Casp9 Cancer Research Results

Casp9, Caspase-9: Click to Expand ⟱

Source:

Type:

Caspase-9 is the apoptotic initiator protease of the intrinsic or mitochondrial apoptotic pathway, which is activated at multi-protein activation platforms.
Caspases are divided into two groups: the initiator caspases (caspase-2, -8, -9 and -10), which are the first to be activated in response to a signal, and the executioner caspases (caspase-3, -6, and -7) that carry out the demolition phase of apoptosis.
Caspase-9:
Role: Initiator caspase in the intrinsic apoptotic pathway.
Cancers: Frequently studied in leukemia and solid tumors.
Prognosis: Reduced expression is often linked to chemoresistance and poor prognosis.

Scientific Papers found: Click to Expand⟱

8330-

,

SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death

-

in-vitro,

GBM,

U87MG

tumCV↓, OCR↓, BAX↑, Bak↑, Bcl-2↓, Bcl-xL↓, Casp3↑, Casp9↑, Apoptosis↑, SOD↓, SIRT3↓, mt-ROS↑,

6461-

1,8-Cin,

1,8-cineole (eucalyptol): A versatile phytochemical with therapeutic applications across multiple diseases

-

Review,

AD,

NA

-

Review,

Var,

NA

*Inflam↓, *antiOx↑, *neuroP↑, *BioAv↑, *Half-Life↝, *toxicity↓, *PGE2↓, *TNF-α↓, *IL1β↓, *NO↓, *NF-kB↓, *PPARγ↓, COX2/PTGS2↓, *ROS↓, *SOD↑, *Catalase↑, *TAC↑, *MDA↓, *lipid-P↓, *NRF2↑, *HO-1↑, *NADPH↑, *GPx↑, *AntiBio↑, *eff↑, *AntiFungal↑, *AntiViral↑, *TRPA1↑, eff↑, TumCCA↑, ROS↑, MAPK↝, mTOR↝, Apoptosis↑, survivin↓, Akt↓, p38↑, cl‑PARP↑, cl‑Casp3⇅, P53↑, BAX↑, Cyt‑c↑, Casp9↑, Dose↝, *Aβ↓, *tau↓, *GSK‐3β↓, *BACE/β-secretase↓, *cardioP↑, MFN2↑,

1295-

AG,

Cisplatin,

Chemosensitizing Effect of Astragalus Polysaccharides on Nasopharyngeal Carcinoma Cells by Inducing Apoptosis and Modulating Expression of Bax/Bcl-2 Ratio and Caspases

-

in-vivo,

Laryn,

NA

mice

AntiTum↑, Apoptosis↑, Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Bax:Bcl2↑,

5431-

AG,

Advances in research on the anti-tumor mechanism of Astragalus polysaccharides

-

Review,

Var,

NA

AntiTum↑, TumCG↓, TumCI↓, Apoptosis↑, Imm↑, Bcl-2↓, BAX↑, Wnt↓, β-catenin/ZEB1↓, TumCG↓, miR-133a-3p↑, JNK↓, Fas↑, P53↑, P21↑, NOTCH1↓, NOTCH3↓, TumCP↓, TumCCA↑, GPx4↓, xCT/SLC7A11↓, AMPK↑, Beclin-1/ATG6↑, NF-kB↓, EMT↓, Vim↓, TumMeta↓, VEGF↓, EGFR↓, eff↑, eff↑, MMP↓, P-gp/ABCB1↓, MMP9↓, ChemoSen↑, SIRT1↓, SREBP1/SREBF1↓, TumAuto↑, PI3K↓, mTOR↓, Casp3↑, Casp9↑, CD133↓, CD44↓, CSCs↓, QoL↑,

5238-

AgNPs,

β-Sitosterol-assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line

-

in-vitro,

HCC,

HepG2

TumCP↓, ROS↑, NRF2↑, BAX↑, P53↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-2↓,

4438-

AgNPs,

ART/DHA,

Biogenic synthesis of AgNPs using Artemisia oliveriana extract and their biological activities for an effective treatment of lung cancer

-

in-vitro,

Lung,

A549

EPR↑, BAX↑, Bcl-2↑, Casp3↑, Casp9↑, DNAdam↑, TumCCA↑, Apoptosis↑,

5145-

AgNPs,

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells

-

in-vitro,

BC,

MCF7

-

in-vitro,

BC,

T47D

Bacteria↓, Apoptosis↑, ER Stress↑, UPR↑, PERK↑, IRE1↑, ATF6↑, ATF4↑, CHOP/DDIT3↑, Casp9↑, Casp7↑, Mcl-1↓, XIAP↓, PARP↝, selectivity↑,

334-

AgNPs,

Silver-Based Nanoparticles Induce Apoptosis in Human Colon Cancer Cells Mediated Through P53

-

in-vitro,

Colon,

HCT116

Bax:Bcl2↑, P53↑, P21↑, Casp3↑, Casp8↑, Casp9↑, Akt↓, NF-kB↓, DNAdam↑, TumCCA↑,

327-

AgNPs,

MS-275,

Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells

-

in-vitro,

Lung,

A549

 1uM,1uM

Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,

324-

AgNPs,

CPT,

Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells

-

in-vitro,

Cerv,

HeLa

ROS↑, Casp3↑, Casp9↑, Casp6↑, GSH↓, SOD↓, GPx↓, MMP↓, P53↑, P21↑, Cyt‑c↑, BID↑, BAX↑, Bcl-2↓, Bcl-xL↓, Akt↓, Raf↓, ERK↓, MAP2K1/MEK1↓, JNK↑, p38↑,

369-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

-

in-vitro,

Liver,

NA

ROS↑, GSH↓, DNAdam↑, lipid-P↝, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Casp9↑, Casp3↑, JNK↑,

363-

AgNPs,

Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

ROS↑, lipid-P↑, Apoptosis↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, Casp9↑, JNK↑,

359-

AgNPs,

Anti-cancer & anti-metastasis properties of bioorganic-capped silver nanoparticles fabricated from Juniperus chinensis extract against lung cancer cells

-

in-vitro,

Lung,

A549

 9.87ug/ml

-

in-vitro,

Nor,

HEK293

111.3ug/ml

normal cells

Casp3↑, Casp9↑, P53↑, ROS↑, MMP2↓, MMP9↓, TumCCA↑, *toxicity↓, TumCMig↓, TumCI↓,

346-

AgNPs,

RSQ,

Investigating Silver Nanoparticles and Resiquimod as a Local Melanoma Treatment

-

in-vivo,

Melanoma,

SK-MEL-28

 AgNP (2 mg/kg) and RSQ (25 mg/kg) administration routes used were peri- and intratumora

 mice

-

in-vivo,

Melanoma,

WM35

ROS↑, Ca+2↝, Casp3↑, Casp8↑, Casp9↑, CD4+↑, CD8+↑, tumCV↓, eff↓, *toxicity↓,

350-

AgNPs,

Cytotoxic and Apoptotic Effects of Green Synthesized Silver Nanoparticles via Reactive Oxygen Species-Mediated Mitochondrial Pathway in Human Breast Cancer Cells

-

in-vitro,

BC,

MCF7

 40ug/mL

ROS↑, MMP↓, P53↑, BAX↑, Casp3↑, Casp9↑, Bcl-2↓,

351-

AgNPs,

Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

-

in-vitro,

BC,

MCF7

 5ug/mL

-

in-vitro,

BC,

T47D

Casp9↑, Casp3↑, Casp7↑, Bcl-2↓,

397-

AgNPs,

GEM,

Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

-

in-vitro,

Ovarian,

A2780S

50 nM GEM, 50 nM AgNPs

6nm

P53↑, P21↑, BAX↑, Bak↑, Cyt‑c↑, Casp3↑, Casp9↑, Bcl-2↓, ROS↑, MMP↓,

387-

AgNPs,

Silver nanoparticles induce mitochondria-dependent apoptosis and late non-canonical autophagy in HT-29 colon cancer cells

