
TumCG↓, Apoptosis↑, DR5↑, FasL↑, FADD↑, Casp8↑, cFLIP↓, Casp9↑, Casp3↑, cl‑PARP↑, MMP↓, BID↑, BAX↑, Cyt‑c↑, ROS↑, eff↓, AMPK↑,
2606- Ba,    Baicalein: A review of its anti-cancer effects and mechanisms in Hepatocellular Carcinoma
- Review, HCC, NA
ChemoSen↑, TumCP↓, TumCCA↑, TumCMig↓, TumCI↓, MMPs↓, MAPK↓, TGF-β↓, ZFX↓, p‑MEK↓, ERK↓, MMP2↓, MMP9↓, uPA↓, TIMP1↓, TIMP2↓, NF-kB↓, p65↓, p‑IKKα↓, Fas↑, Casp2↑, Casp3↑, Casp8↑, Casp9↑, Bcl-xL↓, BAX↑, ER Stress↑, Ca+2↑, JNK↑, P53↑, ROS↑, H2O2↑, cMyc↓, CD24↓, 12LOX↓,
5553- BBM,    A review on berbamine–a potential anticancer drug
- Review, Var, NA
P-gp/ABCB1↓, MDR1↓, survivin↓, NF-kB↓, TumCP↓, TumCCA↑, Apoptosis↑, SMAD3↑, P21↑, cycD1/CCND1↓, cMyc↑, Bcl-2↓, Bcl-xL↓, BAX↑, CaMKII ↓, ChemoSen↑, MMP2↓, MMP9↓, TIMP1↑, cl‑Casp3↑, cl‑Casp9↑, cl‑Casp8↑, cl‑PARP↑, IL6↓, ROS↑,
2691- BBR,    Berberine induces FasL-related apoptosis through p38 activation in KB human oral cancer cells
- in-vitro, Oral, KB
tumCV↓, DNAdam↑, Casp3↑, Casp7↑, FasL↑, Casp8↑, Casp9↑, PARP↑, BAX↑, BAD↑, APAF1↑, MMP2↓, MMP9↓, p‑p38↑, ERK↑, MAPK↑,
2678- BBR,    Berberine as a Potential Agent for the Treatment of Colorectal Cancer
- Review, CRC, NA
*Inflam↓, *antiOx↑, *cardioP↑, *neuroP↑, TumCCA↑, cycD1/CCND1↓, cycE/CCNE↓, CDC2↓, AMPK↝, mTOR↝, Casp8↑, Casp9↑, Cyt‑c↑, TumCMig↓, TumCI↓, EMT↓, MMPs↓, E-cadherin↓, Telomerase↓, *toxicity↓, GRP78/BiP↓, EGFR↓, CDK4↓, COX2/PTGS2↓, PGE2↓, p‑JAK2↓, p‑STAT3↓, MMP2↓, MMP9↓, GutMicro↑, eff↝, *BioAv↓, BioAv↑,
2674- BBR,    Berberine: A novel therapeutic strategy for cancer
- Review, Var, NA - Review, IBD, NA
Inflam↓, AntiCan↑, Apoptosis↑, TumAuto↑, TumCCA↑, TumMeta↓, TumCI↓, eff↑, eff↑, CD4+↓, TNF-α↓, IL1↓, BioAv↓, BioAv↓, other↓, AMPK↑, MAPK↓, NF-kB↓, IL6↓, MCP1/CCL2↓, PGE2↓, COX2/PTGS2↓, *ROS↓, *antiOx↑, *GPx↑, *Catalase↑, AntiTum↑, TumCP↓, angioG↓, Fas↑, FasL↑, ROS↑, ATM↑, P53↑, RB1↑, Casp9↑, Casp8↑, Casp3↓, BAX↑, Bcl-2↓, Bcl-xL↓, IAP1↓, XIAP↓, survivin↓, MMP2↓, MMP9↓, CycB/CCNB1↓, CDC25↓, CDC25↓, Cyt‑c↑, MMP↓, RenoP↑, mTOR↓, MDM2↓, LC3II↑, ERK↓, COX2/PTGS2↓, MMP3↓, TGF-β↓, EMT↑, ROCK1↓, FAK↓, RAS↓, Rho↓, NF-kB↓, uPA↓, MMP1↓, MMP13↓, ChemoSen↑,
2722- BetA,    Betulinic Acid for Cancer Treatment and Prevention
- Review, Var, NA
MMP↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, ROS↑, NF-kB↑, TOP1↓,
2719- BetA,    Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential
- in-vitro, CRC, T24/HTB-9 - in-vitro, Bladder, UMUC3 - in-vitro, Bladder, 5637
TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,
2717- BetA,    Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma
- in-vitro, Melanoma, U266 - in-vivo, Melanoma, NA - in-vitro, Melanoma, RPMI-8226
Apoptosis↑, TumCCA↑, MMP↓, ROS↑, eff↓, NF-kB↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, cl‑PARP1↑, MDA↑, SOD↓, SOD2↓, GCLM↓, GSTA1↓, FTH1↓, GSTs↓, TumVol↓,
5687- BJ,    Seed Oil of Brucea javanica Induces Apoptotic Death of Acute Myeloid Leukemia Cells via Both the Death Receptors and the Mitochondrial-Related Pathways
- vitro+vivo, AML, U937
Apoptosis↑, Casp8↑, TumCCA↑, cl‑PARP↑, eff↝, TumCG↓, necrosis↑, Fas↑, TumCCA↑, selectivity↑,
5692- BJ,    Seed oil of Brucea javanica induces apoptosis through the PI3K/Akt signaling pathway in acute lymphocytic leukemia Jurkat cells
- vitro+vivo, AML, NA
Apoptosis↑, Akt↓, P53↑, FOXO1↑, GSK‐3β↑, TumVol↓, QoL↑, BBB↑, OS↑, Dose↝, MMP↓, ROS↑, XIAP↑, Casp9↑, Casp8↑, Casp3↑, cl‑PARP↑, TumCCA↑,
