mtDam Cancer Research Results

mtDam, mitochondrial damage: Click to Expand ⟱

Source:

Type:

Mitochondrial damage can lead to a shift from oxidative phosphorylation to glycolysis, a process known as the Warburg effect. This shift can provide cancer cells with a selective advantage, allowing them to grow and proliferate more rapidly.
Mitochondrial Damage can also lead to cell death of cancer cells.

Scientific Papers found: Click to Expand⟱

5271-

3BP,

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside

Review,

Var,

selectivity↑, selectivity↑, ATP↓, Glycolysis↓, HK2↓, mt-OXPHOS↓, GAPDH↓, mtDam↑, GSH↓, ROS↑, ER Stress↑, TumAuto↑, LC3‑Ⅱ/LC3‑Ⅰ↑, p62↓, Akt↓, HDAC↓, TumCA↑, Bcl-2↓, cMyc↓, Casp3↑, Cyt‑c↑, Mcl-1↓, PARP↓, ChemoSen↑,

5280-

3BP,

Anticancer Efficacy of the Metabolic Blocker 3-Bromopyruvate: Specific Molecular Targeting

in-vitro,

PC,

mtDam↑, HK2↓, TGF-β↓, Casp3↑, selectivity↑,

5277-

3BP,

3-Bromopyruvate inhibits pancreatic tumor growth by stalling glycolysis, and dismantling mitochondria in a syngeneic mouse model

in-vivo,

PC,

Panc02

mouse model

HK2↓, selectivity↑, ATP↓, mtDam↑, Dose↝, TumCG↓, Casp3↑, Glycolysis↓, NADPH↓, ATP↓, ROS↑, DNAdam↑, GSH↓, Bcl-2↓, Casp↑, lactateProd↓,

5270-

5-ALA,

PDT,

5-Aminolevulinic Acid as a Theranostic Agent for Tumor Fluorescence Imaging and Photodynamic Therapy

Review,

Var,

other↝, ROS↑, other↝, mtDam↑, Ca+2↑, ER Stress↑, Apoptosis↑, TumAuto↑, other↝, Dose↝, Imm↑,

4394-

AgNPs,

Silver nanoparticles provoke apoptosis of Dalton's ascites lymphoma in vivo by mitochondria dependent and independent pathways

in-vivo,

lymphoma,

OS↑, TumVol↓, Weight↑, AntiTum↑, Apoptosis↑, mtDam↑,

4410-

AgNPs,

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy

Review,

Colon,

AntiCan↑, ROS↑, mtDam↑, tumCV↓, selectivity↑,

4435-

AgNPs,

Gluc,

Glucose-Functionalized Silver Nanoparticles as a Potential New Therapy Agent Targeting Hormone-Resistant Prostate Cancer cells

in-vitro,

Pca,

PC3

average size of 61nm

911ug/mL

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

1579ug/mL

selectivity↑, ROS↑, mtDam↑, TumCCA↑, TumCP↓, Apoptosis↑, MMP↓,

342-

AgNPs,

Silver nanoparticles; a new hope in cancer therapy?

Review,

NA,

ROS↑, DNAdam↑, Apoptosis↑, mtDam↑,

375-

AgNPs,

ALA,

Alpha-Lipoic Acid Prevents Side Effects of Therapeutic Nanosilver without Compromising Cytotoxicity in Experimental Pancreatic Cancer

in-vitro,

PC,

Bxpc-3

 we used α-lipoic acid concentrations of 0.5 and 1 mM

in-vitro,

PC,

PANC1

in-vitro,

PC,

MIA PaCa-2

in-vivo,

NA,

dropping 200 µL or 400 µL of a 14 ppm AgNP solution, 200 µL or 400 µL of a 0.5 mM α-lipoic acid solution, or both solutions together on the chorioallantoic membrane (CAM)

chick embryos

mtDam↑, ROS↑, *toxicity↓, Dose∅, selectivity↑,

327-

AgNPs,

MS-275,

Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells

in-vitro,

Lung,

A549

 1uM,1uM

Apoptosis↑, ROS↑, LDH↓, TNF-α↑, mtDam↑, TumAuto↑, Casp3↑, Casp9↑, DNAdam↑,

316-

AgNPs,

Endoplasmic reticulum stress: major player in size-dependent inhibition of P-glycoprotein by silver nanoparticles in multidrug-resistant breast cancer cells