-

in-vitro,

Colon,

HT-29

33.45 μg/mL

Cyt‑c↑, P53↑, BAX↑, Casp3↑, Casp9↑, Casp12↑, Beclin-1/ATG6↑, CHOP/DDIT3↑, LC3s↑, XBP-1↑,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

-

in-vitro,

Testi,

F9

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

7426-

AgNPs,

CS,

Silver Nanoparticles Formulation of Flower Head's Polyphenols of Cynara scolymus L.: A Promising Candidate against Prostate (PC-3) Cancer Cell Line through Apoptosis Activation

-

in-vitro,

Pca,

PC3

0.85 μg/mL

-

in-vitro,

Lung,

A549

 0.94 μg/mL

*antiOx↑, tumCV↓, eff↑, Dose↝, P53↑, BAX↑, Casp3↑, Casp8↑, Casp9↑, Bcl-2↓,

245-

AL,

Allicin: a promising modulator of apoptosis and survival signaling in cancer

-

Review,

Var,

NA

Fas↑, Bcl-2↓, BAX↑, PI3k/Akt/mTOR↝, Casp3↑, Casp8↑, Casp9↑, Apoptosis↓, *toxicity↓, Cyt‑c↑,

251-

AL,

Inhibition of allicin in Eca109 and EC9706 cells via G2/M phase arrest and mitochondrial apoptosis pathway

-

in-vitro,

ESCC,

Eca109

 0-100ug/ml

-

in-vitro,

ESCC,

EC9706

-

in-vivo,

NA,

NA

5mg/kg/bw

mice

Apoptosis↑, P53↑, P21↑, CHK1↑, CycB/CCNB1↓, BAX↑, Casp3↑, Casp9↑, Cyt‑c↑,

241-

AL,

Role of p38 MAPK activation and mitochondrial cytochrome-c release in allicin-induced apoptosis in SK-N-SH cells

-

in-vitro,

neuroblastoma,

SK-N-SH

 5 μmol/l

 (0, 0.5, 1, 5, 10, and 20 Î¼mol/l) of allicin for 12, 24, and 48 h

Casp3↑, Casp9↑, p38↑, MAPK↑, Cyt‑c↑, Apoptosis↑,

239-

AL,

Allicin induces apoptosis in gastric cancer cells through activation of both extrinsic and intrinsic pathways

-

in-vitro,

GC,

SGC-7901

 30ug/ml

Apoptosis↑, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, BAX↑, Fas↑, tumCV↓, DNAdam↑, ROS↑, Telomerase↓,

234-

AL,

Allicin Induces Anti-human Liver Cancer Cells through the p53 Gene Modulating Apoptosis and Autophagy

-

in-vitro,

HCC,

Hep3B

 0, 15, 20, 25, 35, 40 and 50 Î¼M of allicin for 24 h

 35 uM @24h

ROS↑, *toxicity∅, MMP↓, BAX↑, Bcl-2↓, AIF↑, Casp3↑, Casp8↑, Casp9↑, eff↓, γH2AX↑, selectivity↑, DNA-PK↑,

5168-

AL,

Allicin (from garlic) induces caspase-mediated apoptosis in cancer cells

-

in-vitro,

Var,

NA

TumCG↓, Casp3↑, Casp8↑, Casp9↑, chemoPv↑,

2655-

AL,

Allicin and Digestive System Cancers: From Chemical Structure to Its Therapeutic Opportunities

-

Review,

GC,

NA

TGF-β↓, cycD1/CCND1↓, cycE/CCNE↓, CDK1↓, DNAdam↑, ROS↑, BAX↑, JNK↑, MMP↓, p38↑, MAPK↑, Fas↑, Cyt‑c↑, Casp8↑, PARP↑, Casp3↑, Casp9↑, Ca+2↑, ER Stress↑, P21↑, CDK2↓, CDK6↑, TumCCA↑, CDK4↓,

2660-

AL,

Allicin: A review of its important pharmacological activities

-

Review,

AD,

NA

-

Review,

Var,

NA

-

Review,

Park,

NA

-

Review,

Stroke,

NA

*Inflam↓, AntiCan↑, *antiOx↑, *cardioP↑, *hepatoP↑, *BBB↑, *Half-Life↝, *H2S↑, *BP↓, *neuroP↑, *cognitive↑, *neuroP↑, *ROS↓, *GutMicro↑, *LDH↓, *ROS↓, *lipid-P↓, *antiOx↑, *other↑, *PI3K↓, *Akt↓, *NF-kB↓, *NO↓, *iNOS↓, *PGE2↓, *COX2/PTGS2↓, *IL6↓, *TNF-α↓, *MPO↓, *eff↑, *NRF2↑, *Keap1↓, *TBARS↓, *creat↓, *LDH↓, *AST↓, *ALAT↓, *MDA↓, *SOD↑, *GSH↑, *GSTs↑, *memory↑, chemoP↑, IL8↓, Cyt‑c↑, Casp3↑, Casp8↑, Casp9↑, Casp12↑, p38↑, Fas↑, P53↑, P21↑, CHK1↓, CycB/CCNB1↓, GSH↓, ROS↑, TumCCA↑, Hif1a↓, Bcl-2↓, VEGF↓, TumCMig↓, STAT3↓, VEGFR2/KDR/Flk1↓, p‑FAK↓,

3541-

ALA,

Insights on alpha lipoic and dihydrolipoic acids as promising scavengers of oxidative stress and possible chelators in mercury toxicology

-

Review,

Var,

NA

*antiOx↑, *IronCh↑, *GSH↑, *BBB↑, Apoptosis↑, MMP↓, ROS↑, lipid-P↑, PARP1↑, Casp3↑, Casp9↑, *NRF2↑, *GSH↑, *ROS↓, RenoP↑, ChemoSen↑, *BG↓,

278-

ALA,

The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

-

Review,

NA,

NA

ROS↑, NRF2↑, Inflam↓, frataxin↑, *BioAv↓, ChemoSen↑, Hif1a↓, eff↑, FAK↓, ITGB1↓, MMP2↓, MMP9↓, EMT↓, Snail↓, Vim↓, Zeb1↓, P53↑, MGMT↓, Mcl-1↓, Bcl-xL↓, Bcl-2↓, survivin↓, Casp3↑, Casp9↑, BAX↑, p‑Akt↓, GSK‐3β↓, *antiOx↑, *ROS↓, selectivity↑, angioG↓, MMPs↓, NF-kB↓, ITGB3↓, NADPH↓,

281-

ALA,

Reactive oxygen species mediate caspase activation and apoptosis induced by lipoic acid in human lung epithelial cancer cells through Bcl-2 down-regulation

-

in-vitro,

Lung,

H460

0-100uM

mt-ROS↑, Apoptosis↑, Casp9↑, Bcl-2↓, eff↓, eff↑, H2O2↑, Dose↑,

267-

ALA,

α-Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells

-

vitro+vivo,

Lung,

A549

 1.5 mM LA for 24 h

-

vitro+vivo,

Lung,

PC9

Apoptosis↑, ROS↑, PDK1 / PDPK1↓, NRF2↓, PDK1 / PDPK1↓, Bcl-2↓, Casp9↑, Dose∅,

7399-

Amla,

Molecular Mechanisms of Cancer Prevention by Gooseberry (Phyllanthus emblica)

-

Review,

Var,

NA

*Dose↝, *Inflam↓, *AntiCan↑, *antiOx↑, *neuroP↑, *hepatoP↑, *cardioP↑, *P450↓, *SOD↑, *GPx↑, *Catalase↑, *ROS↓, *CD4+↑, *CD19↑, *NK cell↑, Casp3↑, Casp7↑, Casp8↑, Casp9↑, Fas↑, BAX↑, Bcl-2↓, *IL10↑, *TNF-α↓, *IL6↓, *iNOS↓, *COX2/PTGS2↓, *GSTs↑, *NF-kB↓, *AP-1↓, *cJun↓, *lipid-P↓, TumCG↓, DNAdam↑, TumCCA↑, MMP2↓, MMP9↓,

