IL10 Cancer Research Results

IL10, Interleukin-10: Click to Expand ⟱
Source:
Type:
IL-10 is a multifaceted immune-suppressive cytokine and possesses immune-regulatory and angiogenic functions.
It primarily acts as an anti-inflammatory cytokine, protecting the body from an uncontrolled immune response, mostly through the Jak1/Tyk2 and STAT3 signaling pathway. On the other hand, IL-10 can also have immunostimulating functions under certain conditions.
The role of IL-10 in tumor pathogenesis is currently highly controversial, with some findings showing that IL-10 promotes tumor development and angiogenesis, while others supporting that it inhibits tumor growth and metastasis.

IL-10 is often expressed in various cancers, including breast cancer, colorectal cancer, melanoma, and lymphoma. Its expression can vary significantly depending on the tumor type and the immune context.
Elevated levels of IL-10 are frequently associated with the presence of tumor-infiltrating immune cells, particularly Tregs and M2 macrophages.
Scientific Papers found: Click to Expand⟱
6401- ANE,    Anethole and Its Role in Chronic Diseases
- Review, Var, NA - Review, PSA, NA
*BioAv↝, *other↝, eff↓, TNF-α↓, IL10↑, CXCR4↓, MMP2↓, MMP9↓, TIMP1↑, NF-kB↓, AP-1↓, STAT↓, JNK↓, ERK↓, MAPK↓, PI3K↓, Akt↓, JAK↓, *AntiDiabetic↓, *neuroP↑, *Imm↑, chemoP↑, *AntiThr↑, *AntiAg↑, *antiOx↑, *SOD↑, *GSH↑, *Wound Healing↑, chemoPv↑, *GSTs↑, *NF-kB↓,
743- Bor,    Boric Acid (Boron) Attenuates AOM-Induced Colorectal Cancer in Rats by Augmentation of Apoptotic and Antioxidant Mechanisms
- in-vitro, CRC, NA
BAX↑, Bcl-2↓, GPx↑, SOD↑, Catalase↑, MDA↓, TNF-α↓, IL6↓, IL10↑,
5987- Chit,    Chitin, Chitosan, and Glycated Chitosan Regulate Immune Responses: The Novel Adjuvants for Cancer Vaccine
- Review, Var, NA
other↝, other↝, *Weight↝, *toxicity↓, *Bacteria↓, *BioAv↑, DDS↑, *Wound Healing↑, *other↝, *Imm↑, eff↑, *BioAv↝, *BioAv↑, eff↑, NK cell↑, IL2↑, IFN-γ↑, IL10↑,
1574- Citrate,    Citrate Suppresses Tumor Growth in Multiple Models through Inhibition of Glycolysis, the Tricarboxylic Acid Cycle and the IGF-1R Pathway
- in-vitro, Lung, A549 - in-vitro, Melanoma, WM983B - in-vivo, NA, NA
TumCG↓, eff↑, T-Cell↑, p‑IGF-1R↓, p‑Akt↓, PTEN↑, p‑eIF2α↑, OCR↓, ROS↓, ECAR∅, IL1↑, TNF-α↑, IL10↑, IGF-1R↓, eIF2α↑, PTEN↑, TCA↓, Glycolysis↓, selectivity↑, *toxicity∅, Dose∅,
7042- GA,    Gallic acid reduces cell growth by induction of apoptosis and reduction of IL-8 in HepG2 cells
- in-vitro, Liver, HepG2
*Inflam↓, *AntiTum↑, *antiOx↑, TumCP↓, IL8↓, IL10↑, IL12↑, Apoptosis↑,
1708- Lyco,    The Anti-Cancer Activity of Lycopene: A Systematic Review of Human and Animal Studies
- Review, Var, NA
OS↑, ChemoSen↑, QoL↑, PSA∅, eff↑, AntiCan↑, AntiCan↑, angioG↓, VEGF↓, Hif1a↓, SOD↑, Catalase↑, GPx↑, GSH↑, GPx↑, GR↑, MDA↓, NRF2↑, HO-1↑, COX2/PTGS2↓, PGE2↓, NF-kB↓, IL4↑, IL10↑, IL6↓, TNF-α↓, PPARγ↑, TumCCA↑, FOXO3↓, Casp3↑, IGF-1↓, p27/CDKN1B↑, STAT3↓, CDK2↓, CDK4↓, P21↑, PCNA↓, MMP7↓, MMP9↓,
500- MF,    Anti-Oxidative and Immune Regulatory Responses of THP-1 and PBMC to Pulsed EMF Are Field-Strength Dependent
- in-vitro, AML, THP1
ROS↑, Prx6↑, DHCR24↑, IL10↑,
220- MFrot,  MF,    Effect of low frequency magnetic fields on melanoma: tumor inhibition and immune modulation
- in-vitro, Melanoma, B16-F10
OS↑, DCells↑, T-Cell↑, Apoptosis↑, IL1↑, IFN-γ↓, IL10↑, TumCG↓, ROS↑, TumCP↓, TumCCA↑, ChrMod↑, CXCL9↓, CXCL12↓, CD4+↑, CD8+↑,
1806- NarG,    Naringin: Nanotechnological Strategies for Potential Pharmaceutical Applications
- Review, NA, NA
Inflam↓, antiOx↓, AntiCan↑, BioAv↓, BioAv↓, BioAv↑, INF-γ↓, IL6↓, TNF-α↓, IL10↑, CRP↓,
1660- PBG,    Emerging Adjuvant Therapy for Cancer: Propolis and its Constituents
- Review, Var, NA
MMPs↓, angioG↓, TumMeta↓, TumCCA↑, Apoptosis↑, ChemoSideEff↓, eff∅, HDAC↓, PTEN↑, p‑PTEN↓, p‑Akt↓, Casp3↑, p‑ERK↑, p‑FAK↑, Dose?, Akt↓, GSK‐3β↓, FOXO3↓, eff↑, IL2↑, IL10↑, NF-kB↓, VEGF↓, mtDam↑, ER Stress↑, AST↓, ALAT↓, ALP↓, COX2/PTGS2↓, eff↑, Bax:Bcl2↑,
1662- PBG,    The immunomodulatory and anticancer properties of propolis
- Review, Var, NA
IL6↓, IL12↓, IL10↑, CSCs↓, PAK1↓, VEGF↓, MMP2↓, MMP9↓, NF-kB↓, Hif1a↓, ChemoSen↑, RadioS↑,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1,   Catalase↑, 2,   GPx↑, 3,   GSH↑, 1,   HO-1↑, 1,   MDA↓, 2,   NRF2↑, 1,   Prx6↑, 1,   ROS↓, 1,   ROS↑, 2,   SOD↑, 2,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   DHCR24↑, 1,   ECAR∅, 1,   Glycolysis↓, 1,   PPARγ↑, 1,   TCA↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 2,   p‑Akt↓, 2,   Apoptosis↑, 3,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   JNK↓, 1,   MAPK↓, 1,   p27/CDKN1B↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ChrMod↑, 1,   other↝, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