in-vitro,

BC,

MCF7

 75nm

GRP78/BiP↑, ER Stress↑, ROS↑, mtDam↑,

371-

AgNPs,

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

in-vitro,

Lung,

A549

ROS↑, mtDam↑,

368-

AgNPs,

In vitro evaluation of silver nanoparticles on human tumoral and normal cells

in-vitro,

Var,

  6.72-13.45 µg/ml

mtDam↑, LDH↓,

367-

AgNPs,

Presence of an Immune System Increases Anti-Tumor Effect of Ag Nanoparticle Treated Mice

in-vivo,

NA,

 mice

ROS↑, mtDam↑, TumCG↓,

357-

AgNPs,

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Lung,

L132

mtDam↑, ROS↑, Hif1a↑, LC3s↑, p62↑, eff↓,

393-

AgNPs,

Green synthesized plant-based silver nanoparticles: therapeutic prospective for anticancer and antiviral activity

in-vitro,

NA,

HCT116

mtDam↑, ROS↑, TumCCA↑, Casp3↑, BAX↑, Bcl-2↓, P53↑,

384-

AgNPs,

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

in-vitro,

Testi,

LDH↓, ROS↑, mtDam↑, DNAdam↑, P53↑, P21↑, BAX↑, Casp3↑, Bcl-2↓, Casp9↑, Nanog↓, OCT4↓,

2634-

Api,

Apigenin induces both intrinsic and extrinsic pathways of apoptosis in human colon carcinoma HCT-116 cells

in-vitro,

CRC,

HCT116

TumCG↓, TumCCA↑, MMP↓, ROS↑, Ca+2↑, ER Stress↑, mtDam↑, CHOP/DDIT3↑, DR5↑, cl‑BID↑, BAX↑, Cyt‑c↑, cl‑Casp3↑, cl‑Casp8↑, cl‑Casp9↑, Apoptosis↑,

572-

ART/DHA,

High-throughput screening identifies artesunate as selective inhibitor of cancer stemness: Involvement of mitochondrial metabolism

CSCs↓, mtDam↑,

1379-

BBR,

Berberine derivative DCZ0358 induce oxidative damage by ROS-mediated JNK signaling in DLBCL cells

in-vitro,

lymphoma,

TumCP↓, CDK4↓, CDK6↓, cycD1/CCND1↓, TumCCA↑, MMP↓, Ca+2↑, ATP↓, mtDam↑, Apoptosis↑, ROS↑, JNK↑, eff↓,

1399-

BBR,

Rad,

Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review

Review,

NA,

*ROS↓, *MDA↓, *TNF-α↓, *TGF-β↓, *IL10↑, ROS↑, DNAdam↑, mtDam↑, MMP↓, Apoptosis↑, TumCCA↑, Hif1a↓, VEGF↓, RadioS↑,

5511-

bemA,

Inhibition of ACLY overcomes cancer immunotherapy resistance via polyunsaturated fatty acids peroxidation and cGAS-STING activation

in-vitro,

Var,

ACLY↓, PD-L1↑, mtDam↑, cGAS–STING↑, LDL↓, eff↑,

5582-

BetA,

Targeting mitochondrial apoptosis by betulinic acid in human cancers

Review,

Var,

Apoptosis↑, MMP↓, Cyt‑c↑, ROS↑, NF-kB↑, angioG↓, mtDam↑, TOP1↓, selectivity↑, ChemoSen↑, TumCG↓, chemoPv↑, RadioS↑,

5585-

BetA,

Betulinic acid-induced mitochondria-dependent cell death is counterbalanced by an autophagic salvage response

in-vitro,

Cerv,

HeLa

in-vitro,

lymphoma,

U937

mtDam↑, TumAuto↑,

2719-

BetA,

Betulinic Acid Restricts Human Bladder Cancer Cell Proliferation In Vitro by Inducing Caspase-Dependent Cell Death and Cell Cycle Arrest, and Decreasing Metastatic Potential

in-vitro,

CRC,

T24/HTB-9

30 μg/mL BA for 48 h

in-vitro,

Bladder,

UMUC3

33.2 μg/mL

in-vitro,

Bladder,

5637

 28.5 μg/mL

TumCD↑, Apoptosis↑, TumCCA↑, CycB/CCNB1↓, cycA1/CCNA1↓, CDK2↓, CDC25↓, mtDam↑, BAX↑, cl‑PARP↑, Casp3↑, Casp8↑, Casp9↑, Snail↓, Slug↓, MMP9↓, selectivity↑, MMP↓, ROS∅, TumCMig↓, TumCI↓,