1078-

And,

Andrographolide inhibits breast cancer through suppressing COX-2 expression and angiogenesis via inactivation of p300 signaling and VEGF pathway

-

in-vitro,

BC,

MDA-MB-231

5, 10, 25 and 50 μM

20uM

-

in-vitro,

Nor,

HUVECs

50uM

-

in-vivo,

BC,

MCF7

35uM

xenografts nude mice

-

in-vitro,

BC,

T47D

32uM

-

in-vitro,

BC,

BT549

23uM

-

in-vitro,

BC,

MDA-MB-361

31uM

TumCP↓, COX2/PTGS2↓, *angioG↓, Cyt‑c↑, CREB2↓, cFos↓, NF-kB↓, HATs↓, cl‑Casp3↑, cl‑Casp9↑, Bax:Bcl2↑, Apoptosis↑, *toxicity↓,

1009-

And,

5-FU,

Andrographis-mediated chemosensitization through activation of ferroptosis and suppression of β-catenin/Wnt-signaling pathways in colorectal cancer

-

in-vivo,

CRC,

HCT116

-

in-vitro,

CRC,

SW480

ChemoSen↑, Casp9↑, Ferroptosis↑, Wnt/(β-catenin)↓, FTL↑, TP53↑, ACSL5↑, GCLC↑, GCLM↑, SAT1↑, STEAP3↑, ACSL5↑,

6396-

ANE,

FEO,

Anethole Inhibits the Proliferation of Human Prostate Cancer Cells via Induction of Cell Cycle Arrest and Apoptosis

-

in-vitro,

Pca,

PC3

TumCP↓, TumCG↓, TumCMig↓, CSCs↓, ROS↑, MPT↑, Casp3↑, Casp9↑, DNAdam↑, cl‑PARP↑, Bax:Bcl2↑, TumCCA↑, cycD1/CCND1↓, CDK4↓, cMyc↓, P21↑, p27/CDKN1B↑, NF-kB↓, eff↑,

6398-

ANE,

trans-Anethole Abrogates Cell Proliferation and Induces Apoptosis through the Mitochondrial-Mediated Pathway in Human Osteosarcoma Cells

-

in-vitro,

OS,

MG63

*Inflam↓, *AntiTum↑, TumCCA↓, ROS↑, MMP↓, Casp3↑, Casp9↑, P53↑, Bcl-xL↓, MPT↑,

584-

Api,

Cisplatin,

Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

-

in-vivo,

Var,

NA

Eighty Swiss albino male mice

Beclin-1/ATG6↑, Casp3↑, Casp9↑, JNK↑, Mcl-1↓, Ki-67↓,

310-

Api,

Apigenin inhibits renal cell carcinoma cell proliferation

-

vitro+vivo,

RCC,

ACHN

 5-80 uM

39.4 μM for 24 h; 15.4 μM for 48 h

 5, 10 and 20 uM

-

in-vitro,

RCC,

786-O

 39.1 μM for 24 h; 19.0 μM for 48 h

-

in-vitro,

RCC,

Caki-1

 50.9 μM for 24 h; 21.4 μM for 48 h

-

in-vitro,

RCC,

HK-2

 122.1 μM for 24 h; 70.2 μM for 48 h

TumCCA↑, p‑ATM↑, p‑CHK1↑, p‑CDC25↑, p‑cDC2↑, P53↑, BAX↑, Casp9↑, Casp3↑,

206-

Api,

Inhibition of glutamine utilization sensitizes lung cancer cells to apigenin-induced apoptosis resulting from metabolic and oxidative stress

-

in-vitro,

Lung,

H1299

 20 uM

-

in-vitro,

Lung,

H460

-

in-vitro,

Lung,

A549

 40 uM

-

in-vitro,

CRC,

HCT116

-

in-vitro,

Melanoma,

A375

-

in-vitro,

Lung,

H2030

-

in-vitro,

CRC,

SW480

Glycolysis↓, lactateProd↓, PGK1↓, ALDOA↓, GLUT1↓, ENO1↓, ATP↓, Casp9↑, Casp3↑, cl‑PARP↑, PI3K/Akt↓, HK1↓, HK2↓, ROS↑, Apoptosis↑, eff↓, NADPH↓, PPP↓,

270-

Api,

Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo via inactivation of Akt and activation of JNK

-

in-vivo,

AML,

U937

 20-40 uM (12/24h)

Akt↓, JNK↑, Mcl-1↓, cl‑Bcl-2↓, Casp3↑, Casp7↑, Casp9↑, cl‑PARP↑, mTOR↓, GSK‐3β↓,

416-

Api,

In Vitro and In Vivo Anti-tumoral Effects of the Flavonoid Apigenin in Malignant Mesothelioma

-

vitro+vivo,

NA,

NA

20 mg/kg (C57BL/6 mice, oral gavage)

Malignant mesothelioma (MM)

Bax:Bcl2↑, P53↑, ROS↑, Casp9↑, Casp8↑, cl‑PARP1↑, p‑ERK⇅, p‑JNK↓, p‑p38↑, p‑Akt↓, cJun↓, NF-kB↓, EGFR↓, TumCCA↑,

2632-

Api,

Apigenin inhibits migration and induces apoptosis of human endometrial carcinoma Ishikawa cells via PI3K-AKT-GSK-3β pathway and endoplasmic reticulum stress

-

in-vitro,

EC,

NA

 20–60 μM

45.55 μM

TumCP↓, TumCCA↑, Apoptosis↑, Bcl-2↓, BAX↑, Bak↑, Casp↑, ER Stress↑, Ca+2↑, ATF4↑, CHOP/DDIT3↑, ROS↑, MMP↓, TumCMig↓, TumCI↓, eff↑, P53↑, P21↑, Cyt‑c↑, Casp9↑, Casp3↑, Bcl-xL↓,

2634-

Api,

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

-

in-vitro,

CRC,

HCT116

TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP/DDIT3↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,

2639-

Api,

Plant flavone apigenin: An emerging anticancer agent

-

Review,

Var,

NA

*antiOx↑, *Inflam↓, AntiCan↑, ChemoSen↑, BioEnh↑, chemoPv↑, IL6↓, STAT3↓, NF-kB↓, IL8↓, eff↝, Akt↓, PI3K↓, HER2/EBBR2↓, cycD1/CCND1↓, CycD3↓, p27/CDKN1B↑, FOXO3↑, STAT3↓, MMP2↓, MMP9↓, VEGF↓, Twist↓, MMP↓, ROS↑, NADPH↑, NRF2↓, SOD↓, COX2/PTGS2↓, p38↑, Telomerase↓, HDAC↓, HDAC1↓, HDAC3↓, Hif1a↓, angioG↓, uPA↓, Ca+2↑, Bax:Bcl2↑, Cyt‑c↑, Casp9↑, Casp12↑, Casp3↑, cl‑PARP↑, E-cadherin↑, β-catenin/ZEB1↓, cMyc↓, CDK4↓, CDK2↓, CDK6↓, IGF-1↓, CK2↓, CSCs↓, FAK↓, Gli↓, GLUT1↓,

2640-

Api,

Apigenin: A Promising Molecule for Cancer Prevention

-

Review,

Var,

NA

chemoPv↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2/BIRC3↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,

1563-

Api,

MET,

Metformin-induced ROS upregulation as amplified by apigenin causes profound anticancer activity while sparing normal cells

-

in-vitro,

Nor,

HDFa

metformin (5 mM), apigenin (1 or 20 µM),

-

in-vitro,

PC,

AsPC-1

-

in-vitro,

PC,

MIA PaCa-2

-

in-vitro,

Pca,

DU145

-

in-vitro,

Pca,

LNCaP

-

in-vivo,

NA,

NA

mice

selectivity↑, selectivity↑, selectivity↓, ROS↑, eff↑, tumCV↓, MMP↓, Dose∅, eff↓, DNAdam↑, Apoptosis↑, TumAuto↑, Necroptosis↑, p‑P53↑, BIM↑, BAX↑, p‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Cyt‑c↑, Bcl-2↓, AIF↑, p62↑, LC3B↑, MLKL↑, p‑MLKL↓, RIP3↑, p‑RIP3↑, TumCG↑, TumW↓,