5678- BML,    Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy
- in-vivo, CRC, NA
AntiCan↑, TumCG↓, ROS↑, Apoptosis↑, Endoglin↑, Casp3↑, Casp8↑, Casp9↑, ATG5↑, Beclin-1/ATG6↑, p62↑, PARP↑,
5685- BML,    The Therapeutic Effects of Bromelain against Colorectal Cancer: A Systematic Review
- Review, CRC, NA
TumCG↓, TumMeta↓, ROS⇅, Bcl-2↓, Casp3↑, Casp7↑, Casp8↑, Casp9↑, P53↑,
2776- Bos,    Anti-inflammatory and anti-cancer activities of frankincense: Targets, treatments and toxicities
- Review, Var, NA
*5LO↓, *TNF-α↓, *MMP3↓, *COX1↓, *COX2/PTGS2↓, *PGE2↓, *Th2↑, *Catalase↑, *SOD↑, *NO↑, *PGE2↑, *IL1β↓, *IL6↓, *Th1 response↓, *Th2↑, *iNOS↓, *NO↓, *p‑JNK↓, *p38↓, GutMicro↑, p‑Akt↓, GSK‐3β↓, cycD1/CCND1↓, Akt↓, STAT3↓, CSCs↓, AR↓, P21↑, DR5↑, CHOP/DDIT3↑, Casp3↑, Casp8↑, cl‑PARP↑, DNAdam↑, p‑RB1↓, FOXM1↓, TOP2↓, CDC25↓, p‑CDK1↓, p‑ERK↓, MMP9↓, VEGF↓, angioG↓, ROS↑, Cyt‑c↑, AIF↑, Diablo↑, survivin↓, ICAD↓, ChemoSen↑, SOX9↓, ER Stress↑, GRP78/BiP↑, cal2↓, AMPK↓, mTOR↓, ROS↓,
2767- Bos,    The potential role of boswellic acids in cancer prevention and treatment
- Review, Var, NA
*Inflam↓, AntiCan↑, *MAPK↑, *Ca+2↝, p‑ERK↓, TumCI↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓, p‑RB1↓, *NF-kB↓, *TNF-α↓, NF-kB↓, IKKα↓, MCP1/CCL2↓, IL1α↓, MIP2↓, VEGF↓, Tf↓, COX2/PTGS2↓, MMP9↓, CXCR4↓, VEGF↓, eff↑, PPARα↓, lipid-P?, STAT3↓, TOP1↓, TOP2↑, 5HT↓, p‑PDGFR-BB↓, PDGF↓, AR↓, DR5↑, angioG↓, DR4↑, Casp3↑, Casp8↑, cl‑PARP↑, eff↑, chemoPv↑, Wnt↓, β-catenin/ZEB1↓, ascitic↓, Let-7↑, miR-200b↑, eff↑, MMP1↓, MMP2↓, eff↑, BioAv↓, BioAv↑, Half-Life↓, toxicity↓, Dose↑, BioAv↑, ChemoSen↑,
2773- Bos,    Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer
- Review, Var, NA
Inflam↓, TumCCA↑, Casp3↑, Casp8↑, Casp9↑, STAT3↑, SHP1↓, NF-kB↓, cycD1/CCND1↓, COX2/PTGS2↓, Ki-67↓, CD31/PECAM-1↓, IAP1↓, MMPs↓, Bcl-2↓, Bcl-xL↓,
1185- Bos,    The journey of boswellic acids from synthesis to pharmacological activities
- Review, NA, NA
BAX↑, NF-kB↓, cl‑PARP↑, Casp3↑, Casp8↑,
1424- Bos,    Boswellia sacra essential oil induces tumor cell-specific apoptosis and suppresses tumor aggressiveness in cultured human breast cancer cells
- in-vitro, BC, T47D - in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231
tumCV↓, Apoptosis↑, cl‑Casp8↑, cl‑Casp9↑, cl‑PARP↑,
2024- Bos,    Antiproliferative and cell cycle arrest potentials of 3-O-acetyl-11-keto-β-boswellic acid against MCF-7 cells in vitro
- in-vitro, BC, MCF7 - in-vitro, Nor, MCF10
MMP↓, Cyt‑c↑, ROS↑, Casp8↑, Casp9↑, AntiTum↑, selectivity↑, TumCCA↑,
6542- BSB,    Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol
- Review, Var, NA - Review, Park, NA - Review, AD, NA
AntiCan↑, *neuroP↑, *cardioP↑, *AntiBio↑, *BioAv↑, *toxicity↓, *BioAv↑, *motorD↑, *SOD↑, *Catalase↑, *Keap1↑, *MDA↓, *GSH↑, *IL1β↓, *IL6↓, *TNF-α↓, *iNOS↓, *COX2/PTGS2↓, *lipid-P↓, *Cyt‑c↓, *ROS↓, *MMP↑, *antiOx↑, *AChE↓, *Apoptosis↓, *BAX↓, *Casp3↓, *Bcl-2↑, *BACE/β-secretase↓, *BChE↓, *eff↑, *Aβ↓, *ATP↑, RadioS↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Apoptosis↑, PARP↑, BAX↑, BID↑, NF-kB↑, Fas↑, EGFR↑, TIMP2↑, XIAP↓, COX2/PTGS2↓, Bak↓, Bcl-2↓, P53↑, HER2/EBBR2↓, FGF↓, CEA↓, Akt↓, TumCCA↑, *Imm↑, *CD4+↑, *CD8+↑, *BBB↑, *Pain↓, *cardioP↑, *TBARS↓, *SOD↑, *Catalase↑, *GSH↑, *AntiBio↑, *AntiFungal↑, *GastroP↑, *RenoP↑, *creat↓, *uricA↓, *Inflam↓, *iNOS↓, *COX2/PTGS2↓, *TNF-α↓, *IL6↑, *MMP13↓,