eIF2α↑, 1,   p‑eIF2α↑, 1,   ER Stress↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PCNA↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   P21↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   ERK↓, 1,   p‑ERK↑, 1,   FOXO3↓, 2,   GSK‐3β↓, 1,   HDAC↓, 1,   IGF-1↓, 1,   IGF-1R↓, 1,   p‑IGF-1R↓, 1,   PI3K↓, 1,   PTEN↑, 3,   p‑PTEN↓, 1,   STAT↓, 1,   STAT3↓, 1,   TumCG↓, 2,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   CXCL12↓, 1,   p‑FAK↑, 1,   MMP2↓, 2,   MMP7↓, 1,   MMP9↓, 3,   MMPs↓, 1,   PAK1↓, 1,   TIMP1↑, 1,   TumCP↓, 2,   TumMeta↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 2,   VEGF↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   COX2/PTGS2↓, 2,   CRP↓, 1,   CXCL9↓, 1,   CXCR4↓, 1,   DCells↑, 1,   IFN-γ↓, 1,   IFN-γ↑, 1,   IL1↑, 2,   IL10↑, 11,   IL12↓, 1,   IL12↑, 1,   IL2↑, 2,   IL4↑, 1,   IL6↓, 4,   IL8↓, 1,   INF-γ↓, 1,   Inflam↓, 1,   JAK↓, 1,   NF-kB↓, 4,   NK cell↑, 1,   PGE2↓, 1,   PSA∅, 1,   T-Cell↑, 2,   TNF-α↓, 4,   TNF-α↑, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

GR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 2,   DDS↑, 1,   Dose?, 1,   Dose∅, 1,   eff↓, 1,   eff↑, 6,   eff∅, 1,   RadioS↑, 1,   selectivity↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   ALP↓, 1,   AST↓, 1,   CRP↓, 1,   IL6↓, 4,   PSA∅, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 3,   chemoP↑, 1,   chemoPv↑, 1,   ChemoSideEff↓, 1,   OS↑, 2,   QoL↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 1,  
Total Targets: 119

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   GSH↑, 1,   GSTs↑, 1,   SOD↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↝, 2,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Imm↑, 2,   Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↓, 1,   AntiTum↑, 1,   neuroP↑, 1,   toxicity↓, 1,   toxicity∅, 1,   Weight↝, 1,   Wound Healing↑, 2,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  
Total Targets: 20

Scientific Paper Hit Count for: IL10, Interleukin-10
2 Magnetic Fields
2 Propolis -bee glue
1 Anethole/trans-Anethole
1 Boron
1 chitosan
1 Citric Acid
1 Gallic acid
1 Lycopene
1 Magnetic Field Rotating
1 Naringin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:562  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

 

Home Page