3391-

ART/DHA,

Antitumor Activity of Artemisinin and Its Derivatives: From a Well-Known Antimalarial Agent to a Potential Anticancer Drug

-

Review,

Var,

NA

TumCP↓, TumMeta↓, angioG↓, TumVol↓, BioAv↓, Half-Life↓, BioAv↑, eff↑, eff↓, ROS↑, selectivity↑, TumCCA↑, survivin↓, BAX↑, Casp3↓, Casp8↑, Casp9↑, CDC25↓, CycB/CCNB1↓, NF-kB↓, cycD1/CCND1↓, cycE/CCNE↓, E2Fs↓, P21↑, p27/CDKN1B↑, ADP:ATP↑, MDM2↓, VEGF↓, IL8↓, COX2/PTGS2↓, MMP9↓, ER Stress↓, cMyc↓, GRP78/BiP↑, DNAdam↑, AP-1↓, MMP2↓, PKCδ↓, Raf↓, ERK↓, JNK↓, PCNA↓, CDK2↓, CDK4↓, TOP2↓, uPA↓, MMP7↓, TIMP2↑, Cdc42↑, E-cadherin↑,

566-

ART/DHA,

2DG,

Dihydroartemisinin inhibits glucose uptake and cooperates with glycolysis inhibitor to induce apoptosis in non-small cell lung carcinoma cells

-

in-vitro,

Lung,

A549

-

in-vitro,

Lung,

PC9

GlucoseCon↓, ATP↓, lactateProd↓, p‑S6↓, mTOR↓, GLUT1↓, Casp9↑, Casp8↑, Casp3↑, Cyt‑c↑, AIF↑, ROS↑,

1079-

ART/DHA,

Artesunate inhibits the growth and induces apoptosis of human gastric cancer cells by downregulating COX-2

-

in-vitro,

GC,

BGC-823

 20 mg/L

 20 mg/L @ 60hr

-

in-vitro,

GC,

HGC27

-

in-vitro,

GC,

MGC803

TumCP↓, Apoptosis↑, COX2/PTGS2↓, BAX↑, Bcl-2↓, Casp3↑, Casp9↑, MMP↓,

Showing Research Papers: 1 to 50 of 470
Page 1 of 10 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 470

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

ACE/ACE1↓, 1, AKR1B10↓, 1, p‑AMT/GCST/T-protein↑, 1, APE1/APEX1↓, 1, BMP7/OP1↓, 1, CASP4↑, 1, ChrCon↑, 1, CUL1↝, 1, CUL5↝, 1, CX43/GJA1↓, 1, ERCC4/XPF↓, 1, HLA-I/II↑, 1, Ingr↝, 1, IQGAP3↓, 1, Ku70/XRCC6↓, 1, LIMK1↓, 1, miR-106b↓, 1, miR-195↑, 1, miR-339-5p↝, 1, MYCN↓, 1, NA↑, 2, NA?, 1, O-Glc↓, 1, OGFr↑, 2, PFS↓, 1, PLA2↓, 1, SALL4↓, 1, SERPINH1/HSP47↓, 1, SUV39H↓, 2, URGCP/URG4↓, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

4-HNE↑, 1, antiOx↓, 2, antiOx↑, 6, antiOx⇅, 1, ARE↓, 1, ATF3↑, 2, Catalase↓, 13, Catalase↑, 5, compI↓, 2, Copper↑, 1, CYP1A1↓, 2, Fenton↑, 2, Ferroptosis↑, 5, frataxin↑, 1, GCLC↑, 1, GCLM↓, 1, GCLM↑, 1, GPx↓, 5, GPx↑, 3, GPx4↓, 5, GSH↓, 38, GSH↑, 7, GSH/GSSG↓, 4, GSR↑, 3, GSS↑, 1, GSSG↓, 1, GSSG↑, 1, GSTA1↓, 1, GSTA1↑, 1, GSTs↓, 1, GSTs↑, 2, H2O2↓, 1, H2O2↑, 7, i-H2O2↑, 1, HK1↓, 1, HO-1↓, 7, HO-1↑, 13, HO-1↝, 1, HO-2↓, 1, ICD↑, 2, Iron↑, 1, Keap1↓, 1, lipid-P↓, 8, lipid-P↑, 11, lipid-P↝, 1, MDA↓, 3, MDA↑, 5, MFN2↑, 1, MPO↓, 1, NADPH/NADP+↓, 1, NAF1↓, 1, NOX4↑, 1, NQO1↓, 1, NQO1↑, 1, Nrf1↑, 1, NRF2↓, 16, NRF2↑, 22, p‑NRF2↓, 1, p‑NRF2↑, 1, OXPHOS↓, 1, mt-OXPHOS↓, 1, PARK2↑, 1, Prx↓, 1, Prx4↑, 1, PrxII↓, 1, ROS?, 2, ROS↓, 21, ROS↑, 244, ROS⇅, 9, ROS↝, 1, ROS∅, 1, i-ROS↓, 1, i-ROS↑, 5, mt-ROS↑, 6, SAM-e↝, 1, SIRT3↓, 2, SIRT3↑, 3, SOD?, 1, SOD↓, 14, SOD↑, 7, SOD2↓, 3, SOD2↑, 2, TBARS↑, 2, Thiols↓, 1, Trx↓, 1, Trx1↑, 1, ox-Trx1↑, 1, TrxR↓, 6, TrxR1↓, 3, xCT/SLC7A11↓, 2,

Metal & Cofactor Biology(tgid=2) ⓘ

FTH1↓, 2, FTL↑, 1, IronCh↑, 3, NCOA4↑, 1, STEAP3↑, 1, Tf↓, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ABL1↓, 1, ADP:ATP↑, 1, AIF↑, 19, ATP↓, 13, ATP↝, 1, BCR↓, 1, BOK↑, 2, CDC2↓, 8, CDC25↓, 12, CDC25↑, 1, p‑CDC25↑, 1, compIII↓, 1, EGF↓, 4, ETC↓, 1, ETC↝, 1, FGFR1↓, 3, Insulin↓, 2, MEK↓, 6, p‑MEK↓, 3, p‑MEK↑, 1, mitResp↓, 2, MKK4↓, 1, MKK7↓, 1, MMP↓, 177, MMP↑, 1, MPT↑, 8, mtDam↑, 29, OCR↓, 3, PINK1↑, 1, Raf↓, 8, c-Raf↓, 1, SDH↓, 1, XIAP↓, 31, XIAP↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

12LOX↓, 6, p‑ACC↑, 1, ACLY↓, 2, ACSL4↑, 1, ACSL5↑, 2, AKT1↓, 6, ALAT↓, 2, ALAT↑, 1, ALAT↝, 1, ALDOA↓, 1, AMPK↑, 18, AMPK↝, 1, p‑AMPK↑, 1, ATG7↑, 2, CAIX/CA9↑, 1, citrate↓, 1, cMyc↓, 31, cMyc↑, 1, p‑cMyc↑, 1, CPT1A↓, 1, CYP3A4↓, 2, ECAR↝, 1, ENO1↓, 2, ERCC1↓, 1, FASN↓, 2, FASN↑, 2, FBPase↑, 1, glucoNG↑, 1, GlucoseCon↓, 11, GLUT2↓, 1, Glycolysis↓, 21, Histones↑, 1, HK2↓, 10, lactateProd↓, 9, lactateProd↑, 1, LDH↓, 5, LDH↑, 5, LDH↝, 2, LDHA↓, 6, LDL↓, 1, MCU↓, 1, NAD↝, 1, NADPH↓, 2, NADPH↑, 2, PDH↓, 1, PDK1 / PDPK1?, 2, PDK1 / PDPK1↓, 6, PFK↓, 1, PFK1↓, 2, PFK2?, 1, PFK2↓, 2, PFKP↓, 1, PGK1↓, 1, PI3K/Akt↓, 6, PI3K/Akt↝, 1, PI3k/Akt/mTOR↝, 1, PIK3CA↓, 1, PKM2↓, 4, PKM2∅, 1, polyA↓, 1, PPARα↓, 1, cl‑PPARα↓, 1, PPARγ↓, 2, PPARγ↑, 2, PPP↓, 2, Pyruv↓, 1, p‑S6↓, 1, S6K↓, 1, p‑S6K↓, 1, SAT1↑, 1, SIRT1↓, 5, SIRT1↑, 2, SREBP1/SREBF1↓, 2, SREBP2↓, 1, TCA?, 1, TCA↓, 1, TCA↑, 1, TS↓, 3, Warburg↓, 2, β-oxidation↓, 1,