Showing Research Papers: 1 to 50 of 194
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* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 194

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

ANAPC2↑, 1,   AURKB↑, 1,   BMP7/OP1↓, 1,   CASP4↑, 1,   DR6↑, 1,   E2F4↑, 1,   HSP60/HSPD1↑, 1,   Ingr↝, 1,   MTA1↓, 1,   MYCN↓, 1,   SUV39H↓, 1,   TNFRSF25/DR3/APO3/LARD/TRAMP/WSL1↑, 2,   TRADD↑, 1,   WEE1↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   antiOx↑, 3,   ATF3↑, 1,   Catalase↓, 6,   Catalase↑, 1,   CYP1A1↓, 1,   GCLM↓, 1,   GPx↓, 1,   GPx↑, 1,   GSH↓, 18,   GSH↑, 3,   GSH/GSSG↓, 1,   GSR↓, 1,   GSR↑, 1,   GSTA1↓, 1,   GSTA1↑, 1,   GSTs↓, 2,   GSTs↑, 1,   GSTs↝, 1,   H2O2↓, 1,   H2O2↑, 4,   i-H2O2↑, 1,   HO-1↓, 2,   HO-1↑, 5,   HO-1↝, 1,   Iron↓, 1,   lipid-P?, 1,   lipid-P↓, 3,   lipid-P↑, 3,   MDA↑, 4,   MPO↓, 1,   NQO1↓, 1,   NQO1↑, 1,   NRF2↓, 4,   NRF2↑, 5,   OXPHOS↓, 1,   PARK2↑, 1,   ROS?, 1,   ROS↓, 7,   ROS↑, 91,   ROS⇅, 3,   ROS∅, 1,   i-ROS?, 1,   i-ROS↑, 2,   mt-ROS↑, 3,   SOD↓, 5,   SOD↑, 3,   SOD1↑, 1,   SOD2↓, 2,   SOD2↑, 2,   TAC↓, 1,   TBARS↑, 1,   ox-Trx1↑, 1,   TrxR↓, 4,   TrxR1↓, 1,   VitC↓, 1,   VitE↓, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 1,   IronCh↑, 1,   Tf↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ADP:ATP↑, 1,   AIF↑, 13,   ATP↓, 3,   ATP↝, 1,   BOK↑, 1,   CDC2↓, 5,   CDC25↓, 10,   CDC25↑, 1,   EGF↓, 1,   ETC↓, 1,   MEK↓, 2,   p‑MEK↓, 2,   MMP?, 1,   MMP↓, 63,   MMP↑, 1,   MPT↑, 2,   mtDam↑, 8,   OCR↓, 1,   PINK1↑, 1,   Raf↓, 3,   SDH↓, 1,   XIAP↓, 21,   XIAP↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 1,   ACC↑, 1,   ACLY↓, 1,   AKT1↓, 1,   ALAT↓, 3,   AMPK↓, 1,   AMPK↑, 9,   AMPK↝, 1,   ATG7↑, 1,   citrate↓, 1,   cMyc↓, 11,   cMyc↑, 1,   p‑cMyc↑, 1,   CPT1A↓, 1,   ENO1↓, 1,   FASN↓, 2,   FASN↑, 2,   FBPase↑, 1,   glucoNG↑, 1,   GlucoseCon↓, 3,   GLUT2↓, 1,   Glycolysis↓, 6,   H2S↑, 1,   HK2↓, 5,   lactateProd↓, 5,   LDH↑, 1,   LDHA↓, 3,   LDL↓, 1,   PDH↓, 1,   PDK1 / PDPK1↓, 1,   PFK↓, 2,   PFK1↓, 1,   PFK2?, 1,   PFK2↓, 1,   PI3K/Akt↓, 1,   PI3k/Akt/mTOR↝, 1,   PIK3CA↓, 1,   PKM2↓, 3,   PKM2∅, 1,   PPARα↓, 1,   cl‑PPARα↓, 1,   PPARγ↑, 1,   p‑S6↓, 1,   SIRT1↓, 1,   SIRT1↑, 1,   SREBP1/SREBF1↓, 1,   TCA↓, 1,   TCA↑, 1,   Warburg↓, 1,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