5668-

BNL,

Anticancer effect of borneol: Mechanistic insights through literature review and in silico studies

Review,

Var,

AntiCan↑, Apoptosis↑, mtDam↑, ROS↑, mTORC1↓, EIF4E↓, Hif1a↓, NF-kB↓, STAT3↓, PI3K↓, Akt↓, ChemoSen↑, BioEnh↑, BioAv↑, BBB↑, toxicity↝,

6545-

BSB,

The antineoplastic agent α-bisabolol promotes cell death by inducing pores in mitochondria and lysosomes

MPT↑, Casp↑, TumAuto↑, Apoptosis↑, TumCD↑, Dose↝, MMP↓, ROS↑, mtDam↑,

5739-

Buty,

Butyrate as a promising therapeutic target in cancer: From pathogenesis to clinic (Review)

Review,

Var,

GutMicro↑, *Inflam↓, *IL6↓, *TNF-α↓, *IL17↓, *IL10↑, *ROS↝, COX2/PTGS2↓, NLRP3↓, Imm↑, HDAC↓, TumCCA↑, Apoptosis↑, ROS↑, Casp↑, mtDam↑, Cyt‑c↑, eff↑, chemoP↑, ChemoSen↑, eff↑, RadioS↑, HCAR2↑,

5826-

CAP,

Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload

in-vitro,

Thyroid,

TRPV1↑, tumCV↓, Ca+2↑, mtDam↑, ROS↑, MMP↓, MPT↑, Cyt‑c↑, Casp↑, Apoptosis↑,

5861-

CAP,

Anticancer Properties of Capsaicin Against Human Cancer

Review,

Var,

*antiOx↑, *Inflam↓, *Obesity↓, chemoPv↑, Apoptosis↑, selectivity↑, TRPV1↑, Ca+2↑, mtDam↑, Cyt‑c↑, P53↑, SIRT1↓, TumCCA↑, P21↑, CDK4↓, CDK6↓, cycE/CCNE↓, angioG↓, TumMeta↓,

5910-

CAR,

Oregano Phytocomplex Induces Programmed Cell Death in Melanoma Lines via Mitochondria and DNA Damage

in-vitro,

Melanoma,

B16-F10

NA,

A375

ROS↑, TumCP↓, Apoptosis↑, Necroptosis↑, mtDam↑, DNAdam↑, selectivity↑, Dose↝, MPT↓,

5819-

CBD,

The potential role of cannabidiol (CBD) in lung cancer therapy: a systematic review of preclinical and clinical evidence

Review,

Lung,

Apoptosis↑, PPARγ↓, mtDam↑, ROS↑, EMT↓, CD8+↑, NK cell↑, ChemoSen↑, ATP↓, glucose↓, Ca+2↑, TRPV2↑,

5948-

Cela,

Recent Trends in anti-tumor mechanisms and molecular targets of celastrol

TumCP↓, TumCCA↑, Apoptosis↑, TumAuto↑, TumCI↓, TumMeta↓, Imm↝, angioG↓, Cyt‑c↑, ROS↑, BAX↑, Casp3↑, Casp9↑, cl‑PARP↑, PrxII↓, ER Stress↑, mtDam↑, CHOP/DDIT3↑, Inflam↓, NF-kB↓, CXCR4↓, MMP9↓, IL6↓, TNF-α↓, HSP90↓, neuroP↑, STAT3↓, Prx↓, HO-1↑, eff↑, eff↑, BioAv↑, toxicity↑, CardioT↑, hepatoP↓,

6002-

CGA,

Chlorogenic Acid: A Systematic Review on the Biological Functions, Mechanistic Actions, and Therapeutic Potentials

Review,

Var,

Review,

Diabetic,

Review,

AD,

Review,

Park,

Review,

Stroke,

*neuroP↑, *Inflam↓, *antiOx↑, *cardioP↑, *NRF2↑, *AMPK↑, *SOD↑, *Catalase↑, *GSH↑, *GPx↑, *ROS↓, *TNF-α↓, *IL6↓, *NF-kB↓, *COX2/PTGS2↓, *glucose↓, *TRPC1↓, *Ca+2↓, *HO-1↑, *NF-kB↓, *PPARα↝, *Hif1a↓, *JNK↓, *BP↓, *AntiDiabetic↑, *hepatoP↑, *TLR4↓, *NRF2↑, *Casp↓, *neuroP↑, *Aβ↓, *LDH↓, *MDA↓, *memory↑, *AChE↓, *eff↑, EMT↝, N-cadherin↓, E-cadherin↑, TumCCA↑, ROS↑, p‑P53↑, HO-1↑, NRF2↑, ChemoSen↑, mtDam↑, Casp3↑, Casp9↑, PARP↑, Bax:Bcl2↑, TumCG↓, cycD1/CCND1↓, cMyc↓, CDK2↓, mitResp↓, Glycolysis↓, Hif1a↓, PCNA↓, p‑GSK‐3β↓, VEGF↓, PI3K↓, Akt↓, mTOR↓, OS↑,