Cell Death(tgid=5) ⓘ

14-3-3 proteins↓, 1, Akt↓, 112, Akt↑, 5, p‑Akt↓, 41, APAF1↑, 17, Apoptosis↓, 9, Apoptosis↑, 261, mt-Apoptosis↑, 3, ASK1↑, 2, BAD↓, 4, BAD↑, 17, p‑BAD↓, 1, Bak↓, 1, Bak↑, 16, BAX?, 1, BAX↓, 2, BAX↑, 215, BAX⇅, 1, BAX↝, 1, Bax:Bcl2↓, 1, Bax:Bcl2↑, 50, Bcl-2↓, 210, Bcl-2↑, 6, Bcl-2↝, 1, Bcl-2∅, 1, cl‑Bcl-2↓, 1, Bcl-xL↓, 46, Bcl-xL↑, 2, BID↓, 2, BID↑, 16, p‑BID↓, 1, cl‑BID↑, 2, BIM↑, 4, Casp↑, 13, Casp↝, 1, Casp10↓, 1, Casp10↑, 2, Casp12?, 1, Casp12↑, 9, Casp12↝, 1, cl‑Casp12↑, 1, Casp2↑, 5, Casp3↓, 6, Casp3↑, 346, cl‑Casp3↑, 55, cl‑Casp3⇅, 1, proCasp3↓, 2, proCasp3↑, 4, pro‑Casp3↑, 1, Casp6↑, 4, Casp7↑, 37, cl‑Casp7↑, 6, Casp8↓, 2, Casp8↑, 113, Casp8∅, 2, cl‑Casp8↑, 13, proCasp8↓, 1, proCasp8↑, 2, pro‑Casp8↑, 1, Casp9↓, 1, Casp9↑, 405, p‑Casp9↑, 2, cl‑Casp9↑, 60, proCasp9↓, 3, proCasp9↑, 5, pro‑Casp9↑, 1, cFLIP↓, 10, Chk2↓, 1, Chk2↑, 1, CK2↓, 4, Cyt‑c↓, 3, Cyt‑c↑, 170, Cyt‑c↝, 1, Diablo↑, 9, DR4↑, 8, DR4∅, 1, DR5↑, 35, FADD↑, 11, Fas↓, 1, Fas↑, 29, FasL↑, 17, Ferroptosis↑, 5, cl‑GSDME↑, 1, HEY1↓, 1, hTERT/TERT↓, 14, IAP1↓, 11, IAP2/BIRC3↓, 3, cl‑IAP2/BIRC3↑, 1, iNOS↓, 15, JNK↓, 6, JNK↑, 31, p‑JNK↓, 5, p‑JNK↑, 4, cl‑JNK↑, 1, MAPK↓, 30, MAPK↑, 21, MAPK↝, 2, p‑MAPK↓, 1, p‑MAPK↑, 1, Mcl-1↓, 38, Mcl-1↑, 1, p‑Mcl-1↓, 1, MCT1↓, 1, MDM2↓, 11, MDM2↑, 1, MLKL↑, 1, p‑MLKL↓, 1, MOMP↓, 1, MOMP↑, 6, Myc↓, 5, NAIP↓, 2, Necroptosis↑, 3, necrosis↑, 2, NICD↓, 1, NOXA↑, 7, p27/CDKN1B↓, 1, p27/CDKN1B↑, 33, p38↓, 6, p38↑, 28, p‑p38↓, 4, p‑p38↑, 6, PUMA↑, 6, PUMA↝, 1, Pyro↑, 1, RIP1↑, 1, survivin↓, 59, survivin↝, 1, Telomerase↓, 15, TNFR 1↑, 1, TRAIL↑, 7, TRAILR↑, 2, TRPV1↑, 1, TumCD↓, 1, TumCD↑, 21, YAP/TEAD↓, 2,

Kinase & Signal Transduction(tgid=6) ⓘ

AMPKα↑, 1, CaMKII ↓, 2, cSrc↓, 3, EF-1α↓, 1, FOXD3↑, 1, HER2/EBBR2↓, 12, miR-25-5p↓, 1, miR-25-5p↑, 1, p70S6↓, 2, Sp1/3/4↓, 5, TSC2↑, 1,

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↝, 1, cJun↓, 5, cJun↑, 3, p‑cJun↑, 2, EZH2↓, 2, H3↑, 2, ac‑H3↑, 1, H4↑, 2, ac‑H4↑, 1, HATs↓, 5, HATs↑, 1, miR-21↓, 5, miR-21↑, 1, miR-27a-3p↑, 1, other↓, 4, other↑, 5, other↝, 10, PhotoS↑, 2, pRB↑, 1, p‑pRB↓, 2, SETBP1↓, 1, sonoS↑, 1, TET3↑, 1, tumCV?, 1, tumCV↓, 89,

Protein Folding & ER Stress(tgid=8) ⓘ

ATF6↑, 3, cl‑ATF6↑, 1, ATFs↑, 1, CHOP/DDIT3↓, 1, CHOP/DDIT3↑, 28, cl‑CHOP/DDIT3↑, 1, eIF2α↓, 1, eIF2α↑, 8, p‑eIF2α↓, 1, p‑eIF2α↑, 2, ER Stress↓, 2, ER Stress↑, 50, GRP78/BiP?, 1, GRP78/BiP↓, 2, GRP78/BiP↑, 19, GRP94↑, 2, HSF1↓, 1, HSP27↓, 7, HSP27↝, 1, HSP70/HSPA5↓, 4, HSP70/HSPA5↑, 1, HSP70/HSPA5↝, 1, HSP72↓, 1, HSP90↓, 10, HSP90↑, 1, HSPs↓, 1, IRE1↑, 6, PERK↑, 9, p‑PERK↑, 1, UPR↑, 6, XBP-1↑, 3,

Autophagy & Lysosomes(tgid=9) ⓘ

ATG3↑, 1, ATG5↑, 8, ATG5↝, 1, Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 17, Beclin-1/ATG6↝, 1, BNIP3↑, 2, LC3‑Ⅱ/LC3‑Ⅰ↓, 1, LC3‑Ⅱ/LC3‑Ⅰ↑, 4, LC3A↑, 1, LC3B↑, 1, LC3B-II↑, 4, LC3I↑, 1, LC3II↓, 1, LC3II↑, 7, LC3s↑, 2, MitoP↑, 1, p62↓, 4, p62↑, 3, SESN2↑, 1, TumAuto↑, 37,