AhR↑, 1,   Akt↓, 48,   Akt↑, 2,   p‑Akt↓, 11,   APAF1↑, 6,   Apoptosis↓, 4,   Apoptosis↑, 93,   mt-Apoptosis↑, 1,   ASK1↑, 1,   BAD↓, 3,   BAD↑, 9,   Bak↓, 1,   Bak↑, 4,   BAX↑, 74,   BAX⇅, 1,   BAX∅, 1,   Bax:Bcl2↑, 13,   Bcl-2↓, 68,   Bcl-2↑, 3,   Bcl-2∅, 2,   Bcl-xL↓, 16,   Bcl-xL↑, 2,   Bcl-xL∅, 1,   BID↓, 2,   BID↑, 8,   cl‑BID↑, 6,   BIM↑, 3,   Casp↑, 5,   Casp↝, 1,   Casp1↓, 1,   Casp1↑, 2,   Casp10↑, 2,   Casp12↑, 1,   Casp2↑, 4,   Casp3↓, 2,   Casp3↑, 131,   cl‑Casp3↑, 23,   proCasp3↓, 1,   proCasp3↑, 2,   Casp6↑, 1,   Casp7↑, 12,   cl‑Casp7↑, 4,   Casp8↓, 1,   Casp8↑, 166,   cl‑Casp8↑, 24,   proCasp8↓, 1,   proCasp8↑, 4,   pro‑Casp8↑, 1,   Casp9?, 1,   Casp9↓, 1,   Casp9↑, 113,   cl‑Casp9↑, 14,   proCasp9↓, 1,   proCasp9↑, 2,   cFLIP↓, 7,   CK2↓, 2,   Cyt‑c↑, 60,   Cyt‑c↝, 1,   Diablo↑, 4,   DR4↑, 7,   DR4∅, 1,   DR5↑, 25,   FADD↑, 9,   Fas↑, 32,   FasL↑, 14,   HGF/c-Met↓, 1,   hTERT/TERT↓, 5,   IAP1↓, 6,   IAP2/BIRC3↓, 3,   cl‑IAP2/BIRC3↑, 1,   ICAD↓, 1,   iNOS↓, 4,   JNK↓, 2,   JNK↑, 14,   p‑JNK↓, 2,   p‑JNK↑, 2,   cl‑JNK↑, 1,   MAPK↓, 10,   MAPK↑, 7,   Mcl-1↓, 16,   cl‑Mcl-1↑, 1,   MDM2↓, 5,   MDM2↑, 1,   p‑MDM2↓, 1,   MLKL↑, 1,   p‑MLKL↓, 1,   Myc↓, 3,   NAIP↓, 1,   Necroptosis↑, 2,   necrosis↑, 1,   NICD↓, 1,   p27/CDKN1B↑, 15,   p38↓, 2,   p38↑, 14,   p‑p38↓, 1,   p‑p38↑, 6,   PUMA↑, 3,   PUMA↝, 1,   Pyro↑, 1,   RIP1↑, 1,   survivin↓, 29,   Telomerase↓, 6,   TNFR 1↑, 1,   TRAIL↑, 7,   TRAILR↑, 3,   TumCD↑, 7,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1,   CaMKII ↓, 1,   cSrc↓, 2,   FOXD3↑, 1,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   SOX9↓, 1,   Sp1/3/4↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

cJun↓, 2,   cJun↑, 3,   p‑cJun↑, 2,   H3↓, 2,   ac‑H3↑, 1,   H4↓, 1,   ac‑H4↑, 1,   HATs↓, 2,   other↓, 2,   other↑, 1,   other↝, 3,   PCAF↓, 1,   pRB↑, 1,   p‑pRB↓, 1,   tumCV?, 1,   tumCV↓, 31,  