6012-

CGA,

Chlorogenic Acid as a Potential Therapeutic Agent for Cholangiocarcinoma

in-vitro,

CCA,

HCC9810

TumCP↓, TumCMig↓, TumCI↓, EMT↓, Apoptosis↑, TumCCA↑, AKR1B10↓, Akt↓, mtDam↑, BAX↑, Casp9↑, Casp3↑, Bcl-2↓,

4482-

Chit,

Hyaluronic acid-coated chitosan nanoparticles induce ROS-mediated tumor cell apoptosis and enhance antitumor efficiency by targeted drug delivery via CD44

in-vitro,

Lung,

A549

in-vitro,

Liver,

HepG2

EPR↑, mtDam↑, ROS↑, Apoptosis↑,

6126-

CHr,

Chrysin induces cell apoptosis in human uveal melanoma cells via intrinsic apoptosis

in-vitro,

Melanoma,

tumCV↓, selectivity↑, MPT↑, Cyt‑c↑, Casp3↑, Casp9↑, Apoptosis↑, mtDam↑, chemoPv↑,

6141-

Cin,

The role and mechanism of cinnamaldehyde in cancer

Review,

Var,

Apoptosis↑, Casp↑, mtDam↑, angioG↓, TumCP↓, *Inflam↓, *antiOx↑, *ROS↓, *DNAdam↓, ROS↑, *Bcl-2↑, *BAX↓, *NF-kB↓, ChemoSen↑, ICAM-1↓, VCAM-1↓, PI3K↓, Akt↓, mTOR↓, BioAv↝,

1585-

Citrate,

Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer

in-vitro,

Ovarian,

SKOV3

15.93 mM

in-vitro,

Ovarian,

A2780S

16.8 mM

in-vitro,

Nor,

HEK293

Apoptosis↑, Ferroptosis↑, Ca+2↓, CaMKII ↓, Akt↓, mTOR↓, Hif1a↓, ROS↑, ChemoSen↑, Casp3↑, Casp9↑, BAX↑, Bcl-2↓, Cyt‑c↑, GlucoseCon↓, lactateProd↓, Pyruv↓, GLUT1↓, HK2↓, PFKP↓, Glycolysis↓, Hif1a↓, p‑Akt↓, p‑mTOR↓, Iron↑, lipid-P↑, MDA↑, ROS↑, H2O2↑, mtDam↑, GSH↓, GPx↓, GPx4↓, NADPH/NADP+↓, eff↓, FTH1↓, LC3‑Ⅱ/LC3‑Ⅰ↑, NCOA4↑, eff↓, TumCG↓,

6309-

Cro,

Crocin exerts anti-tumor effect in colon cancer cells via repressing the JaK pathway

in-vitro,

CRC,

HCT116

tumCV↓, TumCP↓, Ki-67↓, Apoptosis↓, Inflam↓, ROS↑, MMP↓, JAK2↓, STAT3↓, ERK↓, MIP2↓, IL6↓, MCP1/CCL2↓, IL8↓, IL1β↓, TNF-α↓, SOD↓, Catalase↓, GSH↓, ROS↑, mtDam↑,

1572-

Cu,

Recent Advances in Cancer Therapeutic Copper-Based Nanomaterials for Antitumor Therapy

Review,

NA,

eff↑, Fenton↑, ROS↑, eff↑, mtDam↑, BAX↑, Bcl-2↓, MMP↓, Cyt‑c↑, Casp3↑, ER Stress↑, CHOP/DDIT3↑, Apoptosis↑, selectivity↑, eff↑, Pyro↑, Paraptosis↑, Cupro↑, ChemoSen↑, eff↑,

404-

CUR,

Curcumin induces ferroptosis in non-small-cell lung cancer via activating autophagy

vitro+vivo,

Lung,

A549

mice

vitro+vivo,

Lung,

H1299

TumAuto↑, TumCG↓, TumCP↓, Iron↑, GSH↓, lipid-P↑, GPx↓, mtDam↑, autolysosome↑, Beclin-1/ATG6↑, LC3s↑, p62↓, Ferroptosis↑,