DNA Damage & Repair(tgid=10) ⓘ

ATM↑, 3, p‑ATM↑, 2, ATR↑, 1, p‑BRCA1↑, 1, CHK1↓, 2, CHK1↑, 1, p‑CHK1↑, 1, CYP1B1↑, 1, DFF45↓, 2, DFF45↑, 2, DNA-PK↑, 2, DNAdam↓, 2, DNAdam↑, 77, DNArepair↓, 2, DNArepair↑, 1, DNMT1↓, 7, DNMT3A↓, 2, DNMTs↓, 4, MGMT↓, 2, p16↑, 3, P53?, 1, P53↓, 3, P53↑, 114, P53∅, 1, p‑P53↓, 1, p‑P53↑, 5, p53 Wildtype↓, 1, PARP↓, 4, PARP↑, 38, PARP↝, 1, p‑PARP↑, 1, cl‑PARP↓, 3, cl‑PARP↑, 114, PARP1↑, 2, cl‑PARP1↑, 3, PCNA↓, 24, RAD51↓, 1, SIRT6↑, 1, TP53↑, 1, UHRF1↓, 1, γH2AX↑, 10, γH2AX↝, 1, p‑γH2AX↑, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 15, CDK1↑, 3, p‑CDK1↑, 1, CDK2↓, 36, CDK2↑, 3, p‑CDK2↓, 1, CDK4↓, 45, CDK4↑, 3, p‑CDK4↓, 1, Cyc↓, 2, cycA1/CCNA1↓, 12, cycA1/CCNA1↑, 1, CycB/CCNB1↓, 32, CycB/CCNB1↑, 2, cycD1/CCND1↓, 77, cycD1/CCND1↑, 3, p‑cycD1/CCND1↓, 1, CycD3↓, 4, cycE/CCNE↓, 24, cycE/CCNE↑, 1, cycE1↓, 1, E2Fs↓, 3, mitA↑, 1, p19↑, 1, P21?, 1, P21↓, 4, P21↑, 75, RB1↑, 1, p‑RB1↓, 4, Securin↓, 1, TumCCA?, 1, TumCCA↓, 10, TumCCA↑, 181,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

4E-BP1↓, 1, ALDH↓, 2, ALDH1A1↓, 2, BRAF↝, 1, CD133↓, 7, CD24↓, 2, CD34↓, 1, CD44↓, 11, cDC2↓, 1, p‑cDC2↑, 1, CDK8↓, 1, CEBPA↑, 1, cFos↓, 5, cMET↓, 3, p‑cMET↑, 1, cMYB↓, 1, CREB2↓, 1, CSCs↓, 24, CTSB↓, 2, CTSD↓, 2, Diff↓, 1, Diff↑, 3, EMT↓, 46, EMT↑, 2, EMT↝, 1, EpCAM↓, 1, ERK↓, 43, ERK↑, 10, p‑ERK↓, 16, p‑ERK↑, 3, p‑ERK⇅, 1, e-ERK↑, 1, FGF↓, 4, FGFR2↓, 1, FOXM1↓, 1, FOXO↑, 2, FOXO1↑, 3, FOXO3↓, 3, FOXO3↑, 5, Gli↓, 1, Gli1↓, 4, GSK‐3β↓, 9, GSK‐3β↑, 6, p‑GSK‐3β↓, 5, p‑GSK‐3β↑, 1, HDAC↓, 15, HDAC1↓, 4, HDAC10↑, 1, HDAC2↓, 2, HDAC3↓, 4, HDAC8↓, 2, HH↓, 3, HRAS↓, 2, IGF-1↓, 7, IGF-1R↓, 8, IGF-2↓, 1, IGFBP3↑, 3, Jun↓, 1, p‑Jun↑, 1, Let-7↑, 3, MAP2K1/MEK1↓, 1, miR-34a↓, 1, miR-34a↑, 2, mTOR↓, 52, mTOR↝, 2, p‑mTOR↓, 14, mTORC1↓, 5, p‑mTORC1↓, 1, mTORC2↓, 3, n-MYC↓, 1, Nanog↓, 4, Nanog↑, 1, Nestin↓, 3, NOTCH↓, 11, NOTCH1↓, 8, NOTCH1↑, 1, NOTCH3↓, 2, NRAS↓, 1, OCT4↓, 6, OCT4↑, 1, P70S6K↓, 3, p‑P70S6K↓, 2, P90RSK↓, 1, PDGFRA↓, 1, PI3K↓, 81, PI3K↑, 1, p‑PI3K↓, 6, PTCH1↓, 1, PTEN↓, 1, PTEN↑, 29, PTEN↝, 1, RAS↓, 8, RAS↑, 1, SCF↓, 1, Shh↓, 5, SHP1↓, 1, SHP1↑, 2, Smo↓, 3, SOX2↓, 4, Src↓, 2, STAT↓, 2, STAT1↓, 1, STAT3↓, 50, STAT3↑, 2, p‑STAT3↓, 14, p‑STAT3↑, 2, STAT5↓, 2, STAT6↓, 1, TAZ↓, 1, TCF-4↓, 2, TK1↓, 1, TOP1↓, 2, TOP2↓, 4, TRPM7↓, 1, TumCG↓, 65, TumCG↑, 3, tyrosinase↓, 1, Wnt?, 1, Wnt↓, 23, Wnt/(β-catenin)↓, 6, ZFX↓, 1,

Migration(tgid=13) ⓘ

5LO↓, 2, AEG1↓, 1, Akt2↓, 2, AntiAg?, 1, AntiAg↓, 1, AntiAg↑, 1, AP-1↓, 11, AP-1↑, 1, BACH1↓, 1, Ca+2↓, 6, Ca+2↑, 45, Ca+2↝, 4, i-Ca+2↑, 4, mt-Ca+2↑, 1, CAFs/TAFs↓, 1, cal2↑, 4, CC(CDKs/cyclins)↓, 1, CCN2/CTGF↓, 1, CD31/PECAM-1↓, 3, Cdc42↑, 1, CEA↓, 1, CLDN2↓, 1, CLDN2↑, 1, COL1↓, 1, COL3A1↓, 1, CXCL12↓, 1, DLC1↑, 3, E-cadherin↓, 7, E-cadherin↑, 36, EM↑, 1, ER-α36↓, 1, FAK↓, 16, p‑FAK↓, 2, FOSB↑, 1, GLI2↓, 1, ITGA5↓, 1, ITGB1↓, 1, ITGB3↓, 1, ITGB4↓, 1, Ki-67↓, 13, KRAS↓, 1, LAMs↓, 1, LEF1↓, 1, MALAT1↓, 1, miR-133a-3p↑, 1, miR-155↓, 2, miR-221↓, 1, MMP1↓, 5, MMP13↓, 3, MMP2↓, 73, MMP3↓, 5, MMP7↓, 9, MMP9↓, 84, MMP9↑, 1, MMPs↓, 27, MUC4↓, 1, N-cadherin↓, 27, p‑p44↓, 1, PDGF↓, 4, PKA↓, 2, PKCδ↓, 8, proline↓, 1, Rac1↓, 1, RAGE↓, 2, Rho↓, 2, RIP3↑, 3, p‑RIP3↑, 1, ROCK1↓, 2, Slug?, 1, Slug↓, 8, Smad1↓, 1, SMAD2↓, 1, p‑SMAD2↓, 1, SMAD3↓, 3, SMAD3↑, 1, p‑SMAD3↓, 1, SMAD4↓, 1, p‑SMAD4↓, 2, Snail?, 1, Snail↓, 21, SOX4↓, 1, SOX4↑, 2, TET1↓, 1, TET1↑, 3, TGF-β↓, 16, TGF-β↑, 3, TIMP1↓, 2, TIMP1↑, 8, TIMP2↓, 3, TIMP2↑, 11, TIMP3↑, 1, Treg lymp↓, 1, TSP-1↑, 3, TumCA↓, 2, TumCI↓, 64, TumCI↑, 1, TumCMig↓, 50, TumCP↓, 119, TumCP↑, 3, TumMeta↓, 45, TumMeta↑, 3, TumPF↓, 2, Twist↓, 15, uPA↓, 20, uPAR↓, 1, VCAM-1↓, 1, Vim↓, 28, Zeb1↓, 9, ZEB2↓, 3, ZO-1↑, 2, α-tubulin↑, 1, β-catenin/ZEB1↓, 31, β-catenin/ZEB1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 68, angioG↑, 1, ATF4↑, 11, ATF4↝, 1, EGFR↓, 30, EGFR↑, 1, p‑EGFR↓, 2, Endoglin↑, 2, EPR↑, 3, HIF-1↓, 4, Hif1a↓, 47, Hif1a↑, 1, miR-17↓, 1, NO↓, 3, NO↑, 2, PDGFR-BB↓, 1, PDI↑, 1, VEGF↓, 76, VEGF↑, 1, VEGFR2/KDR/Flk1↓, 15,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 4, BBB∅, 2, GLUT1↓, 11, GLUT1↑, 1, GLUT3↑, 1, GLUT4↓, 1, NHE1↓, 1, P-gp/ABCB1↓, 12,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CCR7↓, 1, CD4+↓, 1, CD4+↑, 2, COX1↓, 1, COX2/PTGS2↓, 66, CRP↓, 1, CXCL1↓, 2, CXCR2↓, 1, CXCR4↓, 13, CXCR4↑, 1, FOXP3↓, 1, FOXP3↑, 1, HMGB1↓, 2, ICAM-1↓, 2, IFN-γ↓, 3, IFN-γ↑, 2, Igs↓, 1, IKKα↓, 5, IKKα↑, 1, p‑IKKα↓, 1, IL1↓, 4, IL10↓, 3, IL12↓, 2, IL12↑, 1, IL17↓, 1, IL1β↓, 12, IL2↓, 2, IL2↑, 2, IL4↓, 1, IL6↓, 32, IL8↓, 6, Imm↑, 8, Imm↝, 1, Inflam↓, 29, IκB↑, 1, p‑IκB↓, 2, JAK↓, 3, JAK1↓, 3, JAK1↑, 1, JAK2↓, 7, p‑JAK2↓, 2, MCP1/CCL2↓, 3, NF-kB↓, 116, NF-kB↑, 3, p‑NF-kB↓, 1, p‑NF-kB↑, 2, NK cell↑, 3, p50↓, 1, p65↓, 6, PD-1↓, 1, PD-L1↓, 3, PGE2↓, 15, PSA↓, 7, SOCS-3↓, 1, T-Cell↑, 2, T-Cell↝, 1, Th1 response↑, 1, TLR4↓, 2, TNF-α↓, 27, TNF-α↑, 5,