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 1,   ATFs↑, 1,   CHOP/DDIT3↑, 16,   eIF2α↓, 1,   eIF2α↑, 1,   p‑eIF2α↑, 4,   ER Stress↓, 2,   ER Stress↑, 12,   GRP78/BiP↓, 1,   GRP78/BiP↑, 8,   HSP27↓, 2,   HSP70/HSPA5↓, 2,   HSP70/HSPA5↑, 1,   HSP72↓, 1,   HSP90↓, 3,   HSPs↓, 1,   IRE1↑, 1,   PERK↑, 3,   UPR↑, 3,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 4,   ATG5↝, 1,   Beclin-1/ATG6↑, 6,   Beclin-1/ATG6↝, 1,   LC3B↑, 2,   LC3B-II↑, 1,   LC3I↑, 1,   LC3II↑, 6,   p62↓, 1,   p62↑, 2,   TumAuto↑, 16,   TumAuto⇅, 1,  

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 2,   ATR↑, 1,   CHK1↓, 1,   CYP1B1↑, 1,   DFF45↑, 2,   DNA-PK↑, 1,   DNAdam↑, 32,   DNArepair↓, 1,   DNMT1↓, 3,   DNMT3A↓, 1,   DNMTs↓, 1,   GADD45A↑, 1,   p16↑, 2,   P53↓, 1,   P53↑, 43,   p‑P53↑, 4,   p53 Wildtype↓, 1,   PARP↓, 1,   PARP↑, 14,   p‑PARP↑, 1,   cl‑PARP↓, 2,   cl‑PARP↑, 62,   cl‑PARP1↑, 2,   PCNA↓, 12,   TP53↓, 1,   TP53↑, 2,   UHRF1↓, 1,   γH2AX↑, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 7,   CDK1↑, 3,   p‑CDK1↓, 2,   p‑CDK1↑, 1,   CDK2↓, 18,   CDK2↑, 1,   p‑CDK2↓, 1,   CDK4↓, 21,   CDK4↑, 1,   Cyc↓, 2,   cycA1/CCNA1↓, 6,   CycB/CCNB1↓, 13,   CycB/CCNB1↑, 2,   cycD1/CCND1↓, 31,   cycD1/CCND1↑, 2,   CycD3↓, 1,   cycE/CCNE↓, 15,   cycE1↓, 1,   cycF↑, 1,   E2Fs↓, 2,   mitA↑, 1,   P21↑, 33,   RB1↓, 1,   RB1↑, 2,   p‑RB1↓, 3,   Securin↓, 1,   TumCCA↑, 78,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH↓, 1,   ALDH1A1↓, 1,   CD133↓, 2,   CD24↓, 1,   CD34↓, 1,   CD44↓, 3,   CDK8↓, 1,   cFos↓, 2,   cFos↑, 1,   cMET↓, 3,   CSCs↓, 8,   CTSB↓, 1,   CTSD↓, 1,   Diff↑, 2,   EMT↓, 15,   EMT↑, 1,   ERK↓, 23,   ERK↑, 5,   p‑ERK↓, 6,   p‑ERK↑, 1,   p‑ERK⇅, 1,   FGF↓, 1,   FOXM1↓, 2,   FOXO↑, 2,   FOXO1↑, 1,   FOXO3↓, 1,   p‑FOXO3↓, 1,   Gli1↓, 2,   GSK‐3β↓, 4,   GSK‐3β↑, 4,   p‑GSK‐3β↓, 3,   HDAC↓, 4,   HDAC1↓, 2,   HDAC3↓, 1,   HH↓, 1,   HRAS↓, 1,   IGF-1↓, 2,   IGF-1R↓, 3,   IGF-1R↑, 1,   IGFBP3↑, 1,   p‑Jun↑, 1,   Let-7↑, 1,   mTOR↓, 24,   mTOR↑, 2,   mTOR↝, 1,   p‑mTOR↓, 2,   mTORC1↓, 2,   mTORC2↓, 1,   Nanog↓, 2,   NOTCH↓, 4,   NOTCH1↓, 5,   NOTCH3↓, 1,   OCT4↓, 2,   p300↓, 1,   P70S6K↓, 5,   p‑P70S6K↓, 1,   P90RSK↓, 1,   PI3K↓, 33,   p‑PI3K↓, 3,   PTEN↓, 1,   PTEN↑, 7,   RAS↓, 6,   Shh↓, 2,   SHP1↓, 1,   Smo↓, 2,   SOX2↓, 1,   p‑Src↓, 2,   STAT3↓, 18,   STAT3↑, 1,   p‑STAT3↓, 5,   STAT6↓, 1,   p‑STAT6↓, 1,   Sufu↑, 1,   TAZ↓, 1,   TCF↑, 1,   TOP1↓, 2,   TOP2↓, 4,   TOP2↑, 1,   TRPM7↓, 1,   TumCG↓, 33,   TumCG↑, 1,   tyrosinase↓, 1,   Wnt↓, 11,   Wnt↑, 2,   Wnt/(β-catenin)↓, 1,   ZFX↓, 1,  