481-

CUR,

CHr,

Api,

Flavonoid-induced glutathione depletion: Potential implications for cancer treatment

in-vitro,

Liver,

A549

in-vitro,

Pca,

PC3

in-vitro,

AML,

HL-60

GSH↓, mtDam↑, MMP↓, Cyt‑c↑,

454-

CUR,

Curcumin-Induced DNA Demethylation in Human Gastric Cancer Cells Is Mediated by the DNA-Damage Response Pathway

in-vitro,

GC,

MGC803

5, 10, 15, 20, 40 and 60 μM, 24, 48 and 72 h

TumCMig↓, TumCP↓, ROS↑, mtDam↑, DNAdam↑, Apoptosis↑, ATR↑, P21↑, p‑P53↑, GADD45A↑, p‑γH2AX↑,

2821-

CUR,

Antioxidant curcumin induces oxidative stress to kill tumor cells (Review)

Review,

Var,

*antiOx↑, *NRF2↑, *ROS↓, *Inflam↓, ROS↑, p‑ERK↑, ER Stress↑, mtDam↑, Apoptosis↑, Akt↓, mTOR↓, HO-1↑, Fenton↑, GSH↓, Iron↑, p‑JNK↑, Cyt‑c↑, ATF6↑, CHOP/DDIT3↑,

6249-

Cyc,

Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells

in-vitro,

NSCLC,

A549

in-vitro,

NSCLC,

H1299

HH↓, OCR↓, TumCP↓, Apoptosis↑, ROS↑, MMP↑, mtDam↑,

7439-

CYN,

Cynaropicrin Induces Reactive Oxygen Species-Dependent Paraptosis-Like Cell Death in Human Liver Cancer Cells

in-vitro,

Liver,

Hep3B

tumCV↓, mtDam↑, ER Stress↑, i-Ca+2↑, ROS↑, Alix/AIP‑1↓, eff↓,

6695-

DFC,

Inhibition of lactate dehydrogenase A by diclofenac sodium induces apoptosis in HeLa cells through activation of AMPK

in-vitro,

Cerv,

HeLa

other↝, Glycolysis↓, LDHA↓, Hypoxia↓, Apoptosis↑, lactateProd↓, ATP↓, mt-ROS↑, DNAdam↑, lipid-P↑, AMPK↑, p‑S6K↓, TumCP↓, Dose↝, selectivity↑, i-MDA↑, mtDam↑,

6689-

DFC,

Diclofenac-Induced Apoptosis in the Neuroblastoma Cell Line SH-SY5Y: Possible Involvement of the Mitochondrial Superoxide Dismutase

in-vitro,

neuroblastoma,

SH-SY5Y

Apoptosis↑, mtDam↑, ROS↑, SOD2↓, MMP↓, Cyt‑c↑, Dose↝, BBB↑,

6745-

DHA,

Omega-3 fatty acid DHA induces ferroptosis in colorectal cancer patient-derived organoids and drug-tolerant cells

in-vitro,

CRC,

HT29

tumCV↓, selectivity↑, Ferroptosis↑, lipid-P↑, mt-ROS↑, ChemoSen↑, *toxicity↓, TumCG↓, eff↑, eff↑, Dose↝, mtDam↑, *Inflam↓, *chemoP↑, Dose↑,

Showing Research Papers: 1 to 50 of 145
Page 1 of 3 Next

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 145

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome(tgid=24) ⓘ

CD8+↑, 2,
Total Targets: 496

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

AntiBio↑, 3, Stress↓, 1, Stroke↝, 1,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↓, 1, antiOx↑, 9, ARE↑, 1, Catalase↑, 3, Ferroptosis↓, 1, GPx↑, 3, GPx4↑, 1, GSH↑, 3, HO-1↑, 4, i-Iron↓, 1, lipid-P↓, 2, MDA↓, 4, NQO1↑, 1, NRF2↑, 9, ROS↓, 13, ROS↝, 1, SIRT3↑, 1, SOD↑, 4, TAC↑, 2, xCT/SLC7A11↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

MMP↑, 1,

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1, AMPK↑, 2, glucose↓, 1, LDH↓, 1, LDHA↑, 1, NADPH↑, 1, PPARα↝, 1, SIRT1↑, 1,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1, BAX↓, 1, Bcl-2↑, 1, Casp↓, 1, Ferroptosis↓, 1, JNK↓, 1, MAPK↓, 1,