Cellular Microenvironment(tgid=17) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 10, CDK6↓, 19, CDK6↑, 2, RANKL↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

ABCG2↓, 1, BioAv↓, 27, BioAv↑, 31, BioAv↝, 6, BioEnh↑, 4, ChemoSen?, 1, ChemoSen↓, 3, ChemoSen↑, 94, ChemoSen↝, 1, DDS↑, 1, Dose?, 3, Dose↓, 4, Dose↑, 9, Dose⇅, 1, Dose↝, 33, Dose∅, 7, eff↓, 73, eff↑, 142, eff↝, 7, Half-Life↓, 3, Half-Life↑, 1, Half-Life↝, 10, MDR1↓, 4, MRP1/ABCC1↓, 2, P450↓, 4, RadioS↑, 34, selectivity?, 1, selectivity↓, 2, selectivity↑, 80, TET2↓, 1, TET2↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

AFP↓, 1, ALAT↓, 2, ALAT↑, 1, ALAT↝, 1, ALP↝, 1, AR↓, 10, AST↓, 2, AST↑, 1, AST↝, 1, BMPs↑, 1, BRAF↝, 1, p‑BRCA1↑, 1, CEA↓, 1, CRP↓, 1, E6↓, 1, E7↓, 1, EGFR↓, 30, EGFR↑, 1, p‑EGFR↓, 2, EZH2↓, 2, FOXM1↓, 1, GutMicro↑, 2, GutMicro↝, 1, HER2/EBBR2↓, 12, hTERT/TERT↓, 14, IL6↓, 32, Ki-67↓, 13, KRAS↓, 1, LDH↓, 5, LDH↑, 5, LDH↝, 2, Myc↓, 5, PD-L1↓, 3, PSA↓, 7, RAGE↓, 2, TP53↑, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 39, antiNeop↑, 1, AntiTum↑, 21, cachexia↓, 1, cardioP↑, 3, CardioT↑, 1, chemoP↑, 16, chemoPv↑, 17, chemoPv⇅, 1, ChemoSideEff↓, 4, hepatoP↓, 1, hepatoP↑, 6, neuroP↑, 1, NP/CIPN↓, 1, OS↑, 7, Pain↓, 2, Pin1↓, 2, QoL↑, 3, QoL∅, 1, radioP↑, 4, RenoP↑, 6, Risk↓, 8, Strength↑, 1, toxicity↓, 7, toxicity↑, 4, toxicity↝, 3, toxicity∅, 1, TumVol↓, 17, TumVol↑, 1, TumW↓, 9, Weight↑, 1, Weight∅, 2,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, Bacteria↓, 2, CD8+↑, 1,
Total Targets: 968

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

15-LOX/ALOX15↓, 1, AntiBio↑, 12, CD19↑, 1, CYP2D6↓, 1, diuretic↑, 2, Mucositis↓, 1, PLA2↓, 1, Stroke↓, 3, TPH1↓, 1, TRPA1↑, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 5, antiOx↑, 57, Catalase↑, 28, CYP2E1↓, 1, GPx↑, 19, GSH↑, 24, GSR↑, 2, GSTA1↑, 1, GSTs↑, 9, H2O2↓, 1, HDL↑, 1, HO-1↓, 1, HO-1↑, 7, Keap1↓, 1, Keap1↑, 1, Keap1↝, 1, lipid-P↓, 17, MDA↓, 16, MPO↓, 1, NADH↓, 1, NQO1↑, 1, NRF2↑, 20, Prx↑, 1, RNS↓, 2, ROS↓, 62, ROS∅, 1, mt-ROS?, 1, SOD↓, 1, SOD↑, 25, SOD2↑, 1, TAC↑, 3, TBARS↓, 2, Trx↑, 1, uricA↓, 1, VitC↑, 1,

Metal & Cofactor Biology(tgid=2) ⓘ

IronCh↑, 2, IronCh↝, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

AIF↓, 1, ATP↑, 3, Insulin↑, 1, MMP↑, 5, PGC-1α↑, 2, PGC-1α↝, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 8, AMPK↑, 2, p‑cMyc↑, 1, DGAT1↓, 1, FASN↓, 1, glucose↓, 3, GlucoseCon↑, 1, H2S↑, 2, LDH↓, 4, LDHA↑, 1, LDL↓, 2, lipidLev↓, 1, NAD↑, 1, NADPH↓, 1, NADPH↑, 2, PPARα↑, 1, PPARα↝, 1, PPARγ↓, 1, PPARγ↑, 1, SIRT1↑, 4,

Cell Death(tgid=5) ⓘ

Akt↓, 3, Akt↑, 2, Apoptosis↓, 2, Apoptosis∅, 1, BAX↓, 3, Bcl-2↑, 1, BMP2↑, 1, Casp↓, 1, Casp3?, 1, Casp3↓, 6, Casp9↓, 1, Cyt‑c↓, 2, Fas↓, 1, FasL↓, 1, iNOS↓, 8, JNK↓, 2, MAPK↓, 4, necrosis↓, 1, p38↓, 1, Pyro↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 2, cJun↓, 1, other↓, 2, other↑, 3, other↝, 1,

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↑, 1, HSPs↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 2, Beclin-1/ATG6↑, 1, LC3II↑, 1, p62↑, 2,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3, p16↓, 1, P53↓, 2, PARP1↓, 1,

Cell Cycle & Senescence(tgid=11) ⓘ

P21↓, 1, TumCCA↑, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Diff↝, 1, ERK↓, 2, ERK↑, 1, GSK‐3β↓, 1, HDAC↓, 2, HDAC3↓, 1, mTOR↓, 1, mTOR↑, 1, PDGFRB↓, 1, PI3K↓, 4, PI3K↑, 2, RUNX2↑, 1, STAT3↓, 2,