Migration(tgid=13) ⓘ

5LO↓, 2,   AEG1↓, 1,   AntiAg↑, 1,   AP-1↓, 5,   AXL↓, 1,   Ca+2↓, 1,   Ca+2↑, 14,   Ca+2↝, 4,   i-Ca+2↑, 3,   cal2↓, 1,   cal2↑, 1,   CCN2/CTGF↓, 1,   CD31/PECAM-1↓, 2,   Cdc42↓, 1,   Cdc42↑, 1,   CDK4/6↓, 1,   CEA↓, 2,   CLDN1↓, 1,   CLDN2↓, 1,   COL1↓, 1,   COL3A1↓, 1,   DLC1↑, 1,   E-cadherin↓, 5,   E-cadherin↑, 7,   EM↑, 1,   FAK↓, 7,   p‑FAK↓, 2,   Fibronectin↓, 1,   GLI2↓, 1,   ITGA5↓, 1,   ITGB1↓, 1,   ITGB4↓, 1,   Ki-67↓, 5,   LEF1↓, 1,   LRP1↓, 1,   MET↓, 1,   p‑MET↓, 1,   miR-200b↑, 1,   miR-200c↑, 1,   MMP1↓, 3,   MMP13↓, 1,   MMP2↓, 31,   MMP3↓, 1,   MMP7↓, 3,   MMP9↓, 33,   MMPs↓, 11,   N-cadherin↓, 9,   PDGF↓, 2,   PKA↓, 1,   PKCδ↓, 5,   Rac1↓, 1,   RAGE↓, 2,   Rho↓, 2,   RIP3↑, 1,   p‑RIP3↑, 1,   ROCK1↓, 1,   Sharpin↓, 1,   Slug?, 1,   Slug↓, 6,   SMAD3↓, 1,   SMAD3↑, 1,   p‑SMAD4↓, 1,   Snail?, 1,   Snail↓, 11,   TET1↓, 1,   TGF-β↓, 6,   TGF-β↑, 1,   TIMP1↓, 1,   TIMP1↑, 3,   TIMP2↓, 3,   TIMP2↑, 7,   TIMP3↑, 1,   TSP-1↑, 1,   TumCI↓, 25,   TumCMig↓, 21,   TumCP↓, 49,   TumMeta↓, 15,   Twist↓, 5,   Tyro3↓, 1,   uPA↓, 10,   VCAM-1↓, 1,   Vim↓, 5,   Vim↑, 1,   Zeb1↓, 2,   Zeb1↑, 1,   ZEB2↓, 1,   ZO-1↑, 1,   α-tubulin↓, 1,   β-catenin/ZEB1↓, 15,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 29,   ATF4↑, 5,   EGFR↓, 15,   EGFR↑, 2,   Endoglin↑, 1,   EPR↑, 1,   HIF-1↓, 2,   Hif1a↓, 12,   NO↑, 1,   p‑PDGFR-BB↓, 1,   VEGF↓, 36,   VEGF↑, 1,   VEGFR2/KDR/Flk1↓, 4,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 3,   GLUT1↓, 3,   P-gp/ABCB1↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD4+↓, 1,   CD4+↑, 1,   COX1↓, 1,   COX2/PTGS2↓, 27,   COX2/PTGS2↑, 1,   CXCL1↓, 1,   CXCR2↓, 1,   CXCR4↓, 6,   FOXP3↑, 1,   HMGB1↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IKKα↓, 7,   IKKα↑, 1,   p‑IKKα↓, 1,   IL1↓, 2,   IL10↓, 1,   IL12↓, 2,   IL17↓, 1,   IL1α↓, 1,   IL1β↓, 6,   IL2↑, 2,   IL6↓, 11,   IL8↓, 5,   Imm↑, 1,   Imm↝, 1,   Inflam↓, 12,   p‑IκB↓, 1,   JAK1↓, 3,   p‑JAK1↓, 1,   JAK2↓, 6,   p‑JAK2↓, 4,   MCP1/CCL2↓, 2,   MIP2↓, 1,   NF-kB↓, 53,   NF-kB↑, 6,   p‑NF-kB↓, 1,   p‑NF-kB↑, 1,   NK cell↑, 1,   p50↓, 1,   p65↓, 3,   p‑p65↓, 1,   PD-1↓, 1,   PD-L1↓, 1,   PGE2↓, 7,   PSA↓, 2,   T-Cell↝, 1,   TLR4↓, 2,   TNF-α↓, 14,   TNF-α↑, 5,  