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↓, 1,

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,

Migration(tgid=13) ⓘ

Ca+2↓, 1, TGF-β↓, 1, TRPC1↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

Hif1a↓, 1, NO↓, 1,

Barriers & Transport(tgid=15) ⓘ

GastroP↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1, IL10↑, 2, IL17↓, 1, IL6↓, 2, Inflam↓, 15, NF-kB↓, 5, PGE2↓, 1, TLR4↓, 1, TNF-α↓, 3,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4, BioAv↝, 1, Dose↓, 1, eff↑, 1,

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1, AST↓, 1, BMD↑, 1, BP↓, 1, GutMicro↑, 2, IL6↓, 2, LDH↓, 1,

Functional Outcomes(tgid=23) ⓘ

AntiCan↓, 1, AntiCan↑, 1, AntiDiabetic↑, 3, AntiP↑, 4, cardioP↑, 5, chemoP↑, 2, hepatoP↑, 4, memory↑, 1, neuroP↑, 8, Obesity↓, 2, RenoP↑, 1, toxicity↓, 10, toxicity↑, 1,

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1, AntiViral↑, 2,
Total Targets: 84

Scientific Paper Hit Count for: mtDam, mitochondrial damage

14 Silver-NanoParticles
8 Ivermectin
5 Honokiol
5 Isobavachalcone
4 Curcumin
4 Licochalcone A
4 Propolis -bee glue
4 Selenite (Sodium)
3 3-bromopyruvate
3 Berberine
3 Betulinic acid
3 Dandelion Root
3 EGCG (Epigallocatechin Gallate)
3 Kaempferol
3 Luteolin
3 SonoDynamic Therapy UltraSound
3 Magnolol
3 Magnetic Fields
3 Phenethyl isothiocyanate
2 Apigenin (mainly Parsley)
2 Capsaicin
2 Chlorogenic acid
2 chitosan
2 Chrysin
2 Copper and Cu NanoParticles
2 Diclofenac
2 D-limonene
2 Electrical Pulses
2 Gallic acid
2 Gossypol/AT-101
2 doxorubicin
2 Hyperthermia
2 Linalool
1 5-Aminolevulinic acid
1 Photodynamic Therapy
1 Glucose
1 Alpha-Lipoic-Acid
1 entinostat
1 Artemisinin
1 Radiotherapy/Radiation
1 bempedoic acid
1 borneol
1 α-Bisabolol / Chamomile oil
1 Butyrate
1 Carvacrol
1 Cannabidiol
1 Celastrol
1 Cinnamon
1 Citric Acid
1 Crocetin
1 Cyclopamine
1 Cynaropicrin
1 Docosahexaenoic Acid
1 Dihydrocaffeic Acid
1 Docetaxel
1 Disulfiram
1 Emodin
1 Ferulic acid
1 Fennel Oil/Foeniculum vulgare
1 Fisetin
1 Formononetin
1 Gambogic Acid
1 Ginger/6-Shogaol/Gingerol
1 Graviola
1 Hibiscus sabdariffa
1 HydroxyTyrosol
1 Hyperoside
1 Indole-3-carbinol
1 Inulin Prebiotic
1 Isoliquiritigenin
1 Lapatinib
1 Lycopene
1 Methylene blue
1 Magnetic Field Rotating
1 Bicarbonate(Sodium)
1 Nimbolide
1 Pachymic acid
1 Piperlongumine
1 Plumbagin
1 salinomycin
1 Sanguinarine
1 Selenium NanoParticles
1 Silymarin (Milk Thistle) silibinin
1 Shikonin
1 Selenium
1 Ursolic acid
1 Vitexin
1 Wogonin

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:0  prod#:%  Target#:614  State#:%  Dir#:2
  wNotes=0  sortOrder:rid,rpid

mtDam Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Metal & Cofactor Biology(tgid=2) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Kinase & Signal Transduction(tgid=6) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

Protein Folding & ER Stress(tgid=8) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Cell Cycle & Senescence(tgid=11) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Cellular Microenvironment(tgid=17) ⓘ

Protein Aggregation(tgid=19) ⓘ

Hormonal & Nuclear Receptors(tgid=20) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Core Metabolism/Glycolysis(tgid=4) ⓘ

Cell Death(tgid=5) ⓘ

Autophagy & Lysosomes(tgid=9) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

Home Page