Migration(tgid=13) ⓘ

5LO↓, 1, AntiAg↑, 3, AP-1↓, 1, Ca+2↓, 1, COL1↑, 1, Ki-67↓, 1, MMP13↓, 2, PKCδ↓, 1, PKCδ↑, 1, p‑Rac1↓, 1, TRPC1↓, 1, VCAM-1↓, 1, ZO-1↑, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, Hif1a↓, 3, Hif1a↑, 1, NO↓, 6, PDGFR-BB↓, 1, VEGF↓, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 7, GastroP↑, 3, GLUT4↑, 1, IBI↑, 1, P-gp/ABCB1↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 2, COX1↓, 2, COX2/PTGS2↓, 15, COX2/PTGS2↑, 1, CRP↓, 1, IFN-γ↓, 1, IKKα↑, 1, IL1↓, 1, IL10↓, 4, IL10↑, 2, IL18↓, 1, IL1β↓, 8, IL2↓, 1, IL4↓, 1, IL5↓, 1, IL6↓, 17, IL6↑, 1, IL8↓, 3, Imm↑, 4, Inflam↓, 63, Inflam↑, 1, IκB?, 1, JAK↓, 1, pol-M2 MC↑, 1, NF-kB↓, 16, NK cell↑, 1, PGE2↓, 7, TLR4↓, 1, TNF-α↓, 21,

Synaptic & Neurotransmission(tgid=18) ⓘ

5HT↓, 1, 5HT↑, 1, AChE↓, 9, BChE↓, 3, BDNF↑, 4, MAOA↓, 1, NGF↑, 2, tau↓, 2, p‑tau↓, 2, TrkB↑, 1,

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1, Aβ↓, 6, BACE/β-secretase↓, 2, NLRP3↓, 2, XO↝, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 20, BioAv↑, 19, BioAv⇅, 1, BioAv↝, 8, Dose↝, 3, eff↓, 1, eff↑, 9, Half-Life↓, 2, Half-Life↑, 2, Half-Life↝, 6, P450↓, 1, selectivity↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 8, ALP↓, 4, AST↓, 7, BG↓, 1, BP↓, 4, creat↓, 4, CRP↓, 1, GutMicro↑, 7, IL6↓, 17, IL6↑, 1, Ki-67↓, 1, LDH↓, 4, NOS2↓, 1, Urea↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiAge↑, 1, antiAll↑, 3, AntiArt↑, 3, AntiCan↑, 11, antiCG↑, 1, AntiDiabetic↑, 17, antiNeop↑, 1, AntiP↑, 2, antiPs↑, 3, AntiTum↓, 2, AntiTum↑, 3, cardioP↑, 24, chemoP↑, 4, chemoPv↑, 1, cognitive↑, 5, hepatoP↑, 20, memory↑, 3, motorD↑, 1, neuroP↓, 1, neuroP↑, 33, Obesity↓, 3, Pain↓, 2, radioP↑, 2, RenoP↑, 5, toxicity?, 1, toxicity↓, 31, toxicity↑, 3, toxicity↝, 3, toxicity∅, 6, Wound Healing↑, 3,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↓, 1, AntiFungal↑, 3, AntiViral↑, 5, Bacteria↓, 13, CD8+↑, 1, Diar↓, 2, Sepsis↓, 1,
Total Targets: 254

Scientific Paper Hit Count for: Casp9, Caspase-9

21 Quercetin
18 Silver-NanoParticles
15 Baicalein
15 Curcumin
14 Thymoquinone
13 Fisetin
12 Kaempferol
12 Luteolin
12 Sulforaphane (mainly Broccoli)
11 Emodin
10 Apigenin (mainly Parsley)
9 Allicin (mainly Garlic)
9 Berberine
9 Betulinic acid
8 Chrysin
7 EGCG (Epigallocatechin Gallate)
7 Gambogic Acid
7 Honokiol
7 Silymarin (Milk Thistle) silibinin
6 Artemisinin
6 Citric Acid
6 Eugenol
6 Garcinol
6 Graviola
6 Magnolol
5 Cisplatin
5 D-limonene
5 Ginkgetin
5 Ivermectin
5 Phenethyl isothiocyanate
5 Shikonin
4 Cynara scolymus/Globe Artichoke/Artichoke Extract
4 Alpha-Lipoic-Acid
4 Ashwagandha(Withaferin A)
4 Bromelain
4 Capsaicin
4 Carvacrol
4 chaetocin
4 Photodynamic Therapy
4 Formononetin
4 Fucoidan
4 Juglone
4 Licochalcone A
4 Magnetic Fields
4 Plumbagin
4 Resveratrol
3 5-fluorouracil
3 Berbamine
3 Boron
3 Boswellia (frankincense)
3 Carnosic acid
3 Radiotherapy/Radiation
3 Evodiamine
3 Ferulic acid
3 Gallic acid
3 Geraniol
3 Gossypol/AT-101
3 HydroxyTyrosol
3 Hyperoside
3 Isoliquiritigenin
3 Vitexin
3 Licorice
3 Propolis -bee glue
3 Piperlongumine
3 Selenium NanoParticles
3 Aflavin-3,3′-digallate
2 Astragalus
2 Andrographis
2 Anethole/trans-Anethole
2 Aloe anthraquinones
2 Beta-Caryophyllene
2 Brucea javanica
2 α-Bisabolol / Chamomile oil
2 Thymol-Thymus vulgaris
2 Centella asiatica / Gotu kola → asiaticoside
2 Chlorogenic acid
2 Cichoric acid / Chicoric acid
2 Carvone
2 Polyphenols
2 Deguelin
2 Docetaxel
2 Dandelion Root
2 Echinacea
2 Electrical Pulses
2 Paclitaxel/Taxol
2 Hibiscus sabdariffa
2 Rutin
2 Isobavachalcone
2 IP6 (Inositol 1,2,3,4,5,6-hexakisphosphate)
2 isoorientin
2 lambertianic acid
2 low dose naltrexone
2 Lycopene
2 Nimbolide
2 Oleuropein
2 salinomycin
2 Selenium
2 chitosan
2 Selenite (Sodium)
2 Ursolic acid
1 1,8-Cineole
1 entinostat
1 Camptothecin
1 Resiquimod
1 Gemcitabine (Gemzar)
1 Phyllanthus emblica/Emblica officinalis/Amla / Indian Gooseberry
1 Fennel Oil/Foeniculum vulgare
1 Metformin
1 2-DeoxyGlucose
1 almonertinib
1 epirubicin
1 Biochanin A
1 Bufalin/Huachansu
1 brusatol
1 borneol
1 Bullatacin
1 Caffeic acid
1 Sorafenib (brand name Nexavar)
1 Celecoxib
1 Celastrol
1 Chlorophyllin
1 Cinnamon
1 immunotherapy
1 Crocetin
1 Cucurbitacin
1 Cynaropicrin
1 Diclofenac
1 diet Methionine-Restricted Diet
1 Ellagic acid
1 Geldanamycin
1 Radicicol/monorden
1 olaparib/LYNPARZA
1 Ginkgolic acids
1 Ginger/6-Shogaol/Gingerol
1 Ginseng
1 Hydroxycinnamic-acid
1 Helleborus niger extracts – Christmas Rose
1 Baicalin
1 Indole-3-carbinol
1 isoquercitrin
1 Isovitexin
1 Lactobacillus
1 tumor necrosis factor-related apoptosis-inducing ligand
1 Lasiodin
1 Lactoferrin/Talactoferrin
1 Melatonin
1 Chemotherapy
1 Magnetic Field Rotating
1 Marjoram (Origanum majorana)
1 sericin
1 Propyl gallate
1 doxorubicin
1 Rauwolfia serpentina/Indian Snakeroot
1 buckwheat sprouts
1 Sanguinarine
1 polyethylene glycol
1 Auranofin
1 Terpinen-4-ol / Tea Tree Oil
1 Urolithin
1 Vitamin C (Ascorbic Acid)
1 Vitamin D3
1 Vitamin K2
1 VitK3,menadione

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:45  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

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