Cellular Microenvironment(tgid=17) ⓘ

IM↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1,  

Protein Aggregation(tgid=19) ⓘ

NLRP3↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 6,   CDK6↓, 7,   CDK6↑, 3,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1,   BioAv↓, 13,   BioAv↑, 24,   BioAv↝, 2,   ChemoSen↓, 2,   ChemoSen↑, 32,   DDS↑, 1,   Dose?, 3,   Dose↓, 2,   Dose↑, 4,   Dose⇅, 1,   Dose↝, 10,   Dose∅, 3,   eff↓, 19,   eff↑, 48,   eff↝, 7,   Half-Life↓, 3,   Half-Life↑, 1,   Half-Life↝, 3,   Half-Life∅, 1,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P450↓, 2,   P450↝, 1,   RadioS↑, 14,   selectivity↓, 1,   selectivity↑, 39,   TET2↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1,   ALAT↓, 3,   ALP↓, 2,   AR↓, 6,   ascitic↓, 1,   AST↓, 3,   CEA↓, 2,   EGFR↓, 15,   EGFR↑, 2,   FOXM1↓, 2,   GutMicro↑, 3,   HER2/EBBR2↓, 5,   p‑HER2/EBBR2↓, 1,   hTERT/TERT↓, 5,   IL6↓, 11,   Ki-67↓, 5,   LDH↑, 1,   Myc↓, 3,   NSE↓, 1,   PD-L1↓, 1,   PSA↓, 2,   RAGE↓, 2,   TP53↓, 1,   TP53↑, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 17,   antiNeop↑, 1,   AntiTum↑, 3,   cachexia↓, 1,   cardioP↑, 2,   chemoP↑, 5,   chemoPv↑, 8,   chemoPv⇅, 1,   ChemoSideEff↓, 1,   hepatoP↑, 2,   OS↑, 4,   QoL↑, 1,   radioP↑, 1,   RenoP↑, 4,   Risk↓, 2,   toxicity↓, 6,   toxicity↑, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 9,   TumW↓, 3,   Weight∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 688

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1,   AntiBio↑, 3,   CD19↑, 1,   Stroke↓, 2,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 2,   antiOx↑, 27,   Catalase↑, 14,   CYP2E1↓, 1,   GPx↑, 11,   GSH↑, 12,   GSR↑, 1,   GSTs↑, 8,   H2O2↓, 1,   HDL↑, 2,   HO-1↑, 2,   Keap1↓, 1,   Keap1↑, 1,   lipid-P↓, 9,   MDA↓, 10,   MPO↓, 2,   NADH↓, 1,   NQO1↑, 1,   NRF2↓, 1,   NRF2↑, 8,   RNS↓, 2,   ROS↓, 23,   ROS∅, 1,   SOD?, 1,   SOD↑, 14,   TBARS↓, 2,   uricA↓, 1,   VitC↑, 1,  

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 1,   IronCh↝, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2,   MMP↑, 3,   PGC-1α↑, 2,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 7,   AMPK↑, 1,   BUN↓, 1,   DGAT1↓, 1,   FASN↓, 1,   glucose↓, 1,   H2S↑, 1,   HMG-CoA↓, 1,   LDH↓, 3,   LDL↓, 3,   PPARα↑, 2,   SIRT1↑, 3,   SREBP1/SREBF1↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   p‑Akt↑, 1,   Apoptosis↓, 2,   BAX↓, 5,   Bcl-2↑, 2,   BMP2↑, 1,   Casp1↓, 3,   Casp3↓, 5,   Casp9↓, 1,   Cyt‑c↓, 3,   iNOS↓, 6,   JNK↓, 1,   p‑JNK↓, 1,   MAPK↓, 2,   MAPK↑, 1,   p38↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   cJun↓, 1,   other↓, 1,   other↑, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   UPR↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

p16↓, 1,   P53↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

GSK‐3β↑, 1,   HDAC↓, 1,   HDAC3↓, 1,   PI3K↓, 1,   RUNX2↑, 1,  

Migration(tgid=13) ⓘ

5LO↓, 1,   AntiAg↑, 1,   AP-1↓, 1,   BACH1↓, 1,   Ca+2?, 1,   Ca+2↝, 1,   COL1↑, 1,   Ki-67↓, 1,   MMP13↓, 1,   MMP3↓, 1,   PAI-1/SERPINE1↓, 1,   PKCδ↓, 1,   TXNIP↓, 1,   VCAM-1↓, 1,   ZO-1↑, 2,  

Angiogenesis & Vasculature(tgid=14) ⓘ

ATF4↓, 1,   NO↓, 4,   NO↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 2,   BBB↝, 1,   GastroP↑, 4,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

ASC↓, 1,   CD4+↑, 2,   COX1↓, 3,   COX2/PTGS2↓, 11,   CRP↓, 1,   ICAM-1↓, 1,   IFN-γ↓, 1,   IL10↑, 2,   IL18↓, 1,   IL1β↓, 6,   IL2↓, 1,   IL6↓, 8,   IL6↑, 1,   IL8↓, 2,   Imm↑, 3,   Inflam↓, 23,   NF-kB↓, 8,   NK cell↑, 1,   PGE2↓, 3,   PGE2↑, 1,   Th1 response↓, 1,   Th2↑, 2,   TLR4↓, 2,   TNF-α↓, 11,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 4,   BChE↓, 2,   BDNF↑, 2,   NGF↑, 1,   TrkB↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,   Aβ↓, 1,   BACE/β-secretase↓, 1,   NLRP3↓, 2,   XO↝, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 9,   BioAv↑, 6,   BioAv↝, 3,   Dose↝, 4,   eff↓, 1,   eff↑, 5,   Half-Life↓, 2,   Half-Life↑, 1,   Half-Life↝, 4,   P450↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 7,   ALP↓, 2,   AST↓, 8,   BP↓, 3,   creat↓, 3,   CRP↓, 1,   GutMicro↑, 3,   IL6↓, 8,   IL6↑, 1,   Ki-67↓, 1,   LDH↓, 3,   NOS2↓, 1,   TG/TAG↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiArt↑, 3,   AntiCan↑, 3,   antiD↓, 1,   AntiDiabetic↑, 5,   antiNeop↑, 1,   AntiTum↑, 1,   cardioP↑, 14,   chemoP↑, 3,   chemoPv↑, 1,   cognitive↑, 3,   hepatoP↑, 13,   memory↑, 2,   motorD↑, 1,   neuroP?, 1,   neuroP↑, 15,   Obesity↓, 1,   Pain↓, 1,   radioP↑, 2,   RenoP↓, 1,   RenoP↑, 3,   toxicity↓, 15,   toxicity∅, 2,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↓, 3,   CD8+↑, 1,   Sepsis↓, 1,  
Total Targets: 191

Scientific Paper Hit Count for: Casp8, CASP8, caspase 8, apoptosis-related cysteine peptidase
10 Fisetin
9 Apigenin (mainly Parsley)
8 Quercetin
7 Allicin (mainly Garlic)
7 Thymoquinone
6 Baicalein
6 Boswellia (frankincense)
6 EGCG (Epigallocatechin Gallate)
6 Sulforaphane (mainly Broccoli)
5 Dandelion Root
4 Silver-NanoParticles
4 Curcumin
4 Gambogic Acid
4 Luteolin
3 Artemisinin
3 Berberine
3 Betulinic acid
3 Citric Acid
3 Garcinol
3 Hibiscus sabdariffa
3 Hyperoside
3 Licorice
3 Phenethyl isothiocyanate
3 Propyl gallate
2 Cynara scolymus/Globe Artichoke/Artichoke Extract
2 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
2 Brucea javanica
2 Bromelain
2 Carvacrol
2 Thymol-Thymus vulgaris
2 chaetocin
2 Chrysin
2 Photodynamic Therapy
2 Emodin
2 Ferulic acid
2 Fucoidan
2 Gallic acid
2 Ginkgetin
2 Graviola
2 Propolis -bee glue
2 Honokiol
2 Rutin
2 Juglone
2 Kaempferol
2 Licochalcone A
2 Magnolol
2 Magnetic Fields
2 Nimbolide
2 Marjoram (Origanum majorana)
2 Shikonin
2 Aflavin-3,3′-digallate
2 Ursolic acid
1 Resiquimod
1 Cisplatin
1 Metformin
1 2-DeoxyGlucose
1 Ashwagandha(Withaferin A)
1 Ascorbyl Palmitate
1 Trastuzumab
1 Berbamine
1 α-Bisabolol / Chamomile oil
1 Cat’s Claw
1 Celecoxib
1 chitosan
1 Crocetin
1 Carvone
1 Cynaropicrin
1 Diclofenac
1 Ellagic acid
1 eicosapentaenoic acid
1 Geraniol
1 Ginger/6-Shogaol/Gingerol
1 Gossypol/AT-101
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Indole-3-carbinol
1 Isoliquiritigenin
1 isoquercitrin
1 lambertianic acid
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lactoferrin/Talactoferrin
1 Radiotherapy/Radiation
1 Lutein
1 Chemotherapy
1 Naringin
1 Phenylbutyrate
1 Piperlongumine
1 Rosmarinic acid
1 buckwheat sprouts
1 Auranofin
1 Docetaxel
1 Silymarin (Milk Thistle) silibinin
1 Vitamin K2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:44  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

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